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Q0VDG4 (SCRN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Secernin-3
Gene names
Name:SCRN3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the peptidase C69 family. Secernin subfamily.

Sequence caution

The sequence AAY24217.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functiondipeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q0VDG4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q0VDG4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MEPFSCDTFVALPPATVDNRIIFGKNS → MPPLATPPSVHLSLRVAGRP
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 424424Secernin-3
PRO_0000262559

Sites

Active site61 Potential

Natural variations

Alternative sequence1 – 2727MEPFS…FGKNS → MPPLATPPSVHLSLRVAGRP in isoform 2.
VSP_042720
Natural variant181D → N.
Corresponds to variant rs10497410 [ dbSNP | Ensembl ].
VAR_053611
Natural variant1081L → S. Ref.6
VAR_069467
Natural variant1791V → A.
Corresponds to variant rs6716400 [ dbSNP | Ensembl ].
VAR_034487

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: C50D5DFFD413AC9D

FASTA42448,544
        10         20         30         40         50         60 
MEPFSCDTFV ALPPATVDNR IIFGKNSDRL YDEVQEVVYF PAVVHDNLGE RLKCTYIEID 

        70         80         90        100        110        120 
QVPETYAVVL SRPAWLWGAE MGANEHGVCI GNEAVWGREE VCDEEALLGM DLVRLGLERA 

       130        140        150        160        170        180 
DTAEKALNVI VDLLEKYGQG GNCTEGRMVF SYHNSFLIAD RNEAWILETA GKYWAAEKVQ 

       190        200        210        220        230        240 
EGVRNISNQL SITTKIAREH PDMRNYAKRK GWWDGKKEFD FAAAYSYLDT AKMMTSSGRY 

       250        260        270        280        290        300 
CEGYKLLNKH KGNITFETMM EILRDKPSGI NMEGEFLTTA SMVSILPQDS SLPCIHFFTG 

       310        320        330        340        350        360 
TPDPERSVFK PFIFVPHISQ LLDTSSPTFE LEDLVKKKSH FKPDRRHPLY QKHQQALEVV 

       370        380        390        400        410        420 
NNNEEKAKIM LDNMRKLEKE LFREMESILQ NKHLDVEKIV NLFPQCTKDE IQIYQSNLSV 


KVSS 

« Hide

Isoform 2 [UniParc].

Checksum: 83721E1C58475D6F
Show »

FASTA41747,670

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 186-424 (ISOFORM 1).
Tissue: Corpus callosum and Lung.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Exome sequencing identifies PDE4D mutations in acrodysostosis."
Lee H., Graham J.M. Jr., Rimoin D.L., Lachman R.S., Krejci P., Tompson S.W., Nelson S.F., Krakow D., Cohn D.H.
Am. J. Hum. Genet. 90:746-751(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT SER-108.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK295357 mRNA. Translation: BAG58323.1.
AC018470 Genomic DNA. Translation: AAY24217.1. Sequence problems.
CH471058 Genomic DNA. Translation: EAX11140.1.
CH471058 Genomic DNA. Translation: EAX11141.1.
CH471058 Genomic DNA. Translation: EAX11142.1.
BC031821 mRNA. Translation: AAH31821.2.
BC119685 mRNA. Translation: AAI19686.1.
AK026795 mRNA. Translation: BAB15555.1.
CCDSCCDS2258.1. [Q0VDG4-1]
CCDS54420.1. [Q0VDG4-2]
RefSeqNP_001180457.1. NM_001193528.1. [Q0VDG4-2]
NP_078859.2. NM_024583.4. [Q0VDG4-1]
XP_005246911.1. XM_005246854.2. [Q0VDG4-1]
XP_005246912.1. XM_005246855.1. [Q0VDG4-1]
XP_005246913.1. XM_005246856.1. [Q0VDG4-1]
XP_005246914.1. XM_005246857.1. [Q0VDG4-1]
UniGeneHs.470679.

3D structure databases

ProteinModelPortalQ0VDG4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122764. 2 interactions.
IntActQ0VDG4. 1 interaction.

Protein family/group databases

MEROPSC69.005.

PTM databases

PhosphoSiteQ0VDG4.

Polymorphism databases

DMDM118573861.

Proteomic databases

MaxQBQ0VDG4.
PaxDbQ0VDG4.
PRIDEQ0VDG4.

Protocols and materials databases

DNASU79634.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000272732; ENSP00000272732; ENSG00000144306. [Q0VDG4-1]
ENST00000409673; ENSP00000387142; ENSG00000144306. [Q0VDG4-2]
GeneID79634.
KEGGhsa:79634.
UCSCuc002uiq.3. human. [Q0VDG4-1]
uc010zen.2. human. [Q0VDG4-2]

Organism-specific databases

CTD79634.
GeneCardsGC02P175260.
HGNCHGNC:30382. SCRN3.
HPAHPA034690.
MIM614967. gene.
neXtProtNX_Q0VDG4.
PharmGKBPA134974313.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4690.
HOGENOMHOG000223307.
HOVERGENHBG056050.
InParanoidQ0VDG4.
KOK14358.
OMASPGRYCE.
OrthoDBEOG7W1545.
PhylomeDBQ0VDG4.
TreeFamTF323890.

Gene expression databases

ArrayExpressQ0VDG4.
BgeeQ0VDG4.
CleanExHS_SCRN3.
GenevestigatorQ0VDG4.

Family and domain databases

InterProIPR005322. Peptidase_C69.
[Graphical view]
PfamPF03577. Peptidase_C69. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSCRN3. human.
GenomeRNAi79634.
NextBio68745.
PROQ0VDG4.
SOURCESearch...

Entry information

Entry nameSCRN3_HUMAN
AccessionPrimary (citable) accession number: Q0VDG4
Secondary accession number(s): B4DI11 expand/collapse secondary AC list , C9JPC1, D3DPE0, Q7L1C5, Q9H5R5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM