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Q0VDG4

- SCRN3_HUMAN

UniProt

Q0VDG4 - SCRN3_HUMAN

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Protein
Secernin-3
Gene
SCRN3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei6 – 61 Reviewed prediction

GO - Molecular functioni

  1. dipeptidase activity Source: InterPro
Complete GO annotation...

Protein family/group databases

MEROPSiC69.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Secernin-3
Gene namesi
Name:SCRN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:30382. SCRN3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134974313.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Secernin-3
PRO_0000262559Add
BLAST

Proteomic databases

MaxQBiQ0VDG4.
PaxDbiQ0VDG4.
PRIDEiQ0VDG4.

PTM databases

PhosphoSiteiQ0VDG4.

Expressioni

Gene expression databases

ArrayExpressiQ0VDG4.
BgeeiQ0VDG4.
CleanExiHS_SCRN3.
GenevestigatoriQ0VDG4.

Organism-specific databases

HPAiHPA034690.

Interactioni

Protein-protein interaction databases

BioGridi122764. 2 interactions.
IntActiQ0VDG4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ0VDG4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4690.
HOGENOMiHOG000223307.
HOVERGENiHBG056050.
InParanoidiQ0VDG4.
KOiK14358.
OMAiSPGRYCE.
OrthoDBiEOG7W1545.
PhylomeDBiQ0VDG4.
TreeFamiTF323890.

Family and domain databases

InterProiIPR005322. Peptidase_C69.
[Graphical view]
PfamiPF03577. Peptidase_C69. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q0VDG4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEPFSCDTFV ALPPATVDNR IIFGKNSDRL YDEVQEVVYF PAVVHDNLGE    50
RLKCTYIEID QVPETYAVVL SRPAWLWGAE MGANEHGVCI GNEAVWGREE 100
VCDEEALLGM DLVRLGLERA DTAEKALNVI VDLLEKYGQG GNCTEGRMVF 150
SYHNSFLIAD RNEAWILETA GKYWAAEKVQ EGVRNISNQL SITTKIAREH 200
PDMRNYAKRK GWWDGKKEFD FAAAYSYLDT AKMMTSSGRY CEGYKLLNKH 250
KGNITFETMM EILRDKPSGI NMEGEFLTTA SMVSILPQDS SLPCIHFFTG 300
TPDPERSVFK PFIFVPHISQ LLDTSSPTFE LEDLVKKKSH FKPDRRHPLY 350
QKHQQALEVV NNNEEKAKIM LDNMRKLEKE LFREMESILQ NKHLDVEKIV 400
NLFPQCTKDE IQIYQSNLSV KVSS 424
Length:424
Mass (Da):48,544
Last modified:September 5, 2006 - v1
Checksum:iC50D5DFFD413AC9D
GO
Isoform 2 (identifier: Q0VDG4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MEPFSCDTFVALPPATVDNRIIFGKNS → MPPLATPPSVHLSLRVAGRP

Note: No experimental confirmation available.

Show »
Length:417
Mass (Da):47,670
Checksum:i83721E1C58475D6F
GO

Sequence cautioni

The sequence AAY24217.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181D → N.
Corresponds to variant rs10497410 [ dbSNP | Ensembl ].
VAR_053611
Natural varianti108 – 1081L → S.1 Publication
VAR_069467
Natural varianti179 – 1791V → A.
Corresponds to variant rs6716400 [ dbSNP | Ensembl ].
VAR_034487

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2727MEPFS…FGKNS → MPPLATPPSVHLSLRVAGRP in isoform 2.
VSP_042720Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK295357 mRNA. Translation: BAG58323.1.
AC018470 Genomic DNA. Translation: AAY24217.1. Sequence problems.
CH471058 Genomic DNA. Translation: EAX11140.1.
CH471058 Genomic DNA. Translation: EAX11141.1.
CH471058 Genomic DNA. Translation: EAX11142.1.
BC031821 mRNA. Translation: AAH31821.2.
BC119685 mRNA. Translation: AAI19686.1.
AK026795 mRNA. Translation: BAB15555.1.
CCDSiCCDS2258.1. [Q0VDG4-1]
CCDS54420.1. [Q0VDG4-2]
RefSeqiNP_001180457.1. NM_001193528.1. [Q0VDG4-2]
NP_078859.2. NM_024583.4. [Q0VDG4-1]
XP_005246911.1. XM_005246854.2. [Q0VDG4-1]
XP_005246912.1. XM_005246855.1. [Q0VDG4-1]
XP_005246913.1. XM_005246856.1. [Q0VDG4-1]
XP_005246914.1. XM_005246857.1. [Q0VDG4-1]
UniGeneiHs.470679.

Genome annotation databases

EnsembliENST00000272732; ENSP00000272732; ENSG00000144306. [Q0VDG4-1]
ENST00000409673; ENSP00000387142; ENSG00000144306. [Q0VDG4-2]
GeneIDi79634.
KEGGihsa:79634.
UCSCiuc002uiq.3. human. [Q0VDG4-1]
uc010zen.2. human. [Q0VDG4-2]

Polymorphism databases

DMDMi118573861.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK295357 mRNA. Translation: BAG58323.1 .
AC018470 Genomic DNA. Translation: AAY24217.1 . Sequence problems.
CH471058 Genomic DNA. Translation: EAX11140.1 .
CH471058 Genomic DNA. Translation: EAX11141.1 .
CH471058 Genomic DNA. Translation: EAX11142.1 .
BC031821 mRNA. Translation: AAH31821.2 .
BC119685 mRNA. Translation: AAI19686.1 .
AK026795 mRNA. Translation: BAB15555.1 .
CCDSi CCDS2258.1. [Q0VDG4-1 ]
CCDS54420.1. [Q0VDG4-2 ]
RefSeqi NP_001180457.1. NM_001193528.1. [Q0VDG4-2 ]
NP_078859.2. NM_024583.4. [Q0VDG4-1 ]
XP_005246911.1. XM_005246854.2. [Q0VDG4-1 ]
XP_005246912.1. XM_005246855.1. [Q0VDG4-1 ]
XP_005246913.1. XM_005246856.1. [Q0VDG4-1 ]
XP_005246914.1. XM_005246857.1. [Q0VDG4-1 ]
UniGenei Hs.470679.

3D structure databases

ProteinModelPortali Q0VDG4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122764. 2 interactions.
IntActi Q0VDG4. 1 interaction.

Protein family/group databases

MEROPSi C69.005.

PTM databases

PhosphoSitei Q0VDG4.

Polymorphism databases

DMDMi 118573861.

Proteomic databases

MaxQBi Q0VDG4.
PaxDbi Q0VDG4.
PRIDEi Q0VDG4.

Protocols and materials databases

DNASUi 79634.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000272732 ; ENSP00000272732 ; ENSG00000144306 . [Q0VDG4-1 ]
ENST00000409673 ; ENSP00000387142 ; ENSG00000144306 . [Q0VDG4-2 ]
GeneIDi 79634.
KEGGi hsa:79634.
UCSCi uc002uiq.3. human. [Q0VDG4-1 ]
uc010zen.2. human. [Q0VDG4-2 ]

Organism-specific databases

CTDi 79634.
GeneCardsi GC02P175260.
HGNCi HGNC:30382. SCRN3.
HPAi HPA034690.
MIMi 614967. gene.
neXtProti NX_Q0VDG4.
PharmGKBi PA134974313.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4690.
HOGENOMi HOG000223307.
HOVERGENi HBG056050.
InParanoidi Q0VDG4.
KOi K14358.
OMAi SPGRYCE.
OrthoDBi EOG7W1545.
PhylomeDBi Q0VDG4.
TreeFami TF323890.

Miscellaneous databases

ChiTaRSi SCRN3. human.
GenomeRNAii 79634.
NextBioi 68745.
PROi Q0VDG4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q0VDG4.
Bgeei Q0VDG4.
CleanExi HS_SCRN3.
Genevestigatori Q0VDG4.

Family and domain databases

InterProi IPR005322. Peptidase_C69.
[Graphical view ]
Pfami PF03577. Peptidase_C69. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 186-424 (ISOFORM 1).
    Tissue: Corpus callosum and Lung.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: VARIANT SER-108.

Entry informationi

Entry nameiSCRN3_HUMAN
AccessioniPrimary (citable) accession number: Q0VDG4
Secondary accession number(s): B4DI11
, C9JPC1, D3DPE0, Q7L1C5, Q9H5R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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