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Q0VCA1

- DCE1_BOVIN

UniProt

Q0VCA1 - DCE1_BOVIN

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Protein

Glutamate decarboxylase 1

Gene
GAD1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the production of GABA By similarity.

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.

Cofactori

Pyridoxal phosphate By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei567 – 5671Substrate By similarity

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. carboxylic acid metabolic process Source: InterPro
  2. neurotransmitter biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Neurotransmitter biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiREACT_211255. GABA synthesis, release, reuptake and degradation.
REACT_221236. GABA synthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylase 1 (EC:4.1.1.15)
Gene namesi
Name:GAD1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. axon terminus Source: Ensembl
  2. cell cortex Source: Ensembl
  3. mitochondrion Source: Ensembl
  4. presynaptic active zone Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Glutamate decarboxylase 1PRO_0000289582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei405 – 4051N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ0VCA1.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009547.

Structurei

3D structure databases

ProteinModelPortaliQ0VCA1.
SMRiQ0VCA1. Positions 93-593.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni190 – 1923Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0076.
GeneTreeiENSGT00730000110441.
HOGENOMiHOG000005382.
HOVERGENiHBG004980.
InParanoidiQ0VCA1.
KOiK01580.
OMAiEYLYTKI.
OrthoDBiEOG7H1JM3.
TreeFamiTF314688.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VCA1-1 [UniParc]FASTAAdd to Basket

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MASSTPSSSA TSSNAGADPN TTNLRPTTYD TWCGVAHGCT RKLGLKICGF    50
LQRTNSLEEK SRLVSAFKER QSSKNLLSCE NSDKDGRFRR TETDFSNLFA 100
RDLLPAKNGE EQTVQFLLEV VDILLNYVRK TFDRSTKVLD FHHPHQLLEG 150
MEGFNLELSD HPESLEQILV DCRDTLKYGV RTGHPRFFNQ LSTGLDIIGL 200
AGEWLTSTAN TNMFTYEIAP VFVLMEQITL KKMREIVGWS SKDGDGIFSP 250
GGAISNMYSI MAARFKYFPE VKTKGMAAVP KLVLFTSEHS HYSIKKAGAA 300
LGFGTDNVIL IKCNERGKII PADLETKILE AKQKGYVPLY VNATAGTTVY 350
GAFDPIQEIA DICEKYNLWL HVDAAWGGGL LMSQKHRHKL SGIERANSVT 400
WNPHKMMGVL LQCSAILVKE KGILQGCNQM CAGYLFQPDK QYDVSYDTGD 450
KAIQCGRHVD IFKFWLMWKA KGTVGFENQI NKCLELAEYL YAKIKNREEF 500
EMVFDGEPEH TNVCFWYIPQ SLRGVPDSPE RREKLHRVAP KIKALMMESG 550
TTMVGYQPQG DKANFFRMVI SNPAATQSDI DFLIEEIERL GQDL 594
Length:594
Mass (Da):66,784
Last modified:September 5, 2006 - v1
Checksum:i2936F526D5E64EDD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC120278 mRNA. Translation: AAI20279.1.
RefSeqiNP_001069224.1. NM_001075756.2.
XP_005202387.1. XM_005202330.1.
UniGeneiBt.26356.

Genome annotation databases

EnsembliENSBTAT00000009547; ENSBTAP00000009547; ENSBTAG00000007258.
GeneIDi517552.
KEGGibta:517552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC120278 mRNA. Translation: AAI20279.1 .
RefSeqi NP_001069224.1. NM_001075756.2.
XP_005202387.1. XM_005202330.1.
UniGenei Bt.26356.

3D structure databases

ProteinModelPortali Q0VCA1.
SMRi Q0VCA1. Positions 93-593.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000009547.

Proteomic databases

PRIDEi Q0VCA1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000009547 ; ENSBTAP00000009547 ; ENSBTAG00000007258 .
GeneIDi 517552.
KEGGi bta:517552.

Organism-specific databases

CTDi 2571.

Phylogenomic databases

eggNOGi COG0076.
GeneTreei ENSGT00730000110441.
HOGENOMi HOG000005382.
HOVERGENi HBG004980.
InParanoidi Q0VCA1.
KOi K01580.
OMAi EYLYTKI.
OrthoDBi EOG7H1JM3.
TreeFami TF314688.

Enzyme and pathway databases

Reactomei REACT_211255. GABA synthesis, release, reuptake and degradation.
REACT_221236. GABA synthesis.

Miscellaneous databases

NextBioi 20872469.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view ]
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal cerebellum.

Entry informationi

Entry nameiDCE1_BOVIN
AccessioniPrimary (citable) accession number: Q0VCA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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