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Protein

Fez family zinc finger protein 1

Gene

Fezf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri260 – 282C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 423C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: MGI
  • forebrain anterior/posterior pattern specification Source: MGI
  • forebrain development Source: MGI
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • neuron migration Source: MGI
  • olfactory bulb development Source: MGI
  • positive regulation of neuron differentiation Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • telencephalon development Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Fez family zinc finger protein 1
Gene namesi
Name:Fezf1
Synonyms:Fez
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1920441. Fezf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Null mutants were born alive but most of them died within one day. The olfactory bulbs were smaller than those of their wild-type at E18.5 and at postnatal day 0. At E14.5 and E18 no abnormalities in the morphology of the telencephalon or diencephalon were detected. There seems to be a redundant role for FEZF1 and FEZF2 in diencephalon development.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951151 – 475Fez family zinc finger protein 1Add BLAST475

Proteomic databases

PaxDbiQ0VDQ9.
PRIDEiQ0VDQ9.

PTM databases

iPTMnetiQ0VDQ9.
PhosphoSitePlusiQ0VDQ9.

Expressioni

Developmental stagei

At E8.0 expressed in prospective forebrain region. At E12.5, detected in the olfactory epithelium, septum, roof of the telencephalon, amygdala, prethalamus and hypothalamus. Expression was barely detected in the vomeronasal organs at E12.5. At E15.5, detected weakly in the olfactory epithelium, amygdala and hypothalamusat E15.5. Expression was not detected in the olfactory bulb or in the ganglionic eminences, where the interneuron progenitors of the olfactory bulb are generated.2 Publications

Gene expression databases

BgeeiENSMUSG00000029697.
CleanExiMM_FEZF1.
GenevisibleiQ0VDQ9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031709.

Structurei

3D structure databases

ProteinModelPortaliQ0VDQ9.
SMRiQ0VDQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi28 – 43Engrailed homology 1 repressorAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi433 – 467Pro-richAdd BLAST35

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri260 – 282C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 423C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00740000115096.
HOGENOMiHOG000013052.
HOVERGENiHBG098441.
InParanoidiQ0VDQ9.
OMAiCHNATAK.
OrthoDBiEOG091G0ISJ.
PhylomeDBiQ0VDQ9.
TreeFamiTF316780.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VDQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSCLNATT KMLATAPARG NVMSTSKPLA FSIERIMART PEPKALPVPH
60 70 80 90 100
FLQGAVPKGD PKHSLHLNSS IPCMIPFVPV AYDTNSKAGV NGSEPRKASL
110 120 130 140 150
EVPAPPAVAP SAPAFSCSDL LNCALSLKGD LARDALPLQQ YKLVRPRVVN
160 170 180 190 200
HSSFHAMGAL CYLNRGDGPC HPAASVNIHP VASYFLSSPL HPQPKTYLAE
210 220 230 240 250
RNKLVVPAVE KLPSGVAFKD LSQAQLQHYM KESAQLLSEK IAFKTSDFSR
260 270 280 290 300
GSPNAKPKVF TCEVCGKVFN AHYNLTRHMP VHTGARPFVC KVCGKGFRQA
310 320 330 340 350
STLCRHKIIH TQEKPHKCNQ CGKAFNRSST LNTHTRIHAG YKPFVCEFCG
360 370 380 390 400
KGFHQKGNYK NHKLTHSGEK QFKCNICNKA FHQVYNLTFH MHTHNDKKPF
410 420 430 440 450
TCPTCGKGFC RNFDLKKHVR KLHDSSLGLT RTPTGEPSSD PPPQLQQPPP
460 470
APLPPLQPTL PPPGPLPSGL HQGHQ
Length:475
Mass (Da):52,006
Last modified:September 5, 2006 - v1
Checksum:iA4DC07D1BA3DE2D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178I → M in BAB29221 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014242 mRNA. Translation: BAB29221.1.
BC119565 mRNA. Translation: AAI19566.1.
BC119566 mRNA. Translation: AAI19567.1.
CCDSiCCDS51725.1.
RefSeqiNP_082738.1. NM_028462.1.
XP_006505238.1. XM_006505175.3.
UniGeneiMm.55115.

Genome annotation databases

EnsembliENSMUST00000031709; ENSMUSP00000031709; ENSMUSG00000029697.
GeneIDi73191.
KEGGimmu:73191.
UCSCiuc009bbd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014242 mRNA. Translation: BAB29221.1.
BC119565 mRNA. Translation: AAI19566.1.
BC119566 mRNA. Translation: AAI19567.1.
CCDSiCCDS51725.1.
RefSeqiNP_082738.1. NM_028462.1.
XP_006505238.1. XM_006505175.3.
UniGeneiMm.55115.

3D structure databases

ProteinModelPortaliQ0VDQ9.
SMRiQ0VDQ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031709.

PTM databases

iPTMnetiQ0VDQ9.
PhosphoSitePlusiQ0VDQ9.

Proteomic databases

PaxDbiQ0VDQ9.
PRIDEiQ0VDQ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031709; ENSMUSP00000031709; ENSMUSG00000029697.
GeneIDi73191.
KEGGimmu:73191.
UCSCiuc009bbd.2. mouse.

Organism-specific databases

CTDi389549.
MGIiMGI:1920441. Fezf1.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00740000115096.
HOGENOMiHOG000013052.
HOVERGENiHBG098441.
InParanoidiQ0VDQ9.
OMAiCHNATAK.
OrthoDBiEOG091G0ISJ.
PhylomeDBiQ0VDQ9.
TreeFamiTF316780.

Miscellaneous databases

PROiQ0VDQ9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029697.
CleanExiMM_FEZF1.
GenevisibleiQ0VDQ9. MM.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFEZF1_MOUSE
AccessioniPrimary (citable) accession number: Q0VDQ9
Secondary accession number(s): Q9CXM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: September 5, 2006
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.