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Protein

DNA polymerase subunit gamma-2, mitochondrial

Gene

POLG2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase subunit gamma-2, mitochondrial (EC:2.7.7.7)
Alternative name(s):
Mitochondrial DNA polymerase accessory subunit
MtPolB
PolG-beta
Gene namesi
Name:POLG2
Synonyms:MTPOLB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 485DNA polymerase subunit gamma-2, mitochondrialPRO_0000285578
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ0VC30.
PRIDEiQ0VC30.

Interactioni

Subunit structurei

Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024509.

Structurei

3D structure databases

ProteinModelPortaliQ0VC30.
SMRiQ0VC30. Positions 67-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2298. Eukaryota.
COG0423. LUCA.
GeneTreeiENSGT00390000000244.
HOGENOMiHOG000049133.
HOVERGENiHBG051401.
InParanoidiQ0VC30.
KOiK02333.
OMAiLYYNFPW.
OrthoDBiEOG7S7SFV.
TreeFamiTF103005.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR027031. Gly-tRNA_synthase/POLG2.
IPR027030. POLG2.
[Graphical view]
PANTHERiPTHR10745. PTHR10745. 1 hit.
PTHR10745:SF8. PTHR10745:SF8. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VC30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSAPAIRAC QRICRCLLSG FGGQVDGRQP EQLSKGTGSF VGPVRSQAEL
60 70 80 90 100
PRNEPREAPE SGGEGSEPLV EICRKRRFLS GTKQQLSRDS LLNGCHPGLG
110 120 130 140 150
PLGIELRKNL AAEWWSSVVV FREQVFPVDA LHREPGPSLP VDNGFRLVSA
160 170 180 190 200
ETLREILQDK ELSKEQLVAF LENLLNTSGK LRENLLHGAL EHYVSYLDLV
210 220 230 240 250
NKRLPFGLAQ IGACFHPVSD TKQTPDGVKR IGEKTEASLV WFTSARTASQ
260 270 280 290 300
WLDFWLRHRL LWWRKFAMSP SNFSSGDCQD EAGRKGNRLY YNFPWGKEPI
310 320 330 340 350
ETLWNLGDHE LLHMYPGSVA QVHGRDGRKN VVPSVLSING DLDRGMLAYL
360 370 380 390 400
YDSFQLTENS FTRKKDLHRK VLKLHPCLAP IKAALDVGRG PTVELRQVCQ
410 420 430 440 450
GLFNELLENG ISVWPGYLET VQSSLEQLYS KYDEMSILFT VLITEATLEN
460 470 480
GLIQLRSRDT TMKEMMHISK VKDFLTKYIS SAKNV
Length:485
Mass (Da):54,663
Last modified:September 5, 2006 - v1
Checksum:i271DF903661C2C48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120380 mRNA. Translation: AAI20381.1.
RefSeqiNP_001068659.1. NM_001075191.1.
UniGeneiBt.52381.

Genome annotation databases

EnsembliENSBTAT00000024509; ENSBTAP00000024509; ENSBTAG00000018420.
GeneIDi505152.
KEGGibta:505152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120380 mRNA. Translation: AAI20381.1.
RefSeqiNP_001068659.1. NM_001075191.1.
UniGeneiBt.52381.

3D structure databases

ProteinModelPortaliQ0VC30.
SMRiQ0VC30. Positions 67-485.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024509.

Proteomic databases

PaxDbiQ0VC30.
PRIDEiQ0VC30.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000024509; ENSBTAP00000024509; ENSBTAG00000018420.
GeneIDi505152.
KEGGibta:505152.

Organism-specific databases

CTDi11232.

Phylogenomic databases

eggNOGiKOG2298. Eukaryota.
COG0423. LUCA.
GeneTreeiENSGT00390000000244.
HOGENOMiHOG000049133.
HOVERGENiHBG051401.
InParanoidiQ0VC30.
KOiK02333.
OMAiLYYNFPW.
OrthoDBiEOG7S7SFV.
TreeFamiTF103005.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR027031. Gly-tRNA_synthase/POLG2.
IPR027030. POLG2.
[Graphical view]
PANTHERiPTHR10745. PTHR10745. 1 hit.
PTHR10745:SF8. PTHR10745:SF8. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal skin.

Entry informationi

Entry nameiDPOG2_BOVIN
AccessioniPrimary (citable) accession number: Q0VC30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 5, 2006
Last modified: June 8, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.