Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sphingomyelin phosphodiesterase

Gene

SMPD1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.By similarity

Miscellaneous

There are two types of sphingomyelinases: ASM (acid), and NSM (neutral).

Catalytic activityi

Sphingomyelin + H2O = N-acylsphingosine + phosphocholine.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit. Zn2+ is particularly important for enzyme activity at neutral pH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi202Zinc 1By similarity1
Metal bindingi204Zinc 1; via tele nitrogenBy similarity1
Metal bindingi274Zinc 1By similarity1
Metal bindingi274Zinc 2By similarity1
Metal bindingi314Zinc 2By similarity1
Metal bindingi421Zinc 2; via tele nitrogenBy similarity1
Metal bindingi453Zinc 2; via pros nitrogenBy similarity1
Metal bindingi455Zinc 1; via tele nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-1660662 Glycosphingolipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingomyelin phosphodiesterase (EC:3.1.4.12By similarity)
Alternative name(s):
Acid sphingomyelinase
Short name:
aSMase
Gene namesi
Name:SMPD1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Organism-specific databases

VGNCiVGNC:35029 SMPD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 40Sequence analysisAdd BLAST40
ChainiPRO_000028877541 – 625Sphingomyelin phosphodiesteraseAdd BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi82N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi85 ↔ 161PROSITE-ProRule annotation
Disulfide bondi88 ↔ 153PROSITE-ProRule annotation
Disulfide bondi116 ↔ 127PROSITE-ProRule annotation
Glycosylationi171N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi217 ↔ 222PROSITE-ProRule annotation
Disulfide bondi223 ↔ 246PROSITE-ProRule annotation
Glycosylationi331N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi381 ↔ 427PROSITE-ProRule annotation
Glycosylationi391N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi499N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi516N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi580 ↔ 584PROSITE-ProRule annotation
Disulfide bondi590 ↔ 603PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ0VD19
PRIDEiQ0VD19

Expressioni

Gene expression databases

BgeeiENSBTAG00000015628

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020758

Structurei

3D structure databases

ProteinModelPortaliQ0VD19
SMRiQ0VD19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 165Saposin B-typePROSITE-ProRule annotationAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi175 – 193Pro-richAdd BLAST19

Sequence similaritiesi

Belongs to the acid sphingomyelinase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3770 Eukaryota
ENOG410YYPB LUCA
GeneTreeiENSGT00530000063095
HOGENOMiHOG000008599
HOVERGENiHBG004288
InParanoidiQ0VD19
KOiK12350
OMAiADPLCCR
OrthoDBiEOG091G03M6
TreeFamiTF313674

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR011001 Saposin-like
IPR008139 SaposinB_dom
IPR011160 Sphingomy_PDE
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PIRSFiPIRSF000948 Sphingomy_PDE, 1 hit
SMARTiView protein in SMART
SM00741 SapB, 1 hit
SUPFAMiSSF47862 SSF47862, 1 hit
PROSITEiView protein in PROSITE
PS50015 SAP_B, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VD19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRHGVSPGQ GLPRSGREQA SDRSLGAPCL RLLWLGLALA LALPNSPVLW
60 70 80 90 100
SPAEARPLPT QGHPAKFIRI APQLQEAFGW WNLTCPTCKG LFTAIDFGLR
110 120 130 140 150
NQASVAWVGS VAIKLCVLLK IAPPAVCQSA VQLFEDDMVE VWTRSVLSPS
160 170 180 190 200
EACGLLLGSS CGHWDIFSSW NISLPAVPKP PPQPPKPPAP GSPVSRVLFL
210 220 230 240 250
TDLHWDHDYL EGTDPNCENP LCCRRDSGPP PASQPGAGYW GEYSKCDLPL
260 270 280 290 300
RTLESLLSGL GPAGPFDMVY WTGDIPAHNI WQQSRQDQLR ALTTITALVK
310 320 330 340 350
KFLGPVPVYP AVGNHESTPV NGFPPPFIKG NQSSHWLYEA MAEAWEPWLP
360 370 380 390 400
AEALRTLRIG GFYALSPRPG LRLISLNMNF CSRENFWLLI NSTDPAGQLQ
410 420 430 440 450
WLVGELQAAE DRGDKVHIIG HIPPGHCLKS WSWNYYRIVE RYENTLAGQF
460 470 480 490 500
FGHTHVDEFE VFYDEETLSR PLSVAFLAPS ATTYIGLNPG YRVYQIDGNY
510 520 530 540 550
SGSSHVVLDH ETYIMNLTEA NEPGATPHWY LLYRARETYG LPNALPTAWH
560 570 580 590 600
DLVYRMRKDT QLFQTFWFLY HKGHPPSEPC GTPCRLATLC AQLSARSDSP
610 620
ALCRHLVPDA SLPDVQSLWS MPLLC
Length:625
Mass (Da):69,392
Last modified:September 5, 2006 - v1
Checksum:i1A87AAFEDDC0C959
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119881 mRNA Translation: AAI19882.1
RefSeqiNP_001068655.1, NM_001075187.1
UniGeneiBt.7951

Genome annotation databases

EnsembliENSBTAT00000020758; ENSBTAP00000020758; ENSBTAG00000015628
GeneIDi505097
KEGGibta:505097

Similar proteinsi

Entry informationi

Entry nameiASM_BOVIN
AccessioniPrimary (citable) accession number: Q0VD19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health