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Q0VCA7

- OXSM_BOVIN

UniProt

Q0VCA7 - OXSM_BOVIN

Protein

3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

Gene

OXSM

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.By similarity

    Catalytic activityi

    Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

    Enzyme regulationi

    Inhibited by cerulenin.By similarity

    Pathwayi

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (EC:2.3.1.41)
    Alternative name(s):
    Beta-ketoacyl-ACP synthase
    Gene namesi
    Name:OXSM
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2828MitochondrionSequence AnalysisAdd
    BLAST
    Chaini29 – 4604323-oxoacyl-[acyl-carrier-protein] synthase, mitochondrialPRO_0000310304Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei110 – 1101N6-acetyllysine; alternateBy similarity
    Modified residuei110 – 1101N6-succinyllysine; alternateBy similarity
    Modified residuei114 – 1141N6-succinyllysineBy similarity
    Modified residuei175 – 1751N6-acetyllysine; alternateBy similarity
    Modified residuei175 – 1751N6-succinyllysine; alternateBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ0VCA7.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000009250.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0VCA7.
    SMRiQ0VCA7. Positions 41-460.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-ketoacyl-ACP synthases family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0304.
    HOGENOMiHOG000060166.
    HOVERGENiHBG082096.
    InParanoidiQ0VCA7.
    KOiK09458.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR017568. 3-oxoacyl-ACP_synth-2.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000447. KAS_II. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    TIGRFAMsiTIGR03150. fabF. 1 hit.
    PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0VCA7-1 [UniParc]FASTAAdd to Basket

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    MLSDGLQIFL RITKCHLIHA RSCQRLVNER RFLATAPAPG LRRRVVITGI    50
    GLVTPLGVGT QLVWDRLVRG ESGIVSLVGD EYQSIPCSVA AYVPRGCDEG 100
    QFNEQNFVPK SDTKSMSPPT VMAIAAAELA LKDAGWHPQS EADQAATGVA 150
    IGMGMVPLEV ISETALTFQT KGYSKVSPFF VPKILVNMAS GQVSIRHKLK 200
    GPNHAVSTAC TTGAHAVGDS FRFVAHGDAD VMVAGGTDSC ISPLSLAGFA 250
    RARALSTNTD PKSACRPFHP QRDGFVMGEG AAVLVLEEHR HALRRGARVY 300
    AEIVGYGLSG DAGHITAPDP GGEGAFRCMA AAVKDAGIQP EEVSYINAHA 350
    TSTPLGDAAE NKAIKQLFKD HAHVLAVSST KGATGHLLGT AGAAEAAFTA 400
    LACYHRKLPP TLNLDCTEPH FDLNYVPLKA QEWKAENRRI ALTNSFGFGG 450
    TNATLCIAGM 460
    Length:460
    Mass (Da):48,617
    Last modified:September 5, 2006 - v1
    Checksum:i34D49F1E15BD27B3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC120268 mRNA. Translation: AAI20269.1.
    RefSeqiNP_001069092.1. NM_001075624.2.
    UniGeneiBt.21584.

    Genome annotation databases

    GeneIDi513530.
    KEGGibta:513530.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC120268 mRNA. Translation: AAI20269.1 .
    RefSeqi NP_001069092.1. NM_001075624.2.
    UniGenei Bt.21584.

    3D structure databases

    ProteinModelPortali Q0VCA7.
    SMRi Q0VCA7. Positions 41-460.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000009250.

    Proteomic databases

    PRIDEi Q0VCA7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 513530.
    KEGGi bta:513530.

    Organism-specific databases

    CTDi 54995.

    Phylogenomic databases

    eggNOGi COG0304.
    HOGENOMi HOG000060166.
    HOVERGENi HBG082096.
    InParanoidi Q0VCA7.
    KOi K09458.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Miscellaneous databases

    NextBioi 20870896.

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR017568. 3-oxoacyl-ACP_synth-2.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000447. KAS_II. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    TIGRFAMsi TIGR03150. fabF. 1 hit.
    PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Thymus.

    Entry informationi

    Entry nameiOXSM_BOVIN
    AccessioniPrimary (citable) accession number: Q0VCA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3