Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q0VD19

- ASM_BOVIN

UniProt

Q0VD19 - ASM_BOVIN

Protein

Sphingomyelin phosphodiesterase

Gene

SMPD1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol By similarity.By similarity

    Catalytic activityi

    Sphingomyelin + H2O = N-acylsphingosine + phosphocholine.

    GO - Molecular functioni

    1. hydrolase activity, acting on glycosyl bonds Source: UniProtKB-KW
    2. sphingomyelin phosphodiesterase activity Source: UniProtKB-EC

    GO - Biological processi

    1. negative regulation of MAP kinase activity Source: Ensembl
    2. positive regulation of protein dephosphorylation Source: Ensembl
    3. sphingomyelin catabolic process Source: InterPro
    4. termination of signal transduction Source: Ensembl

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_204575. Glycosphingolipid metabolism.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sphingomyelin phosphodiesterase (EC:3.1.4.12)
    Alternative name(s):
    Acid sphingomyelinase
    Short name:
    aSMase
    Gene namesi
    Name:SMPD1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 15

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. lysosomal membrane Source: AgBase

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4040Sequence AnalysisAdd
    BLAST
    Chaini41 – 625585Sphingomyelin phosphodiesterasePRO_0000288775Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi82 – 821N-linked (GlcNAc...)PROSITE-ProRule annotation
    Disulfide bondi85 ↔ 161PROSITE-ProRule annotation
    Disulfide bondi88 ↔ 153PROSITE-ProRule annotation
    Disulfide bondi116 ↔ 127PROSITE-ProRule annotation
    Glycosylationi171 – 1711N-linked (GlcNAc...)PROSITE-ProRule annotation
    Disulfide bondi217 ↔ 222PROSITE-ProRule annotation
    Disulfide bondi223 ↔ 246PROSITE-ProRule annotation
    Glycosylationi331 – 3311N-linked (GlcNAc...)PROSITE-ProRule annotation
    Disulfide bondi381 ↔ 427PROSITE-ProRule annotation
    Glycosylationi391 – 3911N-linked (GlcNAc...)PROSITE-ProRule annotation
    Glycosylationi499 – 4991N-linked (GlcNAc...)PROSITE-ProRule annotation
    Glycosylationi516 – 5161N-linked (GlcNAc...)PROSITE-ProRule annotation
    Disulfide bondi580 ↔ 584PROSITE-ProRule annotation
    Disulfide bondi590 ↔ 603PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000020758.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0VD19.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini81 – 16585Saposin B-typePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi175 – 19319Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the acid sphingomyelinase family.Curated
    Contains 1 saposin B-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG303902.
    GeneTreeiENSGT00530000063095.
    HOGENOMiHOG000008599.
    HOVERGENiHBG004288.
    InParanoidiQ0VD19.
    KOiK12350.
    OMAiADPLCCR.
    OrthoDBiEOG79PJP3.
    TreeFamiTF313674.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR011001. Saposin-like.
    IPR008139. SaposinB.
    IPR011160. Sphingomy_PDE.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000948. Sphingomy_PDE. 1 hit.
    SMARTiSM00741. SapB. 1 hit.
    [Graphical view]
    SUPFAMiSSF47862. SSF47862. 1 hit.
    SSF56300. SSF56300. 1 hit.
    PROSITEiPS50015. SAP_B. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0VD19-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRHGVSPGQ GLPRSGREQA SDRSLGAPCL RLLWLGLALA LALPNSPVLW    50
    SPAEARPLPT QGHPAKFIRI APQLQEAFGW WNLTCPTCKG LFTAIDFGLR 100
    NQASVAWVGS VAIKLCVLLK IAPPAVCQSA VQLFEDDMVE VWTRSVLSPS 150
    EACGLLLGSS CGHWDIFSSW NISLPAVPKP PPQPPKPPAP GSPVSRVLFL 200
    TDLHWDHDYL EGTDPNCENP LCCRRDSGPP PASQPGAGYW GEYSKCDLPL 250
    RTLESLLSGL GPAGPFDMVY WTGDIPAHNI WQQSRQDQLR ALTTITALVK 300
    KFLGPVPVYP AVGNHESTPV NGFPPPFIKG NQSSHWLYEA MAEAWEPWLP 350
    AEALRTLRIG GFYALSPRPG LRLISLNMNF CSRENFWLLI NSTDPAGQLQ 400
    WLVGELQAAE DRGDKVHIIG HIPPGHCLKS WSWNYYRIVE RYENTLAGQF 450
    FGHTHVDEFE VFYDEETLSR PLSVAFLAPS ATTYIGLNPG YRVYQIDGNY 500
    SGSSHVVLDH ETYIMNLTEA NEPGATPHWY LLYRARETYG LPNALPTAWH 550
    DLVYRMRKDT QLFQTFWFLY HKGHPPSEPC GTPCRLATLC AQLSARSDSP 600
    ALCRHLVPDA SLPDVQSLWS MPLLC 625
    Length:625
    Mass (Da):69,392
    Last modified:September 5, 2006 - v1
    Checksum:i1A87AAFEDDC0C959
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC119881 mRNA. Translation: AAI19882.1.
    RefSeqiNP_001068655.1. NM_001075187.1.
    UniGeneiBt.7951.

    Genome annotation databases

    EnsembliENSBTAT00000020758; ENSBTAP00000020758; ENSBTAG00000015628.
    GeneIDi505097.
    KEGGibta:505097.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC119881 mRNA. Translation: AAI19882.1 .
    RefSeqi NP_001068655.1. NM_001075187.1.
    UniGenei Bt.7951.

    3D structure databases

    ProteinModelPortali Q0VD19.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000020758.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000020758 ; ENSBTAP00000020758 ; ENSBTAG00000015628 .
    GeneIDi 505097.
    KEGGi bta:505097.

    Organism-specific databases

    CTDi 6609.

    Phylogenomic databases

    eggNOGi NOG303902.
    GeneTreei ENSGT00530000063095.
    HOGENOMi HOG000008599.
    HOVERGENi HBG004288.
    InParanoidi Q0VD19.
    KOi K12350.
    OMAi ADPLCCR.
    OrthoDBi EOG79PJP3.
    TreeFami TF313674.

    Enzyme and pathway databases

    Reactomei REACT_204575. Glycosphingolipid metabolism.

    Miscellaneous databases

    NextBioi 20866981.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR011001. Saposin-like.
    IPR008139. SaposinB.
    IPR011160. Sphingomy_PDE.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000948. Sphingomy_PDE. 1 hit.
    SMARTi SM00741. SapB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47862. SSF47862. 1 hit.
    SSF56300. SSF56300. 1 hit.
    PROSITEi PS50015. SAP_B. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Thalamus.

    Entry informationi

    Entry nameiASM_BOVIN
    AccessioniPrimary (citable) accession number: Q0VD19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two types of sphingomyelinases: ASM (acid), and NSM (neutral).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3