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Q0VD86

- INCA1_HUMAN

UniProt

Q0VD86 - INCA1_HUMAN

Protein

Protein INCA1

Gene

INCA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cyclin binding Source: MGI
    2. cyclin-dependent protein serine/threonine kinase inhibitor activity Source: MGI
    3. protein binding Source: IntAct

    GO - Biological processi

    1. negative regulation of cell proliferation Source: Ensembl
    2. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
    3. positive regulation of apoptotic signaling pathway Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein INCA1
    Alternative name(s):
    Inhibitor of CDK interacting with cyclin A1
    Gene namesi
    Name:INCA1
    ORF Names:HSD45
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:32224. INCA1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi23 – 231S → A: Loss of phosphorylation site. 1 Publication
    Mutagenesisi182 – 1821T → A: Reduced phosphorylation. Phosphorylation is almost abolished; when associated with A-191. 1 Publication
    Mutagenesisi191 – 1911S → A: Strongly reduced phosphorylation. Phosphorylation is almost abolished; when associated with A-182. 1 Publication
    Mutagenesisi194 – 1941S → A: Reduced phosphorylation. 1 Publication

    Organism-specific databases

    PharmGKBiPA165431930.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 236236Protein INCA1PRO_0000331513Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231Phosphoserine1 Publication
    Modified residuei182 – 1821Phosphothreonine1 Publication
    Modified residuei191 – 1911Phosphoserine1 Publication
    Modified residuei194 – 1941Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated when part of a complex with CCNA1 and CDK2. Strongly phosphorylated by CDK2 on its C-terminal region spanning amino acid 149-221. Less intensively phosphorylated by CDK2 on its first 75 amino acid residues.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ0VD86.
    PRIDEiQ0VD86.

    PTM databases

    PhosphoSiteiQ0VD86.

    Expressioni

    Tissue specificityi

    Detected in testis, and at lower levels in ovary. Detected at very low levels in testis tumors.1 Publication

    Gene expression databases

    BgeeiQ0VD86.
    GenevestigatoriQ0VD86.

    Organism-specific databases

    HPAiHPA044359.

    Interactioni

    Subunit structurei

    Interacts with CCNA1. Identified in a complex with CCNA1 and CDK2. Interacts with ZNF16; the interaction inhibits INCA1 activity and induces the cell cycle process.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ZNF16P170202EBI-6509505,EBI-3921553

    Protein-protein interaction databases

    BioGridi132642. 2 interactions.
    IntActiQ0VD86. 1 interaction.
    STRINGi9606.ENSP00000347129.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0VD86.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi90 – 956Nuclear localization signalSequence Analysis

    Sequence similaritiesi

    Belongs to the INCA family.Curated

    Phylogenomic databases

    eggNOGiNOG84185.
    HOGENOMiHOG000113068.
    HOVERGENiHBG095410.
    InParanoidiQ0VD86.
    OMAiQLLWSPW.
    OrthoDBiEOG7ZWD3F.
    PhylomeDBiQ0VD86.
    TreeFamiTF343431.

    Family and domain databases

    InterProiIPR026238. INCA1.
    [Graphical view]
    PfamiPF15142. INCA1. 1 hit.
    [Graphical view]
    PRINTSiPR02102. PROTEININCA1.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q0VD86-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQVQDDGVNL IPFAKCSRVV SRSPPPRLPS QSLRPMPQRY GDVFWKNLNQ    50
    RPTPTWLEEQ HIPPMLRATG CSQLGLYPPE QLPPPEMLWR RKKRRPCLEG 100
    MQQQGLGGVP ARVRAVTYHL EDLRRRQSII NELKKAQWGS SGAASEPVVL 150
    GEEGCGFPST NEYPDLEEER ATYPQEEDRF LTPGRAQLLW SPWSPLDQEE 200
    ACASRQLHSL ASFSTVTARR NPLHNPWGME LAASEE 236
    Length:236
    Mass (Da):26,817
    Last modified:September 5, 2006 - v1
    Checksum:iA9808D24144AB07D
    GO
    Isoform 2 (identifier: Q0VD86-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         67-81: Missing.

    Show »
    Length:221
    Mass (Da):25,216
    Checksum:iA1070CBDD2CA4650
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti153 – 1531E → D in AAT09152. (PubMed:15159402)Curated
    Sequence conflicti153 – 1531E → D in AAT09153. (PubMed:15159402)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei67 – 8115Missing in isoform 2. 2 PublicationsVSP_033235Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY601906 mRNA. Translation: AAT09152.1.
    AY601907 mRNA. Translation: AAT09153.1.
    AY604176 mRNA. Translation: AAT36739.1.
    BC119781 mRNA. Translation: AAI19782.1.
    BC122873 mRNA. Translation: AAI22874.1.
    CCDSiCCDS11064.1. [Q0VD86-2]
    CCDS54074.1. [Q0VD86-1]
    RefSeqiNP_001161457.1. NM_001167985.1. [Q0VD86-2]
    NP_001161458.1. NM_001167986.1. [Q0VD86-1]
    NP_001161459.1. NM_001167987.1. [Q0VD86-1]
    NP_998891.2. NM_213726.2. [Q0VD86-2]
    XP_005256684.1. XM_005256627.1. [Q0VD86-1]
    XP_005256685.1. XM_005256628.2. [Q0VD86-1]
    XP_005256686.1. XM_005256629.1. [Q0VD86-2]
    XP_006721580.1. XM_006721517.1. [Q0VD86-1]
    XP_006721581.1. XM_006721518.1. [Q0VD86-2]
    XP_006721582.1. XM_006721519.1. [Q0VD86-2]
    UniGeneiHs.658926.

    Genome annotation databases

    EnsembliENST00000355025; ENSP00000347129; ENSG00000196388. [Q0VD86-2]
    ENST00000574617; ENSP00000458316; ENSG00000196388. [Q0VD86-1]
    ENST00000575780; ENSP00000461844; ENSG00000196388. [Q0VD86-2]
    ENST00000576820; ENSP00000460673; ENSG00000196388. [Q0VD86-1]
    GeneIDi388324.
    KEGGihsa:388324.
    UCSCiuc002gaj.3. human. [Q0VD86-1]
    uc002gal.3. human. [Q0VD86-2]

    Polymorphism databases

    DMDMi121940471.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY601906 mRNA. Translation: AAT09152.1 .
    AY601907 mRNA. Translation: AAT09153.1 .
    AY604176 mRNA. Translation: AAT36739.1 .
    BC119781 mRNA. Translation: AAI19782.1 .
    BC122873 mRNA. Translation: AAI22874.1 .
    CCDSi CCDS11064.1. [Q0VD86-2 ]
    CCDS54074.1. [Q0VD86-1 ]
    RefSeqi NP_001161457.1. NM_001167985.1. [Q0VD86-2 ]
    NP_001161458.1. NM_001167986.1. [Q0VD86-1 ]
    NP_001161459.1. NM_001167987.1. [Q0VD86-1 ]
    NP_998891.2. NM_213726.2. [Q0VD86-2 ]
    XP_005256684.1. XM_005256627.1. [Q0VD86-1 ]
    XP_005256685.1. XM_005256628.2. [Q0VD86-1 ]
    XP_005256686.1. XM_005256629.1. [Q0VD86-2 ]
    XP_006721580.1. XM_006721517.1. [Q0VD86-1 ]
    XP_006721581.1. XM_006721518.1. [Q0VD86-2 ]
    XP_006721582.1. XM_006721519.1. [Q0VD86-2 ]
    UniGenei Hs.658926.

    3D structure databases

    ProteinModelPortali Q0VD86.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 132642. 2 interactions.
    IntActi Q0VD86. 1 interaction.
    STRINGi 9606.ENSP00000347129.

    PTM databases

    PhosphoSitei Q0VD86.

    Polymorphism databases

    DMDMi 121940471.

    Proteomic databases

    PaxDbi Q0VD86.
    PRIDEi Q0VD86.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355025 ; ENSP00000347129 ; ENSG00000196388 . [Q0VD86-2 ]
    ENST00000574617 ; ENSP00000458316 ; ENSG00000196388 . [Q0VD86-1 ]
    ENST00000575780 ; ENSP00000461844 ; ENSG00000196388 . [Q0VD86-2 ]
    ENST00000576820 ; ENSP00000460673 ; ENSG00000196388 . [Q0VD86-1 ]
    GeneIDi 388324.
    KEGGi hsa:388324.
    UCSCi uc002gaj.3. human. [Q0VD86-1 ]
    uc002gal.3. human. [Q0VD86-2 ]

    Organism-specific databases

    CTDi 388324.
    GeneCardsi GC17M004891.
    H-InvDB HIX0027201.
    HGNCi HGNC:32224. INCA1.
    HPAi HPA044359.
    neXtProti NX_Q0VD86.
    PharmGKBi PA165431930.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG84185.
    HOGENOMi HOG000113068.
    HOVERGENi HBG095410.
    InParanoidi Q0VD86.
    OMAi QLLWSPW.
    OrthoDBi EOG7ZWD3F.
    PhylomeDBi Q0VD86.
    TreeFami TF343431.

    Miscellaneous databases

    GenomeRNAii 388324.
    NextBioi 101955.
    PROi Q0VD86.

    Gene expression databases

    Bgeei Q0VD86.
    Genevestigatori Q0VD86.

    Family and domain databases

    InterProi IPR026238. INCA1.
    [Graphical view ]
    Pfami PF15142. INCA1. 1 hit.
    [Graphical view ]
    PRINTSi PR02102. PROTEININCA1.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH CCNA1, IDENTIFICATION IN A COMPLEX WITH CCNA1 AND CDK2, PHOSPHORYLATION AT SER-23; THR-182; SER-191 AND SER-194, MUTAGENESIS OF SER-23; THR-182; SER-191 AND SER-194, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Testis.
    2. "A new spermatogenesis-related gene."
      Hu T.H., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1."
      Li X.B., Chen J., Deng M.J., Wang F., Du Z.W., Zhang J.W.
      Mol. Med. Report. 4:1131-1137(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZNF16.

    Entry informationi

    Entry nameiINCA1_HUMAN
    AccessioniPrimary (citable) accession number: Q0VD86
    Secondary accession number(s): Q6J273, Q6PKN9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3