Reviewed,
UniProtKB/Swiss-Prot Q0VDF9 (HSP7E_HUMAN)
Last modified
January 19, 2010.
Version 38.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Heat shock 70 kDa protein 14 Alternative name(s): Heat shock protein HSP60 HSP70-like protein 1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 509 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Sequence similarities | Belongs to the heat shock protein 70 family. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Ligand | ATP-binding Nucleotide-binding |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 509 | 509 | Heat shock 70 kDa protein 14 | PRO_0000289946 | |||||
Natural variations | |||||||||
| Natural variant | 85 | 1 | A → V in a breast cancer sample; somatic mutation. Ref.7 | VAR_036347 | |||||
Experimental info | |||||||||
| Sequence conflict | 15 | 1 | V → E in AAF66640. Ref.1 | ||||||
| Sequence conflict | 282 | 1 | L → P in AAF17198. Ref.2 | ||||||
| Sequence conflict | 312 | 1 | I → L in AAF17198. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant." Wan T., Zhou X., Chen G., An H., Chen T., Zhang W., Liu S., Jiang Y., Yang F., Wu Y., Cao X. Blood 103:1747-1754(2004) [PubMed: 14592822] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. Chen J.-L.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal gland. |
| [3] | NHLBI resequencing and genotyping service (RS&G) Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [6] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [7] | "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E.Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-85. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF143723 mRNA. Translation: AAF66640.1. AF112210 mRNA. Translation: AAF17198.1. EF444968 Genomic DNA. Translation: ACA05969.1. EF444968 Genomic DNA. Translation: ACA05970.1. CH471072 Genomic DNA. Translation: EAW86258.1. BC119690 mRNA. Translation: AAI19691.1. |
| IPI | IPI00292499. |
| RefSeq | NP_057383.2. |
| UniGene | Hs.534169 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q0VDF9. |
Proteomic databases | |
| PeptideAtlas | Q0VDF9. |
| PRIDE | Q0VDF9. |
Genome annotation databases | |
| Ensembl | ENST00000378372; ENSP00000367623; ENSG00000187522; Homo sapiens. [Genome view] |
| GeneID | 51182. |
| KEGG | hsa:51182. |
| NMPDR | fig|9606.3.peg.3580. |
| UCSC | uc001inf.1. human. |
Organism-specific databases | |
| CTD | 51182. |
| GeneCards | GC10P014920. |
| HGNC | HGNC:29526. HSPA14. |
| MIM | 610369. gene. |
| PharmGKB | PA134979057. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG334976. |
| HOVERGEN | Q0VDF9. |
| InParanoid | Q0VDF9. |
| OMA | FDFGEKQ. |
| OrthoDB | EOG9HDWD4. |
| PhylomeDB | Q0VDF9. |
Gene expression databases | |
| ArrayExpress | Q0VDF9. |
| Bgee | Q0VDF9. |
| CleanEx | HS_HSPA14. |
| Genevestigator | Q0VDF9. |
Family and domain databases | |
| InterPro | IPR018181. Heat_shock_70_CS. IPR001023. Hsp70. IPR013126. Hsp_70. [Graphical view] |
| PANTHER | PTHR19375. Hsp70. 1 hit. |
| Pfam | PF00012. HSP70. 1 hit. [Graphical view] |
| PRINTS | PR00301. HEATSHOCK70. |
| PROSITE | PS00297. HSP70_1. False negative. PS00329. HSP70_2. False negative. PS01036. HSP70_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 54151. |
| SOURCE | Search... |
Entry information
| Entry name | HSP7E_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q0VDF9 Secondary accession number(s): B0YIY9, Q9P0X2, Q9UI07 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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