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Q0VCA8

- 3HAO_BOVIN

UniProt

Q0VCA8 - 3HAO_BOVIN

Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

HAAO

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

    Catalytic activityi

    3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

    Cofactori

    Fe2+ ion.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431DioxygenUniRule annotation
    Metal bindingi47 – 471Iron; catalytic
    Metal bindingi53 – 531Iron; catalytic
    Binding sitei53 – 531SubstrateUniRule annotation
    Metal bindingi91 – 911Iron; catalytic
    Binding sitei95 – 951SubstrateUniRule annotation
    Binding sitei105 – 1051SubstrateUniRule annotation

    GO - Molecular functioni

    1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
    2. ferrous iron binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. neuron cellular homeostasis Source: Ensembl
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. response to cadmium ion Source: Ensembl
    6. response to zinc ion Source: Ensembl
    7. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_217639. Tryptophan catabolism.
    UniPathwayiUPA00253; UER00330.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
    Alternative name(s):
    3-hydroxyanthranilate oxygenaseUniRule annotation
    Short name:
    3-HAOUniRule annotation
    3-hydroxyanthranilic acid dioxygenaseUniRule annotation
    Short name:
    HADUniRule annotation
    Gene namesi
    Name:HAAOUniRule annotation
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 11

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytosol Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2862863-hydroxyanthranilate 3,4-dioxygenasePRO_0000283033Add
    BLAST

    Proteomic databases

    PRIDEiQ0VCA8.

    Interactioni

    Subunit structurei

    Monomer.1 PublicationUniRule annotation

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000006132.

    Structurei

    Secondary structure

    1
    286
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 63
    Helixi7 – 148
    Helixi15 – 173
    Turni20 – 223
    Beta strandi24 – 4118
    Beta strandi46 – 483
    Beta strandi53 – 608
    Beta strandi62 – 687
    Beta strandi71 – 777
    Beta strandi81 – 855
    Beta strandi91 – 955
    Beta strandi100 – 1067
    Beta strandi114 – 1207
    Beta strandi126 – 1327
    Turni137 – 1393
    Helixi141 – 1499
    Helixi152 – 1565
    Helixi161 – 1633
    Helixi183 – 1886
    Helixi191 – 1966
    Beta strandi200 – 2034
    Beta strandi207 – 2148
    Beta strandi216 – 2238
    Beta strandi228 – 2358
    Beta strandi237 – 2437
    Beta strandi245 – 2484
    Beta strandi252 – 2565
    Beta strandi261 – 2666
    Beta strandi271 – 2777
    Helixi279 – 2813

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3FE5X-ray2.51A2-286[»]
    ProteinModelPortaliQ0VCA8.
    SMRiQ0VCA8. Positions 2-286.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ0VCA8.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 160160Domain A (catalytic)Add
    BLAST
    Regioni161 – 17717LinkerAdd
    BLAST
    Regioni178 – 286109Domain BAdd
    BLAST

    Sequence similaritiesi

    Belongs to the 3-HAO family.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG77058.
    GeneTreeiENSGT00390000013008.
    HOGENOMiHOG000218448.
    HOVERGENiHBG000018.
    InParanoidiQ0VCA8.
    KOiK00452.
    OMAiDMCLKVI.
    OrthoDBiEOG7FFMS4.
    TreeFamiTF300246.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    HAMAPiMF_00825. 3_HAO.
    InterProiIPR010329. 3hydroanth_dOase.
    IPR016700. 3hydroanth_dOase_met.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR15497. PTHR15497. 1 hit.
    PfamiPF06052. 3-HAO. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
    SUPFAMiSSF51182. SSF51182. 2 hits.
    TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0VCA8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERPVRVKAW VEENRGSFLP PVCNKLLHQK QLKIMFVGGP NTRKDYHIEE    50
    GEEVFYQLEG DMLLRVLERG KHRDVVIRQG EIFLLPAGVP HSPQRFANTV 100
    GLVIERRRLK TELDGLRYYV GDTTDVLFEK WFYCEDLGTQ LAPIIQEFFS 150
    SEQYRTGKPN PDQLLKEPPF PLSTRSVMEP MCLEAWLDGH RKELQAGTPL 200
    SLFGDTYESQ VMVHGQGSSE GLRRDVDVWL WQLEGSSVVT MEGQRLSLTL 250
    DDSLLVPAGT LYGWERGQGS VALSVTQDPA CKKSLG 286
    Length:286
    Mass (Da):32,493
    Last modified:September 5, 2006 - v1
    Checksum:i6887DDB93B861F8E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC120265 mRNA. Translation: AAI20266.1.
    RefSeqiNP_001068926.1. NM_001075458.2.
    UniGeneiBt.20241.

    Genome annotation databases

    EnsembliENSBTAT00000006132; ENSBTAP00000006132; ENSBTAG00000004674.
    GeneIDi510602.
    KEGGibta:510602.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC120265 mRNA. Translation: AAI20266.1 .
    RefSeqi NP_001068926.1. NM_001075458.2.
    UniGenei Bt.20241.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3FE5 X-ray 2.51 A 2-286 [» ]
    ProteinModelPortali Q0VCA8.
    SMRi Q0VCA8. Positions 2-286.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000006132.

    Proteomic databases

    PRIDEi Q0VCA8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000006132 ; ENSBTAP00000006132 ; ENSBTAG00000004674 .
    GeneIDi 510602.
    KEGGi bta:510602.

    Organism-specific databases

    CTDi 23498.

    Phylogenomic databases

    eggNOGi NOG77058.
    GeneTreei ENSGT00390000013008.
    HOGENOMi HOG000218448.
    HOVERGENi HBG000018.
    InParanoidi Q0VCA8.
    KOi K00452.
    OMAi DMCLKVI.
    OrthoDBi EOG7FFMS4.
    TreeFami TF300246.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00330 .
    Reactomei REACT_217639. Tryptophan catabolism.

    Miscellaneous databases

    EvolutionaryTracei Q0VCA8.
    NextBioi 20869529.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    HAMAPi MF_00825. 3_HAO.
    InterProi IPR010329. 3hydroanth_dOase.
    IPR016700. 3hydroanth_dOase_met.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR15497. PTHR15497. 1 hit.
    Pfami PF06052. 3-HAO. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017681. 3hydroanth_dOase_animal. 1 hit.
    SUPFAMi SSF51182. SSF51182. 2 hits.
    TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal liver.
    2. "Crystal structure of bovine 3-hydroxyanthranilate 3,4-dioxygenase."
      Dilovic I., Gliubich F., Malpeli G., Zanotti G., Matkovic-Calogovic D.
      Biopolymers 91:1189-1195(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 2-286, SUBUNIT, IRON-BINDING SITES.

    Entry informationi

    Entry namei3HAO_BOVIN
    AccessioniPrimary (citable) accession number: Q0VCA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3