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Protein

Neuromedin-S

Gene

NMS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-416476. G alpha (q) signalling events.
R-BTA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-S
Gene namesi
Name:NMS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Propeptidei26 – 6439By similarityPRO_0000262475Add
BLAST
Propeptidei65 – 10036By similarityPRO_0000262476Add
BLAST
Propeptidei101 – 1033By similarityPRO_0000262477
Peptidei104 – 13633Neuromedin-SPRO_0000262478Add
BLAST
Propeptidei139 – 1457By similarityPRO_0000262479

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei136 – 1361Asparagine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ0VBW8.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045486.

Family & Domainsi

Sequence similaritiesi

Belongs to the NmU family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX42. Eukaryota.
ENOG4111CPK. LUCA.
GeneTreeiENSGT00510000049213.
HOGENOMiHOG000060184.
HOVERGENiHBG082033.
InParanoidiQ0VBW8.
OMAiNRRMKRF.
OrthoDBiEOG091G0YD0.
TreeFamiTF338319.

Family and domain databases

InterProiIPR018070. Neuromedin-U_amidation-site.
[Graphical view]
PROSITEiPS00967. NMU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VBW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYLAQFPSI LAIYCFCLLQ IPSSGFPRPL ADASDGLDIV KFEQMAYWAS
60 70 80 90 100
LSRQPKDNQD IYKRFLFHYS RTQEPAHPVK TGFPPVHPLM RLAAKLADRR
110 120 130 140
MKTFWRRDSR ATAADFTKKD YTATLGRPFF LFRPRNGRNL DFDTW
Length:145
Mass (Da):16,986
Last modified:September 5, 2006 - v1
Checksum:i79BD16B164EE551F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120470 mRNA. Translation: AAI20471.1.
RefSeqiNP_001070990.1. NM_001077522.2.
UniGeneiBt.74246.

Genome annotation databases

EnsembliENSBTAT00000048447; ENSBTAP00000045486; ENSBTAG00000034184.
GeneIDi768331.
KEGGibta:768331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120470 mRNA. Translation: AAI20471.1.
RefSeqiNP_001070990.1. NM_001077522.2.
UniGeneiBt.74246.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045486.

Proteomic databases

PaxDbiQ0VBW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000048447; ENSBTAP00000045486; ENSBTAG00000034184.
GeneIDi768331.
KEGGibta:768331.

Organism-specific databases

CTDi129521.

Phylogenomic databases

eggNOGiENOG410IX42. Eukaryota.
ENOG4111CPK. LUCA.
GeneTreeiENSGT00510000049213.
HOGENOMiHOG000060184.
HOVERGENiHBG082033.
InParanoidiQ0VBW8.
OMAiNRRMKRF.
OrthoDBiEOG091G0YD0.
TreeFamiTF338319.

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-416476. G alpha (q) signalling events.
R-BTA-418594. G alpha (i) signalling events.

Family and domain databases

InterProiIPR018070. Neuromedin-U_amidation-site.
[Graphical view]
PROSITEiPS00967. NMU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNMS_BOVIN
AccessioniPrimary (citable) accession number: Q0VBW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: September 5, 2006
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.