Reviewed, UniProtKB/Swiss-Prot Q0VDF9 (HSP7E_HUMAN)

Names and origin

Protein names

Recommended name:
    Heat shock 70 kDa protein 14
Alternative name(s):
    Heat shock protein HSP60
    HSP70-like protein 1

Gene names

Name:	HSPA14
Synonyms:	HSP60, HSP70L1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	509 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 509	509	Heat shock 70 kDa protein 14		PRO_0000289946
Natural variations
	Natural variant	85	1	A → V in a breast cancer sample; somatic mutation. Ref.7		VAR_036347
Experimental info
	Sequence conflict	15	1	V → E in AAF66640. Ref.1
	Sequence conflict	282	1	L → P in AAF17198. Ref.2
	Sequence conflict	312	1	I → L in AAF17198. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q0VDF9-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: C3B685C7192B95C3	FASTA	509	54,794
	10 20 30 40 50 60 MAAIGVHLGC TSACVAVYKD GRAGVVANDA GDRVTPAVVA YSENEEIVGL AAKQSRIRNI 70 80 90 100 110 120 SNTVMKVKQI LGRSSSDPQA QKYIAESKCL VIEKNGKLRY EIDTGEETKF VNPEDVARLI 130 140 150 160 170 180 FSKMKETAHS VLGSDANDVV ITVPFDFGEK QKNALGEAAR AAGFNVLRLI HEPSAALLAY 190 200 210 220 230 240 GIGQDSPTGK SNILVFKLGG TSLSLSVMEV NSGIYRVLST NTDDNIGGAH FTETLAQYLA 250 260 270 280 290 300 SEFQRSFKHD VRGNARAMMK LTNSAEVAKH SLSTLGSANC FLDSLYEGQD FDCNVSRARF 310 320 330 340 350 360 ELLCSPLFNK CIEAIRGLLD QNGFTADDIN KVVLCGGSSR IPKLQQLIKD LFPAVELLNS 370 380 390 400 410 420 IPPDEVIPIG AAIEAGILIG KENLLVEDSL MIECSARDIL VKGVDESGAS RFTVLFPSGT 430 440 450 460 470 480 PLPARRQHTL QAPGSISSVC LELYESDGKN SAKEETKFAQ VVLQDLDKKE NGLRDILAVL 490 500 TMKRDGSLHV TCTDQETGKC EAISIEIAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant." Wan T., Zhou X., Chen G., An H., Chen T., Zhang W., Liu S., Jiang Y., Yang F., Wu Y., Cao X. Blood 103:1747-1754(2004) [PubMed: 14592822] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal gland.
[3]	NHLBI resequencing and genotyping service (RS&G) Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-85.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF143723 mRNA. Translation: AAF66640.1. AF112210 mRNA. Translation: AAF17198.1. EF444968 Genomic DNA. Translation: ACA05969.1. EF444968 Genomic DNA. Translation: ACA05970.1. CH471072 Genomic DNA. Translation: EAW86258.1. BC119690 mRNA. Translation: AAI19691.1.
IPI	IPI00292499.
RefSeq	NP_057383.2.
UniGene	Hs.534169
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q0VDF9.
Proteomic databases
PeptideAtlas	Q0VDF9.
PRIDE	Q0VDF9.
Genome annotation databases
Ensembl	ENST00000378372; ENSP00000367623; ENSG00000187522; Homo sapiens. [Genome view]
GeneID	51182.
KEGG	hsa:51182.
NMPDR	fig|9606.3.peg.3580.
UCSC	uc001inf.1. human.
Organism-specific databases
CTD	51182.
GeneCards	GC10P014920.
HGNC	HGNC:29526. HSPA14.
MIM	610369. gene.
PharmGKB	PA134979057.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG334976.
HOVERGEN	Q0VDF9.
InParanoid	Q0VDF9.
OMA	FDFGEKQ.
OrthoDB	EOG9HDWD4.
PhylomeDB	Q0VDF9.
Gene expression databases
ArrayExpress	Q0VDF9.
Bgee	Q0VDF9.
CleanEx	HS_HSPA14.
Genevestigator	Q0VDF9.
Family and domain databases
InterPro	IPR018181. Heat_shock_70_CS. IPR001023. Hsp70. IPR013126. Hsp_70. [Graphical view]
PANTHER	PTHR19375. Hsp70. 1 hit.
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
PROSITE	PS00297. HSP70_1. False negative. PS00329. HSP70_2. False negative. PS01036. HSP70_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	54151.
SOURCE	Search...

Entry information

Entry name

HSP7E_HUMAN

Accession

Primary (citable) accession number: Q0VDF9
Secondary accession number(s): B0YIY9, Q9P0X2, Q9UI07

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	September 5, 2006
Last modified:	January 19, 2010
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.