Q0VDD7 (CS057_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C19orf57

Alternative name(s):
Pre-T/NK cell-associated protein 3B3

Gene names

Name:

C19orf57

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	668 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence caution

The sequence AAB02340.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Non-traceable author statement Ref.3. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
AIMP2	Q13155	4	EBI-741210,EBI-745226
COPS4	Q9BT78	2	EBI-741210,EBI-742413

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q0VDD7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q0VDD7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     588-619: RTFVGIQASEASRMEDATNVVRGLIVELSNLN → S

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 668	668	Uncharacterized protein C19orf57		PRO_0000295737
Amino acid modifications
	Modified residue	370	1	Phosphoserine Ref.4
Natural variations
	Alternative sequence	588 – 619	32	RTFVG…LSNLN → S in isoform 2.		VSP_027044
	Natural variant	267	1	G → R. Ref.2 Corresponds to variant rs2305775 [ dbSNP | Ensembl ].		VAR_033356
	Natural variant	500	1	Q → R. Ref.2 Corresponds to variant rs3803892 [ dbSNP | Ensembl ].		VAR_033357
Experimental info
	Sequence conflict	491	1	D → E in AAI19720. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 24, 2007. Version 2. Checksum: 64E4242D2B5C6507	FASTA	668	69,556
	10 20 30 40 50 60 MTKRKKLRTS GEGLCPPKPL KNPRLGDFYG DPQSSMLGCL HHPEEPEGKL GPVPSTQQHG 70 80 90 100 110 120 EEPGKAVSSS PDEETGSPCR LLRQPEKEPA PLPPSQNSFG RFVPQFAKSR KTVTRKEEMK 130 140 150 160 170 180 DEDRGSGAFS LETIAESSAQ SPGCQLLVET LGVPLQEATE LGDPTQADSA RPEQSSQSPV 190 200 210 220 230 240 QAVPGSGDSQ PDDPPDRGTG LSASQRASQD HLSEQGADDS KPETDRVPGD GGQKEHLPSI 250 260 270 280 290 300 DSEGEKPDRG APQEGGAQRT AGAGLPGGPQ EEGDGVPCTP ASAPTSGPAP GLGPASWCLE 310 320 330 340 350 360 PGSVAQGSPD PQQTPSRMGR EGEGTHSSLG CSSLGMVVIA DLSTDPTELE ERALEVAGPD 370 380 390 400 410 420 GQASAISPAS PRRKAADGGH RRALPGCTSL TGETTGESGE AGQDGKPPGD VLVGPTASLA 430 440 450 460 470 480 LAPGSGESMM GAGDSGHASP DTGPCVNQKQ EPGPAQEEAE LGGQNLERDL EGFRVSPQAS 490 500 510 520 530 540 VVLEHREIAD DPLQEPGAQQ GIPDTTSELA GQRDHLPHSA DQGTWADSLA VELDFLLDSQ 550 560 570 580 590 600 IQDALDASDF EAPPEQLFPS GNKPGPCWPG PSSHANGDPV AVAKAQPRTF VGIQASEASR 610 620 630 640 650 660 MEDATNVVRG LIVELSNLNR LIMGTHRDLE AFKRLNYRKT KLGGKAPLPY PSKGPGNIPR GDPPWREL
	Isoform 2 [UniParc]. Checksum: 6A126CCD5C3E9867	FASTA	637	66,170
	10 20 30 40 50 60 MTKRKKLRTS GEGLCPPKPL KNPRLGDFYG DPQSSMLGCL HHPEEPEGKL GPVPSTQQHG 70 80 90 100 110 120 EEPGKAVSSS PDEETGSPCR LLRQPEKEPA PLPPSQNSFG RFVPQFAKSR KTVTRKEEMK 130 140 150 160 170 180 DEDRGSGAFS LETIAESSAQ SPGCQLLVET LGVPLQEATE LGDPTQADSA RPEQSSQSPV 190 200 210 220 230 240 QAVPGSGDSQ PDDPPDRGTG LSASQRASQD HLSEQGADDS KPETDRVPGD GGQKEHLPSI 250 260 270 280 290 300 DSEGEKPDRG APQEGGAQRT AGAGLPGGPQ EEGDGVPCTP ASAPTSGPAP GLGPASWCLE 310 320 330 340 350 360 PGSVAQGSPD PQQTPSRMGR EGEGTHSSLG CSSLGMVVIA DLSTDPTELE ERALEVAGPD 370 380 390 400 410 420 GQASAISPAS PRRKAADGGH RRALPGCTSL TGETTGESGE AGQDGKPPGD VLVGPTASLA 430 440 450 460 470 480 LAPGSGESMM GAGDSGHASP DTGPCVNQKQ EPGPAQEEAE LGGQNLERDL EGFRVSPQAS 490 500 510 520 530 540 VVLEHREIAD DPLQEPGAQQ GIPDTTSELA GQRDHLPHSA DQGTWADSLA VELDFLLDSQ 550 560 570 580 590 600 IQDALDASDF EAPPEQLFPS GNKPGPCWPG PSSHANGDPV AVAKAQPSRL IMGTHRDLEA 610 620 630 FKRLNYRKTK LGGKAPLPYP SKGPGNIPRG DPPWREL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 123-668 (ISOFORM 1), VARIANTS ARG-267 AND ARG-500. Tissue: Lung and Mammary gland.
[3]	"Identification of human pre-T/NK cell-associated genes." Ranes-Goldberg M.G., Hori T., Mohan-Peterson S., Spits H. J. Immunol. 151:5810-5821(1993) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[4]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-370, MASS SPECTROMETRY. Tissue: Leukemic T-cell.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK097431 mRNA. Translation: BAC05049.1. BC002891 mRNA. Translation: AAH02891.2. BC012945 mRNA. Translation: AAH12945.2. BC119719 mRNA. Translation: AAI19720.1. L17327 mRNA. Translation: AAB02340.1. Sequence problems.
IPI	IPI00167300. IPI00550720.
RefSeq	NP_077299.3. NM_024323.3.
UniGene	Hs.143288.
3D structure databases
ProteinModelPortal	Q0VDD7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q0VDD7. 12 interactions.
STRING	9606.ENSP00000254336.
PTM databases
PhosphoSite	Q0VDD7.
Polymorphism databases
DMDM	158564134.
Proteomic databases
PaxDb	Q0VDD7.
PRIDE	Q0VDD7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000346736; ENSP00000254336; ENSG00000132016. ENST00000454313; ENSP00000404382; ENSG00000132016. ENST00000586783; ENSP00000465822; ENSG00000132016.
GeneID	79173.
KEGG	hsa:79173.
UCSC	uc002mxk.1. human. uc002mxl.1. human.
Organism-specific databases
CTD	79173.
GeneCards	GC19M013993.
HGNC	HGNC:28153. C19orf57.
HPA	HPA044012.
neXtProt	NX_Q0VDD7.
PharmGKB	PA162378679.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45524.
HOGENOM	HOG000111997.
HOVERGEN	HBG107766.
InParanoid	Q0VDD7.
OMA	ASWCLEP.
Gene expression databases
Bgee	Q0VDD7.
CleanEx	HS_C19orf57.
Genevestigator	Q0VDD7.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	79173.
NextBio	68141.

Entry information

Entry name

CS057_HUMAN

Accession

Primary (citable) accession number: Q0VDD7
Secondary accession number(s): Q13411 , Q8N825, Q96D63, Q9BU49

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	May 1, 2013
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.