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Protein

Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

Gene

C1GALT1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development (By similarity).By similarity

Catalytic activityi

UDP-alpha-D-galactose + glycoprotein N-acetyl-D-galactosamine = UDP + glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine.

Cofactori

Mg2+By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Glycosyltransferase, Transferase

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-913709. O-linked glycosylation of mucins.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC:2.4.1.122)
Alternative name(s):
Core 1 O-glycan T-synthase
Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1
Core 1 beta1,3-galactosyltransferase 1
Short name:
C1GalT1
Short name:
Core 1 beta3-Gal-T1
Gene namesi
Name:C1GALT1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 6CytoplasmicSequence analysis5
Transmembranei7 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini30 – 368LumenalSequence analysisAdd BLAST339

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002850632 – 368Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1Add BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei235PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ0VC84.
PRIDEiQ0VC84.

Expressioni

Gene expression databases

BgeeiENSBTAG00000004995.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with the C1GALT1C1 chaperone; required for galactosyltransferase activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006571.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2246. Eukaryota.
ENOG410YRJG. LUCA.
GeneTreeiENSGT00530000063264.
HOGENOMiHOG000021316.
HOVERGENiHBG097900.
InParanoidiQ0VC84.
KOiK00731.
OMAiPYGIINT.
OrthoDBiEOG091G0BLV.
TreeFamiTF317293.

Family and domain databases

InterProiIPR026842. C1GALT1.
IPR003378. Fringe-like.
[Graphical view]
PANTHERiPTHR23033:SF13. PTHR23033:SF13. 1 hit.
PfamiPF02434. Fringe. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VC84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKSWLNIL TFLCGSAVGF VLCSQLLSIL FEEQKDIQPS ILHNDPHARH
60 70 80 90 100
SDDNEQNHLE GQMNFDADAS QHKDENTDIA DKLYQKVKIL CWVMTGPQNL
110 120 130 140 150
EKKAKHVKAT WAQRCNKVLF MSSEENKDFP AVGLKTREGR DQLYWKTIKA
160 170 180 190 200
FQYVHDHYLE DADWFMKADD DTYVILDNLR WLLSKYNPEE PIYFGRRFKP
210 220 230 240 250
YVKQGYMSGG AGYVLSKEAL KRFVEAFKTD KCTHSSSIED LALGRCMEII
260 270 280 290 300
NVEAGDSRDT TGKETFHPFV PEHHLIKGYL PRTFWYWNYN YYPPVEGPGC
310 320 330 340 350
CSDLAVSFHY VDPTTMYELE YLVYHLRPYG YLYRYQPALP EKMLKEVSQI
360
YKNEDTNVNQ EPLKEKHK
Length:368
Mass (Da):43,041
Last modified:September 5, 2006 - v1
Checksum:iDF82C20C98CCF250
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120299 mRNA. Translation: AAI20300.1.
RefSeqiNP_001069628.1. NM_001076160.2.
XP_005205216.1. XM_005205159.3.
XP_015323642.1. XM_015468156.1.
UniGeneiBt.22740.

Genome annotation databases

EnsembliENSBTAT00000006572; ENSBTAP00000006571; ENSBTAG00000004995.
GeneIDi539417.
KEGGibta:539417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120299 mRNA. Translation: AAI20300.1.
RefSeqiNP_001069628.1. NM_001076160.2.
XP_005205216.1. XM_005205159.3.
XP_015323642.1. XM_015468156.1.
UniGeneiBt.22740.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006571.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Proteomic databases

PaxDbiQ0VC84.
PRIDEiQ0VC84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000006572; ENSBTAP00000006571; ENSBTAG00000004995.
GeneIDi539417.
KEGGibta:539417.

Organism-specific databases

CTDi56913.

Phylogenomic databases

eggNOGiKOG2246. Eukaryota.
ENOG410YRJG. LUCA.
GeneTreeiENSGT00530000063264.
HOGENOMiHOG000021316.
HOVERGENiHBG097900.
InParanoidiQ0VC84.
KOiK00731.
OMAiPYGIINT.
OrthoDBiEOG091G0BLV.
TreeFamiTF317293.

Enzyme and pathway databases

UniPathwayiUPA00378.
ReactomeiR-BTA-913709. O-linked glycosylation of mucins.

Gene expression databases

BgeeiENSBTAG00000004995.

Family and domain databases

InterProiIPR026842. C1GALT1.
IPR003378. Fringe-like.
[Graphical view]
PANTHERiPTHR23033:SF13. PTHR23033:SF13. 1 hit.
PfamiPF02434. Fringe. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC1GLT_BOVIN
AccessioniPrimary (citable) accession number: Q0VC84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 5, 2006
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.