Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-serine dehydratase/L-threonine deaminase

Gene

SDS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-serine = pyruvate + NH3.
L-threonine = 2-oxobutanoate + NH3.

Cofactori

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
L-serine dehydratase/L-threonine deaminase (EC:4.3.1.17)
Short name:
SDH
Alternative name(s):
L-serine deaminase
L-threonine dehydratase (EC:4.3.1.19)
Short name:
TDH
Gene namesi
Name:SDS
Synonyms:SDH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 327326L-serine dehydratase/L-threonine deaminasePRO_0000264629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiQ0VCW4.
PRIDEiQ0VCW4.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042524.

Structurei

3D structure databases

ProteinModelPortaliQ0VCW4.
SMRiQ0VCW4. Positions 1-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1250. Eukaryota.
COG1171. LUCA.
HOGENOMiHOG000046976.
HOVERGENiHBG017784.
InParanoidiQ0VCW4.
KOiK17989.

Family and domain databases

InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VCW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSGRPLHME TPVRDSMTLS KVAGTTAYLK LDSAQPSGSF KIRGIGHLCK
60 70 80 90 100
MWAERGCEHF VCSSAGNAGM AAAYAARKLG IPSTIVVPST TPALTIQRLK
110 120 130 140 150
NEGATVKVVG ETLDEAIRVA KDLEKNNSGW VYVPPFDDPL IWEGHSSIVK
160 170 180 190 200
ELKETMTEKP GAIVLAVGGG GLLCGVVQGL AEVGWRDVPV ITMETIGAES
210 220 230 240 250
FHASTKAGKL VTLPCITSVA KALGVTTVAA QAMKVYREHP IFSEVVSDQE
260 270 280 290 300
AVAALEKFVD DEKILVEPAC GAALAAVYSN VIQKLQGEGK LRTPLSSLVV
310 320
IVCGGSNISL AQLVALKKQL GMDGLSQ
Length:327
Mass (Da):34,441
Last modified:September 5, 2006 - v1
Checksum:i214129C45F9CF9CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119966 mRNA. Translation: AAI19967.1.
RefSeqiNP_001069130.1. NM_001075662.1.
UniGeneiBt.5878.

Genome annotation databases

GeneIDi514346.
KEGGibta:514346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119966 mRNA. Translation: AAI19967.1.
RefSeqiNP_001069130.1. NM_001075662.1.
UniGeneiBt.5878.

3D structure databases

ProteinModelPortaliQ0VCW4.
SMRiQ0VCW4. Positions 1-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042524.

Proteomic databases

PaxDbiQ0VCW4.
PRIDEiQ0VCW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi514346.
KEGGibta:514346.

Organism-specific databases

CTDi10993.

Phylogenomic databases

eggNOGiKOG1250. Eukaryota.
COG1171. LUCA.
HOGENOMiHOG000046976.
HOVERGENiHBG017784.
InParanoidiQ0VCW4.
KOiK17989.

Enzyme and pathway databases

UniPathwayiUPA00138.

Family and domain databases

InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thalamus.

Entry informationi

Entry nameiSDHL_BOVIN
AccessioniPrimary (citable) accession number: Q0VCW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 5, 2006
Last modified: June 8, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.