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Protein

Secernin-3

Gene

SCRN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei6Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPSiC69.005

Names & Taxonomyi

Protein namesi
Recommended name:
Secernin-3
Gene namesi
Name:SCRN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144306.13
HGNCiHGNC:30382 SCRN3
MIMi614967 gene
neXtProtiNX_Q0VDG4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144306
PharmGKBiPA134974313

Polymorphism and mutation databases

BioMutaiSCRN3
DMDMi118573861

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002625591 – 424Secernin-3Add BLAST424

Proteomic databases

EPDiQ0VDG4
MaxQBiQ0VDG4
PaxDbiQ0VDG4
PeptideAtlasiQ0VDG4
PRIDEiQ0VDG4
ProteomicsDBi58826
58827 [Q0VDG4-2]

PTM databases

iPTMnetiQ0VDG4
PhosphoSitePlusiQ0VDG4

Expressioni

Gene expression databases

BgeeiENSG00000144306
CleanExiHS_SCRN3
ExpressionAtlasiQ0VDG4 baseline and differential
GenevisibleiQ0VDG4 HS

Organism-specific databases

HPAiHPA034689
HPA034690

Interactioni

Protein-protein interaction databases

BioGridi122764, 7 interactors
IntActiQ0VDG4, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ0VDG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IGQK Eukaryota
COG4690 LUCA
GeneTreeiENSGT00390000013474
HOGENOMiHOG000089997
HOVERGENiHBG056050
InParanoidiQ0VDG4
KOiK14358
OMAiEVQEVIY
PhylomeDBiQ0VDG4
TreeFamiTF323890

Family and domain databases

InterProiView protein in InterPro
IPR005322 Peptidase_C69
PANTHERiPTHR12994 PTHR12994, 1 hit
PfamiView protein in Pfam
PF03577 Peptidase_C69, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0VDG4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPFSCDTFV ALPPATVDNR IIFGKNSDRL YDEVQEVVYF PAVVHDNLGE
60 70 80 90 100
RLKCTYIEID QVPETYAVVL SRPAWLWGAE MGANEHGVCI GNEAVWGREE
110 120 130 140 150
VCDEEALLGM DLVRLGLERA DTAEKALNVI VDLLEKYGQG GNCTEGRMVF
160 170 180 190 200
SYHNSFLIAD RNEAWILETA GKYWAAEKVQ EGVRNISNQL SITTKIAREH
210 220 230 240 250
PDMRNYAKRK GWWDGKKEFD FAAAYSYLDT AKMMTSSGRY CEGYKLLNKH
260 270 280 290 300
KGNITFETMM EILRDKPSGI NMEGEFLTTA SMVSILPQDS SLPCIHFFTG
310 320 330 340 350
TPDPERSVFK PFIFVPHISQ LLDTSSPTFE LEDLVKKKSH FKPDRRHPLY
360 370 380 390 400
QKHQQALEVV NNNEEKAKIM LDNMRKLEKE LFREMESILQ NKHLDVEKIV
410 420
NLFPQCTKDE IQIYQSNLSV KVSS
Length:424
Mass (Da):48,544
Last modified:September 5, 2006 - v1
Checksum:iC50D5DFFD413AC9D
GO
Isoform 2 (identifier: Q0VDG4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MEPFSCDTFVALPPATVDNRIIFGKNS → MPPLATPPSVHLSLRVAGRP

Note: No experimental confirmation available.
Show »
Length:417
Mass (Da):47,670
Checksum:i83721E1C58475D6F
GO

Sequence cautioni

The sequence AAY24217 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05361118D → N. Corresponds to variant dbSNP:rs10497410Ensembl.1
Natural variantiVAR_069467108L → S1 Publication1
Natural variantiVAR_034487179V → A. Corresponds to variant dbSNP:rs6716400Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0427201 – 27MEPFS…FGKNS → MPPLATPPSVHLSLRVAGRP in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295357 mRNA Translation: BAG58323.1
AC018470 Genomic DNA Translation: AAY24217.1 Sequence problems.
CH471058 Genomic DNA Translation: EAX11140.1
CH471058 Genomic DNA Translation: EAX11141.1
CH471058 Genomic DNA Translation: EAX11142.1
BC031821 mRNA Translation: AAH31821.2
BC119685 mRNA Translation: AAI19686.1
AK026795 mRNA Translation: BAB15555.1
CCDSiCCDS2258.1 [Q0VDG4-1]
CCDS54420.1 [Q0VDG4-2]
RefSeqiNP_001180457.1, NM_001193528.1 [Q0VDG4-2]
NP_078859.2, NM_024583.4 [Q0VDG4-1]
XP_005246911.1, XM_005246854.4 [Q0VDG4-1]
XP_005246912.1, XM_005246855.2 [Q0VDG4-1]
XP_005246913.1, XM_005246856.2 [Q0VDG4-1]
XP_005246914.1, XM_005246857.2 [Q0VDG4-1]
XP_016860398.1, XM_017004909.1 [Q0VDG4-1]
XP_016860399.1, XM_017004910.1 [Q0VDG4-1]
UniGeneiHs.470679

Genome annotation databases

EnsembliENST00000272732; ENSP00000272732; ENSG00000144306 [Q0VDG4-1]
ENST00000409673; ENSP00000387142; ENSG00000144306 [Q0VDG4-2]
GeneIDi79634
KEGGihsa:79634
UCSCiuc002uiq.4 human [Q0VDG4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSCRN3_HUMAN
AccessioniPrimary (citable) accession number: Q0VDG4
Secondary accession number(s): B4DI11
, C9JPC1, D3DPE0, Q7L1C5, Q9H5R5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: September 5, 2006
Last modified: June 20, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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