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Protein

Secernin-3

Gene

SCRN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei6 – 61Sequence Analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Secernin-3
Gene namesi
Name:SCRN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:30382. SCRN3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134974313.

Polymorphism and mutation databases

BioMutaiSCRN3.
DMDMi118573861.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Secernin-3PRO_0000262559Add
BLAST

Proteomic databases

MaxQBiQ0VDG4.
PaxDbiQ0VDG4.
PRIDEiQ0VDG4.

PTM databases

PhosphoSiteiQ0VDG4.

Expressioni

Gene expression databases

BgeeiQ0VDG4.
CleanExiHS_SCRN3.
ExpressionAtlasiQ0VDG4. baseline and differential.
GenevisibleiQ0VDG4. HS.

Organism-specific databases

HPAiHPA034689.
HPA034690.

Interactioni

Protein-protein interaction databases

BioGridi122764. 4 interactions.
IntActiQ0VDG4. 1 interaction.
STRINGi9606.ENSP00000272732.

Structurei

3D structure databases

ProteinModelPortaliQ0VDG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4690.
GeneTreeiENSGT00390000013474.
HOGENOMiHOG000089997.
HOVERGENiHBG056050.
InParanoidiQ0VDG4.
KOiK14358.
OMAiPRFQSKP.
OrthoDBiEOG7W1545.
PhylomeDBiQ0VDG4.
TreeFamiTF323890.

Family and domain databases

InterProiIPR005322. Peptidase_C69.
[Graphical view]
PfamiPF03577. Peptidase_C69. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0VDG4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPFSCDTFV ALPPATVDNR IIFGKNSDRL YDEVQEVVYF PAVVHDNLGE
60 70 80 90 100
RLKCTYIEID QVPETYAVVL SRPAWLWGAE MGANEHGVCI GNEAVWGREE
110 120 130 140 150
VCDEEALLGM DLVRLGLERA DTAEKALNVI VDLLEKYGQG GNCTEGRMVF
160 170 180 190 200
SYHNSFLIAD RNEAWILETA GKYWAAEKVQ EGVRNISNQL SITTKIAREH
210 220 230 240 250
PDMRNYAKRK GWWDGKKEFD FAAAYSYLDT AKMMTSSGRY CEGYKLLNKH
260 270 280 290 300
KGNITFETMM EILRDKPSGI NMEGEFLTTA SMVSILPQDS SLPCIHFFTG
310 320 330 340 350
TPDPERSVFK PFIFVPHISQ LLDTSSPTFE LEDLVKKKSH FKPDRRHPLY
360 370 380 390 400
QKHQQALEVV NNNEEKAKIM LDNMRKLEKE LFREMESILQ NKHLDVEKIV
410 420
NLFPQCTKDE IQIYQSNLSV KVSS
Length:424
Mass (Da):48,544
Last modified:September 5, 2006 - v1
Checksum:iC50D5DFFD413AC9D
GO
Isoform 2 (identifier: Q0VDG4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MEPFSCDTFVALPPATVDNRIIFGKNS → MPPLATPPSVHLSLRVAGRP

Note: No experimental confirmation available.
Show »
Length:417
Mass (Da):47,670
Checksum:i83721E1C58475D6F
GO

Sequence cautioni

The sequence AAY24217.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181D → N.
Corresponds to variant rs10497410 [ dbSNP | Ensembl ].
VAR_053611
Natural varianti108 – 1081L → S.1 Publication
VAR_069467
Natural varianti179 – 1791V → A.
Corresponds to variant rs6716400 [ dbSNP | Ensembl ].
VAR_034487

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2727MEPFS…FGKNS → MPPLATPPSVHLSLRVAGRP in isoform 2. 1 PublicationVSP_042720Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295357 mRNA. Translation: BAG58323.1.
AC018470 Genomic DNA. Translation: AAY24217.1. Sequence problems.
CH471058 Genomic DNA. Translation: EAX11140.1.
CH471058 Genomic DNA. Translation: EAX11141.1.
CH471058 Genomic DNA. Translation: EAX11142.1.
BC031821 mRNA. Translation: AAH31821.2.
BC119685 mRNA. Translation: AAI19686.1.
AK026795 mRNA. Translation: BAB15555.1.
CCDSiCCDS2258.1. [Q0VDG4-1]
CCDS54420.1. [Q0VDG4-2]
RefSeqiNP_001180457.1. NM_001193528.1. [Q0VDG4-2]
NP_078859.2. NM_024583.4. [Q0VDG4-1]
XP_005246911.1. XM_005246854.3. [Q0VDG4-1]
XP_005246912.1. XM_005246855.1. [Q0VDG4-1]
XP_005246913.1. XM_005246856.1. [Q0VDG4-1]
XP_005246914.1. XM_005246857.1. [Q0VDG4-1]
UniGeneiHs.470679.

Genome annotation databases

EnsembliENST00000272732; ENSP00000272732; ENSG00000144306. [Q0VDG4-1]
ENST00000409673; ENSP00000387142; ENSG00000144306. [Q0VDG4-2]
GeneIDi79634.
KEGGihsa:79634.
UCSCiuc002uiq.3. human. [Q0VDG4-1]
uc010zen.2. human. [Q0VDG4-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295357 mRNA. Translation: BAG58323.1.
AC018470 Genomic DNA. Translation: AAY24217.1. Sequence problems.
CH471058 Genomic DNA. Translation: EAX11140.1.
CH471058 Genomic DNA. Translation: EAX11141.1.
CH471058 Genomic DNA. Translation: EAX11142.1.
BC031821 mRNA. Translation: AAH31821.2.
BC119685 mRNA. Translation: AAI19686.1.
AK026795 mRNA. Translation: BAB15555.1.
CCDSiCCDS2258.1. [Q0VDG4-1]
CCDS54420.1. [Q0VDG4-2]
RefSeqiNP_001180457.1. NM_001193528.1. [Q0VDG4-2]
NP_078859.2. NM_024583.4. [Q0VDG4-1]
XP_005246911.1. XM_005246854.3. [Q0VDG4-1]
XP_005246912.1. XM_005246855.1. [Q0VDG4-1]
XP_005246913.1. XM_005246856.1. [Q0VDG4-1]
XP_005246914.1. XM_005246857.1. [Q0VDG4-1]
UniGeneiHs.470679.

3D structure databases

ProteinModelPortaliQ0VDG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122764. 4 interactions.
IntActiQ0VDG4. 1 interaction.
STRINGi9606.ENSP00000272732.

PTM databases

PhosphoSiteiQ0VDG4.

Polymorphism and mutation databases

BioMutaiSCRN3.
DMDMi118573861.

Proteomic databases

MaxQBiQ0VDG4.
PaxDbiQ0VDG4.
PRIDEiQ0VDG4.

Protocols and materials databases

DNASUi79634.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272732; ENSP00000272732; ENSG00000144306. [Q0VDG4-1]
ENST00000409673; ENSP00000387142; ENSG00000144306. [Q0VDG4-2]
GeneIDi79634.
KEGGihsa:79634.
UCSCiuc002uiq.3. human. [Q0VDG4-1]
uc010zen.2. human. [Q0VDG4-2]

Organism-specific databases

CTDi79634.
GeneCardsiGC02P175260.
HGNCiHGNC:30382. SCRN3.
HPAiHPA034689.
HPA034690.
MIMi614967. gene.
neXtProtiNX_Q0VDG4.
PharmGKBiPA134974313.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG4690.
GeneTreeiENSGT00390000013474.
HOGENOMiHOG000089997.
HOVERGENiHBG056050.
InParanoidiQ0VDG4.
KOiK14358.
OMAiPRFQSKP.
OrthoDBiEOG7W1545.
PhylomeDBiQ0VDG4.
TreeFamiTF323890.

Miscellaneous databases

ChiTaRSiSCRN3. human.
GenomeRNAii79634.
NextBioi68745.
PROiQ0VDG4.
SOURCEiSearch...

Gene expression databases

BgeeiQ0VDG4.
CleanExiHS_SCRN3.
ExpressionAtlasiQ0VDG4. baseline and differential.
GenevisibleiQ0VDG4. HS.

Family and domain databases

InterProiIPR005322. Peptidase_C69.
[Graphical view]
PfamiPF03577. Peptidase_C69. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 186-424 (ISOFORM 1).
    Tissue: Corpus callosum and Lung.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: VARIANT SER-108.

Entry informationi

Entry nameiSCRN3_HUMAN
AccessioniPrimary (citable) accession number: Q0VDG4
Secondary accession number(s): B4DI11
, C9JPC1, D3DPE0, Q7L1C5, Q9H5R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: September 5, 2006
Last modified: June 24, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.