Reviewed, UniProtKB/Swiss-Prot Q0VCP1 (KAD4_BOVIN)

Names and origin

Protein names

Recommended name:
    Adenylate kinase isoenzyme 4, mitochondrial
    EC=2.7.4.3
Alternative name(s):
    Adenylate kinase 3-like
    ATP-AMP transphosphorylase

Gene names

Name:	AK3L1
Synonyms:	AK4

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. May also be active with GTP By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Ligand	ATP-binding GTP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Adenylate kinase isoenzyme 4, mitochondrial		PRO_0000262883
Regions
	Nucleotide binding	12 – 20	9	ATP By similarity
	Nucleotide binding	89 – 96	8	AMP By similarity
Sites
	Binding site	36	1	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0VCP1-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 4CCA67455279F3AF	FASTA	223	25,348
	10 20 30 40 50 60 MASKLLRAVI LGPPGSGKGT VCQRIAQNFG LQHLSSGHFL RENIKANTEV GDMAKQYIEK 70 80 90 100 110 120 GLLVPDHVIT RLMLLELENR RGEHWLLDGF PRTLVQAEAL DRLCDLDLVI TLNIPFETLK 130 140 150 160 170 180 DRLSRRWIHP PSGRVYNLDF NPPHVHGMDD VTGEPLVQQE DDKPEAVAAR LRQYKDVAKP 190 200 210 220 VIELYKSRGV LHQFSGTETN KIWPYVYTLF SNKITPVQSK EAY

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal pons.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC120077 mRNA. Translation: AAI20078.1.
IPI	IPI00712062.
RefSeq	NP_001071401.1.
UniGene	Bt.63820
3D structure databases
SMR	Q0VCP1. Positions 4-223.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000030674. Bos taurus. [Contig view]
GeneID	517063.
KEGG	bta:517063.
Phylogenomic databases
HOVERGEN	Q0VCP1.
OMA	Q0VCP1. HSFSGTE.
Enzyme and pathway databases
BRENDA	2.7.4.3. 251.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_Znf_lid. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
ProDom	PD000657. Adenylate_kin. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD4_BOVIN

Accession

Primary (citable) accession number: Q0VCP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	September 5, 2006
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)