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Protein

Intraflagellar transport protein 27 homolog

Gene

IFT27

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6. Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6. Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 198GTPBy similarity
Nucleotide bindingi64 – 685GTPBy similarity
Nucleotide bindingi123 – 1264GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 27 homolog
Short name:
IFT27
Alternative name(s):
Putative GTP-binding protein RAY-like
Rab-like protein 4
Gene namesi
Name:IFT27
Synonyms:RABL4, RAYL
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Intraflagellar transport protein 27 homologPRO_0000283072Add
BLAST

Proteomic databases

PaxDbiQ0VCN3.
PRIDEiQ0VCN3.

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT25; the interaction is direct. Interacts with RABL2/RABL2A; binding is equal in the presence of GTP or GDP. Interacts with IFT88. Interacts with ARL6; recognizes and binds with the GTP-free form of ARL6.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000037810.

Structurei

3D structure databases

ProteinModelPortaliQ0VCN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0079. Eukaryota.
ENOG4111IWZ. LUCA.
GeneTreeiENSGT00830000128415.
HOVERGENiHBG105393.
InParanoidiQ0VCN3.
KOiK07934.
OMAiFHCLAKQ.
OrthoDBiEOG75J0PC.
TreeFamiTF329292.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VCN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLAAKCIL AGDPTVGKTA LAQLFRSDGA HFQKNYTLTT GVDLVVKTVP
60 70 80 90 100
VPDTGDSVEL FIFDSAGKEL FSEMLDKLWE SPNVLCLVYD VTNEQSFTNC
110 120 130 140 150
SKWLEKARSQ IPGTTLPGVL VGNKTDLAGR RVVDVAQAQA WALGQGLECF
160 170 180
ETSVKEMENY EAPFHYLAKQ FHHLYREKLE VFQALV
Length:186
Mass (Da):20,646
Last modified:September 5, 2006 - v1
Checksum:iB4B999C8E3A548EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120086 mRNA. Translation: AAI20087.1.
BC146031 mRNA. Translation: AAI46032.1.
RefSeqiNP_001069913.1. NM_001076445.1.
UniGeneiBt.87445.

Genome annotation databases

EnsembliENSBTAT00000037991; ENSBTAP00000037810; ENSBTAG00000026657.
GeneIDi617147.
KEGGibta:617147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120086 mRNA. Translation: AAI20087.1.
BC146031 mRNA. Translation: AAI46032.1.
RefSeqiNP_001069913.1. NM_001076445.1.
UniGeneiBt.87445.

3D structure databases

ProteinModelPortaliQ0VCN3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000037810.

Proteomic databases

PaxDbiQ0VCN3.
PRIDEiQ0VCN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000037991; ENSBTAP00000037810; ENSBTAG00000026657.
GeneIDi617147.
KEGGibta:617147.

Organism-specific databases

CTDi11020.

Phylogenomic databases

eggNOGiKOG0079. Eukaryota.
ENOG4111IWZ. LUCA.
GeneTreeiENSGT00830000128415.
HOVERGENiHBG105393.
InParanoidiQ0VCN3.
KOiK07934.
OMAiFHCLAKQ.
OrthoDBiEOG75J0PC.
TreeFamiTF329292.

Enzyme and pathway databases

ReactomeiR-BTA-5620924. Intraflagellar transport.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal brain and Fetal cerebellum.

Entry informationi

Entry nameiIFT27_BOVIN
AccessioniPrimary (citable) accession number: Q0VCN3
Secondary accession number(s): A6H6X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 5, 2006
Last modified: July 6, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.