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Q0VD19

- ASM_BOVIN

UniProt

Q0VD19 - ASM_BOVIN

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Protein
Sphingomyelin phosphodiesterase
Gene
SMPD1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol By similarity.

Catalytic activityi

Sphingomyelin + H2O = N-acylsphingosine + phosphocholine.

GO - Molecular functioni

  1. hydrolase activity, acting on glycosyl bonds Source: UniProtKB-KW
  2. sphingomyelin phosphodiesterase activity Source: UniProtKB-EC

GO - Biological processi

  1. negative regulation of MAP kinase activity Source: Ensembl
  2. positive regulation of protein dephosphorylation Source: Ensembl
  3. sphingomyelin catabolic process Source: InterPro
  4. termination of signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiREACT_204575. Glycosphingolipid metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingomyelin phosphodiesterase (EC:3.1.4.12)
Alternative name(s):
Acid sphingomyelinase
Short name:
aSMase
Gene namesi
Name:SMPD1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 15

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosomal membrane Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4040 Reviewed prediction
Add
BLAST
Chaini41 – 625585Sphingomyelin phosphodiesterase
PRO_0000288775Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi85 ↔ 161 By similarity
Disulfide bondi88 ↔ 153 By similarity
Disulfide bondi116 ↔ 127 By similarity
Glycosylationi171 – 1711N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi217 ↔ 222 By similarity
Disulfide bondi223 ↔ 246 By similarity
Glycosylationi331 – 3311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi381 ↔ 427 By similarity
Glycosylationi391 – 3911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi499 – 4991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi516 – 5161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi580 ↔ 584 By similarity
Disulfide bondi590 ↔ 603 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020758.

Structurei

3D structure databases

ProteinModelPortaliQ0VD19.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini81 – 16585Saposin B-type
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi175 – 19319Pro-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG303902.
GeneTreeiENSGT00530000063095.
HOGENOMiHOG000008599.
HOVERGENiHBG004288.
InParanoidiQ0VD19.
KOiK12350.
OMAiADPLCCR.
OrthoDBiEOG79PJP3.
TreeFamiTF313674.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR011001. Saposin-like.
IPR008139. SaposinB.
IPR011160. Sphingomy_PDE.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000948. Sphingomy_PDE. 1 hit.
SMARTiSM00741. SapB. 1 hit.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 1 hit.
SSF56300. SSF56300. 1 hit.
PROSITEiPS50015. SAP_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VD19-1 [UniParc]FASTAAdd to Basket

« Hide

MPRHGVSPGQ GLPRSGREQA SDRSLGAPCL RLLWLGLALA LALPNSPVLW    50
SPAEARPLPT QGHPAKFIRI APQLQEAFGW WNLTCPTCKG LFTAIDFGLR 100
NQASVAWVGS VAIKLCVLLK IAPPAVCQSA VQLFEDDMVE VWTRSVLSPS 150
EACGLLLGSS CGHWDIFSSW NISLPAVPKP PPQPPKPPAP GSPVSRVLFL 200
TDLHWDHDYL EGTDPNCENP LCCRRDSGPP PASQPGAGYW GEYSKCDLPL 250
RTLESLLSGL GPAGPFDMVY WTGDIPAHNI WQQSRQDQLR ALTTITALVK 300
KFLGPVPVYP AVGNHESTPV NGFPPPFIKG NQSSHWLYEA MAEAWEPWLP 350
AEALRTLRIG GFYALSPRPG LRLISLNMNF CSRENFWLLI NSTDPAGQLQ 400
WLVGELQAAE DRGDKVHIIG HIPPGHCLKS WSWNYYRIVE RYENTLAGQF 450
FGHTHVDEFE VFYDEETLSR PLSVAFLAPS ATTYIGLNPG YRVYQIDGNY 500
SGSSHVVLDH ETYIMNLTEA NEPGATPHWY LLYRARETYG LPNALPTAWH 550
DLVYRMRKDT QLFQTFWFLY HKGHPPSEPC GTPCRLATLC AQLSARSDSP 600
ALCRHLVPDA SLPDVQSLWS MPLLC 625
Length:625
Mass (Da):69,392
Last modified:September 5, 2006 - v1
Checksum:i1A87AAFEDDC0C959
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC119881 mRNA. Translation: AAI19882.1.
RefSeqiNP_001068655.1. NM_001075187.1.
UniGeneiBt.7951.

Genome annotation databases

EnsembliENSBTAT00000020758; ENSBTAP00000020758; ENSBTAG00000015628.
GeneIDi505097.
KEGGibta:505097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC119881 mRNA. Translation: AAI19882.1 .
RefSeqi NP_001068655.1. NM_001075187.1.
UniGenei Bt.7951.

3D structure databases

ProteinModelPortali Q0VD19.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000020758.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000020758 ; ENSBTAP00000020758 ; ENSBTAG00000015628 .
GeneIDi 505097.
KEGGi bta:505097.

Organism-specific databases

CTDi 6609.

Phylogenomic databases

eggNOGi NOG303902.
GeneTreei ENSGT00530000063095.
HOGENOMi HOG000008599.
HOVERGENi HBG004288.
InParanoidi Q0VD19.
KOi K12350.
OMAi ADPLCCR.
OrthoDBi EOG79PJP3.
TreeFami TF313674.

Enzyme and pathway databases

Reactomei REACT_204575. Glycosphingolipid metabolism.

Miscellaneous databases

NextBioi 20866981.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR011001. Saposin-like.
IPR008139. SaposinB.
IPR011160. Sphingomy_PDE.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PIRSFi PIRSF000948. Sphingomy_PDE. 1 hit.
SMARTi SM00741. SapB. 1 hit.
[Graphical view ]
SUPFAMi SSF47862. SSF47862. 1 hit.
SSF56300. SSF56300. 1 hit.
PROSITEi PS50015. SAP_B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thalamus.

Entry informationi

Entry nameiASM_BOVIN
AccessioniPrimary (citable) accession number: Q0VD19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of sphingomyelinases: ASM (acid), and NSM (neutral).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi