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Reviewed, UniProtKB/Swiss-Prot Q0VCQ1 (CTBP2_BOVIN)

Last modified June 16, 2009. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    C-terminal-binding protein 2
      Short name=CtBP2
Gene names
Name: CTBP2
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Corepressor targeting diverse transcription regulators By similarity. Isoform 2 probably acts as a scaffold for specialized synapses.

Subunit structure

Interacts with the C-terminus of adenovirus E1A protein. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with HIPK2. Interacts with PNN, NRIP1 and WIZ By similarity.

Subcellular location

Nucleus Potential. Cell junction › synapse By similarity.

Tissue specificity

Isoform 2 is specifically localized in synaptic ribbon (at protein level). Ref.1

Post-translational modification

Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR at Ser-175 and Ser-179. Phosphorylated. Phosphorylation by HIPK2 on Ser-428 induces proteasomal degradation By similarity.

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

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Ontologies

Keywords
   Cellular componentCell junction
Nucleus
Synapse
   Coding sequence diversityAlternative splicing
   LigandNAD
   Molecular functionOxidoreductase
   PTMPhosphoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcell junction

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

synapse

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNAD or NADH binding

Inferred from electronic annotation. Source: InterPro

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q0VCQ1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q0VCQ1-2)

Also known as: Ribeye;

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MALVDKHKVKRQRLDRICEG → MPVPSRHINI...VSTMLAPEPS
Note: Contains phosphoserine at position 175 (By similarity). Contains a phosphoserine at position 179 (By similarity).

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445C-terminal-binding protein 2
PRO_0000284890

Sites

Active site2721 Potential
Active site3011 Potential
Active site3211 Potential

Amino acid modifications

Modified residue4281Phosphoserine By similarity

Natural variations

Alternative sequence1 – 2020MALVD…RICEG → MPVPSRHINIGRSQSWDAAG WYEGPWEVAEAPGRRSSLTD GGGEGLWYPGLRDVAMPGAA EPCLYREAFYSTAAGRKSSV PDFAFYDSRQAVMSARGALL PGDYYSDPAGAARAPGEPLH HRHPGAGQPLPGYGAPGGRM TWEPVAARAPALQDTGHLYR DPGGKMIPQGQRSHSRAPSP AQYIGEPADSRYGAEAPAYP TGQVYNNASERPVDSAASRQ AAPTCLVVDPGAAAASGIGV GTAPSAPPRGYGPAREGVHP RMAYERCESDPSAFQGPGGS KRSVMPEFLALLRAEGVSEA TPVALLQQGFDSPAVLATME DADIKCVAPNLGQARVLSRL ASGCRTEMQLRRQGRGPPLP RTRSSSFSHRSELQGDQVGL GAAALQPQPQPQAGPLQAAS PRAVDPAHRRPSSAPSQHLL ETAATYSGPRVGAQAAHFPS NSGYSSPTPCALTARPSPAY PLQPGVPLTHPGPRTAYSTA YTVPMELLKRERGAAVSPVP SPHGSPQLLRKPGAPLEPPA LPPASQSLHTPHSPYQKVAR RTGAPIIVSTMLAPEPS in isoform 2.
VSP_027614

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 413399EE65099A09

FASTA44548,947
        10         20         30         40         50         60 
MALVDKHKVK RQRLDRICEG IRPQIMNGPL HPRPLVALLD GRDCTVEMPI LKDLATVAFC 

        70         80         90        100        110        120 
DAQSTQEIHE KVLNEAVGAM MYHTITLTRE DLEKFKALRV IVRIGSGYDN VDIKAAGELG 

       130        140        150        160        170        180 
IAVCNIPSAA VEETADSTIC HILNLYRRNT WLYQALREGT RVQSVEQIRE VASGAARIRG 

       190        200        210        220        230        240 
ETLGLIGFGR TGQAVAVRAK AFGFSVLFYD PYLQDGTERS LGVQRVYTLQ DLLYQSDCVS 

       250        260        270        280        290        300 
LHCNLNEHNH HLINDFTIKQ MRQGAFLVNA ARGGLVDEKA LAQALKEGRI RGAALDVHES 

       310        320        330        340        350        360 
EPFSFAQGPL KDAPNLICTP HTAWYSEQAS LEMREAAATE IRRAITGRIP ESLRNCVNKE 

       370        380        390        400        410        420 
FFVTTAPWSV IDQQAIHPEL NGATYRYPPG IVGVAPGGLP AAMEGIIPGG IPVTHNLPTV 

       430        440 
AHPSQAPSPN QPTKHGDNRE HPNEQ

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Isoform 2 (Ribeye).

Checksum: 2E26F252D19F4C43
Show »

FASTA982104,841

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References

« Hide 'large scale' references
[1]"RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function."
Schmitz F., Koenigstorfer A., Suedhof T.C.
Neuron 28:857-872(2000) [PubMed: 11163272] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PARTIAL PROTEIN SEQUENCE (ISOFORM 2), TISSUE SPECIFICITY.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: Hereford.
Tissue: Fetal liver.

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Cross-references

Sequence databases

AF222713 mRNA. Translation: AAG45953.1.
BC120058 mRNA. Translation: AAI20059.1.
IPIIPI00709990.
IPI00839978.
RefSeqNP_783643.1.
UniGeneBt.6440

3D structure databases

SMRQ0VCQ1. Positions 33-362.
ModBaseSearch...

Genome annotation databases

EnsemblENSBTAG00000003397. Bos taurus. [Contig view]
GeneID281730.
KEGGbta:281730.

Phylogenomic databases

HOVERGENQ0VCQ1.

Family and domain databases

InterProIPR006139. D-isomer_2_OHA_DH.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00065. D_2_HYDROXYACID_DH_1. False negative.
PS00670. D_2_HYDROXYACID_DH_2. False negative.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCTBP2_BOVIN
AccessionPrimary (citable) accession number: Q0VCQ1
Secondary accession number(s): Q9GKK1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 5, 2006
Last modified: June 16, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents