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Q0VD07 (GPM6A_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuronal membrane glycoprotein M6-a

Short name=M6a
Gene names
Name:GPM6A
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca2+ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); may enhance internalization and recycling of mu-type opioid receptor By similarity.

Subunit structure

Interacts with OPRM1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Cell projectionaxon By similarity. Cell projectiondendritic spine By similarity. Cell projectionfilopodium By similarity. Note: Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons. Localized to the growth cone edge membrane of elongating axons By similarity.

Sequence similarities

Belongs to the myelin proteolipid protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Neuronal membrane glycoprotein M6-a
PRO_0000283789

Regions

Topological domain1 – 2222Cytoplasmic Potential
Transmembrane23 – 4321Helical; Potential
Topological domain44 – 8441Extracellular Potential
Transmembrane85 – 10521Helical; Potential
Topological domain106 – 12722Cytoplasmic Potential
Transmembrane128 – 14821Helical; Potential
Topological domain149 – 21365Extracellular By similarity
Transmembrane214 – 23421Helical; Potential
Topological domain235 – 27844Cytoplasmic Potential

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Glycosylation1641N-linked (GlcNAc...) Potential
Glycosylation2081N-linked (GlcNAc...) Potential
Disulfide bond174 ↔ 192 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0VD07 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: DD0DB598C0E86B5D

FASTA27831,210
        10         20         30         40         50         60 
MEENMEEGQT QKGCFECCIK CLGGIPYASL IATILLYAGV ALFCGCGHEA LSGTVNILQT 

        70         80         90        100        110        120 
YFEMARTAGD TLDVFTMIDI FKYVIYGIAA AFFVYGILLM VEGFFTTGAI KDLYGDFKIT 

       130        140        150        160        170        180 
TCGRCVSAWF IMLTYLFMLA WLGVTAFTSL PVYMYFNLWT ICRNTTLVEG ANLCLDLRQF 

       190        200        210        220        230        240 
GIVTIGEEKK ICTVSENFLR MCESTELNMT FHLFIVALAG AGAAVIAMVH YLMVLSANWA 

       250        260        270 
YVKDACRMQK YEDIKSKEEQ ELHDIHSTRS KERLNAYT 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC119902 mRNA. Translation: AAI19903.1.
RefSeqNP_001068777.1. NM_001075309.1.
UniGeneBt.65331.

3D structure databases

ProteinModelPortalQ0VD07.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000005543.

Proteomic databases

PRIDEQ0VD07.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID507389.
KEGGbta:507389.

Organism-specific databases

CTD2823.

Phylogenomic databases

eggNOGNOG322245.
HOGENOMHOG000231338.
HOVERGENHBG000096.
InParanoidQ0VD07.

Family and domain databases

InterProIPR001614. Myelin_PLP.
IPR018237. Myelin_PLP_CS.
[Graphical view]
PANTHERPTHR11683. PTHR11683. 1 hit.
PfamPF01275. Myelin_PLP. 1 hit.
[Graphical view]
PRINTSPR00214. MYELINPLP.
SMARTSM00002. PLP. 1 hit.
[Graphical view]
PROSITEPS00575. MYELIN_PLP_1. 1 hit.
PS01004. MYELIN_PLP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20868036.

Entry information

Entry nameGPM6A_BOVIN
AccessionPrimary (citable) accession number: Q0VD07
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: September 5, 2006
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families