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Protein

Neuronal membrane glycoprotein M6-a

Gene

GPM6A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca2+ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); may enhance internalization and recycling of mu-type opioid receptor (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal membrane glycoprotein M6-a
Short name:
M6a
Gene namesi
Name:GPM6A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Topological domaini44 – 84ExtracellularSequence analysisAdd BLAST41
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 127CytoplasmicSequence analysisAdd BLAST22
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 213ExtracellularBy similarityAdd BLAST65
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 278CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002837891 – 278Neuronal membrane glycoprotein M6-aAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi174 ↔ 192By similarity
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1
Modified residuei256PhosphoserineBy similarity1
Modified residuei278PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ0VD07.

Interactioni

Subunit structurei

Interacts with OPRM1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ0VD07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the myelin proteolipid protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000231338.
HOVERGENiHBG000096.
InParanoidiQ0VD07.

Family and domain databases

InterProiIPR001614. Myelin_PLP.
IPR018237. Myelin_PLP_CS.
[Graphical view]
PANTHERiPTHR11683. PTHR11683. 1 hit.
PfamiPF01275. Myelin_PLP. 1 hit.
[Graphical view]
PRINTSiPR00214. MYELINPLP.
SMARTiSM00002. PLP. 1 hit.
[Graphical view]
PROSITEiPS00575. MYELIN_PLP_1. 1 hit.
PS01004. MYELIN_PLP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VD07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEENMEEGQT QKGCFECCIK CLGGIPYASL IATILLYAGV ALFCGCGHEA
60 70 80 90 100
LSGTVNILQT YFEMARTAGD TLDVFTMIDI FKYVIYGIAA AFFVYGILLM
110 120 130 140 150
VEGFFTTGAI KDLYGDFKIT TCGRCVSAWF IMLTYLFMLA WLGVTAFTSL
160 170 180 190 200
PVYMYFNLWT ICRNTTLVEG ANLCLDLRQF GIVTIGEEKK ICTVSENFLR
210 220 230 240 250
MCESTELNMT FHLFIVALAG AGAAVIAMVH YLMVLSANWA YVKDACRMQK
260 270
YEDIKSKEEQ ELHDIHSTRS KERLNAYT
Length:278
Mass (Da):31,210
Last modified:September 5, 2006 - v1
Checksum:iDD0DB598C0E86B5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119902 mRNA. Translation: AAI19903.1.
RefSeqiNP_001068777.1. NM_001075309.1.
UniGeneiBt.65331.

Genome annotation databases

GeneIDi507389.
KEGGibta:507389.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119902 mRNA. Translation: AAI19903.1.
RefSeqiNP_001068777.1. NM_001075309.1.
UniGeneiBt.65331.

3D structure databases

ProteinModelPortaliQ0VD07.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ0VD07.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi507389.
KEGGibta:507389.

Organism-specific databases

CTDi2823.

Phylogenomic databases

HOGENOMiHOG000231338.
HOVERGENiHBG000096.
InParanoidiQ0VD07.

Family and domain databases

InterProiIPR001614. Myelin_PLP.
IPR018237. Myelin_PLP_CS.
[Graphical view]
PANTHERiPTHR11683. PTHR11683. 1 hit.
PfamiPF01275. Myelin_PLP. 1 hit.
[Graphical view]
PRINTSiPR00214. MYELINPLP.
SMARTiSM00002. PLP. 1 hit.
[Graphical view]
PROSITEiPS00575. MYELIN_PLP_1. 1 hit.
PS01004. MYELIN_PLP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPM6A_BOVIN
AccessioniPrimary (citable) accession number: Q0VD07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: September 5, 2006
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.