Q0VD86Q6J273Q6PKN9INCA1_HUMANProtein INCA1Inhibitor of CDK interacting with cyclin A1INCA1HSD45Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoIdentification of interaction partners and substrates of the cyclin A1-CDK2 complex.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)INTERACTION WITH CCNA1IDENTIFICATION IN A COMPLEX WITH CCNA1 AND CDK2PHOSPHORYLATION AT SER-23; THR-182; SER-191 AND SER-194MUTAGENESIS OF SER-23; THR-182; SER-191 AND SER-194SUBCELLULAR LOCATIONTISSUE SPECIFICITYA new spermatogenesis-related gene.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1.INTERACTION WITH ZNF16A novel testis protein, RSB-66, interacting with INCA1 (inhibitor of Cdk interacting with cyclin A1).INTERACTION WITH SPACA9SUBCELLULAR LOCATIONInhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.FUNCTIONTISSUE SPECIFICITYINTERACTION WITH CCNA1; CCNA2; CCNB1 AND CCNE1INTERACTION WITH THE CCNA1/CDK2 COMPLEXINDUCTIONThe inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects.INTERACTION WITH ING5; DAZAP2; RNF26; USP15; SPOUT1; DPH7; TRIM26 AND RAB5CBinds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187). Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity).Interacts with CCNA1 (PubMed:21540187, PubMed:15159402). Interacts with CCNA2, CCNB1 and CCNE1 (PubMed:21540187). Found in a complex with CCNA1 and CDK2 (PubMed:15159402). Interacts with ZNF16; the interaction inhibits INCA1 activity and induces the cell cycle process (PubMed:21874239). Interacts with SPACA9 (PubMed:18756329). Interacts with the CCNA1/CDK2 complex (PubMed:21540187). Interacts with ING5, DAZAP2, RNF26, USP15, SPOUT1, DPH7, TRIM26 and RAB5C (PubMed:21750715).Q0VD86Q9NYB9-2false3Q0VD86P68133false3Q0VD86Q5BKX5-3false3Q0VD86Q96HD9false5Q0VD86Q9ULX6false3Q0VD86O15084false3Q0VD86Q9H6L4false3Q0VD86Q9BZE9false3Q0VD86Q9H1Y0false3Q0VD86Q86V38false3Q0VD86P13637false3Q0VD86Q8N8Y2false3Q0VD86Q8N5M1false3Q0VD86O95817false3Q0VD86Q9H503-2false3Q0VD86Q53S33false3Q0VD86Q9NP55false3Q0VD86Q5SWW7false3Q0VD86Q9BV19false3Q0VD86Q6P5X5false3Q0VD86Q9NP86false10Q0VD86Q6UXH8-3false3Q0VD86Q2TAC2-2false3Q0VD86A2IDD5-4false3Q0VD86P32320false3Q0VD86Q9UJX2false3Q0VD86Q07002false3Q0VD86P11802false3Q0VD86P38936false3Q0VD86P42772false3Q0VD86P55273false9Q0VD86Q9P209false3Q0VD86Q9Y6H1false3Q0VD86Q9BSY4false3Q0VD86Q9H2X0false3Q0VD86Q9BW66false3Q0VD86P61024false3Q0VD86O95833false3Q0VD86P49761false3Q0VD86Q96A83-2false3Q0VD86P27658false9Q0VD86Q10570false3Q0VD86P02489false3Q0VD86Q9Y534false3Q0VD86P33240false3Q0VD86Q9NSA3false3Q0VD86Q8WZ74false3Q0VD86A8MQ03false3Q0VD86Q15038false2Q0VD86Q9H4E7false3Q0VD86Q9NQL9false6Q0VD86Q96MA1false3Q0VD86Q8TEW6false3Q0VD86Q9BTV6false2Q0VD86Q9UII6false3Q0VD86O95967false3Q0VD86P41091false3Q0VD86P50402false3Q0VD86O15197-2false8Q0VD86O75460-2false3Q0VD86Q96B26false3Q0VD86Q6NZ36-4false3Q0VD86Q9NVQ4-2false3Q0VD86Q9BSK4false3Q0VD86O43320false3Q0VD86Q14192false5Q0VD86Q0VDC6false3Q0VD86O43559false3Q0VD86P55040false3Q0VD86O14893false3Q0VD86P62993false4Q0VD86A8MXD5false3Q0VD86Q9H4Y5false3Q0VD86Q6ZYL4false3Q0VD86Q969Y2false3Q0VD86P13807false3Q0VD86Q96CS2false3Q0VD86P08631-2false3Q0VD86P56524-2false3Q0VD86Q9Y5R4false5Q0VD86Q5T8I9false3Q0VD86P52597false3Q0VD86Q9NSC5false3Q0VD86P49639false3Q0VD86O43593false3Q0VD86Q9BPX1false3Q0VD86P54652false3Q0VD86P10809false3Q0VD86Q9UBH0false3Q0VD86Q12905false3Q0VD86Q0VD86false3Q0VD86Q8WYH8false4Q0VD86Q96MP8-2false3Q0VD86Q7L273false3Q0VD86Q5T5P2-6false3Q0VD86Q99706false3Q0VD86O14901false3Q0VD86Q53HC5false3Q0VD86Q9P2K6false3Q0VD86Q92876false3Q0VD86Q14525false3Q0VD86P13647false3Q0VD86O95678false3Q0VD86Q3LI76false3Q0VD86Q8IUB9false3Q0VD86Q3LI72false5Q0VD86Q3LI70false3Q0VD86Q6L8G9false3Q0VD86Q3LI66false5Q0VD86Q9BYQ3false3Q0VD86Q96PV6false3Q0VD86P17931false3Q0VD86Q9UBR4-2false5Q0VD86Q8IXW0false3Q0VD86P25791-3false3Q0VD86Q8TAP4-4false5Q0VD86P62310false3Q0VD86O95372false3Q0VD86Q9UI95false3Q0VD86Q96JG8false3Q0VD86Q96A72false3Q0VD86Q96EH3false3Q0VD86Q9Y4F3false3Q0VD86Q9P0L2false3Q0VD86O15232false3Q0VD86Q9BUN1false3Q0VD86P53582false3Q0VD86Q9BU76false3Q0VD86Q00013false3Q0VD86Q9NZV6false3Q0VD86Q96QG7false3Q0VD86Q8N6N6false3Q0VD86O43639false3Q0VD86Q9BU61false3Q0VD86Q14511-2false3Q0VD86Q969S2false3Q0VD86Q9HC98false4Q0VD86Q9HC98-4false3Q0VD86Q8NI38false3Q0VD86Q5HYW2false3Q0VD86Q9Y5B8false5Q0VD86Q9NWW6false3Q0VD86Q99743false3Q0VD86Q96HA8false5Q0VD86Q9Y5Y2false3Q0VD86Q9BRJ7false3Q0VD86Q9BRQ3false3Q0VD86O95007false3Q0VD86Q9UJX0false6Q0VD86Q9ULW8false3Q0VD86Q8WXA2false3Q0VD86Q92824-2false3Q0VD86Q99447false3Q0VD86Q9P0J1false3Q0VD86P16284false3Q0VD86Q9UBV8false3Q0VD86Q99471false3Q0VD86O43189false3Q0VD86O15496false3Q0VD86Q13393false3Q0VD86Q9NRY6false3Q0VD86O15160false3Q0VD86Q9BUI4false3Q0VD86Q969H6false3Q0VD86Q12837false3Q0VD86P41219false3Q0VD86P49721false3Q0VD86P28062-2false3Q0VD86P43115-12false3Q0VD86Q9Y2K5false3Q0VD86P20339false3Q0VD86P51148false2Q0VD86P63244false2Q0VD86P11234false3Q0VD86Q9BTL3false6Q0VD86Q93062false3Q0VD86Q93062-3false3Q0VD86Q6P9E2false3Q0VD86P40938false3Q0VD86P57055false3Q0VD86Q9BY78false2Q0VD86O00422false3Q0VD86Q7Z5V6-2false3Q0VD86Q9BWG6false4Q0VD86Q9UDX3false3Q0VD86Q9NUL5-4false3Q0VD86Q8N1D0-2false3Q0VD86Q9H0W8false3Q0VD86Q53HV7-2false3Q0VD86P14678-2false3Q0VD86Q99932-2false3Q0VD86Q9NZD8false6Q0VD86Q5T280false2Q0VD86O43609false3Q0VD86Q96FJ0false3Q0VD86O75716false6Q0VD86Q8TCJ2false3Q0VD86P51687false5Q0VD86Q9P0N9false3Q0VD86P56279false3Q0VD86Q15561false3Q0VD86Q8WW24false3Q0VD86Q9BXU0false3Q0VD86P05549-5false3Q0VD86Q7Z6R9false5Q0VD86Q01664false3Q0VD86Q92734false3Q0VD86Q8TBB0false3Q0VD86Q92748false3Q0VD86Q01085-2false3Q0VD86Q8N7U7-2false3Q0VD86P0DI81-3false3Q0VD86O75865-2false3Q0VD86Q96RU7false3Q0VD86Q12899false2Q0VD86Q6AZZ1false3Q0VD86Q15645false3Q0VD86Q15654false3Q0VD86Q8WW01false3Q0VD86Q99816false3Q0VD86Q96PN8false3Q0VD86Q5T7W7false3Q0VD86Q9BRA2false3Q0VD86Q8TF42false3Q0VD86Q9Y2X8false3Q0VD86Q9H832false3Q0VD86Q8WUN7false3Q0VD86Q14CS0false6Q0VD86P61960false3Q0VD86Q6NVU6false3Q0VD86Q9Y4E8false2Q0VD86Q14119false3Q0VD86A8MV65-2false3Q0VD86P08670false3Q0VD86O14972false3Q0VD86Q548N1false3Q0VD86Q9NZC7-5false3Q0VD86Q9GZM5false3Q0VD86Q5VVQ6false3Q0VD86Q6UX98false3Q0VD86Q9H8U3false3Q0VD86Q9H0C1false3Q0VD86Q96E35false3Q0VD86P17020false2Q0VD86P17041false3Q0VD86Q9NWS9-2false3Q0VD86Q9BV97false3Q0VD86Q7L2R6-2false3Q0VD86O60232false3Q0VD86G4XUV3false3NucleusCytoplasmQ0VD86-11Q0VD86-22Detected in testis, and at lower levels in ovary. Detected at very low levels in testis tumors (PubMed:15159402). Down-regulated in bone marrow cells in acute myeloid and lymphoid leukemia patients as compared with normal bone marrow cells (PubMed:21540187).By serum starvation.Phosphorylated when part of a complex with CCNA1 and CDK2. Strongly phosphorylated by CDK2 on its C-terminal region spanning amino acid 149-221. Less intensively phosphorylated by CDK2 on its first 75 amino acid residues.Belongs to the INCA family.Alternative splicingCytoplasmNucleusPhosphoproteinProtein kinase inhibitorReference proteomeSATASASAEDMQVQDDGVNLIPFAKCSRVVSRSPPPRLPSQSLRPMPQRYGDVFWKNLNQRPTPTWLEEQHIPPMLRATGCSQLGLYPPEQLPPPEMLWRRKKRRPCLEGMQQQGLGGVPARVRAVTYHLEDLRRRQSIINELKKAQWGSSGAASEPVVLGEEGCGFPSTNEYPDLEEERATYPQEEDRFLTPGRAQLLWSPWSPLDQEEACASRQLHSLASFSTVTARRNPLHNPWGMELAASEE
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