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Protein

Gap junction alpha-5 protein

Gene

GJA5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-5 protein
Alternative name(s):
Connexin-40
Short name:
Cx40
Gene namesi
Name:GJA5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 76ExtracellularSequence analysisAdd BLAST36
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 165CytoplasmicSequence analysisAdd BLAST68
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Topological domaini187 – 206ExtracellularSequence analysisAdd BLAST20
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 359CytoplasmicSequence analysisAdd BLAST132

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003130031 – 359Gap junction alpha-5 proteinAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei354PhosphoserineBy similarity1
Modified residuei358PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ0VCR2.
PRIDEiQ0VCR2.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008837.

Structurei

3D structure databases

ProteinModelPortaliQ0VCR2.
SMRiQ0VCR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3Z. Eukaryota.
ENOG410ZC96. LUCA.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ0VCR2.
KOiK07614.

Family and domain databases

InterProiView protein in InterPro
IPR000500. Connexin.
IPR002264. Connexin40.
IPR034634. Connexin_C.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
IPR031862. Cx40_C.
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF13. PTHR11984:SF13. 1 hit.
PfamiView protein in Pfam
PF00029. Connexin. 1 hit.
PF16791. Connexin40_C. 1 hit.
PRINTSiPR00206. CONNEXIN.
PR01135. CONNEXINA5.
SMARTiView protein in SMART
SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
SUPFAMiSSF118220. SSF118220. 1 hit.
PROSITEiView protein in PROSITE
PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0VCR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWSFLGEF LEEVHKHSTV IGKVWLTVLF IFRMLVLGTA AESSWGDEQA
60 70 80 90 100
DFLCDTMQPG CENVCYDQAF PISHIRYWVL QVIFVSTPSL VYLGHAVHMV
110 120 130 140 150
RVQEKRKLLR EAERAKEARA AGSYEYPVAE KTELSCWEEV NGRIALQGSL
160 170 180 190 200
LNTYVCSILI RTTMEVAFIV GQYLLYGVFL DTLHVCRRSP CPHPVNCYVS
210 220 230 240 250
RPTEKNVFIV FMLAVAGLSL FLSLAELYHL GWKKIRQRYV KSQPGVGECQ
260 270 280 290 300
LPGPSAGRVQ SCTPPPDFNQ CLENGPGGKF FSPFSNKMAS QQNTDNLSTE
310 320 330 340 350
QVRSQEQIQR EGFIHIRYAQ KPEVPNEGSP GPSLPHGYQS DKRRLSKASS

KARSDDLSV
Length:359
Mass (Da):40,403
Last modified:September 5, 2006 - v1
Checksum:iC93E5276DCA21709
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120044 mRNA. Translation: AAI20045.1.
RefSeqiNP_001071490.1. NM_001078022.1.
UniGeneiBt.103132.

Genome annotation databases

GeneIDi539491.
KEGGibta:539491.

Similar proteinsi

Entry informationi

Entry nameiCXA5_BOVIN
AccessioniPrimary (citable) accession number: Q0VCR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: October 25, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families