Reviewed, UniProtKB/Swiss-Prot Q0VCS4 (HXA2_BOVIN)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A2

Gene names

Name:

HOXA2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Proboscipedia subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 372	372	Homeobox protein Hox-A2		PRO_0000333800
Regions
	DNA binding	139 – 198	60	Homeobox
	Motif	94 – 99	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	Q0VCS4-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: E9501F910563CF31	FASTA	372	40,840
	10 20 30 40 50 60 MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP PFEQTIPSLN 70 80 90 100 110 120 PGSHPRHGAG GRPKPSPAGS RGSPVPAGAL QPPEYPWMKE KKAAKKTVLP PASAASATGP 130 140 150 160 170 180 ACLSHKESLE IADGSGGGSR RLRTAYTNTQ LLELEKEFHF NKYLCRPRRV EIAALLDLTE 190 200 210 220 230 240 RQVKVWFQNR RMKHKRQTQC KENQNSEGKF KSLEDSEKVD EDEEEKSLFE QALSVSGALL 250 260 270 280 290 300 EREGYTFQQN ALSQQQASNG YNGDSQSFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN 310 320 330 340 350 360 CGSGLNNDSP EALEVPSLQD FNVFSTDSCL QLSDAVSPSL PGSLDSPVDI SADSFDFFTD 370 TLTTIDLQHL NY

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal lung.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC120030 mRNA. Translation: AAI20031.1.
IPI	IPI00689409.
RefSeq	NP_001069322.1.
UniGene	Bt.87350
3D structure databases
SMR	Q0VCS4. Positions 141-197.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000010699; ENSBTAP00000010699; ENSBTAG00000008138; Bos taurus. [Genome view]
GeneID	524150.
KEGG	bta:524150.
Organism-specific databases
CTD	524150.
Phylogenomic databases
HOVERGEN	Q0VCS4.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA2_BOVIN

Accession

Primary (citable) accession number: Q0VCS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	September 5, 2006
Last modified:	November 24, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)