ID   HSP7E_HUMAN             Reviewed;         509 AA.
AC   Q0VDF9; Q9P0X2; Q9UI07;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   07-JUL-2009, entry version 30.
DE   RecName: Full=Heat shock 70 kDa protein 14;
DE   AltName: Full=Heat shock protein HSP60;
DE   AltName: Full=HSP70-like protein 1;
GN   Name=HSPA14; Synonyms=HSP60, HSP70L1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=14592822; DOI=10.1182/blood-2003-08-2828;
RA   Wan T., Zhou X., Chen G., An H., Chen T., Zhang W., Liu S., Jiang Y.,
RA   Yang F., Wu Y., Cao X.;
RT   "Novel heat shock protein Hsp70L1 activates dendritic cells and acts
RT   as a Th1 polarizing adjuvant.";
RL   Blood 103:1747-1754(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Adrenal gland;
RX   MEDLINE=20402571; PubMed=10931946; DOI=10.1073/pnas.160270997;
RA   Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA   Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H.,
RA   Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J.,
RA   Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M.,
RA   Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.;
RT   "Gene expression profiling in the human hypothalamus-pituitary-adrenal
RT   axis and full-length cDNA cloning.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
RA   Colinge J., Superti-Furga G., Bennett K.L.;
RL   Submitted (OCT-2008) to UniProtKB.
RN   [5]
RP   VARIANT [LARGE SCALE ANALYSIS] VAL-85.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA   Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA   Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA   Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA   Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal
RT   cancers.";
RL   Science 314:268-274(2006).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
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DR   EMBL; AF143723; AAF66640.1; -; mRNA.
DR   EMBL; AF112210; AAF17198.1; -; mRNA.
DR   EMBL; BC119690; AAI19691.1; -; mRNA.
DR   IPI; IPI00292499; -.
DR   RefSeq; NP_057383.2; -.
DR   UniGene; Hs.534169; -.
DR   PeptideAtlas; Q0VDF9; -.
DR   PRIDE; Q0VDF9; -.
DR   Ensembl; ENSG00000187522; Homo sapiens.
DR   GeneID; 51182; -.
DR   KEGG; hsa:51182; -.
DR   NMPDR; fig|9606.3.peg.3580; -.
DR   UCSC; uc001inf.1; human.
DR   GeneCards; GC10P014920; -.
DR   HGNC; HGNC:29526; HSPA14.
DR   MIM; 610369; gene.
DR   PharmGKB; PA134979057; -.
DR   HOGENOM; Q0VDF9; -.
DR   HOVERGEN; Q0VDF9; -.
DR   OMA; Q0VDF9; TAHSVLG.
DR   NextBio; 54151; -.
DR   ArrayExpress; Q0VDF9; -.
DR   Bgee; Q0VDF9; -.
DR   CleanEx; HS_HSPA14; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR001023; Hsp70.
DR   InterPro; IPR013126; Hsp_70.
DR   PANTHER; PTHR19375; Hsp70; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   PRINTS; PR00301; HEATSHOCK70.
DR   ProDom; PD000089; Hsp70; 1.
DR   PROSITE; PS00297; HSP70_1; FALSE_NEG.
DR   PROSITE; PS00329; HSP70_2; FALSE_NEG.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Complete proteome; Nucleotide-binding; Polymorphism.
FT   CHAIN         1    509       Heat shock 70 kDa protein 14.
FT                                /FTId=PRO_0000289946.
FT   VARIANT      85     85       A -> V (in a breast cancer sample;
FT                                somatic mutation).
FT                                /FTId=VAR_036347.
FT   CONFLICT     15     15       V -> E (in Ref. 1; AAF66640).
FT   CONFLICT    282    282       L -> P (in Ref. 2; AAF17198).
FT   CONFLICT    312    312       I -> L (in Ref. 2; AAF17198).
SQ   SEQUENCE   509 AA;  54794 MW;  C3B685C7192B95C3 CRC64;
     MAAIGVHLGC TSACVAVYKD GRAGVVANDA GDRVTPAVVA YSENEEIVGL AAKQSRIRNI
     SNTVMKVKQI LGRSSSDPQA QKYIAESKCL VIEKNGKLRY EIDTGEETKF VNPEDVARLI
     FSKMKETAHS VLGSDANDVV ITVPFDFGEK QKNALGEAAR AAGFNVLRLI HEPSAALLAY
     GIGQDSPTGK SNILVFKLGG TSLSLSVMEV NSGIYRVLST NTDDNIGGAH FTETLAQYLA
     SEFQRSFKHD VRGNARAMMK LTNSAEVAKH SLSTLGSANC FLDSLYEGQD FDCNVSRARF
     ELLCSPLFNK CIEAIRGLLD QNGFTADDIN KVVLCGGSSR IPKLQQLIKD LFPAVELLNS
     IPPDEVIPIG AAIEAGILIG KENLLVEDSL MIECSARDIL VKGVDESGAS RFTVLFPSGT
     PLPARRQHTL QAPGSISSVC LELYESDGKN SAKEETKFAQ VVLQDLDKKE NGLRDILAVL
     TMKRDGSLHV TCTDQETGKC EAISIEIAS
//