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Protein

Vacuolar fusion protein CCZ1 homolog

Gene

CCZ1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-BTA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar fusion protein CCZ1 homolog
Gene namesi
Name:CCZ1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003273992 – 480Vacuolar fusion protein CCZ1 homologAdd BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei74PhosphoserineBy similarity1
Modified residuei264PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ0VD30
PRIDEiQ0VD30

Expressioni

Gene expression databases

BgeeiENSBTAG00000003288

Interactioni

Subunit structurei

Interacts with MON1A. Found in a complex with RMC1, CCZ1, MON1A and MON1B.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004259

Structurei

3D structure databases

SMRiQ0VD30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CCZ1 family.Curated

Phylogenomic databases

eggNOGiKOG2622 Eukaryota
ENOG410XRE1 LUCA
GeneTreeiENSGT00390000004713
HOVERGENiHBG053322
InParanoidiQ0VD30
OMAiQYYVILC
OrthoDBiEOG091G0CLR
TreeFamiTF314962

Family and domain databases

InterProiView protein in InterPro
IPR013176 DUF1712_fun
PfamiView protein in Pfam
PF08217 DUF1712, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VD30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAASGAGA GAAQEKQFPP ALLSFFIYNP RFGPREGEEE NKILFYYPNE
60 70 80 90 100
VEKNEKIRNV GLCEAIVQFT RTFSPSKPAK SLHTQKNRQF FNEPEENFWM
110 120 130 140 150
VMVVRNPIIE KQSKDGKPVV EYQEEELLDK VYSSVLQQCY SMYKLFNGTF
160 170 180 190 200
LRAMEDGGVK LLKERLEKFF HRYLQTLHLQ SCDLLDIFGG ISFFPLDKMT
210 220 230 240 250
YLKIQSFINR MEESLSIVKY TAFLYNDQLI WSGLEQDDMR ILYKYLTTSL
260 270 280 290 300
FPRHIEPELA GRDSPIRAEM PGNLQHYGRF LTGPLNLNDP EAKCRFPKIF
310 320 330 340 350
VNTDDTYEAL HLIVYKAMSA AVCFMIDASI QPTLDFCRRL DSIVGPQLTV
360 370 380 390 400
LASDICEQFN INKRMSGSEK EPQFKFIYFN HMNLAEKSTV HMRKTPSVSL
410 420 430 440 450
TSVHPDLMKI LGDINSDFTR VDEDEEIIVK AMSDYWVVGK KSDQRELYVI
460 470 480
LNQKNANLIE VNEEVKKLCA TQFNNIFFLD
Length:480
Mass (Da):55,502
Last modified:September 5, 2006 - v1
Checksum:iCC0B9A83EA233D97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119863 mRNA Translation: AAI19864.1
RefSeqiNP_001068960.1, NM_001075492.1
UniGeneiBt.10947

Genome annotation databases

EnsembliENSBTAT00000004259; ENSBTAP00000004259; ENSBTAG00000003288
GeneIDi511088
KEGGibta:511088

Similar proteinsi

Entry informationi

Entry nameiCCZ1_BOVIN
AccessioniPrimary (citable) accession number: Q0VD30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: September 5, 2006
Last modified: February 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome