Q0VDE8 (ADIG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adipogenin

Gene names

Name:

ADIG

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	80 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a role in stimulating adipocyte differentiation and development By similarity. UniProtKB Q8R400
Subcellular location	Membrane; Single-pass membrane protein Potential. Nucleus By similarity UniProtKB Q8R400.
Sequence similarities	Belongs to the adipogenin family.

Ontologies

Keywords
Cellular component	Membrane Nucleus
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	brown fat cell differentiation Inferred from sequence or structural similarity. Source: HGNC positive regulation of fat cell differentiation Inferred from sequence or structural similarity. Source: HGNC white fat cell differentiation Inferred from sequence or structural similarity. Source: HGNC
Cellular component	cytoplasm Inferred from sequence or structural similarity. Source: HGNC integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from sequence or structural similarity. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 80	80	Adipogenin		PRO_0000296375
Regions
	Transmembrane	14 – 34	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0VDE8 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 7DC102D170BBF86F	FASTA	80	9,465
	10 20 30 40 50 60 MKYPLMPLVN DLTFSFLVFW FCLPVGLLLL LIIWLRFLLS QDSEENDSSV CLDWEPWSKG 70 80 PAEFCWKGTL HGQEKERPCW

References

[1]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL035419 Genomic DNA. No translation available. BC119704 mRNA. Translation: AAI19705.1. BC119705 mRNA. Translation: AAI19706.1.
IPI	IPI00169298.
RefSeq	NP_001018092.1. NM_001018082.1.
UniGene	Hs.368028.
3D structure databases
ProteinModelPortal	Q0VDE8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0VDE8.
PTM databases
PhosphoSite	Q0VDE8.
Polymorphism databases
DMDM	156630981.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	149685.
KEGG	hsa:149685.
UCSC	uc002xjb.1. human.
Organism-specific databases
CTD	149685.
GeneCards	GC20P037209.
HGNC	HGNC:28606. ADIG.
MIM	611396. gene.
neXtProt	NX_Q0VDE8.
PharmGKB	PA162375689.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG099666.
InParanoid	Q0VDE8.
Gene expression databases
ArrayExpress	Q0VDE8.
Bgee	Q0VDE8.
CleanEx	HS_ADIG.
Genevestigator	Q0VDE8.
Family and domain databases
ProtoNet	Search...
Other
NextBio	86229.
SOURCE	Search...

Entry information

Entry name

ADIG_HUMAN

Accession

Primary (citable) accession number: Q0VDE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	February 20, 2007
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.