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Protein

Uncharacterized protein C19orf57

Gene

C19orf57

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • multicellular organism development Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C19orf57
Alternative name(s):
Pre-T/NK cell-associated protein 3B3
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000132016.11
HGNCiHGNC:28153 C19orf57
neXtProtiNX_Q0VDD7

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132016
PharmGKBiPA162378679

Polymorphism and mutation databases

BioMutaiC19orf57
DMDMi158564134

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002957371 – 668Uncharacterized protein C19orf57Add BLAST668

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei370PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ0VDD7
PaxDbiQ0VDD7
PeptideAtlasiQ0VDD7
PRIDEiQ0VDD7

PTM databases

iPTMnetiQ0VDD7
PhosphoSitePlusiQ0VDD7

Expressioni

Gene expression databases

BgeeiENSG00000132016
CleanExiHS_C19orf57
ExpressionAtlasiQ0VDD7 baseline and differential
GenevisibleiQ0VDD7 HS

Organism-specific databases

HPAiHPA044012
HPA054615

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi12259028 interactors.
IntActiQ0VDD7 32 interactors.
MINTiQ0VDD7

Structurei

3D structure databases

ProteinModelPortaliQ0VDD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IV9I Eukaryota
ENOG41119U1 LUCA
GeneTreeiENSGT00390000016855
HOGENOMiHOG000111997
HOVERGENiHBG107766
InParanoidiQ0VDD7
OMAiSTHRDLE
OrthoDBiEOG091G079X
PhylomeDBiQ0VDD7
TreeFamiTF337646

Family and domain databases

InterProiView protein in InterPro
IPR031441 DUF4671
PANTHERiPTHR14583 PTHR14583, 1 hit
PfamiView protein in Pfam
PF15710 DUF4671, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0VDD7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKRKKLRTS GEGLCPPKPL KNPRLGDFYG DPQSSMLGCL HHPEEPEGKL
60 70 80 90 100
GPVPSTQQHG EEPGKAVSSS PDEETGSPCR LLRQPEKEPA PLPPSQNSFG
110 120 130 140 150
RFVPQFAKSR KTVTRKEEMK DEDRGSGAFS LETIAESSAQ SPGCQLLVET
160 170 180 190 200
LGVPLQEATE LGDPTQADSA RPEQSSQSPV QAVPGSGDSQ PDDPPDRGTG
210 220 230 240 250
LSASQRASQD HLSEQGADDS KPETDRVPGD GGQKEHLPSI DSEGEKPDRG
260 270 280 290 300
APQEGGAQRT AGAGLPGGPQ EEGDGVPCTP ASAPTSGPAP GLGPASWCLE
310 320 330 340 350
PGSVAQGSPD PQQTPSRMGR EGEGTHSSLG CSSLGMVVIA DLSTDPTELE
360 370 380 390 400
ERALEVAGPD GQASAISPAS PRRKAADGGH RRALPGCTSL TGETTGESGE
410 420 430 440 450
AGQDGKPPGD VLVGPTASLA LAPGSGESMM GAGDSGHASP DTGPCVNQKQ
460 470 480 490 500
EPGPAQEEAE LGGQNLERDL EGFRVSPQAS VVLEHREIAD DPLQEPGAQQ
510 520 530 540 550
GIPDTTSELA GQRDHLPHSA DQGTWADSLA VELDFLLDSQ IQDALDASDF
560 570 580 590 600
EAPPEQLFPS GNKPGPCWPG PSSHANGDPV AVAKAQPRTF VGIQASEASR
610 620 630 640 650
MEDATNVVRG LIVELSNLNR LIMGTHRDLE AFKRLNYRKT KLGGKAPLPY
660
PSKGPGNIPR GDPPWREL
Length:668
Mass (Da):69,556
Last modified:July 24, 2007 - v2
Checksum:i64E4242D2B5C6507
GO
Isoform 2 (identifier: Q0VDD7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     588-619: RTFVGIQASEASRMEDATNVVRGLIVELSNLN → S

Show »
Length:637
Mass (Da):66,170
Checksum:i6A126CCD5C3E9867
GO

Sequence cautioni

The sequence AAB02340 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti491D → E in AAI19720 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033356267G → R1 PublicationCorresponds to variant dbSNP:rs2305775Ensembl.1
Natural variantiVAR_033357500Q → R1 PublicationCorresponds to variant dbSNP:rs3803892Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027044588 – 619RTFVG…LSNLN → S in isoform 2. 2 PublicationsAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097431 mRNA Translation: BAC05049.1
BC002891 mRNA Translation: AAH02891.2
BC012945 mRNA Translation: AAH12945.2
BC119719 mRNA Translation: AAI19720.1
L17327 mRNA Translation: AAB02340.1 Sequence problems.
CCDSiCCDS12299.1 [Q0VDD7-2]
RefSeqiNP_077299.3, NM_024323.4 [Q0VDD7-2]
UniGeneiHs.143288

Genome annotation databases

EnsembliENST00000346736; ENSP00000254336; ENSG00000132016 [Q0VDD7-2]
ENST00000586783; ENSP00000465822; ENSG00000132016 [Q0VDD7-1]
GeneIDi79173
KEGGihsa:79173
UCSCiuc002mxk.2 human [Q0VDD7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCS057_HUMAN
AccessioniPrimary (citable) accession number: Q0VDD7
Secondary accession number(s): Q13411
, Q8N825, Q96D63, Q9BU49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 25, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome