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Protein

YTH domain-containing family protein 2

Gene

YTHDF2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation. Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei423 – 4231N6-methyladenosineBy similarity
Binding sitei463 – 4631N6-methyladenosineBy similarity
Binding sitei487 – 4871N6-methyladenosineBy similarity
Binding sitei492 – 4921N6-methyladenosineBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
YTH domain-containing family protein 2Curated
Gene namesi
Name:YTHDF2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Nucleus By similarity
  • CytoplasmP-body By similarity

  • Note: Localizes to the cytosol and relocates to the nucleus following heat shock stress.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 580579YTH domain-containing family protein 2PRO_0000284978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei22 – 221PhosphoserineBy similarity
Modified residuei39 – 391PhosphoserineBy similarity
Modified residuei360 – 3601PhosphoserineBy similarity
Modified residuei395 – 3951PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ0VCZ3.
PRIDEiQ0VCZ3.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020940.

Structurei

3D structure databases

ProteinModelPortaliQ0VCZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini411 – 545135YTHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 385384Localization to mRNA processing bodies (P-bodies)By similarityAdd
BLAST
Regioni386 – 580195Interaction with m6A-containing mRNAsBy similarityAdd
BLAST
Regioni417 – 4193N6-methyladenosine bindingBy similarity
Regioni433 – 4342N6-methyladenosine bindingBy similarity

Sequence similaritiesi

Contains 1 YTH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1901. Eukaryota.
ENOG410YABQ. LUCA.
GeneTreeiENSGT00390000017549.
HOGENOMiHOG000232058.
HOVERGENiHBG060315.
InParanoidiQ0VCZ3.
OMAiTGGDPPM.
OrthoDBiEOG71VSSM.
TreeFamiTF323736.

Family and domain databases

InterProiIPR007275. YTH_domain.
[Graphical view]
PfamiPF04146. YTH. 1 hit.
[Graphical view]
PROSITEiPS50882. YTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VCZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASSLLEQR PKGQGNKVQN GSVHQKDGLN DDDFEPYLSP QARPNNAYTA
60 70 80 90 100
MSDSYLPSYY SPSIGFSYSL GEAAWSTGGD TAMPYLTSYG QLSNGEPHFL
110 120 130 140 150
PDAMFGQPGA LGSTPFLGQH GFNFFPSGID FSAWGNNSSQ GQSTQSSGYS
160 170 180 190 200
SNYAYAPSSL GGAMIDGQSA FASETLNKAP GMNTIDQGMA ALKLGSTEVA
210 220 230 240 250
SNVPKVVGSA VGSGSITSNI VASNSLPPAT IAPPKPASWA DIASKPAKQQ
260 270 280 290 300
PKLKTKNGIA GSSLPPPPIK HNMDIGTWDN KGPVAKAPSQ ALVQNIGQQP
310 320 330 340 350
TQGSPQPVGQ QANNSPPVAQ ASVGQQTQPL PPPPPQPAQL SVQQQAAQPT
360 370 380 390 400
RWVAPRNRGS GFGHNGVDGN GVGQTQAGSG STPSEPHPVL EKLRSINNYN
410 420 430 440 450
PKDFDWNLKH GRVFIIKSYS EDDIHRSIKY NIWCSTEHGN KRLDAAYRSM
460 470 480 490 500
NGKGPVYLLF SVNGSGHFCG VAEMKSAVDY NTCAGVWSQD KWKGRFDVRW
510 520 530 540 550
IFVKDVPNSQ LRHIRLENNE NKPVTNSRDT QEVPLEKAKQ VLKIIASYKH
560 570 580
TTSIFDDFSH YEKRQEEEES VKKERQGRGK
Length:580
Mass (Da):62,449
Last modified:September 5, 2006 - v1
Checksum:iAEF0F9550CFC512F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119920 mRNA. Translation: AAI19921.1.
RefSeqiNP_001069721.1. NM_001076253.1.
UniGeneiBt.40475.

Genome annotation databases

EnsembliENSBTAT00000020940; ENSBTAP00000020940; ENSBTAG00000015771.
GeneIDi541050.
KEGGibta:541050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119920 mRNA. Translation: AAI19921.1.
RefSeqiNP_001069721.1. NM_001076253.1.
UniGeneiBt.40475.

3D structure databases

ProteinModelPortaliQ0VCZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020940.

Proteomic databases

PaxDbiQ0VCZ3.
PRIDEiQ0VCZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020940; ENSBTAP00000020940; ENSBTAG00000015771.
GeneIDi541050.
KEGGibta:541050.

Organism-specific databases

CTDi51441.

Phylogenomic databases

eggNOGiKOG1901. Eukaryota.
ENOG410YABQ. LUCA.
GeneTreeiENSGT00390000017549.
HOGENOMiHOG000232058.
HOVERGENiHBG060315.
InParanoidiQ0VCZ3.
OMAiTGGDPPM.
OrthoDBiEOG71VSSM.
TreeFamiTF323736.

Miscellaneous databases

NextBioi20878977.

Family and domain databases

InterProiIPR007275. YTH_domain.
[Graphical view]
PfamiPF04146. YTH. 1 hit.
[Graphical view]
PROSITEiPS50882. YTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal skin.

Entry informationi

Entry nameiYTHD2_BOVIN
AccessioniPrimary (citable) accession number: Q0VCZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 5, 2006
Last modified: March 16, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.