Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q0VDD7 (CS057_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C19orf57
Alternative name(s):
Pre-T/NK cell-associated protein 3B3
Gene names
Name:C19orf57
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length668 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence caution

The sequence AAB02340.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Non-traceable author statement Ref.3. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

AIMP2Q131555EBI-741210,EBI-745226
COPS4Q9BT782EBI-741210,EBI-742413

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q0VDD7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q0VDD7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     588-619: RTFVGIQASEASRMEDATNVVRGLIVELSNLN → S

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 668668Uncharacterized protein C19orf57
PRO_0000295737

Amino acid modifications

Modified residue3701Phosphoserine Ref.4

Natural variations

Alternative sequence588 – 61932RTFVG…LSNLN → S in isoform 2.
VSP_027044
Natural variant2671G → R. Ref.2
Corresponds to variant rs2305775 [ dbSNP | Ensembl ].
VAR_033356
Natural variant5001Q → R. Ref.2
Corresponds to variant rs3803892 [ dbSNP | Ensembl ].
VAR_033357

Experimental info

Sequence conflict4911D → E in AAI19720. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: 64E4242D2B5C6507

FASTA66869,556
        10         20         30         40         50         60 
MTKRKKLRTS GEGLCPPKPL KNPRLGDFYG DPQSSMLGCL HHPEEPEGKL GPVPSTQQHG 

        70         80         90        100        110        120 
EEPGKAVSSS PDEETGSPCR LLRQPEKEPA PLPPSQNSFG RFVPQFAKSR KTVTRKEEMK 

       130        140        150        160        170        180 
DEDRGSGAFS LETIAESSAQ SPGCQLLVET LGVPLQEATE LGDPTQADSA RPEQSSQSPV 

       190        200        210        220        230        240 
QAVPGSGDSQ PDDPPDRGTG LSASQRASQD HLSEQGADDS KPETDRVPGD GGQKEHLPSI 

       250        260        270        280        290        300 
DSEGEKPDRG APQEGGAQRT AGAGLPGGPQ EEGDGVPCTP ASAPTSGPAP GLGPASWCLE 

       310        320        330        340        350        360 
PGSVAQGSPD PQQTPSRMGR EGEGTHSSLG CSSLGMVVIA DLSTDPTELE ERALEVAGPD 

       370        380        390        400        410        420 
GQASAISPAS PRRKAADGGH RRALPGCTSL TGETTGESGE AGQDGKPPGD VLVGPTASLA 

       430        440        450        460        470        480 
LAPGSGESMM GAGDSGHASP DTGPCVNQKQ EPGPAQEEAE LGGQNLERDL EGFRVSPQAS 

       490        500        510        520        530        540 
VVLEHREIAD DPLQEPGAQQ GIPDTTSELA GQRDHLPHSA DQGTWADSLA VELDFLLDSQ 

       550        560        570        580        590        600 
IQDALDASDF EAPPEQLFPS GNKPGPCWPG PSSHANGDPV AVAKAQPRTF VGIQASEASR 

       610        620        630        640        650        660 
MEDATNVVRG LIVELSNLNR LIMGTHRDLE AFKRLNYRKT KLGGKAPLPY PSKGPGNIPR 


GDPPWREL 

« Hide

Isoform 2 [UniParc].

Checksum: 6A126CCD5C3E9867
Show »

FASTA63766,170

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 123-668 (ISOFORM 1), VARIANTS ARG-267 AND ARG-500.
Tissue: Lung and Mammary gland.
[3]"Identification of human pre-T/NK cell-associated genes."
Ranes-Goldberg M.G., Hori T., Mohan-Peterson S., Spits H.
J. Immunol. 151:5810-5821(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-370, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK097431 mRNA. Translation: BAC05049.1.
BC002891 mRNA. Translation: AAH02891.2.
BC012945 mRNA. Translation: AAH12945.2.
BC119719 mRNA. Translation: AAI19720.1.
L17327 mRNA. Translation: AAB02340.1. Sequence problems.
RefSeqNP_077299.3. NM_024323.3.
UniGeneHs.143288.

3D structure databases

ProteinModelPortalQ0VDD7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122590. 15 interactions.
IntActQ0VDD7. 13 interactions.
STRING9606.ENSP00000254336.

PTM databases

PhosphoSiteQ0VDD7.

Polymorphism databases

DMDM158564134.

Proteomic databases

PaxDbQ0VDD7.
PRIDEQ0VDD7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000346736; ENSP00000254336; ENSG00000132016. [Q0VDD7-2]
ENST00000454313; ENSP00000404382; ENSG00000132016. [Q0VDD7-1]
ENST00000586783; ENSP00000465822; ENSG00000132016. [Q0VDD7-1]
GeneID79173.
KEGGhsa:79173.
UCSCuc002mxk.1. human. [Q0VDD7-1]
uc002mxl.1. human. [Q0VDD7-2]

Organism-specific databases

CTD79173.
GeneCardsGC19M013993.
HGNCHGNC:28153. C19orf57.
HPAHPA044012.
neXtProtNX_Q0VDD7.
PharmGKBPA162378679.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45524.
HOGENOMHOG000111997.
HOVERGENHBG107766.
InParanoidQ0VDD7.
OMACLEPGSV.
OrthoDBEOG7060QP.
PhylomeDBQ0VDD7.
TreeFamTF337646.

Gene expression databases

ArrayExpressQ0VDD7.
BgeeQ0VDD7.
CleanExHS_C19orf57.
GenevestigatorQ0VDD7.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi79173.
NextBio68141.

Entry information

Entry nameCS057_HUMAN
AccessionPrimary (citable) accession number: Q0VDD7
Secondary accession number(s): Q13411 expand/collapse secondary AC list , Q8N825, Q96D63, Q9BU49
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM