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Q0VD19 (ASM_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sphingomyelin phosphodiesterase

EC=3.1.4.12
Alternative name(s):
Acid sphingomyelinase
Short name=aSMase
Gene names
Name:SMPD1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length625 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol By similarity.

Catalytic activity

Sphingomyelin + H2O = N-acylsphingosine + phosphocholine.

Subunit structure

Monomer By similarity.

Subcellular location

Lysosome By similarity.

Miscellaneous

There are two types of sphingomyelinases: ASM (acid), and NSM (neutral).

Sequence similarities

Belongs to the acid sphingomyelinase family.

Contains 1 saposin B-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4040 Potential
Chain41 – 625585Sphingomyelin phosphodiesterase
PRO_0000288775

Regions

Domain81 – 16585Saposin B-type
Compositional bias175 – 19319Pro-rich

Amino acid modifications

Glycosylation821N-linked (GlcNAc...) Potential
Glycosylation1711N-linked (GlcNAc...) Potential
Glycosylation3311N-linked (GlcNAc...) Potential
Glycosylation3911N-linked (GlcNAc...) Potential
Glycosylation4991N-linked (GlcNAc...) Potential
Glycosylation5161N-linked (GlcNAc...) Potential
Disulfide bond85 ↔ 161 By similarity
Disulfide bond88 ↔ 153 By similarity
Disulfide bond116 ↔ 127 By similarity
Disulfide bond217 ↔ 222 By similarity
Disulfide bond223 ↔ 246 By similarity
Disulfide bond381 ↔ 427 By similarity
Disulfide bond580 ↔ 584 By similarity
Disulfide bond590 ↔ 603 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0VD19 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 1A87AAFEDDC0C959

FASTA62569,392
        10         20         30         40         50         60 
MPRHGVSPGQ GLPRSGREQA SDRSLGAPCL RLLWLGLALA LALPNSPVLW SPAEARPLPT 

        70         80         90        100        110        120 
QGHPAKFIRI APQLQEAFGW WNLTCPTCKG LFTAIDFGLR NQASVAWVGS VAIKLCVLLK 

       130        140        150        160        170        180 
IAPPAVCQSA VQLFEDDMVE VWTRSVLSPS EACGLLLGSS CGHWDIFSSW NISLPAVPKP 

       190        200        210        220        230        240 
PPQPPKPPAP GSPVSRVLFL TDLHWDHDYL EGTDPNCENP LCCRRDSGPP PASQPGAGYW 

       250        260        270        280        290        300 
GEYSKCDLPL RTLESLLSGL GPAGPFDMVY WTGDIPAHNI WQQSRQDQLR ALTTITALVK 

       310        320        330        340        350        360 
KFLGPVPVYP AVGNHESTPV NGFPPPFIKG NQSSHWLYEA MAEAWEPWLP AEALRTLRIG 

       370        380        390        400        410        420 
GFYALSPRPG LRLISLNMNF CSRENFWLLI NSTDPAGQLQ WLVGELQAAE DRGDKVHIIG 

       430        440        450        460        470        480 
HIPPGHCLKS WSWNYYRIVE RYENTLAGQF FGHTHVDEFE VFYDEETLSR PLSVAFLAPS 

       490        500        510        520        530        540 
ATTYIGLNPG YRVYQIDGNY SGSSHVVLDH ETYIMNLTEA NEPGATPHWY LLYRARETYG 

       550        560        570        580        590        600 
LPNALPTAWH DLVYRMRKDT QLFQTFWFLY HKGHPPSEPC GTPCRLATLC AQLSARSDSP 

       610        620 
ALCRHLVPDA SLPDVQSLWS MPLLC 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Thalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC119881 mRNA. Translation: AAI19882.1.
RefSeqNP_001068655.1. NM_001075187.1.
UniGeneBt.7951.

3D structure databases

ProteinModelPortalQ0VD19.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000020758.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000020758; ENSBTAP00000020758; ENSBTAG00000015628.
GeneID505097.
KEGGbta:505097.

Organism-specific databases

CTD6609.

Phylogenomic databases

eggNOGNOG303902.
GeneTreeENSGT00530000063095.
HOGENOMHOG000008599.
HOVERGENHBG004288.
InParanoidQ0VD19.
KOK12350.
OMAADPLCCR.
OrthoDBEOG79PJP3.
TreeFamTF313674.

Family and domain databases

InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR011001. Saposin-like.
IPR008139. SaposinB.
IPR011160. Sphingomy_PDE.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFPIRSF000948. Sphingomy_PDE. 1 hit.
SMARTSM00741. SapB. 1 hit.
[Graphical view]
SUPFAMSSF47862. SSF47862. 1 hit.
PROSITEPS50015. SAP_B. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20866981.

Entry information

Entry nameASM_BOVIN
AccessionPrimary (citable) accession number: Q0VD19
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families