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Protein

Telomeric repeat-binding factor 2-interacting protein 1

Gene

TERF2IP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-BTA-2559586. DNA Damage/Telomere Stress Induced Senescence.

Names & Taxonomyi

Protein namesi
Recommended name:
Telomeric repeat-binding factor 2-interacting protein 1
Short name:
TERF2-interacting telomeric protein 1
Short name:
TRF2-interacting telomeric protein 1
Alternative name(s):
Repressor/activator protein 1 homolog
Short name:
RAP1 homolog
Gene namesi
Name:TERF2IP
Synonyms:RAP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Chromosome By similarity
  • Chromosometelomere By similarity

  • Note: Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 399398Telomeric repeat-binding factor 2-interacting protein 1PRO_0000398639Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei36 – 361PhosphoserineBy similarity
Cross-linki114 – 114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei156 – 1561PhosphoserineBy similarity
Modified residuei158 – 1581PhosphoserineBy similarity
Modified residuei205 – 2051PhosphoserineBy similarity
Cross-linki214 – 214Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki242 – 242Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ0VCT3.

Interactioni

Subunit structurei

Associates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG (By similarity). Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with TERF2 (but not TERF1) with its C-terminus. Interacts with SLX4/BTBD12. Interacts with TERF2; the interaction is direct (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020830.

Structurei

3D structure databases

ProteinModelPortaliQ0VCT3.
SMRiQ0VCT3. Positions 134-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 10192BRCTAdd
BLAST
Domaini130 – 19061Myb-likeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi383 – 39917Nuclear localization signalSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi216 – 30489Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the RAP1 family.Curated
Contains 1 BRCT domain.Curated
Contains 1 Myb-like domain.Curated

Phylogenomic databases

eggNOGiENOG410IJNC. Eukaryota.
ENOG4111QPC. LUCA.
GeneTreeiENSGT00390000005351.
HOGENOMiHOG000120115.
HOVERGENiHBG054209.
InParanoidiQ0VCT3.
KOiK11113.
OMAiSISFYVR.
OrthoDBiEOG7KDFBG.
TreeFamiTF332348.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR009057. Homeodomain-like.
IPR021661. Rap1_C.
IPR015010. Rap1_Myb_dom.
[Graphical view]
PfamiPF16589. BRCT_2. 1 hit.
PF08914. Myb_DNA-bind_2. 1 hit.
PF11626. Rap1_C. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VCT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAMELGKD PNGPTHSSTL FVREDGSSMS FYVRPSPAKR RLSTLILHGG
60 70 80 90 100
GTLCRVQEPG AVLLAQPGEA AAEASGDFIS TQYILDCVER NEKLELEAYR
110 120 130 140 150
LGPAPAAYQA PETKPGVLAG GVAAAEPEPQ SQAGRMVFTD ADDVAIITYV
160 170 180 190 200
KEHARSASSV TGNALWKAME KSSLTQHSWQ SMKDRYLKRL RGQEHKYLLG
210 220 230 240 250
EAPVSPSSQK LKRKAEQDPE AADSGEPQNK RTPDLPEEEF EKEEIKENEA
260 270 280 290 300
AVKKMLVEAT REFEEIVVDE SPDFEIHITM CDDDPCTPEE DSETQPDEEE
310 320 330 340 350
EEEEKVSAPE VGAAIKIIRQ LMEKFNLDLS TVTQAFLKNS GELEATSSFL
360 370 380 390
ESGQRADGYP IWSRQDDLDL QKDDEATRDA LVKKFGAQNV ARRIEFRKK
Length:399
Mass (Da):44,221
Last modified:September 5, 2006 - v1
Checksum:i484102D9D3271EC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120017 mRNA. Translation: AAI20018.1.
RefSeqiNP_001068880.1. NM_001075412.2.
UniGeneiBt.27086.

Genome annotation databases

EnsembliENSBTAT00000020830; ENSBTAP00000020830; ENSBTAG00000015686.
GeneIDi509625.
KEGGibta:509625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120017 mRNA. Translation: AAI20018.1.
RefSeqiNP_001068880.1. NM_001075412.2.
UniGeneiBt.27086.

3D structure databases

ProteinModelPortaliQ0VCT3.
SMRiQ0VCT3. Positions 134-192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020830.

Proteomic databases

PaxDbiQ0VCT3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020830; ENSBTAP00000020830; ENSBTAG00000015686.
GeneIDi509625.
KEGGibta:509625.

Organism-specific databases

CTDi54386.

Phylogenomic databases

eggNOGiENOG410IJNC. Eukaryota.
ENOG4111QPC. LUCA.
GeneTreeiENSGT00390000005351.
HOGENOMiHOG000120115.
HOVERGENiHBG054209.
InParanoidiQ0VCT3.
KOiK11113.
OMAiSISFYVR.
OrthoDBiEOG7KDFBG.
TreeFamiTF332348.

Enzyme and pathway databases

ReactomeiR-BTA-2559586. DNA Damage/Telomere Stress Induced Senescence.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR009057. Homeodomain-like.
IPR021661. Rap1_C.
IPR015010. Rap1_Myb_dom.
[Graphical view]
PfamiPF16589. BRCT_2. 1 hit.
PF08914. Myb_DNA-bind_2. 1 hit.
PF11626. Rap1_C. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal cerebellum.

Entry informationi

Entry nameiTE2IP_BOVIN
AccessioniPrimary (citable) accession number: Q0VCT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: September 5, 2006
Last modified: June 8, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.