Q0VDD8 (DYH14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dynein heavy chain 14, axonemal

Alternative name(s):
Axonemal beta dynein heavy chain 14
Ciliary dynein heavy chain 14

Gene names

Name:	DNAH14
Synonyms:	C1orf67

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	3507 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly By similarity.
Subunit structure	Consists of at least two heavy chains and a number of intermediate and light chains.
Subcellular location	Cytoplasm › cytoskeleton › cilium axoneme Potential.
Domain	Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function By similarity.
Sequence similarities	Belongs to the dynein heavy chain family.
Sequence caution	The sequence AAI19717.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI19718.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI95150.2 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI95641.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI95642.2 differs from that shown. Reason: Erroneous gene model prediction. The sequence EAW69735.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell projection Cilium Cytoplasm Cytoskeleton Dynein Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	microtubule-based movement Inferred from electronic annotation. Source: InterPro
Cellular_component	cilium axoneme Inferred from electronic annotation. Source: UniProtKB-SubCell dynein complex Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q0VDD8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q0VDD8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-177: Missing.
     249-249: E → EDYLRESIIQQHMVSPEPASLKEKGKSRRKKDQTHACPNVRKARPVSYDRT
     344-344: K → KVINIVGSVK...NNLSAICLVK
     473-3507: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q0VDD8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-177: Missing.
     249-249: E → EDYLRESIIQQHMVSPEPASLKEKGKSRRKKDQTHACPNVRKARPVSYDRT
     345-355: LDSSRTYSLDE → RYLVICGAVYI
     356-3507: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q0VDD8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-177: Missing.
     249-249: E → EDYLRESIIQQHMVSPEPASLKEKGKSRRKKDQTHACPNVRKARPVSYDRT
     344-344: K → KVINIVGSVK...NNLSAICLVK
     609-609: A → DTEIETEFENKYMYYEFPEFPTNLFIDPNRLEFSVKIQNMLTNMEKCIT
     744-744: V → SLDYQSECLLYIDNVIHMSHTLIQSVIEKKNKNLLEVV
     979-979: K → KGLPKSDMVT...TPLPLILHHT
     1017-1017: K → KDLVNEWDQN...YIYNIILLFQ
     1180-1219: CALFAFKCNT...VLVMNTVMSF → SLGKHCVVFN...IKAAKDNYSA
     1332-1336: Missing.
     1823-1823: G → GWKHWGQSQGRRRKGNC
     1861-1861: R → RGTSLLTNLQ...ETHKTATGSS
     2011-2011: Q → QAHLGIYFSI...LSRELENCFQ
     2495-2495: L → LVEEHLLFLQ...LIKVMAQKYE
     2573-2582: SCQASTWRKK → NLLETLAPGLKAILKKDIYQKKGHYFIRVGDAEFEYNSNFR
     2949-3016: KHTFCLLLRA...FYGHCVDKYH → TELLNENKETCNPINFPWEKLTSFQRLIL
     3069-3069: G → GIDLTNILLR...VLKDDFSFSR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 3507	3507	Dynein heavy chain 14, axonemal		PRO_0000286560
Regions
	Nucleotide binding	1164 – 1171	8	ATP Potential
	Nucleotide binding	1427 – 1434	8	ATP Potential
	Motif	1164 – 1171	8	GPAGTGKT motif By similarity
Amino acid modifications
	Glycosylation	1818	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 177	177	Missing in isoform 2, isoform 3 and isoform 4.		VSP_031314
	Alternative sequence	249	1	E → EDYLRESIIQQHMVSPEPAS LKEKGKSRRKKDQTHACPNV RKARPVSYDRT in isoform 2, isoform 3 and isoform 4.		VSP_031315
	Alternative sequence	344	1	K → KVINIVGSVKEVELIPTLEW LSERRHYYLLRQFKIFSDFR MNKAFVTWKLNVKRIKTEKS RSFLYHHLFLADDLFQTCLV YIRGLCEDAINLKNYNDHEN NLSAICLVK in isoform 2 and isoform 4.		VSP_031316
	Alternative sequence	345 – 355	11	LDSSRTYSLDE → RYLVICGAVYI in isoform 3.		VSP_038241
	Alternative sequence	356 – 3507	3152	Missing in isoform 3.		VSP_038242
	Alternative sequence	473 – 3507	3035	Missing in isoform 2.		VSP_031317
	Alternative sequence	609	1	A → DTEIETEFENKYMYYEFPEF PTNLFIDPNRLEFSVKIQNM LTNMEKCIT in isoform 4.		VSP_038243
	Alternative sequence	744	1	V → SLDYQSECLLYIDNVIHMSH TLIQSVIEKKNKNLLEVV in isoform 4.		VSP_038244
	Alternative sequence	979	1	K → KGLPKSDMVTHLKQVVTEFK QELPIIIALGNPCLKPRHWE ALQEIIGKSVPLDKNCKVEN LLALKMFQYENEINDMSTSA TNEAALEKMLFKIIDFWNTT PLPLILHHT in isoform 4.		VSP_038245
	Alternative sequence	1017	1	K → KDLVNEWDQNLTLFSYTLEE WMNCQRNWLYLEPVFHSSEI RRQLPAETELFSQVISMWKK IMSKIQNKQNALQITTSAGV LEILQNCNIHLEHIKKSLED YLEVKRLIFPRFYFLSNAEL LDILADSRNPESVQPHLVKC FENIKQLLIWKQDIGPPAVK MLISAEGEGLVLPKKIRVRS AVEQWLVNVEKSMFDVLKKE RYIYNIILLFQ in isoform 4.		VSP_038246
	Alternative sequence	1180 – 1219	40	CALFA…TVMSF → SLGKHCVVFNCFEDLDYKIV RKFFFGLVQSGAWSCFDEFN LIDLEVLSVIASQILTIKAA KDNYSA in isoform 4.		VSP_038247
	Alternative sequence	1332 – 1336	5	Missing in isoform 4.		VSP_038248
	Alternative sequence	1823	1	G → GWKHWGQSQGRRRKGNC in isoform 4.		VSP_038249
	Alternative sequence	1861	1	R → RGTSLLTNLQRSGGNFLKIT ECGECINYTATRDTTCLSFL MSLLLKNSCPVLLTGESGVG KTAAINQMLEKLEGPGAFDI KHGSILGDTLLYSEIKKSSS LKQNITILIPETHKTATGSS in isoform 4.		VSP_038250
	Alternative sequence	2011	1	Q → QAHLGIYFSINNFTPEVQKS KDQIISCSLAIYHQVRQNML PTPTKCHYMFNLRDMFKLLL GLLQADRTVVNSKEMAALLF VHEATRVFHDRLIDFTDKSL FYRLLSRELENCFQ in isoform 4.		VSP_038251
	Alternative sequence	2495	1	L → LVEEHLLFLQAAYKDTVAEK QLLANRKTMASRRFQCASVL LTVLEDEKTRWQETINQIDN KLEGILGDILLSAACIVYSG ILTPEFRQLIVNKWETFCIE NGISLSSKFSLIKVMAQKYE in isoform 4.		VSP_038252
	Alternative sequence	2573 – 2582	10	SCQASTWRKK → NLLETLAPGLKAILKKDIYQ KKGHYFIRVGDAEFEYNSNF R in isoform 4.		VSP_038253
	Alternative sequence	2949 – 3016	68	KHTFC…VDKYH → TELLNENKETCNPINFPWEK LTSFQRLIL in isoform 4.		VSP_038254
	Alternative sequence	3069	1	G → GIDLTNILLRFAQELKGTTH HVTIISLGRDQAAKAEDLIL KALTKTQQWVFLQNCHLATS FMPRLCTIVESFNSPNVTID PEFRLWLSSKSYSSFPIPVL KKGLKIAVESPQGLKSNLLQ TFGCTGSGEVTEEIFENPDC GQWWKKLLFSLCFFNAVINE RKNYGILGWNIAYKFNSSDL GVAIKVLENSLRGQPSISWQ ALRYLIGEVIYGGRVIDNWD KRCLKTLLYKFCNPEVLKDD FSFSR in isoform 4.		VSP_038255
	Natural variant	220	1	T → S. Ref.3 Corresponds to variant rs41267347 [ dbSNP | Ensembl ].		VAR_032116
	Natural variant	274	1	P → L. Ref.3 Corresponds to variant rs41267349 [ dbSNP | Ensembl ].		VAR_032117
	Natural variant	2671	1	K → E. Corresponds to variant rs6667999 [ dbSNP | Ensembl ].		VAR_057764
Experimental info
	Sequence conflict	424	1	F → L in AAI19718. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 26, 2008. Version 3. Checksum: CF0471356846EEA9	FASTA	3,507	399,895
	10 20 30 40 50 60 MGRRSQWIWA MRCQMLVPVL SLHIGLARAL GCGCIASKIE CLIRCNAPFP LLDAVGSVAS 70 80 90 100 110 120 QELQSLTGTV GVTSGAAAYP RWNLARARAP PHLPGTQDPL RRVRDPTPIV ASSPGRRRGS 130 140 150 160 170 180 WSGGYGQEAS EPGVVGLCCA VLPIHPSLAL AGVGGPDLRR FQEGPQRPSD HGAAEKHMET 190 200 210 220 230 240 FIPIDLTTEN QEMDKEETKT KPRLLRYEEK KYEDVKPLET QPAEIAEKET LEYKTVRTFS 250 260 270 280 290 300 ESLKSEKTEE PKDDDVIRNI IRLREKLGWQ TILPQHSLKY GSSKIAIQKI TLKKPLEDDG 310 320 330 340 350 360 EFVYCLPRKS PKSLYNPYDL QVVSAHTAKH CKEFWVITAS FISKLDSSRT YSLDEFCEEQ 370 380 390 400 410 420 LQQATQALKQ LEDIRNKAIS EMKSTFLKVA EKNEIKEYFE SKLSEDDTTH FKLPKYRRLL 430 440 450 460 470 480 ETFFKFVMLV DYIFQELIRQ LMNTAVTLLL ELFNGSAGMP FSVEKKNENL IRTFKDNSFP 490 500 510 520 530 540 TGKTTNDCEE LVDNSKLHAI SVQKSEVKTD TDINEILNSV EVGKDLRKTY APIFEVNLCL 550 560 570 580 590 600 RIPAESDSSE NSKENFHESD QCPEECVMFE DEMSENKDNC VKKHSSEELL PKAKKSKEIS 610 620 630 640 650 660 YNLEDIISAT ITPLCQDPQL SIFIDLVSIM DLPNKTGSII HYKEQTRWPD CHILFETDPA 670 680 690 700 710 720 YQNIIVNLLT IIGNSMGLVN AYSHKFIKYC TMTEKAKIMS MKISSMGELT SKEFEAILNR 730 740 750 760 770 780 FRNYFRHIVN MAIEKRIGIF NVVVESSLQQ LECDPTEIEE FLEHFIFLNA ISSKISKLEK 790 800 810 820 830 840 EFLTMSQLYS VAKHHQIHIS EEQIAIFQVL LLKFSQLKSS MKLSKINKDT AITKFRDNLE 850 860 870 880 890 900 ACISGLHVDV GNLKAKIRTP LLLCAGTQVS TAMEMIQTLS GEAASLTNKA KAYSHYQDCF 910 920 930 940 950 960 SDSQSHMHSV NVEEITQIVL SEISDIEGDL TLRKKLWEAQ EEWKRASWEW RNSSLQSIDV 970 980 990 1000 1010 1020 ESVQRNVSKL MHIISVLEKE IYSIFIIPSI DDISAQLEES QVILATIKGS PHIGPIKSQI 1030 1040 1050 1060 1070 1080 MFYNDCVKSF VSSYSREKLE KVHAGLMCHL EEVADLVVLD TSNSRTKAIL GALLILYVHC 1090 1100 1110 1120 1130 1140 RDIVINLLLK NIFNAEDFEW TRHLQYKWNE KQKLCYVSQG NASFTYGYEY LGCTSRLVIT 1150 1160 1170 1180 1190 1200 PLTDRCWLTL MEALHLNLGG CPAGPAGTGK TETVKDLAKC ALFAFKCNTA LIKLPNSLIV 1210 1220 1230 1240 1250 1260 LTCFGLEKTV LVMNTVMSFR FVLEGKEIRI NMSCAVFITM NPRYGGGVEL PDNLKSLFRP 1270 1280 1290 1300 1310 1320 VAMMVPHYQM IAEIILFSFG FKSANSLSGK LTNLYELARK QLSQQDHYNF GLRSLKIVLI 1330 1340 1350 1360 1370 1380 MAGTKKREFK CDTSDSLSEA DETLIVIEAI REASLPKCPP EDVPLFENII GDIFPEVTVL 1390 1400 1410 1420 1430 1440 KVNQLALEKV IYTATQQLGL QNWSSQKEKI IQFYNQLQVC VGVMLVGPTG GGKTTVRRIL 1450 1460 1470 1480 1490 1500 EKALTLLPIA DFLSVAERKS ASKISERKGK VDICVLNPKC VTLSELYGQL DPNTMEWTDG 1510 1520 1530 1540 1550 1560 LLSATIRSYV YFNTPKNTKK DIDLRLKSRI SDLSNVFKLD SSDTTETDDN IFEEIEKVVK 1570 1580 1590 1600 1610 1620 IPENHNFDWQ WIILDGPVDT FWVENLNSVL DDTRTLCLAN SERIALTNKI RVIFEVDNLS 1630 1640 1650 1660 1670 1680 QASPATVSRC AMVYMDPVDL GWEPYVKSWL LKTSKIISQS GVDCLEFMIK NSVTDGLQFI 1690 1700 1710 1720 1730 1740 RNRQKFQPYP MEDITVVITL CRILDAFFDF MGKNGGFEQS DDLNDTSSKE ANSQRESVTF 1750 1760 1770 1780 1790 1800 KDIEKRDENT WYPEKNPDKL TKIIQKLFVF AFTWAFGGAL NREDEHRENI PFCPSLEPDS 1810 1820 1830 1840 1850 1860 LAKVTYDFDK LVHELFGNSS QVGINLPTGE CSIFGYFVDI EQCEFIPWSD LVPNDQTLIQ 1870 1880 1890 1900 1910 1920 RDNPTKKPEV RTNKKLLKNN DHKGVVVSTI NFSTNVTAAK TKEMILKKLI RRTKDTLGAP 1930 1940 1950 1960 1970 1980 KNNRILIFID DMNMPVSDMY GAQPPLELIR QLLDLGGVYD TEKNTWKNIQ DLSIVAACVP 1990 2000 2010 2020 2030 2040 VVNDISPRLL KHFSMLVLPH PSQDILCTIF QIGIDGCGKK TCATLACYLT DNKLYRVPIS 2050 2060 2070 2080 2090 2100 HKCAYIEFKE VFKKVFIHAG LKGKPTVLMV PNLNIEQDSF LEDLNYIISS GRIPDLFENV 2110 2120 2130 2140 2150 2160 ELDSIAMKIR YLTEQSGHMD NRQSLLSFFQ KRIYKNLHIF VIMSPEGPSF RQNCRVYPSM 2170 2180 2190 2200 2210 2220 ISSCTIDWYE RWPEEALLIV ANSFLKEKVN FENRENLKEK LAPTCVQIHK SMKDLNRKYF 2230 2240 2250 2260 2270 2280 EETGRFYYTT PNSYLQFMET FAHILRAREE EMQTKRDRFH MGLSTILEAT TLVTEMQEEL 2290 2300 2310 2320 2330 2340 LILGPQVEQK TKETETLMEK LRKDSQVVEK VQMLVKQDEE IVAEEVRIVE DYAQKTANEL 2350 2360 2370 2380 2390 2400 KSVLPAFDKA IVALNALDKA DVAELRVYTR PPFLVLTVMN AVCILLQKKP NWATAKLLLS 2410 2420 2430 2440 2450 2460 ETGFLKKLIN LDKDSIPDKV FVKLKKIVTL PDFNPHKISL VSVACCSLCQ WVIALNNYHE 2470 2480 2490 2500 2510 2520 VQKVVGPKQI QVAEAQNVLK IARQRLAEKQ RGLQLISRWH NQGLPHGQYS VENAILIKNG 2530 2540 2550 2560 2570 2580 QQWPLLIDPH RQAHKWIRQM EGSRLQKLSI EDSNYTKKIE NAMKTGGSVL LQSCQASTWR 2590 2600 2610 2620 2630 2640 KKLYLSTEID NPHFLPSVYN FVTMINFTVT FQGLQDQLLS TVVTHEVPHL EDQRSKLLES 2650 2660 2670 2680 2690 2700 ISLDAITLEE LEEKTLNLLQ KALGSILDDD KIVDTLRKSK MTSNEISKRI EATKKAESEI 2710 2720 2730 2740 2750 2760 QAIRKNYLPI ATRGALLYFL VADLTQINYM YQFSLDWFHQ VFVSSVVSKS KEQEHSFKRE 2770 2780 2790 2800 2810 2820 KVSPKEVHEF ISISKEPNLE NEKNLLDKHI KSAIDMLTKS IFKVVSSALF NEDKLCFSFR 2830 2840 2850 2860 2870 2880 LCTVIMQNNA NGNLIQDDIG FLPEEEWNIF LYSGILINIK SALSQSRLTS TFEIGESQHL 2890 2900 2910 2920 2930 2940 QWLSDSRWRQ CQYVSTHLEP FSLLCKSLLS NVSQWDTFKN SKAVYSLIST PFSSENASLE 2950 2960 2970 2980 2990 3000 ENTKPPEEKH TFCLLLRAIN HTGTDLGPVG RGQWLTSTAC DRHTDVCSFS FALNDGVPDV 3010 3020 3030 3040 3050 3060 EHVQDIFYGH CVDKYHVKVL RPESLNNSVR KFITEKMGNK YLQRTGVNLK DAYKGSNART 3070 3080 3090 3100 3110 3120 PLILIQTHGS ASIKDYIHII QSLPDDDLPE VLGIHPEAIR SCWETQGEKF IENLIAMQPK 3130 3140 3150 3160 3170 3180 TTTANLMIRP EQSKDELVME ILSDLLKRLP LTVEKEEIAV GTPSTLKSMM SSSIWESLSK 3190 3200 3210 3220 3230 3240 NLKDHDPLIH CVLLTFLKQE IKRFDKLLFV IHKSLKDLQL AIKGEIILTQ ELEEIFNSFL 3250 3260 3270 3280 3290 3300 NMRVPTLWQK HAYRSCKPLS SWIDDLIQRL NFFNTWAKVA YTAIQRRYMR FVTVWKQSIP 3310 3320 3330 3340 3350 3360 STSQKCKHPE DSENNFFEGF PSRYWLPAFF FPQAFLAAVL QDYGRSRGIA VDALTFTHHV 3370 3380 3390 3400 3410 3420 ISNTTDKDEK FSVFMPKKLN IVRRAFKGSA SSHTGVYIFG LFIEGARWNR EQKILEDSLP 3430 3440 3450 3460 3470 3480 LEMCCDFPDI YFLPTKISTK TPNASNQTDS ELYAFECPVY QTPERSRILA TTGLPTNFLT 3490 3500 SVYLSTKKPP SHWITMRVAL LCEKNEK
	Isoform 2 [UniParc]. Checksum: 4FCBD670CE50E236	FASTA	453	53,464
	10 20 30 40 50 60 METFIPIDLT TENQEMDKEE TKTKPRLLRY EEKKYEDVKP LETQPAEIAE KETLEYKTVR 70 80 90 100 110 120 TFSESLKSEK TEDYLRESII QQHMVSPEPA SLKEKGKSRR KKDQTHACPN VRKARPVSYD 130 140 150 160 170 180 RTEPKDDDVI RNIIRLREKL GWQTILPQHS LKYGSSKIAI QKITLKKPLE DDGEFVYCLP 190 200 210 220 230 240 RKSPKSLYNP YDLQVVSAHT AKHCKEFWVI TASFISKVIN IVGSVKEVEL IPTLEWLSER 250 260 270 280 290 300 RHYYLLRQFK IFSDFRMNKA FVTWKLNVKR IKTEKSRSFL YHHLFLADDL FQTCLVYIRG 310 320 330 340 350 360 LCEDAINLKN YNDHENNLSA ICLVKLDSSR TYSLDEFCEE QLQQATQALK QLEDIRNKAI 370 380 390 400 410 420 SEMKSTFLKV AEKNEIKEYF ESKLSEDDTT HFKLPKYRRL LETFFKFVML VDYIFQELIR 430 440 450 QLMNTAVTLL LELFNGSAGM PFSVEKKNEN LIR
	Isoform 3 [UniParc]. Checksum: B038A7FB9772243D	FASTA	228	26,682
	10 20 30 40 50 60 METFIPIDLT TENQEMDKEE TKTKPRLLRY EEKKYEDVKP LETQPAEIAE KETLEYKTVR 70 80 90 100 110 120 TFSESLKSEK TEDYLRESII QQHMVSPEPA SLKEKGKSRR KKDQTHACPN VRKARPVSYD 130 140 150 160 170 180 RTEPKDDDVI RNIIRLREKL GWQTILPQHS LKYGSSKIAI QKITLKKPLE DDGEFVYCLP 190 200 210 220 RKSPKSLYNP YDLQVVSAHT AKHCKEFWVI TASFISKRYL VICGAVYI
	Isoform 4 [UniParc]. Checksum: F59EF01CCCED2401	FASTA	4,515	518,565
	10 20 30 40 50 60 METFIPIDLT TENQEMDKEE TKTKPRLLRY EEKKYEDVKP LETQPAEIAE KETLEYKTVR 70 80 90 100 110 120 TFSESLKSEK TEDYLRESII QQHMVSPEPA SLKEKGKSRR KKDQTHACPN VRKARPVSYD 130 140 150 160 170 180 RTEPKDDDVI RNIIRLREKL GWQTILPQHS LKYGSSKIAI QKITLKKPLE DDGEFVYCLP 190 200 210 220 230 240 RKSPKSLYNP YDLQVVSAHT AKHCKEFWVI TASFISKVIN IVGSVKEVEL IPTLEWLSER 250 260 270 280 290 300 RHYYLLRQFK IFSDFRMNKA FVTWKLNVKR IKTEKSRSFL YHHLFLADDL FQTCLVYIRG 310 320 330 340 350 360 LCEDAINLKN YNDHENNLSA ICLVKLDSSR TYSLDEFCEE QLQQATQALK QLEDIRNKAI 370 380 390 400 410 420 SEMKSTFLKV AEKNEIKEYF ESKLSEDDTT HFKLPKYRRL LETFFKFVML VDYIFQELIR 430 440 450 460 470 480 QLMNTAVTLL LELFNGSAGM PFSVEKKNEN LIRTFKDNSF PTGKTTNDCE ELVDNSKLHA 490 500 510 520 530 540 ISVQKSEVKT DTDINEILNS VEVGKDLRKT YAPIFEVNLC LRIPAESDSS ENSKENFHES 550 560 570 580 590 600 DQCPEECVMF EDEMSENKDN CVKKHSSEEL LPKAKKSKEI SYNLEDIISD TEIETEFENK 610 620 630 640 650 660 YMYYEFPEFP TNLFIDPNRL EFSVKIQNML TNMEKCITTI TPLCQDPQLS IFIDLVSIMD 670 680 690 700 710 720 LPNKTGSIIH YKEQTRWPDC HILFETDPAY QNIIVNLLTI IGNSMGLVNA YSHKFIKYCT 730 740 750 760 770 780 MTEKAKIMSM KISSMGELTS KEFEAILNRF RNYFRHIVNM AIEKRIGIFN VVSLDYQSEC 790 800 810 820 830 840 LLYIDNVIHM SHTLIQSVIE KKNKNLLEVV ESSLQQLECD PTEIEEFLEH FIFLNAISSK 850 860 870 880 890 900 ISKLEKEFLT MSQLYSVAKH HQIHISEEQI AIFQVLLLKF SQLKSSMKLS KINKDTAITK 910 920 930 940 950 960 FRDNLEACIS GLHVDVGNLK AKIRTPLLLC AGTQVSTAME MIQTLSGEAA SLTNKAKAYS 970 980 990 1000 1010 1020 HYQDCFSDSQ SHMHSVNVEE ITQIVLSEIS DIEGDLTLRK KLWEAQEEWK RASWEWRNSS 1030 1040 1050 1060 1070 1080 LQSIDVESVQ RNVSKLMHII SVLEKGLPKS DMVTHLKQVV TEFKQELPII IALGNPCLKP 1090 1100 1110 1120 1130 1140 RHWEALQEII GKSVPLDKNC KVENLLALKM FQYENEINDM STSATNEAAL EKMLFKIIDF 1150 1160 1170 1180 1190 1200 WNTTPLPLIL HHTEIYSIFI IPSIDDISAQ LEESQVILAT IKGSPHIGPI KDLVNEWDQN 1210 1220 1230 1240 1250 1260 LTLFSYTLEE WMNCQRNWLY LEPVFHSSEI RRQLPAETEL FSQVISMWKK IMSKIQNKQN 1270 1280 1290 1300 1310 1320 ALQITTSAGV LEILQNCNIH LEHIKKSLED YLEVKRLIFP RFYFLSNAEL LDILADSRNP 1330 1340 1350 1360 1370 1380 ESVQPHLVKC FENIKQLLIW KQDIGPPAVK MLISAEGEGL VLPKKIRVRS AVEQWLVNVE 1390 1400 1410 1420 1430 1440 KSMFDVLKKE RYIYNIILLF QSQIMFYNDC VKSFVSSYSR EKLEKVHAGL MCHLEEVADL 1450 1460 1470 1480 1490 1500 VVLDTSNSRT KAILGALLIL YVHCRDIVIN LLLKNIFNAE DFEWTRHLQY KWNEKQKLCY 1510 1520 1530 1540 1550 1560 VSQGNASFTY GYEYLGCTSR LVITPLTDRC WLTLMEALHL NLGGCPAGPA GTGKTETVKD 1570 1580 1590 1600 1610 1620 LAKSLGKHCV VFNCFEDLDY KIVRKFFFGL VQSGAWSCFD EFNLIDLEVL SVIASQILTI 1630 1640 1650 1660 1670 1680 KAAKDNYSAR FVLEGKEIRI NMSCAVFITM NPRYGGGVEL PDNLKSLFRP VAMMVPHYQM 1690 1700 1710 1720 1730 1740 IAEIILFSFG FKSANSLSGK LTNLYELARK QLSQQDHYNF GLRSLKIVLI MAGTKKREFK 1750 1760 1770 1780 1790 1800 CLSEADETLI VIEAIREASL PKCPPEDVPL FENIIGDIFP EVTVLKVNQL ALEKVIYTAT 1810 1820 1830 1840 1850 1860 QQLGLQNWSS QKEKIIQFYN QLQVCVGVML VGPTGGGKTT VRRILEKALT LLPIADFLSV 1870 1880 1890 1900 1910 1920 AERKSASKIS ERKGKVDICV LNPKCVTLSE LYGQLDPNTM EWTDGLLSAT IRSYVYFNTP 1930 1940 1950 1960 1970 1980 KNTKKDIDLR LKSRISDLSN VFKLDSSDTT ETDDNIFEEI EKVVKIPENH NFDWQWIILD 1990 2000 2010 2020 2030 2040 GPVDTFWVEN LNSVLDDTRT LCLANSERIA LTNKIRVIFE VDNLSQASPA TVSRCAMVYM 2050 2060 2070 2080 2090 2100 DPVDLGWEPY VKSWLLKTSK IISQSGVDCL EFMIKNSVTD GLQFIRNRQK FQPYPMEDIT 2110 2120 2130 2140 2150 2160 VVITLCRILD AFFDFMGKNG GFEQSDDLND TSSKEANSQR ESVTFKDIEK RDENTWYPEK 2170 2180 2190 2200 2210 2220 NPDKLTKIIQ KLFVFAFTWA FGGALNREDE HRENIPFCPS LEPDSLAKVT YDFDKLVHEL 2230 2240 2250 2260 2270 2280 FGNSSQVGWK HWGQSQGRRR KGNCINLPTG ECSIFGYFVD IEQCEFIPWS DLVPNDQTLI 2290 2300 2310 2320 2330 2340 QRGTSLLTNL QRSGGNFLKI TECGECINYT ATRDTTCLSF LMSLLLKNSC PVLLTGESGV 2350 2360 2370 2380 2390 2400 GKTAAINQML EKLEGPGAFD IKHGSILGDT LLYSEIKKSS SLKQNITILI PETHKTATGS 2410 2420 2430 2440 2450 2460 SDNPTKKPEV RTNKKLLKNN DHKGVVVSTI NFSTNVTAAK TKEMILKKLI RRTKDTLGAP 2470 2480 2490 2500 2510 2520 KNNRILIFID DMNMPVSDMY GAQPPLELIR QLLDLGGVYD TEKNTWKNIQ DLSIVAACVP 2530 2540 2550 2560 2570 2580 VVNDISPRLL KHFSMLVLPH PSQDILCTIF QAHLGIYFSI NNFTPEVQKS KDQIISCSLA 2590 2600 2610 2620 2630 2640 IYHQVRQNML PTPTKCHYMF NLRDMFKLLL GLLQADRTVV NSKEMAALLF VHEATRVFHD 2650 2660 2670 2680 2690 2700 RLIDFTDKSL FYRLLSRELE NCFQIGIDGC GKKTCATLAC YLTDNKLYRV PISHKCAYIE 2710 2720 2730 2740 2750 2760 FKEVFKKVFI HAGLKGKPTV LMVPNLNIEQ DSFLEDLNYI ISSGRIPDLF ENVELDSIAM 2770 2780 2790 2800 2810 2820 KIRYLTEQSG HMDNRQSLLS FFQKRIYKNL HIFVIMSPEG PSFRQNCRVY PSMISSCTID 2830 2840 2850 2860 2870 2880 WYERWPEEAL LIVANSFLKE KVNFENRENL KEKLAPTCVQ IHKSMKDLNR KYFEETGRFY 2890 2900 2910 2920 2930 2940 YTTPNSYLQF METFAHILRA REEEMQTKRD RFHMGLSTIL EATTLVTEMQ EELLILGPQV 2950 2960 2970 2980 2990 3000 EQKTKETETL MEKLRKDSQV VEKVQMLVKQ DEEIVAEEVR IVEDYAQKTA NELKSVLPAF 3010 3020 3030 3040 3050 3060 DKAIVALNAL DKADVAELRV YTRPPFLVLT VMNAVCILLQ KKPNWATAKL LLSETGFLKK 3070 3080 3090 3100 3110 3120 LINLDKDSIP DKVFVKLKKI VTLPDFNPHK ISLVSVACCS LCQWVIALNN YHEVQKVVGP 3130 3140 3150 3160 3170 3180 KQIQVAEAQN VLKIARQRLA EKQRGLQLVE EHLLFLQAAY KDTVAEKQLL ANRKTMASRR 3190 3200 3210 3220 3230 3240 FQCASVLLTV LEDEKTRWQE TINQIDNKLE GILGDILLSA ACIVYSGILT PEFRQLIVNK 3250 3260 3270 3280 3290 3300 WETFCIENGI SLSSKFSLIK VMAQKYEISR WHNQGLPHGQ YSVENAILIK NGQQWPLLID 3310 3320 3330 3340 3350 3360 PHRQAHKWIR QMEGSRLQKL SIEDSNYTKK IENAMKTGGS VLLQNLLETL APGLKAILKK 3370 3380 3390 3400 3410 3420 DIYQKKGHYF IRVGDAEFEY NSNFRLYLST EIDNPHFLPS VYNFVTMINF TVTFQGLQDQ 3430 3440 3450 3460 3470 3480 LLSTVVTHEV PHLEDQRSKL LESISLDAIT LEELEEKTLN LLQKALGSIL DDDKIVDTLR 3490 3500 3510 3520 3530 3540 KSKMTSNEIS KRIEATKKAE SEIQAIRKNY LPIATRGALL YFLVADLTQI NYMYQFSLDW 3550 3560 3570 3580 3590 3600 FHQVFVSSVV SKSKEQEHSF KREKVSPKEV HEFISISKEP NLENEKNLLD KHIKSAIDML 3610 3620 3630 3640 3650 3660 TKSIFKVVSS ALFNEDKLCF SFRLCTVIMQ NNANGNLIQD DIGFLPEEEW NIFLYSGILI 3670 3680 3690 3700 3710 3720 NIKSALSQSR LTSTFEIGES QHLQWLSDSR WRQCQYVSTH LEPFSLLCKS LLSNVSQWDT 3730 3740 3750 3760 3770 3780 FKNSKAVYSL ISTPFSSENA SLEENTKPPE ETELLNENKE TCNPINFPWE KLTSFQRLIL 3790 3800 3810 3820 3830 3840 VKVLRPESLN NSVRKFITEK MGNKYLQRTG VNLKDAYKGS NARTPLILIQ THGIDLTNIL 3850 3860 3870 3880 3890 3900 LRFAQELKGT THHVTIISLG RDQAAKAEDL ILKALTKTQQ WVFLQNCHLA TSFMPRLCTI 3910 3920 3930 3940 3950 3960 VESFNSPNVT IDPEFRLWLS SKSYSSFPIP VLKKGLKIAV ESPQGLKSNL LQTFGCTGSG 3970 3980 3990 4000 4010 4020 EVTEEIFENP DCGQWWKKLL FSLCFFNAVI NERKNYGILG WNIAYKFNSS DLGVAIKVLE 4030 4040 4050 4060 4070 4080 NSLRGQPSIS WQALRYLIGE VIYGGRVIDN WDKRCLKTLL YKFCNPEVLK DDFSFSRSAS 4090 4100 4110 4120 4130 4140 IKDYIHIIQS LPDDDLPEVL GIHPEAIRSC WETQGEKFIE NLIAMQPKTT TANLMIRPEQ 4150 4160 4170 4180 4190 4200 SKDELVMEIL SDLLKRLPLT VEKEEIAVGT PSTLKSMMSS SIWESLSKNL KDHDPLIHCV 4210 4220 4230 4240 4250 4260 LLTFLKQEIK RFDKLLFVIH KSLKDLQLAI KGEIILTQEL EEIFNSFLNM RVPTLWQKHA 4270 4280 4290 4300 4310 4320 YRSCKPLSSW IDDLIQRLNF FNTWAKVAYT AIQRRYMRFV TVWKQSIPST SQKCKHPEDS 4330 4340 4350 4360 4370 4380 ENNFFEGFPS RYWLPAFFFP QAFLAAVLQD YGRSRGIAVD ALTFTHHVIS NTTDKDEKFS 4390 4400 4410 4420 4430 4440 VFMPKKLNIV RRAFKGSASS HTGVYIFGLF IEGARWNREQ KILEDSLPLE MCCDFPDIYF 4450 4460 4470 4480 4490 4500 LPTKISTKTP NASNQTDSEL YAFECPVYQT PERSRILATT GLPTNFLTSV YLSTKKPPSH 4510 WITMRVALLC EKNEK

References

[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS SER-220 AND LEU-274.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC093560 Genomic DNA. No translation available. AL590547 Genomic DNA. No translation available. AL596134 Genomic DNA. No translation available. AL645769 Genomic DNA. No translation available. AL357912 Genomic DNA. Translation: CAI95150.2. Sequence problems. AL162738 Genomic DNA. Translation: CAI95641.1. Sequence problems. AL162738, AC092811 Genomic DNA. Translation: CAI95642.2. Sequence problems. CH471098 Genomic DNA. Translation: EAW69735.1. Sequence problems. BC119716 mRNA. Translation: AAI19717.1. Different initiation. BC119717 mRNA. Translation: AAI19718.1. Different initiation.
IPI	IPI00479838. IPI00884997. IPI00885037. IPI00925578.
RefSeq	NP_001138626.1. NM_001145154.1. NP_001364.1. NM_001373.1. NP_659426.2. NM_144989.2.
UniGene	Hs.133977.
3D structure databases
ProteinModelPortal	Q0VDD8.
ModBase	Search...
PTM databases
PhosphoSite	Q0VDD8.
Polymorphism databases
DMDM	172046085.
Proteomic databases
PaxDb	Q0VDD8.
PRIDE	Q0VDD8.
Protocols and materials databases
DNASU	127602.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000366848; ENSP00000355813; ENSG00000185842. ENST00000366850; ENSP00000355815; ENSG00000185842. ENST00000400952; ENSP00000383737; ENSG00000185842. ENST00000430092; ENSP00000414402; ENSG00000185842. ENST00000439375; ENSP00000392061; ENSG00000185842. ENST00000445597; ENSP00000409472; ENSG00000185842.
GeneID	127602.
KEGG	hsa:127602.
UCSC	uc001hot.4. human. uc001hov.4. human. uc001how.2. human.
Organism-specific databases
CTD	127602.
GeneCards	GC01P225083.
HGNC	HGNC:2945. DNAH14.
HPA	HPA027718.
MIM	603341. gene.
neXtProt	NX_Q0VDD8.
PharmGKB	PA27399.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5245.
OMA	MIFPRFY.
Gene expression databases
ArrayExpress	Q0VDD8.
Bgee	Q0VDD8.
Genevestigator	Q0VDD8.
Family and domain databases
InterPro	IPR026983. DHC_fam. IPR024743. Dynein_HC_stalk. IPR024317. Dynein_heavy_chain_D4_dom. IPR004273. Dynein_heavy_dom. [Graphical view]
PANTHER	PTHR10676. PTHR10676. 1 hit.
Pfam	PF12780. AAA_8. 1 hit. PF03028. Dynein_heavy. 3 hits. PF12777. MT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	127602.
NextBio	82137.
SOURCE	Search...

Entry information

Entry name

DYH14_HUMAN

Accession

Primary (citable) accession number: Q0VDD8
Secondary accession number(s): A6NG62 , A6NNL2, Q0VDD9, Q4VXC7, Q4VXG4, Q4VXG5, Q5VU33, Q5VU34

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	February 26, 2008
Last modified:	May 1, 2013
This is version 63 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.