Reviewed, UniProtKB/Swiss-Prot Q0VCW4 (SDHL_BOVIN)

Names and origin

Protein names

Recommended name:
    L-serine dehydratase/L-threonine deaminase
    EC=4.3.1.17
Alternative name(s):
    L-serine deaminase
    SDH
    L-threonine dehydratase
    EC=4.3.1.19
    TDH

Gene names

Name:	SDS
Synonyms:	SDH

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-serine = pyruvate + NH3. L-threonine = 2-oxobutanoate + NH3.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Carbohydrate biosynthesis; gluconeogenesis.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the serine/threonine dehydratase family.

Ontologies

Keywords
Biological process	Gluconeogenesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Gene Ontology (GO)
Biological process	L-serine catabolic process Inferred from sequence or structural similarity. Source: UniProtKB gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW pyruvate biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-serine ammonia-lyase activity Inferred from sequence or structural similarity. Source: UniProtKB L-threonine ammonia-lyase activity Inferred from electronic annotation. Source: EC protein homodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB pyridoxal phosphate binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 327	327	L-serine dehydratase/L-threonine deaminase		PRO_0000264629
Amino acid modifications
	Modified residue	41	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0VCW4-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 214129C45F9CF9CE	FASTA	327	34,441
	10 20 30 40 50 60 MMSGRPLHME TPVRDSMTLS KVAGTTAYLK LDSAQPSGSF KIRGIGHLCK MWAERGCEHF 70 80 90 100 110 120 VCSSAGNAGM AAAYAARKLG IPSTIVVPST TPALTIQRLK NEGATVKVVG ETLDEAIRVA 130 140 150 160 170 180 KDLEKNNSGW VYVPPFDDPL IWEGHSSIVK ELKETMTEKP GAIVLAVGGG GLLCGVVQGL 190 200 210 220 230 240 AEVGWRDVPV ITMETIGAES FHASTKAGKL VTLPCITSVA KALGVTTVAA QAMKVYREHP 250 260 270 280 290 300 IFSEVVSDQE AVAALEKFVD DEKILVEPAC GAALAAVYSN VIQKLQGEGK LRTPLSSLVV 310 320 IVCGGSNISL AQLVALKKQL GMDGLSQ

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thalamus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC119966 mRNA. Translation: AAI19967.1.
IPI	IPI00707557.
RefSeq	NP_001069130.1.
UniGene	Bt.5878
3D structure databases
SMR	Q0VCW4. Positions 1-325.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0VCW4.
Genome annotation databases
Ensembl	ENSBTAT00000045109; ENSBTAP00000042524; ENSBTAG00000031814; Bos taurus. [Genome view]
GeneID	514346.
KEGG	bta:514346.
Organism-specific databases
CTD	514346.
Phylogenomic databases
eggNOG	maNOG17826.
HOVERGEN	Q0VCW4.
InParanoid	Q0VCW4.
PhylomeDB	Q0VCW4.
Enzyme and pathway databases
BRENDA	4.3.1.17. 251.
Family and domain databases
InterPro	IPR001926. PyrdxlP-dep_enz_bsu. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. [Graphical view]
Pfam	PF00291. PALP. 1 hit. [Graphical view]
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SDHL_BOVIN

Accession

Primary (citable) accession number: Q0VCW4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	September 5, 2006
Last modified:	January 19, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)