ID   HXA2_BOVIN              Reviewed;         372 AA.
AC   Q0VCS4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   08-NOV-2023, entry version 92.
DE   RecName: Full=Homeobox protein Hox-A2;
GN   Name=HOXA2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal lung;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Proboscipedia
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BC120030; AAI20031.1; -; mRNA.
DR   RefSeq; NP_001069322.1; NM_001075854.1.
DR   AlphaFoldDB; Q0VCS4; -.
DR   SMR; Q0VCS4; -.
DR   STRING; 9913.ENSBTAP00000010699; -.
DR   PaxDb; 9913-ENSBTAP00000010699; -.
DR   GeneID; 524150; -.
DR   KEGG; bta:524150; -.
DR   CTD; 3199; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   InParanoid; Q0VCS4; -.
DR   OrthoDB; 728401at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45664:SF3; HOMEOBOX PROTEIN HOX-A2; 1.
DR   PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..372
FT                   /note="Homeobox protein Hox-A2"
FT                   /id="PRO_0000333800"
FT   DNA_BIND        139..198
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          42..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          194..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           94..99
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        42..61
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..216
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   372 AA;  40840 MW;  E9501F910563CF31 CRC64;
     MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP PFEQTIPSLN
     PGSHPRHGAG GRPKPSPAGS RGSPVPAGAL QPPEYPWMKE KKAAKKTVLP PASAASATGP
     ACLSHKESLE IADGSGGGSR RLRTAYTNTQ LLELEKEFHF NKYLCRPRRV EIAALLDLTE
     RQVKVWFQNR RMKHKRQTQC KENQNSEGKF KSLEDSEKVD EDEEEKSLFE QALSVSGALL
     EREGYTFQQN ALSQQQASNG YNGDSQSFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN
     CGSGLNNDSP EALEVPSLQD FNVFSTDSCL QLSDAVSPSL PGSLDSPVDI SADSFDFFTD
     TLTTIDLQHL NY
//