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Protein

Heat shock 70 kDa protein 14

Gene

HSPA14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.1 Publication

Miscellaneous

Acts as a potent immunoadjuvant, capable to interact with antigen-presenting cells and generating efficient CD8+ T-cell responses. May be used as adjuvant to enhance effect of vaccine G1F/M2, a candidate vaccine against respiratory syncytial virus (RSV), a major respiratory pathogen in newborns (PubMed:18851947). May also be used as adjuvant to prepare antigenic fusion protein for the therapeutics of cancers (PubMed:15930317).2 Publications

GO - Molecular functioni

GO - Biological processi

  • 'de novo' cotranslational protein folding Source: UniProtKB

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 14
Alternative name(s):
HSP70-like protein 1
Heat shock protein HSP60
Gene namesi
Name:HSPA14
Synonyms:HSP60, HSP70L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000187522.13
HGNCiHGNC:29526 HSPA14
MIMi610369 gene
neXtProtiNX_Q0VDF9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi51182
OpenTargetsiENSG00000187522
PharmGKBiPA134979057

Polymorphism and mutation databases

DMDMi121948121

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002899461 – 509Heat shock 70 kDa protein 14Add BLAST509

Proteomic databases

EPDiQ0VDF9
MaxQBiQ0VDF9
PaxDbiQ0VDF9
PeptideAtlasiQ0VDF9
PRIDEiQ0VDF9

PTM databases

iPTMnetiQ0VDF9
PhosphoSitePlusiQ0VDF9

Expressioni

Gene expression databases

BgeeiENSG00000187522
CleanExiHS_HSPA14
ExpressionAtlasiQ0VDF9 baseline and differential
GenevisibleiQ0VDF9 HS

Organism-specific databases

HPAiHPA046180

Interactioni

Subunit structurei

Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.1 Publication

Protein-protein interaction databases

BioGridi119358, 34 interactors
DIPiDIP-62114N
IntActiQ0VDF9, 5 interactors
MINTiQ0VDF9
STRINGi9606.ENSP00000367623

Structurei

3D structure databases

ProteinModelPortaliQ0VDF9
SMRiQ0VDF9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00910000144045
HOGENOMiHOG000228135
HOVERGENiHBG099873
InParanoidiQ0VDF9
OMAiMMKLTNS
OrthoDBiEOG091G06RS
PhylomeDBiQ0VDF9
TreeFamiTF105045

Family and domain databases

Gene3Di2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
PROSITEiView protein in PROSITE
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q0VDF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAIGVHLGC TSACVAVYKD GRAGVVANDA GDRVTPAVVA YSENEEIVGL
60 70 80 90 100
AAKQSRIRNI SNTVMKVKQI LGRSSSDPQA QKYIAESKCL VIEKNGKLRY
110 120 130 140 150
EIDTGEETKF VNPEDVARLI FSKMKETAHS VLGSDANDVV ITVPFDFGEK
160 170 180 190 200
QKNALGEAAR AAGFNVLRLI HEPSAALLAY GIGQDSPTGK SNILVFKLGG
210 220 230 240 250
TSLSLSVMEV NSGIYRVLST NTDDNIGGAH FTETLAQYLA SEFQRSFKHD
260 270 280 290 300
VRGNARAMMK LTNSAEVAKH SLSTLGSANC FLDSLYEGQD FDCNVSRARF
310 320 330 340 350
ELLCSPLFNK CIEAIRGLLD QNGFTADDIN KVVLCGGSSR IPKLQQLIKD
360 370 380 390 400
LFPAVELLNS IPPDEVIPIG AAIEAGILIG KENLLVEDSL MIECSARDIL
410 420 430 440 450
VKGVDESGAS RFTVLFPSGT PLPARRQHTL QAPGSISSVC LELYESDGKN
460 470 480 490 500
SAKEETKFAQ VVLQDLDKKE NGLRDILAVL TMKRDGSLHV TCTDQETGKC

EAISIEIAS
Length:509
Mass (Da):54,794
Last modified:September 5, 2006 - v1
Checksum:iC3B685C7192B95C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6V → A in BAF85012 (PubMed:14702039).Curated1
Sequence conflicti15V → E in AAF66640 (PubMed:14592822).Curated1
Sequence conflicti282L → P in AAF17198 (PubMed:10931946).Curated1
Sequence conflicti312I → L in AAF17198 (PubMed:10931946).Curated1
Sequence conflicti350D → G in BAF85012 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03634785A → V in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs374837716Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143723 mRNA Translation: AAF66640.1
AF112210 mRNA Translation: AAF17198.1
AK292323 mRNA Translation: BAF85012.1
EF444968 Genomic DNA Translation: ACA05969.1
EF444968 Genomic DNA Translation: ACA05970.1
AC069544 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86258.1
BC119690 mRNA Translation: AAI19691.1
CCDSiCCDS7103.1
RefSeqiNP_057383.2, NM_016299.3
UniGeneiHs.534169
Hs.736996

Genome annotation databases

EnsembliENST00000378372; ENSP00000367623; ENSG00000187522
GeneIDi51182
KEGGihsa:51182
UCSCiuc001inf.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHSP7E_HUMAN
AccessioniPrimary (citable) accession number: Q0VDF9
Secondary accession number(s): A8K8F8
, B0YIY9, Q9P0X2, Q9UI07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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