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Protein

Beta-citrylglutamate synthase B

Gene

RIMKLB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate.By similarity

Catalytic activityi

ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate.By similarity
ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei158ATPBy similarity1
Binding sitei219ATPBy similarity1
Metal bindingi264Magnesium or manganese 1PROSITE-ProRule annotation1
Metal bindingi277Magnesium or manganese 1PROSITE-ProRule annotation1
Metal bindingi277Magnesium or manganese 2PROSITE-ProRule annotation1
Metal bindingi279Magnesium or manganese 2PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi193 – 203ATPPROSITE-ProRule annotationAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-citrylglutamate synthase B (EC:6.3.1.17By similarity)
Alternative name(s):
N-acetyl-aspartylglutamate synthetase B (EC:6.3.2.41By similarity)
Short name:
NAAG synthetase B
Short name:
NAAGS
Ribosomal protein S6 modification-like protein B
Gene namesi
Name:RIMKLB
Synonyms:FAM80B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002825701 – 386Beta-citrylglutamate synthase BAdd BLAST386

Proteomic databases

PaxDbiQ0VCE9.
PRIDEiQ0VCE9.

Expressioni

Gene expression databases

BgeeiENSBTAG00000003291.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004262.

Structurei

3D structure databases

ProteinModelPortaliQ0VCE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 304ATP-graspPROSITE-ProRule annotationAdd BLAST186

Sequence similaritiesi

Belongs to the RimK family.Curated
Contains 1 ATP-grasp domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IGDC. Eukaryota.
COG0189. LUCA.
GeneTreeiENSGT00390000014577.
HOGENOMiHOG000043112.
HOVERGENiHBG108408.
InParanoidiQ0VCE9.
KOiK18310.
OMAiPEAVCNM.
OrthoDBiEOG091G09CF.
TreeFamiTF332035.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013651. ATP-grasp_RimK-type.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR004666. RpS6_RimK/Lys_biosynth_LsyX.
[Graphical view]
PfamiPF08443. RimK. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00768. rimK_fam. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VCE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSSVAAKLW FLTDRRIRED YPQKEILRAL KAKCCEEELD FRAVVMDELV
60 70 80 90 100
LTVEQGNLGL RINGELITAY PQVVVVRVPT PWVQSDSDIT VLRHLEKMGC
110 120 130 140 150
RLMNRPQAIL NCVNKFWTFQ ELAGHGVPLP DTFSYGGHEN FAKMIDEAEV
160 170 180 190 200
LEFPMVVKNT RGHRGKAVFL ARDKHHLADL SHLIRHEAPY LFQKYVKESH
210 220 230 240 250
GRDVRVIVVG GRVVGTMLRC STDGRMQSNC SLGGVGMMCS LSEQGKQLAI
260 270 280 290 300
QVSNILGMDV CGIDLLMKDD GSFCVCEANA NVGFIAFDKA CNLDVAGIIA
310 320 330 340 350
DYAASLLPSG RLTRRMSLLS VVSTASETSE PELGPQANTA VDNMSASSSS
360 370 380
VDSDPETTER ELLTKLPGGL FNMNQLLANE IKLLVE
Length:386
Mass (Da):42,550
Last modified:September 5, 2006 - v1
Checksum:i6E4A2A43E068114D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120203 mRNA. Translation: AAI20204.1.
RefSeqiNP_001069581.1. NM_001076113.2.
XP_005207126.1. XM_005207069.3.
XP_010803841.1. XM_010805539.2.
XP_015326757.1. XM_015471271.1.
XP_015326758.1. XM_015471272.1.
XP_015326759.1. XM_015471273.1.
XP_015326760.1. XM_015471274.1.
UniGeneiBt.28956.

Genome annotation databases

EnsembliENSBTAT00000004262; ENSBTAP00000004262; ENSBTAG00000003291.
GeneIDi538579.
KEGGibta:538579.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120203 mRNA. Translation: AAI20204.1.
RefSeqiNP_001069581.1. NM_001076113.2.
XP_005207126.1. XM_005207069.3.
XP_010803841.1. XM_010805539.2.
XP_015326757.1. XM_015471271.1.
XP_015326758.1. XM_015471272.1.
XP_015326759.1. XM_015471273.1.
XP_015326760.1. XM_015471274.1.
UniGeneiBt.28956.

3D structure databases

ProteinModelPortaliQ0VCE9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004262.

Proteomic databases

PaxDbiQ0VCE9.
PRIDEiQ0VCE9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000004262; ENSBTAP00000004262; ENSBTAG00000003291.
GeneIDi538579.
KEGGibta:538579.

Organism-specific databases

CTDi57494.

Phylogenomic databases

eggNOGiENOG410IGDC. Eukaryota.
COG0189. LUCA.
GeneTreeiENSGT00390000014577.
HOGENOMiHOG000043112.
HOVERGENiHBG108408.
InParanoidiQ0VCE9.
KOiK18310.
OMAiPEAVCNM.
OrthoDBiEOG091G09CF.
TreeFamiTF332035.

Gene expression databases

BgeeiENSBTAG00000003291.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013651. ATP-grasp_RimK-type.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR004666. RpS6_RimK/Lys_biosynth_LsyX.
[Graphical view]
PfamiPF08443. RimK. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00768. rimK_fam. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIMKB_BOVIN
AccessioniPrimary (citable) accession number: Q0VCE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 5, 2006
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

N-acetyl-L-aspartyl-L-glutamate (NAAG) is the most abundant dipeptide present in vertebrate central nervous system (CNS). Beta-citryl-L-glutamate, a structural analog of NAAG, is present in testis and immature brain.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.