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Protein

Tribbles homolog 3

Gene

TRIB3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity (By similarity). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (By similarity). Can inhibit APOBEC3A editing of nuclear DNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-BTA-1257604. PIP3 activates AKT signaling.
R-BTA-165158. Activation of AKT2.
R-BTA-199418. Negative regulation of the PI3K/AKT network.
R-BTA-389357. CD28 dependent PI3K/Akt signaling.
R-BTA-5218920. VEGFR2 mediated vascular permeability.

Names & Taxonomyi

Protein namesi
Recommended name:
Tribbles homolog 3
Short name:
TRB-3
Gene namesi
Name:TRIB3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Tribbles homolog 3PRO_0000284059Add
BLAST

Proteomic databases

PaxDbiQ0VCE3.

Interactioni

Subunit structurei

Interacts with AKT1, AKT2, ATF4, MAP2K1 and MAP2K7. Interacts with DDIT3/CHOP and inhibits its interaction with EP300/P300. Interacts (via N-terminus) with APOBEC3A. Interacts with APOBEC3C.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022616.

Structurei

3D structure databases

ProteinModelPortaliQ0VCE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 316249Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 127127Interaction with DDIT3/CHOPBy similarityAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00840000129780.
HOGENOMiHOG000231872.
HOVERGENiHBG067729.
InParanoidiQ0VCE3.
KOiK19518.
OMAiYTCKVYP.
OrthoDBiEOG7RJPR4.
TreeFamiTF329785.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024104. Tribbles/Ser_Thr_kinase_40.
IPR024106. Tribbles_TRB3.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PTHR22961:SF14. PTHR22961:SF14. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VCE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRASPLAVPA NAPSRKKRLE LDDDLDTECP SQKQARSGPQ PRLPSCPLTL
60 70 80 90 100
NPPPAPVHAP DVTTPSRLGP YVLLEPEEGS RTYRALHCPT GTEYICKVYP
110 120 130 140 150
ACERLAVLEP YWRLPHHGHV ARPAEVLAGT QLLYAFFLRP HGDMHSLVRR
160 170 180 190 200
RRRLPEPEAA ALFRQMAAAL AHCHQHGLVL RDLKLRRFVF TDRERTKLVL
210 220 230 240 250
ENLEDACVLT GPDDSLWDKH ACPAYVGPEI LSSRASYSGK AADVWSLGVA
260 270 280 290 300
LFTMLAGHYP FQDSEPALLF GKIRRGAFAL PEGLSAPARC LVRCLLRREP
310 320 330 340 350
TERLTASGIL LHPWLRENAI PAALPRSRHC EADQVVPEGP GLEEAEEEGE

RDMGLYG
Length:357
Mass (Da):39,657
Last modified:September 5, 2006 - v1
Checksum:i18B65E01109CAB6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120209 mRNA. Translation: AAI20210.1.
RefSeqiNP_001069571.1. NM_001076103.1.
XP_005214869.1. XM_005214812.3.
UniGeneiBt.45499.

Genome annotation databases

EnsembliENSBTAT00000022616; ENSBTAP00000022616; ENSBTAG00000017007.
GeneIDi538465.
KEGGibta:538465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120209 mRNA. Translation: AAI20210.1.
RefSeqiNP_001069571.1. NM_001076103.1.
XP_005214869.1. XM_005214812.3.
UniGeneiBt.45499.

3D structure databases

ProteinModelPortaliQ0VCE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022616.

Proteomic databases

PaxDbiQ0VCE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000022616; ENSBTAP00000022616; ENSBTAG00000017007.
GeneIDi538465.
KEGGibta:538465.

Organism-specific databases

CTDi57761.

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00840000129780.
HOGENOMiHOG000231872.
HOVERGENiHBG067729.
InParanoidiQ0VCE3.
KOiK19518.
OMAiYTCKVYP.
OrthoDBiEOG7RJPR4.
TreeFamiTF329785.

Enzyme and pathway databases

ReactomeiR-BTA-1257604. PIP3 activates AKT signaling.
R-BTA-165158. Activation of AKT2.
R-BTA-199418. Negative regulation of the PI3K/AKT network.
R-BTA-389357. CD28 dependent PI3K/Akt signaling.
R-BTA-5218920. VEGFR2 mediated vascular permeability.

Miscellaneous databases

NextBioi20877374.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024104. Tribbles/Ser_Thr_kinase_40.
IPR024106. Tribbles_TRB3.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PTHR22961:SF14. PTHR22961:SF14. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Placenta.

Entry informationi

Entry nameiTRIB3_BOVIN
AccessioniPrimary (citable) accession number: Q0VCE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: September 5, 2006
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.