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Q0VD07

- GPM6A_BOVIN

UniProt

Q0VD07 - GPM6A_BOVIN

Protein

Neuronal membrane glycoprotein M6-a

Gene

GPM6A

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca2+ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); may enhance internalization and recycling of mu-type opioid receptor By similarity.By similarity

    GO - Biological processi

    1. neural retina development Source: UniProtKB
    2. neuron migration Source: UniProtKB
    3. neuron projection morphogenesis Source: UniProtKB
    4. positive regulation of filopodium assembly Source: UniProtKB
    5. stem cell differentiation Source: UniProtKB
    6. synapse assembly Source: UniProtKB

    Keywords - Biological processi

    Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuronal membrane glycoprotein M6-a
    Short name:
    M6a
    Gene namesi
    Name:GPM6A
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Cell projectionaxon By similarity. Cell projectiondendritic spine By similarity. Cell projectionfilopodium By similarity
    Note: Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons. Localized to the growth cone edge membrane of elongating axons By similarity.By similarity

    GO - Cellular componenti

    1. axonal growth cone Source: UniProtKB
    2. dendritic spine Source: UniProtKB-SubCell
    3. filopodium Source: UniProtKB
    4. integral component of membrane Source: UniProtKB-KW
    5. neuronal cell body Source: UniProtKB
    6. neuron projection Source: UniProtKB
    7. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278Neuronal membrane glycoprotein M6-aPRO_0000283789Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi174 ↔ 192By similarity
    Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Acetylation, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ0VD07.

    Interactioni

    Subunit structurei

    Interacts with OPRM1.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000005543.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0VD07.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini44 – 8441ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini106 – 12722CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini149 – 21365ExtracellularBy similarityAdd
    BLAST
    Topological domaini235 – 27844CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei128 – 14821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the myelin proteolipid protein family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG322245.
    HOGENOMiHOG000231338.
    HOVERGENiHBG000096.
    InParanoidiQ0VD07.

    Family and domain databases

    InterProiIPR001614. Myelin_PLP.
    IPR018237. Myelin_PLP_CS.
    [Graphical view]
    PANTHERiPTHR11683. PTHR11683. 1 hit.
    PfamiPF01275. Myelin_PLP. 1 hit.
    [Graphical view]
    PRINTSiPR00214. MYELINPLP.
    SMARTiSM00002. PLP. 1 hit.
    [Graphical view]
    PROSITEiPS00575. MYELIN_PLP_1. 1 hit.
    PS01004. MYELIN_PLP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0VD07-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEENMEEGQT QKGCFECCIK CLGGIPYASL IATILLYAGV ALFCGCGHEA    50
    LSGTVNILQT YFEMARTAGD TLDVFTMIDI FKYVIYGIAA AFFVYGILLM 100
    VEGFFTTGAI KDLYGDFKIT TCGRCVSAWF IMLTYLFMLA WLGVTAFTSL 150
    PVYMYFNLWT ICRNTTLVEG ANLCLDLRQF GIVTIGEEKK ICTVSENFLR 200
    MCESTELNMT FHLFIVALAG AGAAVIAMVH YLMVLSANWA YVKDACRMQK 250
    YEDIKSKEEQ ELHDIHSTRS KERLNAYT 278
    Length:278
    Mass (Da):31,210
    Last modified:September 5, 2006 - v1
    Checksum:iDD0DB598C0E86B5D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC119902 mRNA. Translation: AAI19903.1.
    RefSeqiNP_001068777.1. NM_001075309.1.
    UniGeneiBt.65331.

    Genome annotation databases

    GeneIDi507389.
    KEGGibta:507389.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC119902 mRNA. Translation: AAI19903.1 .
    RefSeqi NP_001068777.1. NM_001075309.1.
    UniGenei Bt.65331.

    3D structure databases

    ProteinModelPortali Q0VD07.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000005543.

    Proteomic databases

    PRIDEi Q0VD07.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 507389.
    KEGGi bta:507389.

    Organism-specific databases

    CTDi 2823.

    Phylogenomic databases

    eggNOGi NOG322245.
    HOGENOMi HOG000231338.
    HOVERGENi HBG000096.
    InParanoidi Q0VD07.

    Miscellaneous databases

    NextBioi 20868036.

    Family and domain databases

    InterProi IPR001614. Myelin_PLP.
    IPR018237. Myelin_PLP_CS.
    [Graphical view ]
    PANTHERi PTHR11683. PTHR11683. 1 hit.
    Pfami PF01275. Myelin_PLP. 1 hit.
    [Graphical view ]
    PRINTSi PR00214. MYELINPLP.
    SMARTi SM00002. PLP. 1 hit.
    [Graphical view ]
    PROSITEi PS00575. MYELIN_PLP_1. 1 hit.
    PS01004. MYELIN_PLP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiGPM6A_BOVIN
    AccessioniPrimary (citable) accession number: Q0VD07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3