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Protein

Tribbles homolog 3

Gene

TRIB3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity (By similarity). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (By similarity). Can inhibit APOBEC3A editing of nuclear DNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein kinase inhibitor
Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-BTA-1257604 PIP3 activates AKT signaling
R-BTA-165158 Activation of AKT2
R-BTA-199418 Negative regulation of the PI3K/AKT network
R-BTA-389357 CD28 dependent PI3K/Akt signaling
R-BTA-5218920 VEGFR2 mediated vascular permeability

Names & Taxonomyi

Protein namesi
Recommended name:
Tribbles homolog 3
Short name:
TRB-3
Gene namesi
Name:TRIB3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Organism-specific databases

VGNCiVGNC:36310 TRIB3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002840591 – 357Tribbles homolog 3Add BLAST357

Proteomic databases

PaxDbiQ0VCE3
PRIDEiQ0VCE3

Expressioni

Gene expression databases

BgeeiENSBTAG00000017007

Interactioni

Subunit structurei

Interacts with AKT1, AKT2, ATF4, MAP2K1 and MAP2K7. Interacts with DDIT3/CHOP and inhibits its interaction with EP300/P300. Interacts (via N-terminus) with APOBEC3A. Interacts with APOBEC3C.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022616

Structurei

3D structure databases

ProteinModelPortaliQ0VCE3
SMRiQ0VCE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 316Protein kinasePROSITE-ProRule annotationAdd BLAST249

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 127Interaction with DDIT3/CHOPBy similarityAdd BLAST127

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00900000140868
HOGENOMiHOG000231872
HOVERGENiHBG067729
InParanoidiQ0VCE3
KOiK19518
OMAiYTCKVYP
OrthoDBiEOG091G07JM
TreeFamiTF329785

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR024104 Tribbles/Ser_Thr_kinase_40
IPR024106 Tribbles_TRB3
PANTHERiPTHR22961 PTHR22961, 1 hit
PTHR22961:SF14 PTHR22961:SF14, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q0VCE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRASPLAVPA NAPSRKKRLE LDDDLDTECP SQKQARSGPQ PRLPSCPLTL
60 70 80 90 100
NPPPAPVHAP DVTTPSRLGP YVLLEPEEGS RTYRALHCPT GTEYICKVYP
110 120 130 140 150
ACERLAVLEP YWRLPHHGHV ARPAEVLAGT QLLYAFFLRP HGDMHSLVRR
160 170 180 190 200
RRRLPEPEAA ALFRQMAAAL AHCHQHGLVL RDLKLRRFVF TDRERTKLVL
210 220 230 240 250
ENLEDACVLT GPDDSLWDKH ACPAYVGPEI LSSRASYSGK AADVWSLGVA
260 270 280 290 300
LFTMLAGHYP FQDSEPALLF GKIRRGAFAL PEGLSAPARC LVRCLLRREP
310 320 330 340 350
TERLTASGIL LHPWLRENAI PAALPRSRHC EADQVVPEGP GLEEAEEEGE

RDMGLYG
Length:357
Mass (Da):39,657
Last modified:September 5, 2006 - v1
Checksum:i18B65E01109CAB6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120209 mRNA Translation: AAI20210.1
RefSeqiNP_001069571.1, NM_001076103.1
XP_005214869.1, XM_005214812.3
UniGeneiBt.45499

Genome annotation databases

EnsembliENSBTAT00000022616; ENSBTAP00000022616; ENSBTAG00000017007
GeneIDi538465
KEGGibta:538465

Similar proteinsi

Entry informationi

Entry nameiTRIB3_BOVIN
AccessioniPrimary (citable) accession number: Q0VCE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: September 5, 2006
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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