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Q0VCA8

- 3HAO_BOVIN

UniProt

Q0VCA8 - 3HAO_BOVIN

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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

HAAO

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+ ion.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431DioxygenUniRule annotation
Metal bindingi47 – 471Iron; catalytic
Metal bindingi53 – 531Iron; catalytic
Binding sitei53 – 531SubstrateUniRule annotation
Metal bindingi91 – 911Iron; catalytic
Binding sitei95 – 951SubstrateUniRule annotation
Binding sitei105 – 1051SubstrateUniRule annotation

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. neuron cellular homeostasis Source: Ensembl
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. response to cadmium ion Source: Ensembl
  6. response to zinc ion Source: Ensembl
  7. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_217639. Tryptophan catabolism.
UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Gene namesi
Name:HAAOUniRule annotation
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 11

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2862863-hydroxyanthranilate 3,4-dioxygenasePRO_0000283033Add
BLAST

Proteomic databases

PRIDEiQ0VCA8.

Interactioni

Subunit structurei

Monomer.1 PublicationUniRule annotation

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006132.

Structurei

Secondary structure

1
286
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 63
Helixi7 – 148
Helixi15 – 173
Turni20 – 223
Beta strandi24 – 4118
Beta strandi46 – 483
Beta strandi53 – 608
Beta strandi62 – 687
Beta strandi71 – 777
Beta strandi81 – 855
Beta strandi91 – 955
Beta strandi100 – 1067
Beta strandi114 – 1207
Beta strandi126 – 1327
Turni137 – 1393
Helixi141 – 1499
Helixi152 – 1565
Helixi161 – 1633
Helixi183 – 1886
Helixi191 – 1966
Beta strandi200 – 2034
Beta strandi207 – 2148
Beta strandi216 – 2238
Beta strandi228 – 2358
Beta strandi237 – 2437
Beta strandi245 – 2484
Beta strandi252 – 2565
Beta strandi261 – 2666
Beta strandi271 – 2777
Helixi279 – 2813

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FE5X-ray2.51A2-286[»]
ProteinModelPortaliQ0VCA8.
SMRiQ0VCA8. Positions 2-286.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ0VCA8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 160160Domain A (catalytic)Add
BLAST
Regioni161 – 17717LinkerAdd
BLAST
Regioni178 – 286109Domain BAdd
BLAST

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

eggNOGiNOG77058.
GeneTreeiENSGT00390000013008.
HOGENOMiHOG000218448.
HOVERGENiHBG000018.
InParanoidiQ0VCA8.
KOiK00452.
OMAiDMCLKVI.
OrthoDBiEOG7FFMS4.
TreeFamiTF300246.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
PIRSFiPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMiSSF51182. SSF51182. 2 hits.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0VCA8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERPVRVKAW VEENRGSFLP PVCNKLLHQK QLKIMFVGGP NTRKDYHIEE
60 70 80 90 100
GEEVFYQLEG DMLLRVLERG KHRDVVIRQG EIFLLPAGVP HSPQRFANTV
110 120 130 140 150
GLVIERRRLK TELDGLRYYV GDTTDVLFEK WFYCEDLGTQ LAPIIQEFFS
160 170 180 190 200
SEQYRTGKPN PDQLLKEPPF PLSTRSVMEP MCLEAWLDGH RKELQAGTPL
210 220 230 240 250
SLFGDTYESQ VMVHGQGSSE GLRRDVDVWL WQLEGSSVVT MEGQRLSLTL
260 270 280
DDSLLVPAGT LYGWERGQGS VALSVTQDPA CKKSLG
Length:286
Mass (Da):32,493
Last modified:September 5, 2006 - v1
Checksum:i6887DDB93B861F8E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC120265 mRNA. Translation: AAI20266.1.
RefSeqiNP_001068926.1. NM_001075458.2.
UniGeneiBt.20241.

Genome annotation databases

EnsembliENSBTAT00000006132; ENSBTAP00000006132; ENSBTAG00000004674.
GeneIDi510602.
KEGGibta:510602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC120265 mRNA. Translation: AAI20266.1 .
RefSeqi NP_001068926.1. NM_001075458.2.
UniGenei Bt.20241.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3FE5 X-ray 2.51 A 2-286 [» ]
ProteinModelPortali Q0VCA8.
SMRi Q0VCA8. Positions 2-286.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000006132.

Proteomic databases

PRIDEi Q0VCA8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000006132 ; ENSBTAP00000006132 ; ENSBTAG00000004674 .
GeneIDi 510602.
KEGGi bta:510602.

Organism-specific databases

CTDi 23498.

Phylogenomic databases

eggNOGi NOG77058.
GeneTreei ENSGT00390000013008.
HOGENOMi HOG000218448.
HOVERGENi HBG000018.
InParanoidi Q0VCA8.
KOi K00452.
OMAi DMCLKVI.
OrthoDBi EOG7FFMS4.
TreeFami TF300246.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .
Reactomei REACT_217639. Tryptophan catabolism.

Miscellaneous databases

EvolutionaryTracei Q0VCA8.
NextBioi 20869529.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
PIRSFi PIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMi SSF51182. SSF51182. 2 hits.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal liver.
  2. "Crystal structure of bovine 3-hydroxyanthranilate 3,4-dioxygenase."
    Dilovic I., Gliubich F., Malpeli G., Zanotti G., Matkovic-Calogovic D.
    Biopolymers 91:1189-1195(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 2-286, SUBUNIT, IRON-BINDING SITES.

Entry informationi

Entry namei3HAO_BOVIN
AccessioniPrimary (citable) accession number: Q0VCA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3