Q0VDG4 (SCRN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Secernin-3

Gene names

Name:

SCRN3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	424 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the peptidase C69 family. Secernin subfamily.
Sequence caution	The sequence AAY24217.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular_function	dipeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q0VDG4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q0VDG4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MEPFSCDTFVALPPATVDNRIIFGKNS → MPPLATPPSVHLSLRVAGRP

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 424	424	Secernin-3		PRO_0000262559
Sites
	Active site	6	1	Potential
Natural variations
	Alternative sequence	1 – 27	27	MEPFS…FGKNS → MPPLATPPSVHLSLRVAGRP in isoform 2.		VSP_042720
	Natural variant	18	1	D → N. Corresponds to variant rs10497410 [ dbSNP | Ensembl ].		VAR_053611
	Natural variant	179	1	V → A. Corresponds to variant rs6716400 [ dbSNP | Ensembl ].		VAR_034487

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: C50D5DFFD413AC9D	FASTA	424	48,544
	10 20 30 40 50 60 MEPFSCDTFV ALPPATVDNR IIFGKNSDRL YDEVQEVVYF PAVVHDNLGE RLKCTYIEID 70 80 90 100 110 120 QVPETYAVVL SRPAWLWGAE MGANEHGVCI GNEAVWGREE VCDEEALLGM DLVRLGLERA 130 140 150 160 170 180 DTAEKALNVI VDLLEKYGQG GNCTEGRMVF SYHNSFLIAD RNEAWILETA GKYWAAEKVQ 190 200 210 220 230 240 EGVRNISNQL SITTKIAREH PDMRNYAKRK GWWDGKKEFD FAAAYSYLDT AKMMTSSGRY 250 260 270 280 290 300 CEGYKLLNKH KGNITFETMM EILRDKPSGI NMEGEFLTTA SMVSILPQDS SLPCIHFFTG 310 320 330 340 350 360 TPDPERSVFK PFIFVPHISQ LLDTSSPTFE LEDLVKKKSH FKPDRRHPLY QKHQQALEVV 370 380 390 400 410 420 NNNEEKAKIM LDNMRKLEKE LFREMESILQ NKHLDVEKIV NLFPQCTKDE IQIYQSNLSV KVSS
	Isoform 2 [UniParc]. Checksum: 83721E1C58475D6F	FASTA	417	47,670
	10 20 30 40 50 60 MPPLATPPSV HLSLRVAGRP DRLYDEVQEV VYFPAVVHDN LGERLKCTYI EIDQVPETYA 70 80 90 100 110 120 VVLSRPAWLW GAEMGANEHG VCIGNEAVWG REEVCDEEAL LGMDLVRLGL ERADTAEKAL 130 140 150 160 170 180 NVIVDLLEKY GQGGNCTEGR MVFSYHNSFL IADRNEAWIL ETAGKYWAAE KVQEGVRNIS 190 200 210 220 230 240 NQLSITTKIA REHPDMRNYA KRKGWWDGKK EFDFAAAYSY LDTAKMMTSS GRYCEGYKLL 250 260 270 280 290 300 NKHKGNITFE TMMEILRDKP SGINMEGEFL TTASMVSILP QDSSLPCIHF FTGTPDPERS 310 320 330 340 350 360 VFKPFIFVPH ISQLLDTSSP TFELEDLVKK KSHFKPDRRH PLYQKHQQAL EVVNNNEEKA 370 380 390 400 410 KIMLDNMRKL EKELFREMES ILQNKHLDVE KIVNLFPQCT KDEIQIYQSN LSVKVSS

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 186-424 (ISOFORM 1). Tissue: Corpus callosum and Lung.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK295357 mRNA. Translation: BAG58323.1. AC018470 Genomic DNA. Translation: AAY24217.1. Sequence problems. CH471058 Genomic DNA. Translation: EAX11140.1. CH471058 Genomic DNA. Translation: EAX11141.1. CH471058 Genomic DNA. Translation: EAX11142.1. BC031821 mRNA. Translation: AAH31821.2. BC119685 mRNA. Translation: AAI19686.1. AK026795 mRNA. Translation: BAB15555.1.
IPI	IPI00002311. IPI00916931.
RefSeq	NP_001180457.1. NM_001193528.1. NP_078859.2. NM_024583.4.
UniGene	Hs.470679.
3D structure databases
ProteinModelPortal	Q0VDG4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q0VDG4. 1 interaction.
Protein family/group databases
MEROPS	C69.005.
PTM databases
PhosphoSite	Q0VDG4.
Polymorphism databases
DMDM	118573861.
Proteomic databases
PaxDb	Q0VDG4.
PRIDE	Q0VDG4.
Protocols and materials databases
DNASU	79634.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000272732; ENSP00000272732; ENSG00000144306. ENST00000409673; ENSP00000387142; ENSG00000144306.
GeneID	79634.
KEGG	hsa:79634.
UCSC	uc002uiq.3. human.
Organism-specific databases
CTD	79634.
GeneCards	GC02P175260.
HGNC	HGNC:30382. SCRN3.
HPA	HPA034690.
MIM	614967. gene.
neXtProt	NX_Q0VDG4.
PharmGKB	PA134974313.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4690.
HOGENOM	HOG000223307.
HOVERGEN	HBG056050.
InParanoid	Q0VDG4.
KO	K14358.
OMA	NCTEGRM.
PhylomeDB	Q0VDG4.
Gene expression databases
ArrayExpress	Q0VDG4.
Bgee	Q0VDG4.
CleanEx	HS_SCRN3.
Genevestigator	Q0VDG4.
Family and domain databases
InterPro	IPR005322. Peptidase_C69. [Graphical view]
Pfam	PF03577. Peptidase_C69. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SCRN3. human.
GenomeRNAi	79634.
NextBio	68745.
SOURCE	Search...

Entry information

Entry name

SCRN3_HUMAN

Accession

Primary (citable) accession number: Q0VDG4
Secondary accession number(s): B4DI11 , C9JPC1, D3DPE0, Q7L1C5, Q9H5R5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	September 5, 2006
Last modified:	March 6, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.