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Protein

YTH domain-containing family protein 2

Gene

YTHDF2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation. Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development. Also involved in haematopoietic stem cells specification: acts by binding to m6A-containing mRNAs, leading to decrease Notch dignaling and promote endothelial to haematopoietic transition (By similarity). Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei423N6-methyladenosineBy similarity1
Binding sitei463N6-methyladenosineBy similarity1
Binding sitei487N6-methyladenosineBy similarity1
Binding sitei492N6-methyladenosineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processDifferentiation, Oogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
YTH domain-containing family protein 2Curated
Gene namesi
Name:YTHDF2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Organism-specific databases

VGNCiVGNC:37042 YTHDF2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002849782 – 580YTH domain-containing family protein 2Add BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei4PhosphoserineBy similarity1
Modified residuei5PhosphoserineBy similarity1
Modified residuei22PhosphoserineBy similarity1
Modified residuei39PhosphoserineBy similarity1
Modified residuei196PhosphoserineBy similarity1
Modified residuei360PhosphoserineBy similarity1
Modified residuei395PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ0VCZ3
PRIDEiQ0VCZ3

Expressioni

Gene expression databases

BgeeiENSBTAG00000015771

Interactioni

Subunit structurei

Interacts with YTHDF3.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020940

Structurei

3D structure databases

ProteinModelPortaliQ0VCZ3
SMRiQ0VCZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini411 – 545YTHPROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 385Localization to mRNA processing bodies (P-bodies)By similarityAdd BLAST384
Regioni386 – 580Interaction with m6A-containing mRNAsBy similarityAdd BLAST195
Regioni417 – 419N6-methyladenosine bindingBy similarity3
Regioni433 – 434N6-methyladenosine bindingBy similarity2

Sequence similaritiesi

Belongs to the YTHDF2 family.Curated

Phylogenomic databases

eggNOGiKOG1901 Eukaryota
ENOG410YABQ LUCA
GeneTreeiENSGT00390000017549
HOGENOMiHOG000232058
HOVERGENiHBG060315
InParanoidiQ0VCZ3
KOiK20102
OMAiKDFDWNP
OrthoDBiEOG091G0D17
TreeFamiTF323736

Family and domain databases

InterProiView protein in InterPro
IPR007275 YTH_domain
PfamiView protein in Pfam
PF04146 YTH, 1 hit
PROSITEiView protein in PROSITE
PS50882 YTH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VCZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASSLLEQR PKGQGNKVQN GSVHQKDGLN DDDFEPYLSP QARPNNAYTA
60 70 80 90 100
MSDSYLPSYY SPSIGFSYSL GEAAWSTGGD TAMPYLTSYG QLSNGEPHFL
110 120 130 140 150
PDAMFGQPGA LGSTPFLGQH GFNFFPSGID FSAWGNNSSQ GQSTQSSGYS
160 170 180 190 200
SNYAYAPSSL GGAMIDGQSA FASETLNKAP GMNTIDQGMA ALKLGSTEVA
210 220 230 240 250
SNVPKVVGSA VGSGSITSNI VASNSLPPAT IAPPKPASWA DIASKPAKQQ
260 270 280 290 300
PKLKTKNGIA GSSLPPPPIK HNMDIGTWDN KGPVAKAPSQ ALVQNIGQQP
310 320 330 340 350
TQGSPQPVGQ QANNSPPVAQ ASVGQQTQPL PPPPPQPAQL SVQQQAAQPT
360 370 380 390 400
RWVAPRNRGS GFGHNGVDGN GVGQTQAGSG STPSEPHPVL EKLRSINNYN
410 420 430 440 450
PKDFDWNLKH GRVFIIKSYS EDDIHRSIKY NIWCSTEHGN KRLDAAYRSM
460 470 480 490 500
NGKGPVYLLF SVNGSGHFCG VAEMKSAVDY NTCAGVWSQD KWKGRFDVRW
510 520 530 540 550
IFVKDVPNSQ LRHIRLENNE NKPVTNSRDT QEVPLEKAKQ VLKIIASYKH
560 570 580
TTSIFDDFSH YEKRQEEEES VKKERQGRGK
Length:580
Mass (Da):62,449
Last modified:September 5, 2006 - v1
Checksum:iAEF0F9550CFC512F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119920 mRNA Translation: AAI19921.1
RefSeqiNP_001069721.1, NM_001076253.1
UniGeneiBt.40475

Genome annotation databases

EnsembliENSBTAT00000020940; ENSBTAP00000020940; ENSBTAG00000015771
GeneIDi541050
KEGGibta:541050

Similar proteinsi

Entry informationi

Entry nameiYTHD2_BOVIN
AccessioniPrimary (citable) accession number: Q0VCZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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