Reviewed, UniProtKB/Swiss-Prot Q0VCA8 (3HAO_BOVIN)

Names and origin

Protein names

Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenase
    EC=1.13.11.6
Alternative name(s):
    3-hydroxyanthranilic acid dioxygenase
    3-hydroxyanthranilate oxygenase
      Short name=3-HAO

Gene names

Name:

HAAO

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the synthesis of the excitotoxin quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. The direct product of the reaction spontaneously rearranges to QUIN By similarity.
Catalytic activity	3-hydroxyanthranilate + O(2) = 2-amino-3-carboxymuconate semialdehyde.
Cofactor	Fe(2+) ion By similarity.
Subunit structure	Monomer By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the 3-HAO family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	3-hydroxyanthranilate 3,4-dioxygenase activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	3-hydroxyanthranilate 3,4-dioxygenase		PRO_0000283033
Sites
	Metal binding	47	1	Iron; catalytic By similarity
	Metal binding	53	1	Iron; catalytic By similarity
	Metal binding	91	1	Iron; catalytic By similarity
	Binding site	43	1	Dioxygen By similarity
	Binding site	53	1	Substrate By similarity
	Binding site	95	1	Substrate By similarity
	Binding site	105	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0VCA8-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 6887DDB93B861F8E	FASTA	286	32,493
	10 20 30 40 50 60 MERPVRVKAW VEENRGSFLP PVCNKLLHQK QLKIMFVGGP NTRKDYHIEE GEEVFYQLEG 70 80 90 100 110 120 DMLLRVLERG KHRDVVIRQG EIFLLPAGVP HSPQRFANTV GLVIERRRLK TELDGLRYYV 130 140 150 160 170 180 GDTTDVLFEK WFYCEDLGTQ LAPIIQEFFS SEQYRTGKPN PDQLLKEPPF PLSTRSVMEP 190 200 210 220 230 240 MCLEAWLDGH RKELQAGTPL SLFGDTYESQ VMVHGQGSSE GLRRDVDVWL WQLEGSSVVT 250 260 270 280 MEGQRLSLTL DDSLLVPAGT LYGWERGQGS VALSVTQDPA CKKSLG

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC120265 mRNA. Translation: AAI20266.1.
RefSeq	NP_001068926.1.
UniGene	Bt.20241
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000004674. Bos taurus. [Contig view]
GeneID	510602.
KEGG	bta:510602.
Phylogenomic databases
HOVERGEN	Q0VCA8.
Family and domain databases
InterPro	IPR010329. 3hydroanth_dOase. IPR016700. 3hydroanth_dOase_met. [Graphical view]
Pfam	PF06052. 3-HAO. 1 hit. [Graphical view]
PIRSF	PIRSF017681. 3hydroanth_dOase_animal. 1 hit.
TIGRFAMs	TIGR03037. anthran_nbaC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

3HAO_BOVIN

Accession

Primary (citable) accession number: Q0VCA8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	September 5, 2006
Last modified:	November 25, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)