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Q0VCQ1 (CTBP2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
C-terminal-binding protein 2
Short name=CtBP2
Gene names
Name:CTBP2
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation By similarity. Isoform 2 probably acts as a scaffold for specialized synapses.

Subunit structure

Interacts with the C-terminus of adenovirus E1A protein. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with HIPK2. Interacts with ZNF217, PNN, NRIP1 and WIZ. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression By similarity.

Subcellular location

Nucleus Potential. Cell junction › synapse By similarity.

Tissue specificity

Isoform 2 is specifically localized in synaptic ribbon (at protein level). Ref.1

Post-translational modification

Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR at Ser-175 and Ser-179. Phosphorylated. Phosphorylation by HIPK2 on Ser-428 induces proteasomal degradation By similarity.

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q0VCQ1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q0VCQ1-2)

Also known as: Ribeye;

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MALVDKHKVKRQRLDRICEG → MPVPSRHINI...VSTMLAPEPS
Note: Contains phosphoserine at position 175 (By similarity). Contains a phosphoserine at position 179 (By similarity).

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445C-terminal-binding protein 2
PRO_0000284890

Regions

Nucleotide binding186 – 1916NAD By similarity
Nucleotide binding243 – 2497NAD By similarity
Nucleotide binding270 – 2723NAD By similarity
Nucleotide binding321 – 3244NAD By similarity

Sites

Active site2721 By similarity
Active site3011 By similarity
Active site3211Proton donor By similarity
Binding site1061NAD By similarity
Binding site2101NAD By similarity
Binding site2961NAD By similarity

Amino acid modifications

Modified residue4281Phosphoserine By similarity

Natural variations

Alternative sequence1 – 2020MALVD…RICEG → MPVPSRHINIGRSQSWDAAG WYEGPWEVAEAPGRRSSLTD GGGEGLWYPGLRDVAMPGAA EPCLYREAFYSTAAGRKSSV PDFAFYDSRQAVMSARGALL PGDYYSDPAGAARAPGEPLH HRHPGAGQPLPGYGAPGGRM TWEPVAARAPALQDTGHLYR DPGGKMIPQGQRSHSRAPSP AQYIGEPADSRYGAEAPAYP TGQVYNNASERPVDSAASRQ AAPTCLVVDPGAAAASGIGV GTAPSAPPRGYGPAREGVHP RMAYERCESDPSAFQGPGGS KRSVMPEFLALLRAEGVSEA TPVALLQQGFDSPAVLATME DADIKCVAPNLGQARVLSRL ASGCRTEMQLRRQGRGPPLP RTRSSSFSHRSELQGDQVGL GAAALQPQPQPQAGPLQAAS PRAVDPAHRRPSSAPSQHLL ETAATYSGPRVGAQAAHFPS NSGYSSPTPCALTARPSPAY PLQPGVPLTHPGPRTAYSTA YTVPMELLKRERGAAVSPVP SPHGSPQLLRKPGAPLEPPA LPPASQSLHTPHSPYQKVAR RTGAPIIVSTMLAPEPS in isoform 2.
VSP_027614

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 413399EE65099A09

FASTA44548,947
        10         20         30         40         50         60 
MALVDKHKVK RQRLDRICEG IRPQIMNGPL HPRPLVALLD GRDCTVEMPI LKDLATVAFC 

        70         80         90        100        110        120 
DAQSTQEIHE KVLNEAVGAM MYHTITLTRE DLEKFKALRV IVRIGSGYDN VDIKAAGELG 

       130        140        150        160        170        180 
IAVCNIPSAA VEETADSTIC HILNLYRRNT WLYQALREGT RVQSVEQIRE VASGAARIRG 

       190        200        210        220        230        240 
ETLGLIGFGR TGQAVAVRAK AFGFSVLFYD PYLQDGTERS LGVQRVYTLQ DLLYQSDCVS 

       250        260        270        280        290        300 
LHCNLNEHNH HLINDFTIKQ MRQGAFLVNA ARGGLVDEKA LAQALKEGRI RGAALDVHES 

       310        320        330        340        350        360 
EPFSFAQGPL KDAPNLICTP HTAWYSEQAS LEMREAAATE IRRAITGRIP ESLRNCVNKE 

       370        380        390        400        410        420 
FFVTTAPWSV IDQQAIHPEL NGATYRYPPG IVGVAPGGLP AAMEGIIPGG IPVTHNLPTV 

       430        440 
AHPSQAPSPN QPTKHGDNRE HPNEQ

« Hide

Isoform 2 (Ribeye) [UniParc].

Checksum: 2E26F252D19F4C43
Show »

FASTA982104,841

References

« Hide 'large scale' references
[1]"RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function."
Schmitz F., Koenigstorfer A., Suedhof T.C.
Neuron 28:857-872(2000) [PubMed: 11163272] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PARTIAL PROTEIN SEQUENCE (ISOFORM 2), TISSUE SPECIFICITY.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: Hereford.
Tissue: Fetal liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF222713 mRNA. Translation: AAG45953.1.
BC120058 mRNA. Translation: AAI20059.1.
IPIIPI00709990.
IPI00839978.
RefSeqNP_783643.1. NM_175712.1.
UniGeneBt.6440.

3D structure databases

ProteinModelPortalQ0VCQ1.
SMRQ0VCQ1. Positions 33-362.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0VCQ1.

Proteomic databases

PRIDEQ0VCQ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000004404; ENSBTAP00000004404; ENSBTAG00000003397.
GeneID281730.
KEGGbta:281730.

Organism-specific databases

CTD1488.

Phylogenomic databases

eggNOGmaNOG15408.
GeneTreeENSGT00530000063021.
HOVERGENHBG001898.
PhylomeDBQ0VCQ1.

Family and domain databases

InterProIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
KOK04496.
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00065. D_2_HYDROXYACID_DH_1. False negative.
PS00670. D_2_HYDROXYACID_DH_2. False negative.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCTBP2_BOVIN
AccessionPrimary (citable) accession number: Q0VCQ1
Secondary accession number(s): Q9GKK1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 5, 2006
Last modified: November 16, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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