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Protein

Parvalbumin alpha

Gene

PVALB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi52 – 631PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi91 – 1022PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin alpha
Gene namesi
Name:PVALB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002602572 – 110Parvalbumin alphaAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei24PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ0VCG3.
PRIDEiQ0VCG3.

Expressioni

Gene expression databases

BgeeiENSBTAG00000019159.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025499.

Structurei

3D structure databases

ProteinModelPortaliQ0VCG3.
SMRiQ0VCG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 74EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini78 – 110EF-hand 2PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the parvalbumin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiQ0VCG3.
OMAiAVDSFDH.
OrthoDBiEOG091G0ZAO.
TreeFamiTF332342.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiView protein in Pfam
PF13499. EF-hand_7. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VCG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMTDLLHAE DIKKAVGAFT AVDSFDHKKF FQMVGLKKKS PEDVKKVFHI
60 70 80 90 100
LDKDKSGFIE EEELGFILKG FSPDARDLSV KETKTLLAAG DKDGDGKIGA
110
DEFSTLVAES
Length:110
Mass (Da):12,082
Last modified:January 23, 2007 - v3
Checksum:iB5240B6252E9B62C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120184 mRNA. Translation: AAI20185.1.
RefSeqiNP_001069582.1. NM_001076114.2.
XP_010803641.1. XM_010805339.2.
UniGeneiBt.61440.

Genome annotation databases

EnsembliENSBTAT00000025499; ENSBTAP00000025499; ENSBTAG00000019159.
GeneIDi538603.
KEGGibta:538603.

Similar proteinsi

Entry informationi

Entry nameiPRVA_BOVIN
AccessioniPrimary (citable) accession number: Q0VCG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 73 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families