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Protein

Adenosine receptor A3

Gene

ADORA3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-417973. Adenosine P1 receptors.
R-BTA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A3
Gene namesi
Name:ADORA3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14ExtracellularBy similarityAdd BLAST14
Transmembranei15 – 37Helical; Name=1By similarityAdd BLAST23
Topological domaini38 – 48CytoplasmicBy similarityAdd BLAST11
Transmembranei49 – 72Helical; Name=2By similarityAdd BLAST24
Topological domaini73 – 84ExtracellularBy similarityAdd BLAST12
Transmembranei85 – 106Helical; Name=3By similarityAdd BLAST22
Topological domaini107 – 126CytoplasmicBy similarityAdd BLAST20
Transmembranei127 – 148Helical; Name=4By similarityAdd BLAST22
Topological domaini149 – 176ExtracellularBy similarityAdd BLAST28
Transmembranei177 – 197Helical; Name=5By similarityAdd BLAST21
Topological domaini198 – 230CytoplasmicBy similarityAdd BLAST33
Transmembranei231 – 254Helical; Name=6By similarityAdd BLAST24
Topological domaini255 – 260ExtracellularBy similarity6
Transmembranei261 – 283Helical; Name=7By similarityAdd BLAST23
Topological domaini284 – 317CytoplasmicBy similarityAdd BLAST34

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1287626.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002900081 – 317Adenosine receptor A3Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi83 ↔ 165PROSITE-ProRule annotation
Lipidationi302S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ0VC81.
PRIDEiQ0VC81.

Expressioni

Gene expression databases

BgeeiENSBTAG00000007642.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010057.

Chemistry databases

BindingDBiQ0VC81.

Structurei

3D structure databases

ProteinModelPortaliQ0VC81.
SMRiQ0VC81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiQ0VC81.
KOiK04268.
OMAiMRMDYMV.
OrthoDBiEOG091G0I3U.
TreeFamiTF325296.

Family and domain databases

InterProiView protein in InterPro
IPR000466. Adeno_A3_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00555. ADENOSINEA3R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0VC81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVNSTAVSL ASVTYISVEI LIGLCAIVGN VLVIWVVKLN PSLQTTTFYF
60 70 80 90 100
IVSLALADIA VGVLVMPLAI VISLGVTIHF YSCLLMTCLL MIFTHASIMS
110 120 130 140 150
LLAIAVDRYL RVKLTVRYRR VTTQRRIWLA LGLCWLVSFL VGLTPMFGWN
160 170 180 190 200
MKLSSADKNL TFLPCQFRSV MRMDYMVYFS FFTWILIPLV VMCAIYFDIF
210 220 230 240 250
YVIRNRLSQN FSGSKETGAF YGREFKTAKS LSLVLFLFAL SWLPLSIINC
260 270 280 290 300
IIYFNGEVPQ IVLYLGILLS HANSMMNPIV YAYKIKKFKE TYLLILKACV
310
ICQPSKSMDP SIEQTSE
Length:317
Mass (Da):35,911
Last modified:September 5, 2006 - v1
Checksum:i4843F7A27DDF0907
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120305 mRNA. Translation: AAI20306.1.
RefSeqiNP_001098081.1. NM_001104611.2.
NP_001289697.1. NM_001302768.1.
UniGeneiBt.40521.

Genome annotation databases

EnsembliENSBTAT00000010057; ENSBTAP00000010057; ENSBTAG00000007642.
GeneIDi780806.
KEGGibta:780806.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAA3R_BOVIN
AccessioniPrimary (citable) accession number: Q0VC81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: September 5, 2006
Last modified: June 7, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families