SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q0VCK0

- PUR9_BOVIN

UniProt

Q0VCK0 - PUR9_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Bifunctional purine biosynthesis protein PURH

Gene
ATIC, PURH
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis By similarity.

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei137 – 1371Proton acceptor Reviewed prediction
Sitei266 – 2661Transition state stabilizer Reviewed prediction
Active sitei267 – 2671Proton acceptor Inferred
Binding sitei316 – 3161AICAR; via carbonyl oxygen By similarity
Binding sitei339 – 3391AICAR By similarity
Binding sitei431 – 4311AICAR; shared with dimeric partner By similarity
Binding sitei451 – 4511AICAR; shared with dimeric partner By similarity
Binding sitei541 – 5411AICAR; via carbonyl oxygen; shared with dimeric partner By similarity
Binding sitei588 – 5881AICAR; shared with dimeric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 143IMP By similarity
Nucleotide bindingi34 – 374IMP By similarity
Nucleotide bindingi64 – 674IMP By similarity
Nucleotide bindingi101 – 1044IMP By similarity
Nucleotide bindingi125 – 1273IMP By similarity

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-EC
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-EC
  3. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

ReactomeiREACT_226478. Purine ribonucleoside monophosphate biosynthesis.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PURH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:ATIC
Synonyms:PURH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 592592Bifunctional purine biosynthesis protein PURHPRO_0000270212Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei199 – 1991N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ0VCK0.
PRIDEiQ0VCK0.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000048873.

Structurei

3D structure databases

ProteinModelPortaliQ0VCK0.
SMRiQ0VCK0. Positions 4-592.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni207 – 2082AICAR binding By similarity

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
GeneTreeiENSGT00390000004553.
HOGENOMiHOG000230372.
HOVERGENiHBG006912.
InParanoidiQ0VCK0.
KOiK00602.
OMAiAGDKANC.
OrthoDBiEOG74N5GD.
TreeFamiTF105642.

Family and domain databases

Gene3Di1.10.287.440. 1 hit.
3.40.140.20. 3 hits.
3.40.50.1380. 1 hit.
InterProiIPR024051. AICAR_Tfase_dom.
IPR024050. AICAR_Tfase_insert_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0VCK0-1 [UniParc]FASTAAdd to Basket

« Hide

MAPGQLALFS VSDKNGLVEF ARNLASVGLN LIASGGTAKA LRDAGLAVRD    50
VSELTGFPEM LGGRVKTLHP AVHAGILARD IPEDSADMAK LDFNLIRVVV 100
CNLYPFGKTV ASPGVTVEEA VEHIDIGGVT LLRAAAKNHA RVTVVCEPED 150
YAAVASEMQD SDSKDTSLET RRQLALKAFT HTAQYDEAIS DYFRKEYSKG 200
VSQMPLRYGM NPHQTPAQLY TLKPKLPITV LNGAPGFINL CDALNAWQLV 250
KELKEALGLP AAASFKHVSP AGAAVGIPLS EDEANVCMVY DLYKTLTPVA 300
TAYARARGAD RMSSFGDFVA LSDVCDVPTA KIISREVSDG IIAPGYENEA 350
LKILSKKKNG NYCVLQMDQS YIPDENEVRT LFGLRLSQKR NNSVVNRSLF 400
SNIVTKNKDL PESALRDLIV ATIAVKYTQS NSVCYAKNGQ VIGIGAGQQS 450
RIHCTRLAGD KANCWWLRHH PQVLSMKFKT GVKRAEISNA IDQYVTGTIG 500
EGEDLIKWKA LFEEVPELLT ETEKKEWIDK LNEVSISSDA FFPFRDNVDR 550
AKRSGVAYIA APSGSAADKV VIEACDELGI ILAHTNLRLF HH 592
Length:592
Mass (Da):64,483
Last modified:September 5, 2006 - v1
Checksum:iEBD94993555935D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC120131 mRNA. Translation: AAI20132.1.
RefSeqiNP_001068722.1. NM_001075254.2.
UniGeneiBt.61076.

Genome annotation databases

EnsembliENSBTAT00000025662; ENSBTAP00000025662; ENSBTAG00000019274.
GeneIDi506343.
KEGGibta:506343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC120131 mRNA. Translation: AAI20132.1 .
RefSeqi NP_001068722.1. NM_001075254.2.
UniGenei Bt.61076.

3D structure databases

ProteinModelPortali Q0VCK0.
SMRi Q0VCK0. Positions 4-592.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000048873.

Proteomic databases

PaxDbi Q0VCK0.
PRIDEi Q0VCK0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000025662 ; ENSBTAP00000025662 ; ENSBTAG00000019274 .
GeneIDi 506343.
KEGGi bta:506343.

Organism-specific databases

CTDi 471.

Phylogenomic databases

eggNOGi COG0138.
GeneTreei ENSGT00390000004553.
HOGENOMi HOG000230372.
HOVERGENi HBG006912.
InParanoidi Q0VCK0.
KOi K00602.
OMAi AGDKANC.
OrthoDBi EOG74N5GD.
TreeFami TF105642.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
Reactomei REACT_226478. Purine ribonucleoside monophosphate biosynthesis.

Miscellaneous databases

NextBioi 20867570.

Family and domain databases

Gene3Di 1.10.287.440. 1 hit.
3.40.140.20. 3 hits.
3.40.50.1380. 1 hit.
InterProi IPR024051. AICAR_Tfase_dom.
IPR024050. AICAR_Tfase_insert_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal lung.

Entry informationi

Entry nameiPUR9_BOVIN
AccessioniPrimary (citable) accession number: Q0VCK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi