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Q0VCA7

- OXSM_BOVIN

UniProt

Q0VCA7 - OXSM_BOVIN

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Protein

3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

Gene

OXSM

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.By similarity

Catalytic activityi

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Enzyme regulationi

Inhibited by cerulenin.By similarity

Pathwayi

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (EC:2.3.1.41)
Alternative name(s):
Beta-ketoacyl-ACP synthase
Gene namesi
Name:OXSM
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2828MitochondrionSequence AnalysisAdd
BLAST
Chaini29 – 4604323-oxoacyl-[acyl-carrier-protein] synthase, mitochondrialPRO_0000310304Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei110 – 1101N6-acetyllysine; alternateBy similarity
Modified residuei110 – 1101N6-succinyllysine; alternateBy similarity
Modified residuei114 – 1141N6-succinyllysineBy similarity
Modified residuei175 – 1751N6-acetyllysine; alternateBy similarity
Modified residuei175 – 1751N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ0VCA7.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009250.

Structurei

3D structure databases

ProteinModelPortaliQ0VCA7.
SMRiQ0VCA7. Positions 41-460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0304.
HOGENOMiHOG000060166.
HOVERGENiHBG082096.
InParanoidiQ0VCA7.
KOiK09458.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR017568. 3-oxoacyl-ACP_synth-2.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000447. KAS_II. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR03150. fabF. 1 hit.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VCA7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSDGLQIFL RITKCHLIHA RSCQRLVNER RFLATAPAPG LRRRVVITGI
60 70 80 90 100
GLVTPLGVGT QLVWDRLVRG ESGIVSLVGD EYQSIPCSVA AYVPRGCDEG
110 120 130 140 150
QFNEQNFVPK SDTKSMSPPT VMAIAAAELA LKDAGWHPQS EADQAATGVA
160 170 180 190 200
IGMGMVPLEV ISETALTFQT KGYSKVSPFF VPKILVNMAS GQVSIRHKLK
210 220 230 240 250
GPNHAVSTAC TTGAHAVGDS FRFVAHGDAD VMVAGGTDSC ISPLSLAGFA
260 270 280 290 300
RARALSTNTD PKSACRPFHP QRDGFVMGEG AAVLVLEEHR HALRRGARVY
310 320 330 340 350
AEIVGYGLSG DAGHITAPDP GGEGAFRCMA AAVKDAGIQP EEVSYINAHA
360 370 380 390 400
TSTPLGDAAE NKAIKQLFKD HAHVLAVSST KGATGHLLGT AGAAEAAFTA
410 420 430 440 450
LACYHRKLPP TLNLDCTEPH FDLNYVPLKA QEWKAENRRI ALTNSFGFGG
460
TNATLCIAGM
Length:460
Mass (Da):48,617
Last modified:September 5, 2006 - v1
Checksum:i34D49F1E15BD27B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC120268 mRNA. Translation: AAI20269.1.
RefSeqiNP_001069092.1. NM_001075624.2.
UniGeneiBt.21584.

Genome annotation databases

GeneIDi513530.
KEGGibta:513530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC120268 mRNA. Translation: AAI20269.1 .
RefSeqi NP_001069092.1. NM_001075624.2.
UniGenei Bt.21584.

3D structure databases

ProteinModelPortali Q0VCA7.
SMRi Q0VCA7. Positions 41-460.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000009250.

Proteomic databases

PRIDEi Q0VCA7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 513530.
KEGGi bta:513530.

Organism-specific databases

CTDi 54995.

Phylogenomic databases

eggNOGi COG0304.
HOGENOMi HOG000060166.
HOVERGENi HBG082096.
InParanoidi Q0VCA7.
KOi K09458.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Miscellaneous databases

NextBioi 20870896.

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR017568. 3-oxoacyl-ACP_synth-2.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000447. KAS_II. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
TIGRFAMsi TIGR03150. fabF. 1 hit.
PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiOXSM_BOVIN
AccessioniPrimary (citable) accession number: Q0VCA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3