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Q0VC36 (1433S_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
14-3-3 protein sigma
Alternative name(s):
Stratifin
Gene names
Name:SFN
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway By similarity.

Subunit structure

Homodimer. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with KRT17. Interacts with GAB2 and SAMSN1 By similarity. Interacts with SRPK2 By similarity. Interacts with COPS6 By similarity. Interacts with RFWD2; this interaction leads to proteasomal degradation By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Secreted By similarity. Note: May be secreted by a non-classical secretory pathway By similarity.

Miscellaneous

14-3-3 proteins have been shown to be PKC activators, but this effect could be non-specific and only due to the acidic nature of the protein.

Sequence similarities

Belongs to the 14-3-3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 24824814-3-3 protein sigma
PRO_0000262593

Sites

Site561Interaction with phosphoserine on interacting protein By similarity
Site1291Interaction with phosphoserine on interacting protein By similarity

Amino acid modifications

Modified residue641Phosphoserine By similarity
Modified residue2161Phosphoserine By similarity
Modified residue2481Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0VC36 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: F1166FB40B23A9B3

FASTA24827,849
        10         20         30         40         50         60 
MERASLIQKA KLAEQAERYE DMAAFMKSAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR 

        70         80         90        100        110        120 
VLSSIEQKSN EESSEEKGPE VQEYREKVET ELRGVCDTVL GLLDTHLIKE AGDAESRVFY 

       130        140        150        160        170        180 
LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH 

       190        200        210        220        230        240 
YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG 


EAPEEPQS

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal skin.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC120373 mRNA. Translation: AAI20374.1.
IPIIPI00715354.
RefSeqNP_001069380.1. NM_001075912.1.
UniGeneBt.9957.

3D structure databases

ProteinModelPortalQ0VC36.
SMRQ0VC36. Positions 1-231.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000012154.

Proteomic databases

PaxDbQ0VC36.
PRIDEQ0VC36.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000012154; ENSBTAP00000012154; ENSBTAG00000009223.
GeneID528453.
KEGGbta:528453.

Organism-specific databases

CTD2810.

Phylogenomic databases

eggNOGCOG5040.
GeneTreeENSGT00690000101991.
HOGENOMHOG000240379.
HOVERGENHBG050423.
InParanoidQ0VC36.
KOK06644.
OMAAFMKSAV.
OrthoDBEOG4XH00X.

Family and domain databases

Gene3D1.20.190.20. 1 hit.
InterProIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERPTHR18860. PTHR18860. 1 hit.
PfamPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFPIRSF000868. 14-3-3. 1 hit.
PRINTSPR00305. 1433ZETA.
SMARTSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMSSF48445. 14-3-3. 1 hit.
PROSITEPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20874828.

Entry information

Entry name1433S_BOVIN
AccessionPrimary (citable) accession number: Q0VC36
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: September 5, 2006
Last modified: May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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