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Protein

Probable palmitoyltransferase ZDHHC20

Gene

ZDHHC20

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC20 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 20
Short name:
DHHC-20
Gene namesi
Name:ZDHHC20
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002692301 – 365Probable palmitoyltransferase ZDHHC20Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei305PhosphoserineBy similarity1
Modified residuei330PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ0VC89.
PRIDEiQ0VC89.

Expressioni

Gene expression databases

BgeeiENSBTAG00000006177.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008119.

Structurei

3D structure databases

SMRiQ0VC89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 176DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1315. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00880000137864.
HOGENOMiHOG000234777.
HOVERGENiHBG055108.
InParanoidiQ0VC89.
KOiK20028.
OMAiSRTIRYC.
OrthoDBiEOG091G0AXR.
TreeFamiTF316044.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0VC89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPCTLWRCC QRTVGWVPVL FITFVVVWSY YAYVVELCVF TLSGNGENGK
60 70 80 90 100
AVVYLVAFHL FFVMFVWSYW MTIFTSPASP SKEFCLSNSE KERYEKEFSQ
110 120 130 140 150
ERQQEILRRA ARDLPIYTTS ASKTVRYCER CQLIKPDRAH HCSACDMCIL
160 170 180 190 200
KMDHHCPWVN NCVGFSNYKF FLLFLFYSLL YCLFVATTVL QYFIKFWTNE
210 220 230 240 250
LTDTRAKFHV LFLFFVSTMF FISVLSLLSY HCWLVGKNRT TIESFRAPMF
260 270 280 290 300
SYGTDGNGFS LGCSKNWRQV FGDEKKYWLL PVFSSQGDGC SFPTRLVGTD
310 320 330 340 350
PEQASVSNQS ESARSIGSNQ PFPIKPLSES KNRLLDSDPQ WLESGSEEGV
360
GGSGTNNHVT VAIEN
Length:365
Mass (Da):41,907
Last modified:September 5, 2006 - v1
Checksum:iB6C65283C2308463
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120294 mRNA. Translation: AAI20295.1.
RefSeqiNP_001069856.1. NM_001076388.2.
XP_005213858.1. XM_005213801.1.
XP_005213859.1. XM_005213802.1.
UniGeneiBt.74269.

Genome annotation databases

EnsembliENSBTAT00000008119; ENSBTAP00000008119; ENSBTAG00000006177.
GeneIDi615659.
KEGGibta:615659.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZDH20_BOVIN
AccessioniPrimary (citable) accession number: Q0VC89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 5, 2006
Last modified: June 7, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families