Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA polymerase subunit gamma-2, mitochondrial

Gene

POLG2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase subunit gamma-2, mitochondrial (EC:2.7.7.7)
Alternative name(s):
Mitochondrial DNA polymerase accessory subunit
MtPolB
PolG-beta
Gene namesi
Name:POLG2
Synonyms:MTPOLB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:33123 POLG2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000285578? – 485DNA polymerase subunit gamma-2, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ0VC30
PRIDEiQ0VC30

Expressioni

Gene expression databases

BgeeiENSBTAG00000018420

Interactioni

Subunit structurei

Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024509

Structurei

3D structure databases

ProteinModelPortaliQ0VC30
SMRiQ0VC30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2298 Eukaryota
COG0423 LUCA
GeneTreeiENSGT00390000000244
HOGENOMiHOG000049133
HOVERGENiHBG051401
InParanoidiQ0VC30
KOiK02333
OMAiKEMMHIS
OrthoDBiEOG091G0B28
TreeFamiTF103005

Family and domain databases

Gene3Di3.40.50.800, 1 hit
InterProiView protein in InterPro
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR027031 Gly-tRNA_synthase/POLG2
IPR027030 POLG2
PANTHERiPTHR10745 PTHR10745, 1 hit
PTHR10745:SF8 PTHR10745:SF8, 1 hit
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VC30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSAPAIRAC QRICRCLLSG FGGQVDGRQP EQLSKGTGSF VGPVRSQAEL
60 70 80 90 100
PRNEPREAPE SGGEGSEPLV EICRKRRFLS GTKQQLSRDS LLNGCHPGLG
110 120 130 140 150
PLGIELRKNL AAEWWSSVVV FREQVFPVDA LHREPGPSLP VDNGFRLVSA
160 170 180 190 200
ETLREILQDK ELSKEQLVAF LENLLNTSGK LRENLLHGAL EHYVSYLDLV
210 220 230 240 250
NKRLPFGLAQ IGACFHPVSD TKQTPDGVKR IGEKTEASLV WFTSARTASQ
260 270 280 290 300
WLDFWLRHRL LWWRKFAMSP SNFSSGDCQD EAGRKGNRLY YNFPWGKEPI
310 320 330 340 350
ETLWNLGDHE LLHMYPGSVA QVHGRDGRKN VVPSVLSING DLDRGMLAYL
360 370 380 390 400
YDSFQLTENS FTRKKDLHRK VLKLHPCLAP IKAALDVGRG PTVELRQVCQ
410 420 430 440 450
GLFNELLENG ISVWPGYLET VQSSLEQLYS KYDEMSILFT VLITEATLEN
460 470 480
GLIQLRSRDT TMKEMMHISK VKDFLTKYIS SAKNV
Length:485
Mass (Da):54,663
Last modified:September 5, 2006 - v1
Checksum:i271DF903661C2C48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120380 mRNA Translation: AAI20381.1
RefSeqiNP_001068659.1, NM_001075191.1
UniGeneiBt.52381

Genome annotation databases

EnsembliENSBTAT00000024509; ENSBTAP00000024509; ENSBTAG00000018420
GeneIDi505152
KEGGibta:505152

Similar proteinsi

Entry informationi

Entry nameiDPOG2_BOVIN
AccessioniPrimary (citable) accession number: Q0VC30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health