ID   PUR9_BOVIN              Reviewed;         592 AA.
AC   Q0VCK0;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Bifunctional purine biosynthesis protein PURH;
DE   Includes:
DE     RecName: Full=Phosphoribosylaminoimidazolecarboxamide formyltransferase;
DE              EC=2.1.2.3;
DE     AltName: Full=5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase;
DE     AltName: Full=AICAR transformylase;
DE   Includes:
DE     RecName: Full=IMP cyclohydrolase;
DE              EC=3.5.4.10;
DE     AltName: Full=Inosinicase;
DE     AltName: Full=IMP synthetase;
DE     AltName: Full=ATIC;
GN   Name=ATIC; Synonyms=PURH;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal lung;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + 5-amino-1-(5-
CC       phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-
CC       formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
CC   -!- CATALYTIC ACTIVITY: IMP + H(2)O = 5-formamido-1-(5-phospho-D-
CC       ribosyl)imidazole-4-carboxamide.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl
CC       THF route): step 1/1.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-
CC       carboxamide: step 1/1.
CC   -!- DOMAIN: The IMP cyclohydrolase activity resides in the N-terminal
CC       region.
CC   -!- SIMILARITY: Belongs to the purH family.
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DR   EMBL; BC120131; AAI20132.1; -; mRNA.
DR   IPI; IPI00724051; -.
DR   RefSeq; NP_001068722.1; -.
DR   UniGene; Bt.61076; -.
DR   SMR; Q0VCK0; 5-592.
DR   Ensembl; ENSBTAG00000019274; Bos taurus.
DR   GeneID; 506343; -.
DR   KEGG; bta:506343; -.
DR   HOVERGEN; Q0VCK0; -.
DR   BRENDA; 2.1.2.3; 251.
DR   BRENDA; 3.5.4.10; 251.
DR   GO; GO:0003937; F:IMP cyclohydrolase activity; IEA:EC.
DR   GO; GO:0004643; F:phosphoribosylaminoimidazolecarboxamide for...; IEA:EC.
DR   GO; GO:0006188; P:IMP biosynthetic process; IEA:InterPro.
DR   InterPro; IPR002695; AICARFT_IMPCHas.
DR   InterPro; IPR013982; AICARFT_IMPCHas_formly.
DR   InterPro; IPR011607; MGS.
DR   PANTHER; PTHR11692; AICARFT_IMPCHas; 1.
DR   Pfam; PF01808; AICARFT_IMPCHas; 1.
DR   Pfam; PF02142; MGS; 1.
DR   PIRSF; PIRSF000414; AICARFT_IMPCHas; 1.
DR   SMART; SM00798; AICARFT_IMPCHas; 1.
DR   TIGRFAMs; TIGR00355; purH; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Multifunctional enzyme; Phosphoprotein;
KW   Purine biosynthesis; Transferase.
FT   CHAIN         1    592       Bifunctional purine biosynthesis protein
FT                                PURH.
FT                                /FTId=PRO_0000270212.
FT   MOD_RES     104    104       Phosphotyrosine (By similarity).
SQ   SEQUENCE   592 AA;  64483 MW;  EBD94993555935D7 CRC64;
     MAPGQLALFS VSDKNGLVEF ARNLASVGLN LIASGGTAKA LRDAGLAVRD VSELTGFPEM
     LGGRVKTLHP AVHAGILARD IPEDSADMAK LDFNLIRVVV CNLYPFGKTV ASPGVTVEEA
     VEHIDIGGVT LLRAAAKNHA RVTVVCEPED YAAVASEMQD SDSKDTSLET RRQLALKAFT
     HTAQYDEAIS DYFRKEYSKG VSQMPLRYGM NPHQTPAQLY TLKPKLPITV LNGAPGFINL
     CDALNAWQLV KELKEALGLP AAASFKHVSP AGAAVGIPLS EDEANVCMVY DLYKTLTPVA
     TAYARARGAD RMSSFGDFVA LSDVCDVPTA KIISREVSDG IIAPGYENEA LKILSKKKNG
     NYCVLQMDQS YIPDENEVRT LFGLRLSQKR NNSVVNRSLF SNIVTKNKDL PESALRDLIV
     ATIAVKYTQS NSVCYAKNGQ VIGIGAGQQS RIHCTRLAGD KANCWWLRHH PQVLSMKFKT
     GVKRAEISNA IDQYVTGTIG EGEDLIKWKA LFEEVPELLT ETEKKEWIDK LNEVSISSDA
     FFPFRDNVDR AKRSGVAYIA APSGSAADKV VIEACDELGI ILAHTNLRLF HH
//