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Protein

Heat shock 70 kDa protein 14

Gene

HSPA14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.1 Publication

GO - Molecular functioni

GO - Biological processi

  • 'de novo' cotranslational protein folding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 14
Alternative name(s):
HSP70-like protein 1
Heat shock protein HSP60
Gene namesi
Name:HSPA14
Synonyms:HSP60, HSP70L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:29526. HSPA14.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi51182.
OpenTargetsiENSG00000187522.
PharmGKBiPA134979057.

Polymorphism and mutation databases

DMDMi121948121.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002899461 – 509Heat shock 70 kDa protein 14Add BLAST509

Proteomic databases

EPDiQ0VDF9.
MaxQBiQ0VDF9.
PaxDbiQ0VDF9.
PeptideAtlasiQ0VDF9.
PRIDEiQ0VDF9.

PTM databases

iPTMnetiQ0VDF9.
PhosphoSitePlusiQ0VDF9.

Expressioni

Gene expression databases

BgeeiENSG00000187522.
CleanExiHS_HSPA14.
ExpressionAtlasiQ0VDF9. baseline and differential.
GenevisibleiQ0VDF9. HS.

Organism-specific databases

HPAiHPA046180.

Interactioni

Subunit structurei

Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.1 Publication

Protein-protein interaction databases

BioGridi119358. 25 interactors.
IntActiQ0VDF9. 4 interactors.
STRINGi9606.ENSP00000367623.

Structurei

3D structure databases

ProteinModelPortaliQ0VDF9.
SMRiQ0VDF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00820000127001.
HOGENOMiHOG000228135.
HOVERGENiHBG099873.
InParanoidiQ0VDF9.
OMAiSLMIECS.
OrthoDBiEOG091G06RS.
PhylomeDBiQ0VDF9.
TreeFamiTF105045.

Family and domain databases

Gene3Di2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VDF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAIGVHLGC TSACVAVYKD GRAGVVANDA GDRVTPAVVA YSENEEIVGL
60 70 80 90 100
AAKQSRIRNI SNTVMKVKQI LGRSSSDPQA QKYIAESKCL VIEKNGKLRY
110 120 130 140 150
EIDTGEETKF VNPEDVARLI FSKMKETAHS VLGSDANDVV ITVPFDFGEK
160 170 180 190 200
QKNALGEAAR AAGFNVLRLI HEPSAALLAY GIGQDSPTGK SNILVFKLGG
210 220 230 240 250
TSLSLSVMEV NSGIYRVLST NTDDNIGGAH FTETLAQYLA SEFQRSFKHD
260 270 280 290 300
VRGNARAMMK LTNSAEVAKH SLSTLGSANC FLDSLYEGQD FDCNVSRARF
310 320 330 340 350
ELLCSPLFNK CIEAIRGLLD QNGFTADDIN KVVLCGGSSR IPKLQQLIKD
360 370 380 390 400
LFPAVELLNS IPPDEVIPIG AAIEAGILIG KENLLVEDSL MIECSARDIL
410 420 430 440 450
VKGVDESGAS RFTVLFPSGT PLPARRQHTL QAPGSISSVC LELYESDGKN
460 470 480 490 500
SAKEETKFAQ VVLQDLDKKE NGLRDILAVL TMKRDGSLHV TCTDQETGKC

EAISIEIAS
Length:509
Mass (Da):54,794
Last modified:September 5, 2006 - v1
Checksum:iC3B685C7192B95C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6V → A in BAF85012 (PubMed:14702039).Curated1
Sequence conflicti15V → E in AAF66640 (PubMed:14592822).Curated1
Sequence conflicti282L → P in AAF17198 (PubMed:10931946).Curated1
Sequence conflicti312I → L in AAF17198 (PubMed:10931946).Curated1
Sequence conflicti350D → G in BAF85012 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03634785A → V in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs374837716dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143723 mRNA. Translation: AAF66640.1.
AF112210 mRNA. Translation: AAF17198.1.
AK292323 mRNA. Translation: BAF85012.1.
EF444968 Genomic DNA. Translation: ACA05969.1.
EF444968 Genomic DNA. Translation: ACA05970.1.
AC069544 Genomic DNA. No translation available.
CH471072 Genomic DNA. Translation: EAW86258.1.
BC119690 mRNA. Translation: AAI19691.1.
CCDSiCCDS7103.1.
RefSeqiNP_057383.2. NM_016299.3.
UniGeneiHs.534169.
Hs.736996.

Genome annotation databases

EnsembliENST00000378372; ENSP00000367623; ENSG00000187522.
GeneIDi51182.
KEGGihsa:51182.
UCSCiuc001inf.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143723 mRNA. Translation: AAF66640.1.
AF112210 mRNA. Translation: AAF17198.1.
AK292323 mRNA. Translation: BAF85012.1.
EF444968 Genomic DNA. Translation: ACA05969.1.
EF444968 Genomic DNA. Translation: ACA05970.1.
AC069544 Genomic DNA. No translation available.
CH471072 Genomic DNA. Translation: EAW86258.1.
BC119690 mRNA. Translation: AAI19691.1.
CCDSiCCDS7103.1.
RefSeqiNP_057383.2. NM_016299.3.
UniGeneiHs.534169.
Hs.736996.

3D structure databases

ProteinModelPortaliQ0VDF9.
SMRiQ0VDF9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119358. 25 interactors.
IntActiQ0VDF9. 4 interactors.
STRINGi9606.ENSP00000367623.

PTM databases

iPTMnetiQ0VDF9.
PhosphoSitePlusiQ0VDF9.

Polymorphism and mutation databases

DMDMi121948121.

Proteomic databases

EPDiQ0VDF9.
MaxQBiQ0VDF9.
PaxDbiQ0VDF9.
PeptideAtlasiQ0VDF9.
PRIDEiQ0VDF9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378372; ENSP00000367623; ENSG00000187522.
GeneIDi51182.
KEGGihsa:51182.
UCSCiuc001inf.5. human.

Organism-specific databases

CTDi51182.
DisGeNETi51182.
GeneCardsiHSPA14.
H-InvDBHIX0008667.
HGNCiHGNC:29526. HSPA14.
HPAiHPA046180.
MIMi610369. gene.
neXtProtiNX_Q0VDF9.
OpenTargetsiENSG00000187522.
PharmGKBiPA134979057.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00820000127001.
HOGENOMiHOG000228135.
HOVERGENiHBG099873.
InParanoidiQ0VDF9.
OMAiSLMIECS.
OrthoDBiEOG091G06RS.
PhylomeDBiQ0VDF9.
TreeFamiTF105045.

Enzyme and pathway databases

ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

ChiTaRSiHSPA14. human.
GeneWikiiHSPA14.
GenomeRNAii51182.
PROiQ0VDF9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187522.
CleanExiHS_HSPA14.
ExpressionAtlasiQ0VDF9. baseline and differential.
GenevisibleiQ0VDF9. HS.

Family and domain databases

Gene3Di2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSP7E_HUMAN
AccessioniPrimary (citable) accession number: Q0VDF9
Secondary accession number(s): A8K8F8
, B0YIY9, Q9P0X2, Q9UI07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Acts as a potent immunoadjuvant, capable to interact with antigen-presenting cells and generating efficient CD8+ T-cell responses. May be used as adjuvant to enhance effect of vaccine G1F/M2, a candidate vaccine against respiratory syncytial virus (RSV), a major respiratory pathogen in newborns (PubMed:18851947). May also be used as adjuvant to prepare antigenic fusion protein for the therapeutics of cancers (PubMed:15930317).2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.