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Q0VBU9

- PPC1A_MOUSE

UniProt

Q0VBU9 - PPC1A_MOUSE

Protein

Phosphatidate phosphatase PPAPDC1A

Gene

Ppapdc1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol By similarity.By similarity

    Catalytic activityi

    A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

    Enzyme regulationi

    Inhibited by N-ethylmaleimide.By similarity

    GO - Molecular functioni

    1. phosphatidate phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. phospholipid dephosphorylation Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_210240. Role of phospholipids in phagocytosis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidate phosphatase PPAPDC1A (EC:3.1.3.4)
    Alternative name(s):
    Phosphatidic acid phosphatase type 2 domain-containing protein 1A
    Gene namesi
    Name:Ppapdc1a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2685936. Ppapdc1a.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271Phosphatidate phosphatase PPAPDC1APRO_0000286944Add
    BLAST

    Proteomic databases

    PRIDEiQ0VBU9.

    PTM databases

    PhosphoSiteiQ0VBU9.

    Expressioni

    Gene expression databases

    BgeeiQ0VBU9.
    GenevestigatoriQ0VBU9.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000091557.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0VBU9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei49 – 6921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni102 – 1109Phosphatase sequence motif IBy similarity
    Regioni143 – 1464Phosphatase sequence motif IIBy similarity
    Regioni195 – 20511Phosphatase sequence motif IIIBy similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0671.
    GeneTreeiENSGT00510000046723.
    HOGENOMiHOG000215098.
    HOVERGENiHBG056764.
    InParanoidiQ0VBU9.
    OMAiNTACHKS.
    OrthoDBiEOG79CZ0D.
    PhylomeDBiQ0VBU9.
    TreeFamiTF323722.

    Family and domain databases

    Gene3Di1.20.144.10. 1 hit.
    InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
    IPR028668. PPAPDC1A/PPAPDC1B.
    [Graphical view]
    PANTHERiPTHR10165:SF90. PTHR10165:SF90. 1 hit.
    PfamiPF01569. PAP2. 1 hit.
    [Graphical view]
    SMARTiSM00014. acidPPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48317. SSF48317. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0VBU9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRELAIEIGV RALLFGVFVF TEFLDPFQRV IQPEEIWLYK NPLVQSDNIP    50
    TRLMFAISFL TPLAVICVVK IIRRTDKTEI KEAFLAVSLA LALNGVCTNT 100
    IKLIVGRPRP DFFYRCFPDG VMNSEMRCTG DPDLVSEGRK SFPSIHSSFA 150
    FSGLGFTTFY LAGKLHCFTE SGRGKSWRLC AAILPLYCAM MIALSRMCDY 200
    KHHWQDSFVG GVIGLIFAYI CYRQHYPPLA NTACHKPYVS LRVPTSLKKE 250
    ERPTADSAPS LPLEGITEGP V 271
    Length:271
    Mass (Da):30,444
    Last modified:September 5, 2006 - v1
    Checksum:i944F8A1561DDA97B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC120497 mRNA. Translation: AAI20498.1.
    CCDSiCCDS40154.1.
    RefSeqiNP_001074432.1. NM_001080963.1.
    UniGeneiMm.39184.

    Genome annotation databases

    EnsembliENSMUST00000094018; ENSMUSP00000091557; ENSMUSG00000070366.
    GeneIDi381925.
    KEGGimmu:381925.
    UCSCiuc009jzl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC120497 mRNA. Translation: AAI20498.1 .
    CCDSi CCDS40154.1.
    RefSeqi NP_001074432.1. NM_001080963.1.
    UniGenei Mm.39184.

    3D structure databases

    ProteinModelPortali Q0VBU9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000091557.

    PTM databases

    PhosphoSitei Q0VBU9.

    Proteomic databases

    PRIDEi Q0VBU9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000094018 ; ENSMUSP00000091557 ; ENSMUSG00000070366 .
    GeneIDi 381925.
    KEGGi mmu:381925.
    UCSCi uc009jzl.1. mouse.

    Organism-specific databases

    CTDi 196051.
    MGIi MGI:2685936. Ppapdc1a.

    Phylogenomic databases

    eggNOGi COG0671.
    GeneTreei ENSGT00510000046723.
    HOGENOMi HOG000215098.
    HOVERGENi HBG056764.
    InParanoidi Q0VBU9.
    OMAi NTACHKS.
    OrthoDBi EOG79CZ0D.
    PhylomeDBi Q0VBU9.
    TreeFami TF323722.

    Enzyme and pathway databases

    Reactomei REACT_210240. Role of phospholipids in phagocytosis.

    Miscellaneous databases

    NextBioi 402755.
    PROi Q0VBU9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q0VBU9.
    Genevestigatori Q0VBU9.

    Family and domain databases

    Gene3Di 1.20.144.10. 1 hit.
    InterProi IPR000326. P_Acid_Pase_2/haloperoxidase.
    IPR028668. PPAPDC1A/PPAPDC1B.
    [Graphical view ]
    PANTHERi PTHR10165:SF90. PTHR10165:SF90. 1 hit.
    Pfami PF01569. PAP2. 1 hit.
    [Graphical view ]
    SMARTi SM00014. acidPPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48317. SSF48317. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiPPC1A_MOUSE
    AccessioniPrimary (citable) accession number: Q0VBU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3