Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q0VDG4

- SCRN3_HUMAN

UniProt

Q0VDG4 - SCRN3_HUMAN

Protein

Secernin-3

Gene

SCRN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei6 – 61Sequence Analysis

    GO - Molecular functioni

    1. dipeptidase activity Source: InterPro

    Protein family/group databases

    MEROPSiC69.005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secernin-3
    Gene namesi
    Name:SCRN3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:30382. SCRN3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134974313.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424Secernin-3PRO_0000262559Add
    BLAST

    Proteomic databases

    MaxQBiQ0VDG4.
    PaxDbiQ0VDG4.
    PRIDEiQ0VDG4.

    PTM databases

    PhosphoSiteiQ0VDG4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ0VDG4.
    BgeeiQ0VDG4.
    CleanExiHS_SCRN3.
    GenevestigatoriQ0VDG4.

    Organism-specific databases

    HPAiHPA034690.

    Interactioni

    Protein-protein interaction databases

    BioGridi122764. 2 interactions.
    IntActiQ0VDG4. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0VDG4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG4690.
    HOGENOMiHOG000223307.
    HOVERGENiHBG056050.
    InParanoidiQ0VDG4.
    KOiK14358.
    OMAiSPGRYCE.
    OrthoDBiEOG7W1545.
    PhylomeDBiQ0VDG4.
    TreeFamiTF323890.

    Family and domain databases

    InterProiIPR005322. Peptidase_C69.
    [Graphical view]
    PfamiPF03577. Peptidase_C69. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q0VDG4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPFSCDTFV ALPPATVDNR IIFGKNSDRL YDEVQEVVYF PAVVHDNLGE    50
    RLKCTYIEID QVPETYAVVL SRPAWLWGAE MGANEHGVCI GNEAVWGREE 100
    VCDEEALLGM DLVRLGLERA DTAEKALNVI VDLLEKYGQG GNCTEGRMVF 150
    SYHNSFLIAD RNEAWILETA GKYWAAEKVQ EGVRNISNQL SITTKIAREH 200
    PDMRNYAKRK GWWDGKKEFD FAAAYSYLDT AKMMTSSGRY CEGYKLLNKH 250
    KGNITFETMM EILRDKPSGI NMEGEFLTTA SMVSILPQDS SLPCIHFFTG 300
    TPDPERSVFK PFIFVPHISQ LLDTSSPTFE LEDLVKKKSH FKPDRRHPLY 350
    QKHQQALEVV NNNEEKAKIM LDNMRKLEKE LFREMESILQ NKHLDVEKIV 400
    NLFPQCTKDE IQIYQSNLSV KVSS 424
    Length:424
    Mass (Da):48,544
    Last modified:September 5, 2006 - v1
    Checksum:iC50D5DFFD413AC9D
    GO
    Isoform 2 (identifier: Q0VDG4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-27: MEPFSCDTFVALPPATVDNRIIFGKNS → MPPLATPPSVHLSLRVAGRP

    Note: No experimental confirmation available.

    Show »
    Length:417
    Mass (Da):47,670
    Checksum:i83721E1C58475D6F
    GO

    Sequence cautioni

    The sequence AAY24217.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181D → N.
    Corresponds to variant rs10497410 [ dbSNP | Ensembl ].
    VAR_053611
    Natural varianti108 – 1081L → S.1 Publication
    VAR_069467
    Natural varianti179 – 1791V → A.
    Corresponds to variant rs6716400 [ dbSNP | Ensembl ].
    VAR_034487

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2727MEPFS…FGKNS → MPPLATPPSVHLSLRVAGRP in isoform 2. 1 PublicationVSP_042720Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK295357 mRNA. Translation: BAG58323.1.
    AC018470 Genomic DNA. Translation: AAY24217.1. Sequence problems.
    CH471058 Genomic DNA. Translation: EAX11140.1.
    CH471058 Genomic DNA. Translation: EAX11141.1.
    CH471058 Genomic DNA. Translation: EAX11142.1.
    BC031821 mRNA. Translation: AAH31821.2.
    BC119685 mRNA. Translation: AAI19686.1.
    AK026795 mRNA. Translation: BAB15555.1.
    CCDSiCCDS2258.1. [Q0VDG4-1]
    CCDS54420.1. [Q0VDG4-2]
    RefSeqiNP_001180457.1. NM_001193528.1. [Q0VDG4-2]
    NP_078859.2. NM_024583.4. [Q0VDG4-1]
    XP_005246911.1. XM_005246854.2. [Q0VDG4-1]
    XP_005246912.1. XM_005246855.1. [Q0VDG4-1]
    XP_005246913.1. XM_005246856.1. [Q0VDG4-1]
    XP_005246914.1. XM_005246857.1. [Q0VDG4-1]
    UniGeneiHs.470679.

    Genome annotation databases

    EnsembliENST00000272732; ENSP00000272732; ENSG00000144306. [Q0VDG4-1]
    ENST00000409673; ENSP00000387142; ENSG00000144306. [Q0VDG4-2]
    GeneIDi79634.
    KEGGihsa:79634.
    UCSCiuc002uiq.3. human. [Q0VDG4-1]
    uc010zen.2. human. [Q0VDG4-2]

    Polymorphism databases

    DMDMi118573861.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK295357 mRNA. Translation: BAG58323.1 .
    AC018470 Genomic DNA. Translation: AAY24217.1 . Sequence problems.
    CH471058 Genomic DNA. Translation: EAX11140.1 .
    CH471058 Genomic DNA. Translation: EAX11141.1 .
    CH471058 Genomic DNA. Translation: EAX11142.1 .
    BC031821 mRNA. Translation: AAH31821.2 .
    BC119685 mRNA. Translation: AAI19686.1 .
    AK026795 mRNA. Translation: BAB15555.1 .
    CCDSi CCDS2258.1. [Q0VDG4-1 ]
    CCDS54420.1. [Q0VDG4-2 ]
    RefSeqi NP_001180457.1. NM_001193528.1. [Q0VDG4-2 ]
    NP_078859.2. NM_024583.4. [Q0VDG4-1 ]
    XP_005246911.1. XM_005246854.2. [Q0VDG4-1 ]
    XP_005246912.1. XM_005246855.1. [Q0VDG4-1 ]
    XP_005246913.1. XM_005246856.1. [Q0VDG4-1 ]
    XP_005246914.1. XM_005246857.1. [Q0VDG4-1 ]
    UniGenei Hs.470679.

    3D structure databases

    ProteinModelPortali Q0VDG4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122764. 2 interactions.
    IntActi Q0VDG4. 1 interaction.

    Protein family/group databases

    MEROPSi C69.005.

    PTM databases

    PhosphoSitei Q0VDG4.

    Polymorphism databases

    DMDMi 118573861.

    Proteomic databases

    MaxQBi Q0VDG4.
    PaxDbi Q0VDG4.
    PRIDEi Q0VDG4.

    Protocols and materials databases

    DNASUi 79634.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000272732 ; ENSP00000272732 ; ENSG00000144306 . [Q0VDG4-1 ]
    ENST00000409673 ; ENSP00000387142 ; ENSG00000144306 . [Q0VDG4-2 ]
    GeneIDi 79634.
    KEGGi hsa:79634.
    UCSCi uc002uiq.3. human. [Q0VDG4-1 ]
    uc010zen.2. human. [Q0VDG4-2 ]

    Organism-specific databases

    CTDi 79634.
    GeneCardsi GC02P175260.
    HGNCi HGNC:30382. SCRN3.
    HPAi HPA034690.
    MIMi 614967. gene.
    neXtProti NX_Q0VDG4.
    PharmGKBi PA134974313.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4690.
    HOGENOMi HOG000223307.
    HOVERGENi HBG056050.
    InParanoidi Q0VDG4.
    KOi K14358.
    OMAi SPGRYCE.
    OrthoDBi EOG7W1545.
    PhylomeDBi Q0VDG4.
    TreeFami TF323890.

    Miscellaneous databases

    ChiTaRSi SCRN3. human.
    GenomeRNAii 79634.
    NextBioi 68745.
    PROi Q0VDG4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q0VDG4.
    Bgeei Q0VDG4.
    CleanExi HS_SCRN3.
    Genevestigatori Q0VDG4.

    Family and domain databases

    InterProi IPR005322. Peptidase_C69.
    [Graphical view ]
    Pfami PF03577. Peptidase_C69. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 186-424 (ISOFORM 1).
      Tissue: Corpus callosum and Lung.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: VARIANT SER-108.

    Entry informationi

    Entry nameiSCRN3_HUMAN
    AccessioniPrimary (citable) accession number: Q0VDG4
    Secondary accession number(s): B4DI11
    , C9JPC1, D3DPE0, Q7L1C5, Q9H5R5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3