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Q0VCA1

- DCE1_BOVIN

UniProt

Q0VCA1 - DCE1_BOVIN

Protein

Glutamate decarboxylase 1

Gene

GAD1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the production of GABA.By similarity

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei567 – 5671SubstrateBy similarity

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. carboxylic acid metabolic process Source: InterPro
    2. neurotransmitter biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Neurotransmitter biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_211255. GABA synthesis, release, reuptake and degradation.
    REACT_221236. GABA synthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylase 1 (EC:4.1.1.15)
    Gene namesi
    Name:GAD1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 2

    Subcellular locationi

    GO - Cellular componenti

    1. axon terminus Source: Ensembl
    2. cell cortex Source: Ensembl
    3. mitochondrion Source: Ensembl
    4. presynaptic active zone Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 594594Glutamate decarboxylase 1PRO_0000289582Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei405 – 4051N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiQ0VCA1.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000009547.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0VCA1.
    SMRiQ0VCA1. Positions 93-593.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni190 – 1923Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0076.
    GeneTreeiENSGT00730000110441.
    HOGENOMiHOG000005382.
    HOVERGENiHBG004980.
    InParanoidiQ0VCA1.
    KOiK01580.
    OMAiEYLYTKI.
    OrthoDBiEOG7H1JM3.
    TreeFamiTF314688.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0VCA1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSTPSSSA TSSNAGADPN TTNLRPTTYD TWCGVAHGCT RKLGLKICGF    50
    LQRTNSLEEK SRLVSAFKER QSSKNLLSCE NSDKDGRFRR TETDFSNLFA 100
    RDLLPAKNGE EQTVQFLLEV VDILLNYVRK TFDRSTKVLD FHHPHQLLEG 150
    MEGFNLELSD HPESLEQILV DCRDTLKYGV RTGHPRFFNQ LSTGLDIIGL 200
    AGEWLTSTAN TNMFTYEIAP VFVLMEQITL KKMREIVGWS SKDGDGIFSP 250
    GGAISNMYSI MAARFKYFPE VKTKGMAAVP KLVLFTSEHS HYSIKKAGAA 300
    LGFGTDNVIL IKCNERGKII PADLETKILE AKQKGYVPLY VNATAGTTVY 350
    GAFDPIQEIA DICEKYNLWL HVDAAWGGGL LMSQKHRHKL SGIERANSVT 400
    WNPHKMMGVL LQCSAILVKE KGILQGCNQM CAGYLFQPDK QYDVSYDTGD 450
    KAIQCGRHVD IFKFWLMWKA KGTVGFENQI NKCLELAEYL YAKIKNREEF 500
    EMVFDGEPEH TNVCFWYIPQ SLRGVPDSPE RREKLHRVAP KIKALMMESG 550
    TTMVGYQPQG DKANFFRMVI SNPAATQSDI DFLIEEIERL GQDL 594
    Length:594
    Mass (Da):66,784
    Last modified:September 5, 2006 - v1
    Checksum:i2936F526D5E64EDD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC120278 mRNA. Translation: AAI20279.1.
    RefSeqiNP_001069224.1. NM_001075756.2.
    XP_005202387.1. XM_005202330.1.
    UniGeneiBt.26356.

    Genome annotation databases

    EnsembliENSBTAT00000009547; ENSBTAP00000009547; ENSBTAG00000007258.
    GeneIDi517552.
    KEGGibta:517552.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC120278 mRNA. Translation: AAI20279.1 .
    RefSeqi NP_001069224.1. NM_001075756.2.
    XP_005202387.1. XM_005202330.1.
    UniGenei Bt.26356.

    3D structure databases

    ProteinModelPortali Q0VCA1.
    SMRi Q0VCA1. Positions 93-593.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000009547.

    Proteomic databases

    PRIDEi Q0VCA1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000009547 ; ENSBTAP00000009547 ; ENSBTAG00000007258 .
    GeneIDi 517552.
    KEGGi bta:517552.

    Organism-specific databases

    CTDi 2571.

    Phylogenomic databases

    eggNOGi COG0076.
    GeneTreei ENSGT00730000110441.
    HOGENOMi HOG000005382.
    HOVERGENi HBG004980.
    InParanoidi Q0VCA1.
    KOi K01580.
    OMAi EYLYTKI.
    OrthoDBi EOG7H1JM3.
    TreeFami TF314688.

    Enzyme and pathway databases

    Reactomei REACT_211255. GABA synthesis, release, reuptake and degradation.
    REACT_221236. GABA synthesis.

    Miscellaneous databases

    NextBioi 20872469.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal cerebellum.

    Entry informationi

    Entry nameiDCE1_BOVIN
    AccessioniPrimary (citable) accession number: Q0VCA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3