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Protein

C-type lectin domain family 1 member A

Gene

CLEC1A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 1 member A
Alternative name(s):
C-type lectin-like receptor 1
Short name:
CLEC-1
Gene namesi
Name:CLEC1A
Synonyms:CLEC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252CytoplasmicSequence analysisAdd
BLAST
Transmembranei53 – 7321Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini74 – 278205ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278C-type lectin domain family 1 member APRO_0000313577Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence analysis
Disulfide bondi165 ↔ 257PROSITE-ProRule annotation
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence analysis
Disulfide bondi236 ↔ 249PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ0VCS6.
PRIDEiQ0VCS6.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019328.

Structurei

3D structure databases

ProteinModelPortaliQ0VCS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini144 – 258115C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104266.
HOGENOMiHOG000111777.
HOVERGENiHBG103475.
InParanoidiQ0VCS6.
KOiK10069.
OMAiFQFYQLS.
OrthoDBiEOG7DVDBK.
TreeFamiTF336674.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VCS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAKYSSTRD MLDADGDTTM SLHSQASATS QRPELGHTEH QRPSSAWRPV
60 70 80 90 100
ALILLTLCLV LLIGLAALGL VFFQFYQLSN TQQDSILQKE EKLGNLSRQL
110 120 130 140 150
QSLRTQNRKL AETLHHVAEK LCRELYNKTG EHRCSPCPEK WKWHGDKCYQ
160 170 180 190 200
FYKESKSWQG CEYFCIAENS TMLKINTQEV LEFAMPQSYS EFFYSYWTGL
210 220 230 240 250
SRNSSGKAWL WMDGTPYSSE LFDVMIDLTS LRSRDCVTIL NGKAFSKDCR
260 270
ELRRCACEKA AAMVKVQSLH EPLSRRWR
Length:278
Mass (Da):32,094
Last modified:September 5, 2006 - v1
Checksum:iB31FA5B249463283
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120028 mRNA. Translation: AAI20029.1.
RefSeqiNP_001069549.1. NM_001076081.1.
UniGeneiBt.37940.

Genome annotation databases

EnsembliENSBTAT00000019328; ENSBTAP00000019328; ENSBTAG00000030424.
GeneIDi536944.
KEGGibta:536944.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120028 mRNA. Translation: AAI20029.1.
RefSeqiNP_001069549.1. NM_001076081.1.
UniGeneiBt.37940.

3D structure databases

ProteinModelPortaliQ0VCS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019328.

Proteomic databases

PaxDbiQ0VCS6.
PRIDEiQ0VCS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000019328; ENSBTAP00000019328; ENSBTAG00000030424.
GeneIDi536944.
KEGGibta:536944.

Organism-specific databases

CTDi51267.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104266.
HOGENOMiHOG000111777.
HOVERGENiHBG103475.
InParanoidiQ0VCS6.
KOiK10069.
OMAiFQFYQLS.
OrthoDBiEOG7DVDBK.
TreeFamiTF336674.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal lung.

Entry informationi

Entry nameiCLC1A_BOVIN
AccessioniPrimary (citable) accession number: Q0VCS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: June 8, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.