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Q0VD49

- Q0VD49_BOVIN

UniProt

Q0VD49 - Q0VD49_BOVIN

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Protein
Submitted name:

Histone deacetylase 10

Gene

HDAC10

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. histone deacetylase activity Source: UniProtKB
  2. histone deacetylase binding Source: UniProtKB
  3. protein deacetylase activity Source: UniProtKB

GO - Biological processi

  1. histone deacetylation Source: UniProtKB
  2. negative regulation of transcription, DNA-templated Source: UniProtKB
  3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. protein deacetylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_211655. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_221028. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_225370. Constitutive Signaling by NOTCH1 PEST Domain Mutants.

Names & Taxonomyi

Protein namesi
Submitted name:
Histone deacetylase 10Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:HDAC10Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. histone deacetylase complex Source: UniProtKB
  3. nucleoplasm Source: UniProtKB
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ0VD49. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ0VD49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000062809.
HOGENOMiHOG000225183.
HOVERGENiHBG051892.
InParanoidiQ0VD49.
KOiK11407.
OMAiGLEQRCL.
OrthoDBiEOG7992PT.
TreeFamiTF106173.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q0VD49-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTALVYHED MTATRLLWDD PECEIECPER LTTALERLQQ HGLKQRCLQL
60 70 80 90 100
VAREASEAEL GLVHSPEYVA LLQGTQALGT RELQALSKEY DAVYLHPSTF
110 120 130 140 150
HCARLAVGAA LQLVDAVLTG AVRNGLALVR PPGHHSQRAT ANGFCVFNNV
160 170 180 190 200
AIAAKHAQQK HGLRRILIVD WDVHHGQGIQ YIFEDDPSVL YFSWHRYEHG
210 220 230 240 250
HFWPCLRESD ADAVGRGRGL GFTVNLPWNQ VGMGNADYVA AFLHVLLPLA
260 270 280 290 300
FEFDPELVLV SAGFDSAIGD PEGQMLATPE CFAHLTHLLQ VLAGGRVCAV
310 320 330 340 350
LEGGYHLESL SQSVCMMVRA LLGDPALPLS GPMEPHGSAL ESLQCVRAAQ
360 370 380 390 400
APHWVSLQQQ GAAPVLSPGT PCPEGRPSPL PLGEPQFKAV VTQAAAALSS
410 420 430 440 450
LLDQLRLHPT PPVRVAVALI APDTGLALPP GVLCEEGSLP QEETQAWARP
460 470 480 490 500
HEALAQDGAL TALGKVLYLL DRILDGQVSS GMAATPVPAA AATLDVAVRY
510 520 530 540 550
GLSHGAQRLL CVAVGQLDRP PGLTDDGRNL WLNIGGEEAA APSMFHVSVP
560 570 580 590 600
LPVTTGGFLS CALALVLPLA YSFQPDLVLV ALGPAHGLRD PQAALLAALL
610 620 630 640 650
RGPAGGRVFA LVDEESTPQL ATVLARVLNG EAPPSLGPFS MAAPEDTQAL
660 670
MYLRGRLEPR WKMLQVAAPH
Length:670
Mass (Da):71,493
Last modified:September 5, 2006 - v1
Checksum:i38DBE66CB8BBD0D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DAAA02015043 Genomic DNA. No translation available.
BC119835 mRNA. Translation: AAI19836.1.
RefSeqiNP_001068928.1. NM_001075460.1.
UniGeneiBt.24581.

Genome annotation databases

EnsembliENSBTAT00000014602; ENSBTAP00000014602; ENSBTAG00000011000.
GeneIDi510654.
KEGGibta:510654.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DAAA02015043 Genomic DNA. No translation available.
BC119835 mRNA. Translation: AAI19836.1 .
RefSeqi NP_001068928.1. NM_001075460.1.
UniGenei Bt.24581.

3D structure databases

ProteinModelPortali Q0VD49.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000014602 ; ENSBTAP00000014602 ; ENSBTAG00000011000 .
GeneIDi 510654.
KEGGi bta:510654.

Organism-specific databases

CTDi 83933.

Phylogenomic databases

GeneTreei ENSGT00530000062809.
HOGENOMi HOG000225183.
HOVERGENi HBG051892.
InParanoidi Q0VD49.
KOi K11407.
OMAi GLEQRCL.
OrthoDBi EOG7992PT.
TreeFami TF106173.

Enzyme and pathway databases

Reactomei REACT_211655. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_221028. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_225370. Constitutive Signaling by NOTCH1 PEST Domain Mutants.

Miscellaneous databases

NextBioi 20869552.

Gene expression databases

ExpressionAtlasi Q0VD49. baseline.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: L1 HerefordImported.
    Tissue: Ascending colonImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiQ0VD49_BOVIN
AccessioniPrimary (citable) accession number: Q0VD49
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3