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Q0VCA1 (DCE1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutamate decarboxylase 1
EC=4.1.1.15
Gene names
Name:GAD1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length594 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the production of GABA By similarity.

Catalytic activity

L-glutamate = 4-aminobutanoate + CO2.

Cofactor

Pyridoxal phosphate By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the group II decarboxylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 594594Glutamate decarboxylase 1
PRO_0000289582

Regions

Region190 – 1923Substrate binding By similarity

Sites

Binding site5671Substrate By similarity

Amino acid modifications

Modified residue4051N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0VCA1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 2936F526D5E64EDD

FASTA59466,784
        10         20         30         40         50         60 
MASSTPSSSA TSSNAGADPN TTNLRPTTYD TWCGVAHGCT RKLGLKICGF LQRTNSLEEK 

        70         80         90        100        110        120 
SRLVSAFKER QSSKNLLSCE NSDKDGRFRR TETDFSNLFA RDLLPAKNGE EQTVQFLLEV 

       130        140        150        160        170        180 
VDILLNYVRK TFDRSTKVLD FHHPHQLLEG MEGFNLELSD HPESLEQILV DCRDTLKYGV 

       190        200        210        220        230        240 
RTGHPRFFNQ LSTGLDIIGL AGEWLTSTAN TNMFTYEIAP VFVLMEQITL KKMREIVGWS 

       250        260        270        280        290        300 
SKDGDGIFSP GGAISNMYSI MAARFKYFPE VKTKGMAAVP KLVLFTSEHS HYSIKKAGAA 

       310        320        330        340        350        360 
LGFGTDNVIL IKCNERGKII PADLETKILE AKQKGYVPLY VNATAGTTVY GAFDPIQEIA 

       370        380        390        400        410        420 
DICEKYNLWL HVDAAWGGGL LMSQKHRHKL SGIERANSVT WNPHKMMGVL LQCSAILVKE 

       430        440        450        460        470        480 
KGILQGCNQM CAGYLFQPDK QYDVSYDTGD KAIQCGRHVD IFKFWLMWKA KGTVGFENQI 

       490        500        510        520        530        540 
NKCLELAEYL YAKIKNREEF EMVFDGEPEH TNVCFWYIPQ SLRGVPDSPE RREKLHRVAP 

       550        560        570        580        590 
KIKALMMESG TTMVGYQPQG DKANFFRMVI SNPAATQSDI DFLIEEIERL GQDL

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal cerebellum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC120278 mRNA. Translation: AAI20279.1.
IPIIPI00698114.
RefSeqNP_001069224.1. NM_001075756.2.
UniGeneBt.26356.

3D structure databases

ProteinModelPortalQ0VCA1.
SMRQ0VCA1. Positions 93-593.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000009547.

Proteomic databases

PRIDEQ0VCA1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000009547; ENSBTAP00000009547; ENSBTAG00000007258.
GeneID517552.
KEGGbta:517552.

Organism-specific databases

CTD2571.

Phylogenomic databases

eggNOGCOG0076.
GeneTreeENSGT00550000074275.
HOGENOMHOG000005382.
HOVERGENHBG004980.
InParanoidQ0VCA1.
KOK01580.
OMAISMAGEW.
OrthoDBEOG4QJRMS.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20872469.

Entry information

Entry nameDCE1_BOVIN
AccessionPrimary (citable) accession number: Q0VCA1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: April 3, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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