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Q0VDD7

- CS057_HUMAN

UniProt

Q0VDD7 - CS057_HUMAN

Protein

Uncharacterized protein C19orf57

Gene

C19orf57

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 2 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein C19orf57
    Alternative name(s):
    Pre-T/NK cell-associated protein 3B3
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:28153. C19orf57.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162378679.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 668668Uncharacterized protein C19orf57PRO_0000295737Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei370 – 3701Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ0VDD7.
    PRIDEiQ0VDD7.

    PTM databases

    PhosphoSiteiQ0VDD7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ0VDD7.
    BgeeiQ0VDD7.
    CleanExiHS_C19orf57.
    GenevestigatoriQ0VDD7.

    Organism-specific databases

    HPAiHPA044012.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AIMP2Q131555EBI-741210,EBI-745226
    COPS4Q9BT782EBI-741210,EBI-742413

    Protein-protein interaction databases

    BioGridi122590. 15 interactions.
    IntActiQ0VDD7. 13 interactions.
    STRINGi9606.ENSP00000254336.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0VDD7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG45524.
    HOGENOMiHOG000111997.
    HOVERGENiHBG107766.
    InParanoidiQ0VDD7.
    OMAiCLEPGSV.
    OrthoDBiEOG7060QP.
    PhylomeDBiQ0VDD7.
    TreeFamiTF337646.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q0VDD7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTKRKKLRTS GEGLCPPKPL KNPRLGDFYG DPQSSMLGCL HHPEEPEGKL    50
    GPVPSTQQHG EEPGKAVSSS PDEETGSPCR LLRQPEKEPA PLPPSQNSFG 100
    RFVPQFAKSR KTVTRKEEMK DEDRGSGAFS LETIAESSAQ SPGCQLLVET 150
    LGVPLQEATE LGDPTQADSA RPEQSSQSPV QAVPGSGDSQ PDDPPDRGTG 200
    LSASQRASQD HLSEQGADDS KPETDRVPGD GGQKEHLPSI DSEGEKPDRG 250
    APQEGGAQRT AGAGLPGGPQ EEGDGVPCTP ASAPTSGPAP GLGPASWCLE 300
    PGSVAQGSPD PQQTPSRMGR EGEGTHSSLG CSSLGMVVIA DLSTDPTELE 350
    ERALEVAGPD GQASAISPAS PRRKAADGGH RRALPGCTSL TGETTGESGE 400
    AGQDGKPPGD VLVGPTASLA LAPGSGESMM GAGDSGHASP DTGPCVNQKQ 450
    EPGPAQEEAE LGGQNLERDL EGFRVSPQAS VVLEHREIAD DPLQEPGAQQ 500
    GIPDTTSELA GQRDHLPHSA DQGTWADSLA VELDFLLDSQ IQDALDASDF 550
    EAPPEQLFPS GNKPGPCWPG PSSHANGDPV AVAKAQPRTF VGIQASEASR 600
    MEDATNVVRG LIVELSNLNR LIMGTHRDLE AFKRLNYRKT KLGGKAPLPY 650
    PSKGPGNIPR GDPPWREL 668
    Length:668
    Mass (Da):69,556
    Last modified:July 24, 2007 - v2
    Checksum:i64E4242D2B5C6507
    GO
    Isoform 2 (identifier: Q0VDD7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         588-619: RTFVGIQASEASRMEDATNVVRGLIVELSNLN → S

    Show »
    Length:637
    Mass (Da):66,170
    Checksum:i6A126CCD5C3E9867
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti491 – 4911D → E in AAI19720. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti267 – 2671G → R.1 Publication
    Corresponds to variant rs2305775 [ dbSNP | Ensembl ].
    VAR_033356
    Natural varianti500 – 5001Q → R.1 Publication
    Corresponds to variant rs3803892 [ dbSNP | Ensembl ].
    VAR_033357

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei588 – 61932RTFVG…LSNLN → S in isoform 2. 2 PublicationsVSP_027044Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK097431 mRNA. Translation: BAC05049.1.
    BC002891 mRNA. Translation: AAH02891.2.
    BC012945 mRNA. Translation: AAH12945.2.
    BC119719 mRNA. Translation: AAI19720.1.
    L17327 mRNA. Translation: AAB02340.1. Sequence problems.
    CCDSiCCDS12299.1. [Q0VDD7-2]
    RefSeqiNP_077299.3. NM_024323.3. [Q0VDD7-2]
    XP_006722948.1. XM_006722885.1. [Q0VDD7-2]
    UniGeneiHs.143288.

    Genome annotation databases

    EnsembliENST00000346736; ENSP00000254336; ENSG00000132016. [Q0VDD7-2]
    ENST00000586783; ENSP00000465822; ENSG00000132016. [Q0VDD7-1]
    GeneIDi79173.
    KEGGihsa:79173.
    UCSCiuc002mxk.1. human. [Q0VDD7-1]
    uc002mxl.1. human. [Q0VDD7-2]

    Polymorphism databases

    DMDMi158564134.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK097431 mRNA. Translation: BAC05049.1 .
    BC002891 mRNA. Translation: AAH02891.2 .
    BC012945 mRNA. Translation: AAH12945.2 .
    BC119719 mRNA. Translation: AAI19720.1 .
    L17327 mRNA. Translation: AAB02340.1 . Sequence problems.
    CCDSi CCDS12299.1. [Q0VDD7-2 ]
    RefSeqi NP_077299.3. NM_024323.3. [Q0VDD7-2 ]
    XP_006722948.1. XM_006722885.1. [Q0VDD7-2 ]
    UniGenei Hs.143288.

    3D structure databases

    ProteinModelPortali Q0VDD7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122590. 15 interactions.
    IntActi Q0VDD7. 13 interactions.
    STRINGi 9606.ENSP00000254336.

    PTM databases

    PhosphoSitei Q0VDD7.

    Polymorphism databases

    DMDMi 158564134.

    Proteomic databases

    PaxDbi Q0VDD7.
    PRIDEi Q0VDD7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000346736 ; ENSP00000254336 ; ENSG00000132016 . [Q0VDD7-2 ]
    ENST00000586783 ; ENSP00000465822 ; ENSG00000132016 . [Q0VDD7-1 ]
    GeneIDi 79173.
    KEGGi hsa:79173.
    UCSCi uc002mxk.1. human. [Q0VDD7-1 ]
    uc002mxl.1. human. [Q0VDD7-2 ]

    Organism-specific databases

    CTDi 79173.
    GeneCardsi GC19M013993.
    HGNCi HGNC:28153. C19orf57.
    HPAi HPA044012.
    neXtProti NX_Q0VDD7.
    PharmGKBi PA162378679.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45524.
    HOGENOMi HOG000111997.
    HOVERGENi HBG107766.
    InParanoidi Q0VDD7.
    OMAi CLEPGSV.
    OrthoDBi EOG7060QP.
    PhylomeDBi Q0VDD7.
    TreeFami TF337646.

    Miscellaneous databases

    GenomeRNAii 79173.
    NextBioi 68141.

    Gene expression databases

    ArrayExpressi Q0VDD7.
    Bgeei Q0VDD7.
    CleanExi HS_C19orf57.
    Genevestigatori Q0VDD7.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 123-668 (ISOFORM 1), VARIANTS ARG-267 AND ARG-500.
      Tissue: Lung and Mammary gland.
    3. "Identification of human pre-T/NK cell-associated genes."
      Ranes-Goldberg M.G., Hori T., Mohan-Peterson S., Spits H.
      J. Immunol. 151:5810-5821(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-370, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiCS057_HUMAN
    AccessioniPrimary (citable) accession number: Q0VDD7
    Secondary accession number(s): Q13411
    , Q8N825, Q96D63, Q9BU49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 68 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3