SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q0VBU9

- PPC1A_MOUSE

UniProt

Q0VBU9 - PPC1A_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Phosphatidate phosphatase PPAPDC1A
Gene
Ppapdc1a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol By similarity.

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

Enzyme regulationi

Inhibited by N-ethylmaleimide By similarity.

GO - Molecular functioni

  1. phosphatidate phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. phospholipid dephosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiREACT_210240. Role of phospholipids in phagocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate phosphatase PPAPDC1A (EC:3.1.3.4)
Alternative name(s):
Phosphatidic acid phosphatase type 2 domain-containing protein 1A
Gene namesi
Name:Ppapdc1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2685936. Ppapdc1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421Helical; Reviewed prediction
Add
BLAST
Transmembranei49 – 6921Helical; Reviewed prediction
Add
BLAST
Transmembranei84 – 10421Helical; Reviewed prediction
Add
BLAST
Transmembranei142 – 16221Helical; Reviewed prediction
Add
BLAST
Transmembranei179 – 19921Helical; Reviewed prediction
Add
BLAST
Transmembranei202 – 22221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Phosphatidate phosphatase PPAPDC1A
PRO_0000286944Add
BLAST

Proteomic databases

PRIDEiQ0VBU9.

PTM databases

PhosphoSiteiQ0VBU9.

Expressioni

Gene expression databases

BgeeiQ0VBU9.
GenevestigatoriQ0VBU9.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091557.

Structurei

3D structure databases

ProteinModelPortaliQ0VBU9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni102 – 1109Phosphatase sequence motif I By similarity
Regioni143 – 1464Phosphatase sequence motif II By similarity
Regioni195 – 20511Phosphatase sequence motif III By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0671.
GeneTreeiENSGT00510000046723.
HOGENOMiHOG000215098.
HOVERGENiHBG056764.
InParanoidiQ0VBU9.
OMAiNTACHKS.
OrthoDBiEOG79CZ0D.
PhylomeDBiQ0VBU9.
TreeFamiTF323722.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
IPR028668. PPAPDC1A/PPAPDC1B.
[Graphical view]
PANTHERiPTHR10165:SF90. PTHR10165:SF90. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0VBU9-1 [UniParc]FASTAAdd to Basket

« Hide

MRELAIEIGV RALLFGVFVF TEFLDPFQRV IQPEEIWLYK NPLVQSDNIP    50
TRLMFAISFL TPLAVICVVK IIRRTDKTEI KEAFLAVSLA LALNGVCTNT 100
IKLIVGRPRP DFFYRCFPDG VMNSEMRCTG DPDLVSEGRK SFPSIHSSFA 150
FSGLGFTTFY LAGKLHCFTE SGRGKSWRLC AAILPLYCAM MIALSRMCDY 200
KHHWQDSFVG GVIGLIFAYI CYRQHYPPLA NTACHKPYVS LRVPTSLKKE 250
ERPTADSAPS LPLEGITEGP V 271
Length:271
Mass (Da):30,444
Last modified:September 5, 2006 - v1
Checksum:i944F8A1561DDA97B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC120497 mRNA. Translation: AAI20498.1.
CCDSiCCDS40154.1.
RefSeqiNP_001074432.1. NM_001080963.1.
UniGeneiMm.39184.

Genome annotation databases

EnsembliENSMUST00000094018; ENSMUSP00000091557; ENSMUSG00000070366.
GeneIDi381925.
KEGGimmu:381925.
UCSCiuc009jzl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC120497 mRNA. Translation: AAI20498.1 .
CCDSi CCDS40154.1.
RefSeqi NP_001074432.1. NM_001080963.1.
UniGenei Mm.39184.

3D structure databases

ProteinModelPortali Q0VBU9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000091557.

PTM databases

PhosphoSitei Q0VBU9.

Proteomic databases

PRIDEi Q0VBU9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000094018 ; ENSMUSP00000091557 ; ENSMUSG00000070366 .
GeneIDi 381925.
KEGGi mmu:381925.
UCSCi uc009jzl.1. mouse.

Organism-specific databases

CTDi 196051.
MGIi MGI:2685936. Ppapdc1a.

Phylogenomic databases

eggNOGi COG0671.
GeneTreei ENSGT00510000046723.
HOGENOMi HOG000215098.
HOVERGENi HBG056764.
InParanoidi Q0VBU9.
OMAi NTACHKS.
OrthoDBi EOG79CZ0D.
PhylomeDBi Q0VBU9.
TreeFami TF323722.

Enzyme and pathway databases

Reactomei REACT_210240. Role of phospholipids in phagocytosis.

Miscellaneous databases

NextBioi 402755.
PROi Q0VBU9.
SOURCEi Search...

Gene expression databases

Bgeei Q0VBU9.
Genevestigatori Q0VBU9.

Family and domain databases

Gene3Di 1.20.144.10. 1 hit.
InterProi IPR000326. P_Acid_Pase_2/haloperoxidase.
IPR028668. PPAPDC1A/PPAPDC1B.
[Graphical view ]
PANTHERi PTHR10165:SF90. PTHR10165:SF90. 1 hit.
Pfami PF01569. PAP2. 1 hit.
[Graphical view ]
SMARTi SM00014. acidPPc. 1 hit.
[Graphical view ]
SUPFAMi SSF48317. SSF48317. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPPC1A_MOUSE
AccessioniPrimary (citable) accession number: Q0VBU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi