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Q0VD86

- INCA1_HUMAN

UniProt

Q0VD86 - INCA1_HUMAN

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Protein
Protein INCA1
Gene
INCA1, HSD45
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. cyclin binding Source: MGI
  2. cyclin-dependent protein serine/threonine kinase inhibitor activity Source: MGI
  3. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. negative regulation of cell proliferation Source: Ensembl
  2. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
  3. positive regulation of apoptotic signaling pathway Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein INCA1
Alternative name(s):
Inhibitor of CDK interacting with cyclin A1
Gene namesi
Name:INCA1
ORF Names:HSD45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:32224. INCA1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi23 – 231S → A: Loss of phosphorylation site. 1 Publication
Mutagenesisi182 – 1821T → A: Reduced phosphorylation. Phosphorylation is almost abolished; when associated with A-191. 1 Publication
Mutagenesisi191 – 1911S → A: Strongly reduced phosphorylation. Phosphorylation is almost abolished; when associated with A-182. 1 Publication
Mutagenesisi194 – 1941S → A: Reduced phosphorylation. 1 Publication

Organism-specific databases

PharmGKBiPA165431930.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Protein INCA1
PRO_0000331513Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231Phosphoserine1 Publication
Modified residuei182 – 1821Phosphothreonine1 Publication
Modified residuei191 – 1911Phosphoserine1 Publication
Modified residuei194 – 1941Phosphoserine Inferred

Post-translational modificationi

Phosphorylated when part of a complex with CCNA1 and CDK2. Strongly phosphorylated by CDK2 on its C-terminal region spanning amino acid 149-221. Less intensively phosphorylated by CDK2 on its first 75 amino acid residues.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ0VD86.
PRIDEiQ0VD86.

PTM databases

PhosphoSiteiQ0VD86.

Expressioni

Tissue specificityi

Detected in testis, and at lower levels in ovary. Detected at very low levels in testis tumors.1 Publication

Gene expression databases

BgeeiQ0VD86.
GenevestigatoriQ0VD86.

Organism-specific databases

HPAiHPA044359.

Interactioni

Subunit structurei

Interacts with CCNA1. Identified in a complex with CCNA1 and CDK2. Interacts with ZNF16; the interaction inhibits INCA1 activity and induces the cell cycle process.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ZNF16P170202EBI-6509505,EBI-3921553

Protein-protein interaction databases

BioGridi132642. 2 interactions.
IntActiQ0VD86. 1 interaction.
STRINGi9606.ENSP00000347129.

Structurei

3D structure databases

ProteinModelPortaliQ0VD86.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi90 – 956Nuclear localization signal Reviewed prediction

Sequence similaritiesi

Belongs to the INCA family.

Phylogenomic databases

eggNOGiNOG84185.
HOGENOMiHOG000113068.
HOVERGENiHBG095410.
InParanoidiQ0VD86.
OMAiQLLWSPW.
OrthoDBiEOG7ZWD3F.
PhylomeDBiQ0VD86.
TreeFamiTF343431.

Family and domain databases

InterProiIPR026238. INCA1.
[Graphical view]
PfamiPF15142. INCA1. 1 hit.
[Graphical view]
PRINTSiPR02102. PROTEININCA1.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q0VD86-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQVQDDGVNL IPFAKCSRVV SRSPPPRLPS QSLRPMPQRY GDVFWKNLNQ    50
RPTPTWLEEQ HIPPMLRATG CSQLGLYPPE QLPPPEMLWR RKKRRPCLEG 100
MQQQGLGGVP ARVRAVTYHL EDLRRRQSII NELKKAQWGS SGAASEPVVL 150
GEEGCGFPST NEYPDLEEER ATYPQEEDRF LTPGRAQLLW SPWSPLDQEE 200
ACASRQLHSL ASFSTVTARR NPLHNPWGME LAASEE 236
Length:236
Mass (Da):26,817
Last modified:September 5, 2006 - v1
Checksum:iA9808D24144AB07D
GO
Isoform 2 (identifier: Q0VD86-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-81: Missing.

Show »
Length:221
Mass (Da):25,216
Checksum:iA1070CBDD2CA4650
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei67 – 8115Missing in isoform 2.
VSP_033235Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531E → D in AAT09152. 1 Publication
Sequence conflicti153 – 1531E → D in AAT09153. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY601906 mRNA. Translation: AAT09152.1.
AY601907 mRNA. Translation: AAT09153.1.
AY604176 mRNA. Translation: AAT36739.1.
BC119781 mRNA. Translation: AAI19782.1.
BC122873 mRNA. Translation: AAI22874.1.
CCDSiCCDS11064.1. [Q0VD86-2]
CCDS54074.1. [Q0VD86-1]
RefSeqiNP_001161457.1. NM_001167985.1. [Q0VD86-2]
NP_001161458.1. NM_001167986.1. [Q0VD86-1]
NP_001161459.1. NM_001167987.1. [Q0VD86-1]
NP_998891.2. NM_213726.2. [Q0VD86-2]
XP_005256684.1. XM_005256627.1. [Q0VD86-1]
XP_005256685.1. XM_005256628.2. [Q0VD86-1]
XP_005256686.1. XM_005256629.1. [Q0VD86-2]
XP_006721580.1. XM_006721517.1. [Q0VD86-1]
XP_006721581.1. XM_006721518.1. [Q0VD86-2]
XP_006721582.1. XM_006721519.1. [Q0VD86-2]
UniGeneiHs.658926.

Genome annotation databases

EnsembliENST00000355025; ENSP00000347129; ENSG00000196388. [Q0VD86-2]
ENST00000396829; ENSP00000380041; ENSG00000196388. [Q0VD86-1]
ENST00000574617; ENSP00000458316; ENSG00000196388. [Q0VD86-1]
ENST00000575780; ENSP00000461844; ENSG00000196388. [Q0VD86-2]
ENST00000576820; ENSP00000460673; ENSG00000196388. [Q0VD86-1]
GeneIDi388324.
KEGGihsa:388324.
UCSCiuc002gaj.3. human. [Q0VD86-1]
uc002gal.3. human. [Q0VD86-2]

Polymorphism databases

DMDMi121940471.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY601906 mRNA. Translation: AAT09152.1 .
AY601907 mRNA. Translation: AAT09153.1 .
AY604176 mRNA. Translation: AAT36739.1 .
BC119781 mRNA. Translation: AAI19782.1 .
BC122873 mRNA. Translation: AAI22874.1 .
CCDSi CCDS11064.1. [Q0VD86-2 ]
CCDS54074.1. [Q0VD86-1 ]
RefSeqi NP_001161457.1. NM_001167985.1. [Q0VD86-2 ]
NP_001161458.1. NM_001167986.1. [Q0VD86-1 ]
NP_001161459.1. NM_001167987.1. [Q0VD86-1 ]
NP_998891.2. NM_213726.2. [Q0VD86-2 ]
XP_005256684.1. XM_005256627.1. [Q0VD86-1 ]
XP_005256685.1. XM_005256628.2. [Q0VD86-1 ]
XP_005256686.1. XM_005256629.1. [Q0VD86-2 ]
XP_006721580.1. XM_006721517.1. [Q0VD86-1 ]
XP_006721581.1. XM_006721518.1. [Q0VD86-2 ]
XP_006721582.1. XM_006721519.1. [Q0VD86-2 ]
UniGenei Hs.658926.

3D structure databases

ProteinModelPortali Q0VD86.
ModBasei Search...

Protein-protein interaction databases

BioGridi 132642. 2 interactions.
IntActi Q0VD86. 1 interaction.
STRINGi 9606.ENSP00000347129.

PTM databases

PhosphoSitei Q0VD86.

Polymorphism databases

DMDMi 121940471.

Proteomic databases

PaxDbi Q0VD86.
PRIDEi Q0VD86.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355025 ; ENSP00000347129 ; ENSG00000196388 . [Q0VD86-2 ]
ENST00000396829 ; ENSP00000380041 ; ENSG00000196388 . [Q0VD86-1 ]
ENST00000574617 ; ENSP00000458316 ; ENSG00000196388 . [Q0VD86-1 ]
ENST00000575780 ; ENSP00000461844 ; ENSG00000196388 . [Q0VD86-2 ]
ENST00000576820 ; ENSP00000460673 ; ENSG00000196388 . [Q0VD86-1 ]
GeneIDi 388324.
KEGGi hsa:388324.
UCSCi uc002gaj.3. human. [Q0VD86-1 ]
uc002gal.3. human. [Q0VD86-2 ]

Organism-specific databases

CTDi 388324.
GeneCardsi GC17M004891.
H-InvDB HIX0027201.
HGNCi HGNC:32224. INCA1.
HPAi HPA044359.
neXtProti NX_Q0VD86.
PharmGKBi PA165431930.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG84185.
HOGENOMi HOG000113068.
HOVERGENi HBG095410.
InParanoidi Q0VD86.
OMAi QLLWSPW.
OrthoDBi EOG7ZWD3F.
PhylomeDBi Q0VD86.
TreeFami TF343431.

Miscellaneous databases

GenomeRNAii 388324.
NextBioi 101955.
PROi Q0VD86.

Gene expression databases

Bgeei Q0VD86.
Genevestigatori Q0VD86.

Family and domain databases

InterProi IPR026238. INCA1.
[Graphical view ]
Pfami PF15142. INCA1. 1 hit.
[Graphical view ]
PRINTSi PR02102. PROTEININCA1.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH CCNA1, IDENTIFICATION IN A COMPLEX WITH CCNA1 AND CDK2, PHOSPHORYLATION AT SER-23; THR-182; SER-191 AND SER-194, MUTAGENESIS OF SER-23; THR-182; SER-191 AND SER-194, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "A new spermatogenesis-related gene."
    Hu T.H., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1."
    Li X.B., Chen J., Deng M.J., Wang F., Du Z.W., Zhang J.W.
    Mol. Med. Report. 4:1131-1137(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZNF16.

Entry informationi

Entry nameiINCA1_HUMAN
AccessioniPrimary (citable) accession number: Q0VD86
Secondary accession number(s): Q6J273, Q6PKN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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