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Q0VDF9

- HSP7E_HUMAN

UniProt

Q0VDF9 - HSP7E_HUMAN

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Protein
Heat shock 70 kDa protein 14
Gene
HSPA14, HSP60, HSP70L1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.1 Publication

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. 'de novo' cotranslational protein folding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 14
Alternative name(s):
HSP70-like protein 1
Heat shock protein HSP60
Gene namesi
Name:HSPA14
Synonyms:HSP60, HSP70L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:29526. HSPA14.

Subcellular locationi

Cytoplasmcytosol 1 Publication

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134979057.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Heat shock 70 kDa protein 14
PRO_0000289946Add
BLAST

Proteomic databases

MaxQBiQ0VDF9.
PaxDbiQ0VDF9.
PeptideAtlasiQ0VDF9.
PRIDEiQ0VDF9.

PTM databases

PhosphoSiteiQ0VDF9.

Expressioni

Gene expression databases

ArrayExpressiQ0VDF9.
BgeeiQ0VDF9.
CleanExiHS_HSPA14.
GenevestigatoriQ0VDF9.

Organism-specific databases

HPAiHPA046180.

Interactioni

Subunit structurei

Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.1 Publication

Protein-protein interaction databases

BioGridi119358. 7 interactions.
IntActiQ0VDF9. 1 interaction.
STRINGi9606.ENSP00000367623.

Structurei

3D structure databases

ProteinModelPortaliQ0VDF9.
SMRiQ0VDF9. Positions 3-505.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0443.
HOGENOMiHOG000228135.
HOVERGENiHBG099873.
InParanoidiQ0VDF9.
OMAiSLMIECS.
OrthoDBiEOG73804J.
PhylomeDBiQ0VDF9.
TreeFamiTF105045.

Family and domain databases

Gene3Di2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VDF9-1 [UniParc]FASTAAdd to Basket

« Hide

MAAIGVHLGC TSACVAVYKD GRAGVVANDA GDRVTPAVVA YSENEEIVGL    50
AAKQSRIRNI SNTVMKVKQI LGRSSSDPQA QKYIAESKCL VIEKNGKLRY 100
EIDTGEETKF VNPEDVARLI FSKMKETAHS VLGSDANDVV ITVPFDFGEK 150
QKNALGEAAR AAGFNVLRLI HEPSAALLAY GIGQDSPTGK SNILVFKLGG 200
TSLSLSVMEV NSGIYRVLST NTDDNIGGAH FTETLAQYLA SEFQRSFKHD 250
VRGNARAMMK LTNSAEVAKH SLSTLGSANC FLDSLYEGQD FDCNVSRARF 300
ELLCSPLFNK CIEAIRGLLD QNGFTADDIN KVVLCGGSSR IPKLQQLIKD 350
LFPAVELLNS IPPDEVIPIG AAIEAGILIG KENLLVEDSL MIECSARDIL 400
VKGVDESGAS RFTVLFPSGT PLPARRQHTL QAPGSISSVC LELYESDGKN 450
SAKEETKFAQ VVLQDLDKKE NGLRDILAVL TMKRDGSLHV TCTDQETGKC 500
EAISIEIAS 509
Length:509
Mass (Da):54,794
Last modified:September 5, 2006 - v1
Checksum:iC3B685C7192B95C3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851A → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_036347

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61V → A in BAF85012. 1 Publication
Sequence conflicti15 – 151V → E in AAF66640. 1 Publication
Sequence conflicti282 – 2821L → P in AAF17198. 1 Publication
Sequence conflicti312 – 3121I → L in AAF17198. 1 Publication
Sequence conflicti350 – 3501D → G in BAF85012. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF143723 mRNA. Translation: AAF66640.1.
AF112210 mRNA. Translation: AAF17198.1.
AK292323 mRNA. Translation: BAF85012.1.
EF444968 Genomic DNA. Translation: ACA05969.1.
EF444968 Genomic DNA. Translation: ACA05970.1.
AC069544 Genomic DNA. No translation available.
CH471072 Genomic DNA. Translation: EAW86258.1.
BC119690 mRNA. Translation: AAI19691.1.
CCDSiCCDS7103.1.
RefSeqiNP_057383.2. NM_016299.3.
UniGeneiHs.534169.
Hs.736996.

Genome annotation databases

EnsembliENST00000378372; ENSP00000367623; ENSG00000187522.
GeneIDi51182.
KEGGihsa:51182.
UCSCiuc001inf.4. human.

Polymorphism databases

DMDMi121948121.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF143723 mRNA. Translation: AAF66640.1 .
AF112210 mRNA. Translation: AAF17198.1 .
AK292323 mRNA. Translation: BAF85012.1 .
EF444968 Genomic DNA. Translation: ACA05969.1 .
EF444968 Genomic DNA. Translation: ACA05970.1 .
AC069544 Genomic DNA. No translation available.
CH471072 Genomic DNA. Translation: EAW86258.1 .
BC119690 mRNA. Translation: AAI19691.1 .
CCDSi CCDS7103.1.
RefSeqi NP_057383.2. NM_016299.3.
UniGenei Hs.534169.
Hs.736996.

3D structure databases

ProteinModelPortali Q0VDF9.
SMRi Q0VDF9. Positions 3-505.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119358. 7 interactions.
IntActi Q0VDF9. 1 interaction.
STRINGi 9606.ENSP00000367623.

PTM databases

PhosphoSitei Q0VDF9.

Polymorphism databases

DMDMi 121948121.

Proteomic databases

MaxQBi Q0VDF9.
PaxDbi Q0VDF9.
PeptideAtlasi Q0VDF9.
PRIDEi Q0VDF9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000378372 ; ENSP00000367623 ; ENSG00000187522 .
GeneIDi 51182.
KEGGi hsa:51182.
UCSCi uc001inf.4. human.

Organism-specific databases

CTDi 51182.
GeneCardsi GC10P014790.
H-InvDB HIX0008667.
HGNCi HGNC:29526. HSPA14.
HPAi HPA046180.
MIMi 610369. gene.
neXtProti NX_Q0VDF9.
PharmGKBi PA134979057.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0443.
HOGENOMi HOG000228135.
HOVERGENi HBG099873.
InParanoidi Q0VDF9.
OMAi SLMIECS.
OrthoDBi EOG73804J.
PhylomeDBi Q0VDF9.
TreeFami TF105045.

Miscellaneous databases

ChiTaRSi HSPA14. human.
GeneWikii HSPA14.
GenomeRNAii 51182.
NextBioi 54151.
PROi Q0VDF9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q0VDF9.
Bgeei Q0VDF9.
CleanExi HS_HSPA14.
Genevestigatori Q0VDF9.

Family and domain databases

Gene3Di 2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
PROSITEi PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant."
    Wan T., Zhou X., Chen G., An H., Chen T., Zhang W., Liu S., Jiang Y., Yang F., Wu Y., Cao X.
    Blood 103:1747-1754(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Hsp70-like protein 1 fusion protein enhances induction of carcinoembryonic antigen-specific CD8+ CTL response by dendritic cell vaccine."
    Wu Y., Wan T., Zhou X., Wang B., Yang F., Li N., Chen G., Dai S., Liu S., Zhang M., Cao X.
    Cancer Res. 65:4947-4954(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IMMUNOADJUVANT ABILITY.
  9. "The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex."
    Otto H., Conz C., Maier P., Wolfle T., Suzuki C.K., Jeno P., Rucknagel P., Stahl J., Rospert S.
    Proc. Natl. Acad. Sci. U.S.A. 102:10064-10069(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE RAC COMPLEX, INTERACTION WITH DNAJC2.
  10. "Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous."
    Hundley H.A., Walter W., Bairstow S., Craig E.A.
    Science 308:1032-1034(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  11. "Protective effect of a RSV subunit vaccine candidate G1F/M2 was enhanced by a HSP70-Like protein in mice."
    Zeng R., Zhang Z., Mei X., Gong W., Wei L.
    Biochem. Biophys. Res. Commun. 377:495-499(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IMMUNOADJUVANT ABILITY.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-85.

Entry informationi

Entry nameiHSP7E_HUMAN
AccessioniPrimary (citable) accession number: Q0VDF9
Secondary accession number(s): A8K8F8
, B0YIY9, Q9P0X2, Q9UI07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Acts as a potent immunoadjuvant, capable to interact with antigen-presenting cells and generating efficient CD8+ T-cell responses. May be used as adjuvant to enhance effect of vaccine G1F/M2, a candidate vaccine against respiratory syncytial virus (RSV), a major respiratory pathogen in newborns (1 Publication). May also be used as adjuvant to prepare antigenic fusion protein for the therapeutics of cancers (1 Publication).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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