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Protein

Neuromedin-S

Gene

NMS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-BTA-375276 Peptide ligand-binding receptors
R-BTA-416476 G alpha (q) signalling events
R-BTA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-S
Gene namesi
Name:NMS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:32136 NMS

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000026247526 – 64By similarityAdd BLAST39
PropeptideiPRO_000026247665 – 100By similarityAdd BLAST36
PropeptideiPRO_0000262477101 – 103By similarity3
PeptideiPRO_0000262478104 – 136Neuromedin-SAdd BLAST33
PropeptideiPRO_0000262479139 – 145By similarity7

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei136Asparagine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ0VBW8

Expressioni

Gene expression databases

BgeeiENSBTAG00000034184

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045486

Family & Domainsi

Sequence similaritiesi

Belongs to the NmU family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX42 Eukaryota
ENOG4111CPK LUCA
GeneTreeiENSGT00510000049213
HOGENOMiHOG000060184
HOVERGENiHBG082033
InParanoidiQ0VBW8
OMAiNRRMKRF
OrthoDBiEOG091G0YD0
TreeFamiTF338319

Family and domain databases

InterProiView protein in InterPro
IPR018070 Neuromedin-U_amidation-site
PROSITEiView protein in PROSITE
PS00967 NMU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VBW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYLAQFPSI LAIYCFCLLQ IPSSGFPRPL ADASDGLDIV KFEQMAYWAS
60 70 80 90 100
LSRQPKDNQD IYKRFLFHYS RTQEPAHPVK TGFPPVHPLM RLAAKLADRR
110 120 130 140
MKTFWRRDSR ATAADFTKKD YTATLGRPFF LFRPRNGRNL DFDTW
Length:145
Mass (Da):16,986
Last modified:September 5, 2006 - v1
Checksum:i79BD16B164EE551F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120470 mRNA Translation: AAI20471.1
RefSeqiNP_001070990.1, NM_001077522.2
UniGeneiBt.74246

Genome annotation databases

EnsembliENSBTAT00000048447; ENSBTAP00000045486; ENSBTAG00000034184
GeneIDi768331
KEGGibta:768331

Similar proteinsi

Entry informationi

Entry nameiNMS_BOVIN
AccessioniPrimary (citable) accession number: Q0VBW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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