ID   TM267_HUMAN             Reviewed;         215 AA.
AC   Q0VDI3; B2RDA6; Q9H6Z2;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   24-JAN-2024, entry version 112.
DE   RecName: Full=Transmembrane protein 267 {ECO:0000312|HGNC:HGNC:26139};
GN   Name=TMEM267 {ECO:0000312|HGNC:HGNC:26139}; Synonyms=C5orf28;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lymph, and PNS;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q0VDI3; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-17555467, EBI-18013275;
CC       Q0VDI3; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-17555467, EBI-10244780;
CC       Q0VDI3; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-17555467, EBI-3920694;
CC       Q0VDI3; O15400: STX7; NbExp=3; IntAct=EBI-17555467, EBI-3221827;
CC       Q0VDI3; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-17555467, EBI-8638294;
CC       Q0VDI3; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-17555467, EBI-18178701;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK025310; BAB15108.1; -; mRNA.
DR   EMBL; AK315466; BAG37853.1; -; mRNA.
DR   EMBL; CH471119; EAW56061.1; -; Genomic_DNA.
DR   EMBL; BC063832; AAH63832.1; -; mRNA.
DR   EMBL; BC013351; AAH13351.1; -; mRNA.
DR   EMBL; BC119658; AAI19659.1; -; mRNA.
DR   EMBL; BC119659; AAI19660.1; -; mRNA.
DR   CCDS; CCDS3945.1; -.
DR   RefSeq; NP_071928.2; NM_022483.4.
DR   RefSeq; XP_005248390.1; XM_005248333.4.
DR   RefSeq; XP_005248392.1; XM_005248335.3.
DR   RefSeq; XP_006714549.1; XM_006714486.3.
DR   RefSeq; XP_011512376.1; XM_011514074.2.
DR   RefSeq; XP_011512377.1; XM_011514075.2.
DR   AlphaFoldDB; Q0VDI3; -.
DR   BioGRID; 122166; 15.
DR   IntAct; Q0VDI3; 9.
DR   STRING; 9606.ENSP00000426067; -.
DR   SwissPalm; Q0VDI3; -.
DR   BioMuta; TMEM267; -.
DR   DMDM; 121940485; -.
DR   EPD; Q0VDI3; -.
DR   jPOST; Q0VDI3; -.
DR   MassIVE; Q0VDI3; -.
DR   MaxQB; Q0VDI3; -.
DR   PaxDb; 9606-ENSP00000426067; -.
DR   PeptideAtlas; Q0VDI3; -.
DR   ProteomicsDB; 58829; -.
DR   Pumba; Q0VDI3; -.
DR   Antibodypedia; 67211; 34 antibodies from 9 providers.
DR   DNASU; 64417; -.
DR   Ensembl; ENST00000397080.8; ENSP00000380270.3; ENSG00000151881.15.
DR   Ensembl; ENST00000500337.6; ENSP00000426067.1; ENSG00000151881.15.
DR   Ensembl; ENST00000512085.5; ENSP00000422881.1; ENSG00000151881.15.
DR   GeneID; 64417; -.
DR   KEGG; hsa:64417; -.
DR   MANE-Select; ENST00000397080.8; ENSP00000380270.3; NM_022483.5; NP_071928.2.
DR   UCSC; uc003jnv.5; human.
DR   AGR; HGNC:26139; -.
DR   CTD; 64417; -.
DR   DisGeNET; 64417; -.
DR   GeneCards; TMEM267; -.
DR   HGNC; HGNC:26139; TMEM267.
DR   HPA; ENSG00000151881; Tissue enhanced (thyroid).
DR   neXtProt; NX_Q0VDI3; -.
DR   OpenTargets; ENSG00000151881; -.
DR   PharmGKB; PA162380004; -.
DR   VEuPathDB; HostDB:ENSG00000151881; -.
DR   eggNOG; ENOG502QQ1U; Eukaryota.
DR   GeneTree; ENSGT00390000003050; -.
DR   InParanoid; Q0VDI3; -.
DR   OMA; FYICTAC; -.
DR   OrthoDB; 2957831at2759; -.
DR   PhylomeDB; Q0VDI3; -.
DR   TreeFam; TF323520; -.
DR   PathwayCommons; Q0VDI3; -.
DR   SignaLink; Q0VDI3; -.
DR   BioGRID-ORCS; 64417; 5 hits in 1135 CRISPR screens.
DR   ChiTaRS; TMEM267; human.
DR   GenomeRNAi; 64417; -.
DR   Pharos; Q0VDI3; Tdark.
DR   PRO; PR:Q0VDI3; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q0VDI3; Protein.
DR   Bgee; ENSG00000151881; Expressed in islet of Langerhans and 162 other cell types or tissues.
DR   ExpressionAtlas; Q0VDI3; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR026572; TMEM267.
DR   PANTHER; PTHR13628:SF1; TRANSMEMBRANE PROTEIN 267; 1.
DR   PANTHER; PTHR13628; UNCHARACTERIZED; 1.
DR   Genevisible; Q0VDI3; HS.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..215
FT                   /note="Transmembrane protein 267"
FT                   /id="PRO_0000281921"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        86
FT                   /note="L -> F (in Ref. 1; BAB15108)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   215 AA;  24217 MW;  7E18288823B3BDE6 CRC64;
     MASETEKTHA LLQTCSTESL ISSLGLGAFC LVADRLLQFS TIQQNDWLRA LSDNAVHCVI
     GMWSWAVVTG IKKKTDFGEI ILAGFLASVI DVDHFFLAGS MSLKAALTLP RRPFLHCSTV
     IPVVVLTLKF TMHLFKLKDS WCFLPWMLFI SWTSHHIRDG IRHGLWICPF GKTSPLPFWL
     YVIITSSLPH ICSFVMYLTG TRQMMSSKHG VRIDV
//