ID   SDHL_BOVIN              Reviewed;         327 AA.
AC   Q0VCW4;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=L-serine dehydratase;
DE            EC=4.3.1.17;
DE   AltName: Full=L-serine deaminase;
GN   Name=SDS; Synonyms=SDH;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-serine = pyruvate + NH(3).
CC   -!- COFACTOR: Pyridoxal phosphate (By similarity).
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the serine/threonine dehydratase family.
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DR   EMBL; BC119966; AAI19967.1; -; mRNA.
DR   IPI; IPI00707557; -.
DR   RefSeq; NP_001069130.1; -.
DR   UniGene; Bt.5878; -.
DR   SMR; Q0VCW4; 1-325.
DR   Ensembl; ENSBTAG00000031814; Bos taurus.
DR   GeneID; 514346; -.
DR   KEGG; bta:514346; -.
DR   HOVERGEN; Q0VCW4; -.
DR   BRENDA; 4.3.1.17; 251.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003941; F:L-serine ammonia-lyase activity; IEA:EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR001926; PyrdxlP-dep_enz_bsu.
DR   InterPro; IPR000634; Ser/Thr_deHydtase_PyrdxlP-BS.
DR   Pfam; PF00291; PALP; 1.
DR   PROSITE; PS00165; DEHYDRATASE_SER_THR; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Gluconeogenesis; Lyase; Pyridoxal phosphate.
FT   CHAIN         1    327       L-serine dehydratase.
FT                                /FTId=PRO_0000264629.
FT   MOD_RES      41     41       N6-(pyridoxal phosphate)lysine (By
FT                                similarity).
SQ   SEQUENCE   327 AA;  34441 MW;  214129C45F9CF9CE CRC64;
     MMSGRPLHME TPVRDSMTLS KVAGTTAYLK LDSAQPSGSF KIRGIGHLCK MWAERGCEHF
     VCSSAGNAGM AAAYAARKLG IPSTIVVPST TPALTIQRLK NEGATVKVVG ETLDEAIRVA
     KDLEKNNSGW VYVPPFDDPL IWEGHSSIVK ELKETMTEKP GAIVLAVGGG GLLCGVVQGL
     AEVGWRDVPV ITMETIGAES FHASTKAGKL VTLPCITSVA KALGVTTVAA QAMKVYREHP
     IFSEVVSDQE AVAALEKFVD DEKILVEPAC GAALAAVYSN VIQKLQGEGK LRTPLSSLVV
     IVCGGSNISL AQLVALKKQL GMDGLSQ
//