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Q0VDD7

- CS057_HUMAN

UniProt

Q0VDD7 - CS057_HUMAN

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Protein

Uncharacterized protein C19orf57

Gene

C19orf57

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C19orf57
Alternative name(s):
Pre-T/NK cell-associated protein 3B3
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:28153. C19orf57.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162378679.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 668668Uncharacterized protein C19orf57PRO_0000295737Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei370 – 3701Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ0VDD7.
PaxDbiQ0VDD7.
PRIDEiQ0VDD7.

PTM databases

PhosphoSiteiQ0VDD7.

Expressioni

Gene expression databases

BgeeiQ0VDD7.
CleanExiHS_C19orf57.
ExpressionAtlasiQ0VDD7. baseline.
GenevestigatoriQ0VDD7.

Organism-specific databases

HPAiHPA044012.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AIMP2Q131555EBI-741210,EBI-745226
COPS4Q9BT782EBI-741210,EBI-742413

Protein-protein interaction databases

BioGridi122590. 15 interactions.
IntActiQ0VDD7. 13 interactions.
STRINGi9606.ENSP00000254336.

Structurei

3D structure databases

ProteinModelPortaliQ0VDD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG45524.
GeneTreeiENSGT00390000016855.
HOGENOMiHOG000111997.
HOVERGENiHBG107766.
InParanoidiQ0VDD7.
OMAiCLEPGSV.
OrthoDBiEOG7060QP.
PhylomeDBiQ0VDD7.
TreeFamiTF337646.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q0VDD7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKRKKLRTS GEGLCPPKPL KNPRLGDFYG DPQSSMLGCL HHPEEPEGKL
60 70 80 90 100
GPVPSTQQHG EEPGKAVSSS PDEETGSPCR LLRQPEKEPA PLPPSQNSFG
110 120 130 140 150
RFVPQFAKSR KTVTRKEEMK DEDRGSGAFS LETIAESSAQ SPGCQLLVET
160 170 180 190 200
LGVPLQEATE LGDPTQADSA RPEQSSQSPV QAVPGSGDSQ PDDPPDRGTG
210 220 230 240 250
LSASQRASQD HLSEQGADDS KPETDRVPGD GGQKEHLPSI DSEGEKPDRG
260 270 280 290 300
APQEGGAQRT AGAGLPGGPQ EEGDGVPCTP ASAPTSGPAP GLGPASWCLE
310 320 330 340 350
PGSVAQGSPD PQQTPSRMGR EGEGTHSSLG CSSLGMVVIA DLSTDPTELE
360 370 380 390 400
ERALEVAGPD GQASAISPAS PRRKAADGGH RRALPGCTSL TGETTGESGE
410 420 430 440 450
AGQDGKPPGD VLVGPTASLA LAPGSGESMM GAGDSGHASP DTGPCVNQKQ
460 470 480 490 500
EPGPAQEEAE LGGQNLERDL EGFRVSPQAS VVLEHREIAD DPLQEPGAQQ
510 520 530 540 550
GIPDTTSELA GQRDHLPHSA DQGTWADSLA VELDFLLDSQ IQDALDASDF
560 570 580 590 600
EAPPEQLFPS GNKPGPCWPG PSSHANGDPV AVAKAQPRTF VGIQASEASR
610 620 630 640 650
MEDATNVVRG LIVELSNLNR LIMGTHRDLE AFKRLNYRKT KLGGKAPLPY
660
PSKGPGNIPR GDPPWREL
Length:668
Mass (Da):69,556
Last modified:July 24, 2007 - v2
Checksum:i64E4242D2B5C6507
GO
Isoform 2 (identifier: Q0VDD7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     588-619: RTFVGIQASEASRMEDATNVVRGLIVELSNLN → S

Show »
Length:637
Mass (Da):66,170
Checksum:i6A126CCD5C3E9867
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti491 – 4911D → E in AAI19720. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti267 – 2671G → R.1 Publication
Corresponds to variant rs2305775 [ dbSNP | Ensembl ].
VAR_033356
Natural varianti500 – 5001Q → R.1 Publication
Corresponds to variant rs3803892 [ dbSNP | Ensembl ].
VAR_033357

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei588 – 61932RTFVG…LSNLN → S in isoform 2. 2 PublicationsVSP_027044Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097431 mRNA. Translation: BAC05049.1.
BC002891 mRNA. Translation: AAH02891.2.
BC012945 mRNA. Translation: AAH12945.2.
BC119719 mRNA. Translation: AAI19720.1.
L17327 mRNA. Translation: AAB02340.1. Sequence problems.
CCDSiCCDS12299.1. [Q0VDD7-2]
RefSeqiNP_077299.3. NM_024323.3. [Q0VDD7-2]
XP_006722948.1. XM_006722885.1. [Q0VDD7-2]
UniGeneiHs.143288.

Genome annotation databases

EnsembliENST00000346736; ENSP00000254336; ENSG00000132016. [Q0VDD7-2]
ENST00000586783; ENSP00000465822; ENSG00000132016. [Q0VDD7-1]
GeneIDi79173.
KEGGihsa:79173.
UCSCiuc002mxk.1. human. [Q0VDD7-1]
uc002mxl.1. human. [Q0VDD7-2]

Polymorphism databases

DMDMi158564134.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097431 mRNA. Translation: BAC05049.1 .
BC002891 mRNA. Translation: AAH02891.2 .
BC012945 mRNA. Translation: AAH12945.2 .
BC119719 mRNA. Translation: AAI19720.1 .
L17327 mRNA. Translation: AAB02340.1 . Sequence problems.
CCDSi CCDS12299.1. [Q0VDD7-2 ]
RefSeqi NP_077299.3. NM_024323.3. [Q0VDD7-2 ]
XP_006722948.1. XM_006722885.1. [Q0VDD7-2 ]
UniGenei Hs.143288.

3D structure databases

ProteinModelPortali Q0VDD7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122590. 15 interactions.
IntActi Q0VDD7. 13 interactions.
STRINGi 9606.ENSP00000254336.

PTM databases

PhosphoSitei Q0VDD7.

Polymorphism databases

DMDMi 158564134.

Proteomic databases

MaxQBi Q0VDD7.
PaxDbi Q0VDD7.
PRIDEi Q0VDD7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000346736 ; ENSP00000254336 ; ENSG00000132016 . [Q0VDD7-2 ]
ENST00000586783 ; ENSP00000465822 ; ENSG00000132016 . [Q0VDD7-1 ]
GeneIDi 79173.
KEGGi hsa:79173.
UCSCi uc002mxk.1. human. [Q0VDD7-1 ]
uc002mxl.1. human. [Q0VDD7-2 ]

Organism-specific databases

CTDi 79173.
GeneCardsi GC19M013993.
HGNCi HGNC:28153. C19orf57.
HPAi HPA044012.
neXtProti NX_Q0VDD7.
PharmGKBi PA162378679.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45524.
GeneTreei ENSGT00390000016855.
HOGENOMi HOG000111997.
HOVERGENi HBG107766.
InParanoidi Q0VDD7.
OMAi CLEPGSV.
OrthoDBi EOG7060QP.
PhylomeDBi Q0VDD7.
TreeFami TF337646.

Miscellaneous databases

ChiTaRSi C19orf57. human.
GenomeRNAii 79173.
NextBioi 68141.

Gene expression databases

Bgeei Q0VDD7.
CleanExi HS_C19orf57.
ExpressionAtlasi Q0VDD7. baseline.
Genevestigatori Q0VDD7.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 123-668 (ISOFORM 1), VARIANTS ARG-267 AND ARG-500.
    Tissue: Lung and Mammary gland.
  3. "Identification of human pre-T/NK cell-associated genes."
    Ranes-Goldberg M.G., Hori T., Mohan-Peterson S., Spits H.
    J. Immunol. 151:5810-5821(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-370, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiCS057_HUMAN
AccessioniPrimary (citable) accession number: Q0VDD7
Secondary accession number(s): Q13411
, Q8N825, Q96D63, Q9BU49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: November 26, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3