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Reviewed, UniProtKB/Swiss-Prot Q0VCW4 (SDHL_BOVIN)

Last modified January 19, 2010. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    L-serine dehydratase/L-threonine deaminase
    EC=4.3.1.17
Alternative name(s):
    L-serine deaminase
    SDH
    L-threonine dehydratase
    EC=4.3.1.19
    TDH
Gene names
Name: SDS
Synonyms: SDH
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

L-serine = pyruvate + NH3.

L-threonine = 2-oxobutanoate + NH3.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the serine/threonine dehydratase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327L-serine dehydratase/L-threonine deaminase
PRO_0000264629

Amino acid modifications

Modified residue411N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0VCW4-1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 214129C45F9CF9CE

FASTA32734,441
        10         20         30         40         50         60 
MMSGRPLHME TPVRDSMTLS KVAGTTAYLK LDSAQPSGSF KIRGIGHLCK MWAERGCEHF 

        70         80         90        100        110        120 
VCSSAGNAGM AAAYAARKLG IPSTIVVPST TPALTIQRLK NEGATVKVVG ETLDEAIRVA 

       130        140        150        160        170        180 
KDLEKNNSGW VYVPPFDDPL IWEGHSSIVK ELKETMTEKP GAIVLAVGGG GLLCGVVQGL 

       190        200        210        220        230        240 
AEVGWRDVPV ITMETIGAES FHASTKAGKL VTLPCITSVA KALGVTTVAA QAMKVYREHP 

       250        260        270        280        290        300 
IFSEVVSDQE AVAALEKFVD DEKILVEPAC GAALAAVYSN VIQKLQGEGK LRTPLSSLVV 

       310        320 
IVCGGSNISL AQLVALKKQL GMDGLSQ 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Thalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC119966 mRNA. Translation: AAI19967.1.
IPIIPI00707557.
RefSeqNP_001069130.1.
UniGeneBt.5878

3D structure databases

SMRQ0VCW4. Positions 1-325.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0VCW4.

Genome annotation databases

EnsemblENSBTAT00000045109; ENSBTAP00000042524; ENSBTAG00000031814; Bos taurus. [Genome view]
GeneID514346.
KEGGbta:514346.

Organism-specific databases

CTD514346.

Phylogenomic databases

eggNOGmaNOG17826.
HOVERGENQ0VCW4.
InParanoidQ0VCW4.
PhylomeDBQ0VCW4.

Enzyme and pathway databases

BRENDA4.3.1.17. 251.

Family and domain databases

InterProIPR001926. PyrdxlP-dep_enz_bsu.
IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
[Graphical view]
PfamPF00291. PALP. 1 hit.
[Graphical view]
PROSITEPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHL_BOVIN
AccessionPrimary (citable) accession number: Q0VCW4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 5, 2006
Last modified: January 19, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents