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Protein

Adipogenin

Gene

ADIG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays a role in stimulating adipocyte differentiation and development.By similarity

GO - Biological processi

  • brown fat cell differentiation Source: HGNC
  • positive regulation of fat cell differentiation Source: HGNC
  • spermatogenesis Source: Ensembl
  • white fat cell differentiation Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Adipogenin
Gene namesi
Name:ADIGImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:28606. ADIG.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: HGNC
  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162375689.

Polymorphism and mutation databases

BioMutaiADIG.
DMDMi156630981.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8080AdipogeninPRO_0000296375Add
BLAST

Proteomic databases

PaxDbiQ0VDE8.
PRIDEiQ0VDE8.

PTM databases

PhosphoSiteiQ0VDE8.

Expressioni

Gene expression databases

BgeeiQ0VDE8.
CleanExiHS_ADIG.
ExpressionAtlasiQ0VDE8. baseline and differential.
GenevisibleiQ0VDE8. HS.

Structurei

3D structure databases

ProteinModelPortaliQ0VDE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adipogenin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1UB. Eukaryota.
ENOG4111AXW. LUCA.
GeneTreeiENSGT00390000018723.
HOVERGENiHBG099666.
InParanoidiQ0VDE8.
OMAiEKERPCW.
OrthoDBiEOG7MD4SV.
PhylomeDBiQ0VDE8.

Family and domain databases

InterProiIPR027938. Adipogenin.
[Graphical view]
PANTHERiPTHR38499. PTHR38499. 1 hit.
PfamiPF15202. Adipogenin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VDE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYPLMPLVN DLTFSFLVFW FCLPVGLLLL LIIWLRFLLS QDSEENDSSV
60 70 80
CLDWEPWSKG PAEFCWKGTL HGQEKERPCW
Length:80
Mass (Da):9,465
Last modified:February 20, 2007 - v1
Checksum:i7DC102D170BBF86F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035419 Genomic DNA. No translation available.
BC119704 mRNA. Translation: AAI19705.1.
BC119705 mRNA. Translation: AAI19706.1.
CCDSiCCDS54461.1.
RefSeqiNP_001018092.1. NM_001018082.2.
UniGeneiHs.368028.

Genome annotation databases

EnsembliENST00000470147; ENSP00000434385; ENSG00000182035.
ENST00000537425; ENSP00000440331; ENSG00000182035.
GeneIDi149685.
KEGGihsa:149685.
UCSCiuc002xjb.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035419 Genomic DNA. No translation available.
BC119704 mRNA. Translation: AAI19705.1.
BC119705 mRNA. Translation: AAI19706.1.
CCDSiCCDS54461.1.
RefSeqiNP_001018092.1. NM_001018082.2.
UniGeneiHs.368028.

3D structure databases

ProteinModelPortaliQ0VDE8.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ0VDE8.

Polymorphism and mutation databases

BioMutaiADIG.
DMDMi156630981.

Proteomic databases

PaxDbiQ0VDE8.
PRIDEiQ0VDE8.

Protocols and materials databases

DNASUi149685.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000470147; ENSP00000434385; ENSG00000182035.
ENST00000537425; ENSP00000440331; ENSG00000182035.
GeneIDi149685.
KEGGihsa:149685.
UCSCiuc002xjb.1. human.

Organism-specific databases

CTDi149685.
GeneCardsiADIG.
HGNCiHGNC:28606. ADIG.
MIMi611396. gene.
neXtProtiNX_Q0VDE8.
PharmGKBiPA162375689.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1UB. Eukaryota.
ENOG4111AXW. LUCA.
GeneTreeiENSGT00390000018723.
HOVERGENiHBG099666.
InParanoidiQ0VDE8.
OMAiEKERPCW.
OrthoDBiEOG7MD4SV.
PhylomeDBiQ0VDE8.

Miscellaneous databases

GenomeRNAii149685.
PROiQ0VDE8.
SOURCEiSearch...

Gene expression databases

BgeeiQ0VDE8.
CleanExiHS_ADIG.
ExpressionAtlasiQ0VDE8. baseline and differential.
GenevisibleiQ0VDE8. HS.

Family and domain databases

InterProiIPR027938. Adipogenin.
[Graphical view]
PANTHERiPTHR38499. PTHR38499. 1 hit.
PfamiPF15202. Adipogenin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiADIG_HUMAN
AccessioniPrimary (citable) accession number: Q0VDE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: February 20, 2007
Last modified: June 8, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.