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Q0VBU9 (PPC1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidate phosphatase PPAPDC1A

EC=3.1.3.4
Alternative name(s):
Phosphatidic acid phosphatase type 2 domain-containing protein 1A
Gene names
Name:Ppapdc1a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol By similarity.

Catalytic activity

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

Enzyme regulation

Inhibited by N-ethylmaleimide By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the PA-phosphatase related phosphoesterase family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processphospholipid dephosphorylation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionphosphatidate phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Phosphatidate phosphatase PPAPDC1A
PRO_0000286944

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane49 – 6921Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane142 – 16221Helical; Potential
Transmembrane179 – 19921Helical; Potential
Transmembrane202 – 22221Helical; Potential
Region102 – 1109Phosphatase sequence motif I By similarity
Region143 – 1464Phosphatase sequence motif II By similarity
Region195 – 20511Phosphatase sequence motif III By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0VBU9 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 944F8A1561DDA97B

FASTA27130,444
        10         20         30         40         50         60 
MRELAIEIGV RALLFGVFVF TEFLDPFQRV IQPEEIWLYK NPLVQSDNIP TRLMFAISFL 

        70         80         90        100        110        120 
TPLAVICVVK IIRRTDKTEI KEAFLAVSLA LALNGVCTNT IKLIVGRPRP DFFYRCFPDG 

       130        140        150        160        170        180 
VMNSEMRCTG DPDLVSEGRK SFPSIHSSFA FSGLGFTTFY LAGKLHCFTE SGRGKSWRLC 

       190        200        210        220        230        240 
AAILPLYCAM MIALSRMCDY KHHWQDSFVG GVIGLIFAYI CYRQHYPPLA NTACHKPYVS 

       250        260        270 
LRVPTSLKKE ERPTADSAPS LPLEGITEGP V 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC120497 mRNA. Translation: AAI20498.1.
CCDSCCDS40154.1.
RefSeqNP_001074432.1. NM_001080963.1.
UniGeneMm.39184.

3D structure databases

ProteinModelPortalQ0VBU9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000091557.

PTM databases

PhosphoSiteQ0VBU9.

Proteomic databases

PRIDEQ0VBU9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000094018; ENSMUSP00000091557; ENSMUSG00000070366.
GeneID381925.
KEGGmmu:381925.
UCSCuc009jzl.1. mouse.

Organism-specific databases

CTD196051.
MGIMGI:2685936. Ppapdc1a.

Phylogenomic databases

eggNOGCOG0671.
GeneTreeENSGT00510000046723.
HOGENOMHOG000215098.
HOVERGENHBG056764.
InParanoidQ0VBU9.
OMANTACHKS.
OrthoDBEOG79CZ0D.
PhylomeDBQ0VBU9.
TreeFamTF323722.

Gene expression databases

BgeeQ0VBU9.
GenevestigatorQ0VBU9.

Family and domain databases

Gene3D1.20.144.10. 1 hit.
InterProIPR000326. P_Acid_Pase_2/haloperoxidase.
IPR028668. PPAPDC1A/PPAPDC1B.
[Graphical view]
PANTHERPTHR10165:SF90. PTHR10165:SF90. 1 hit.
PfamPF01569. PAP2. 1 hit.
[Graphical view]
SMARTSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMSSF48317. SSF48317. 1 hit.
ProtoNetSearch...

Other

NextBio402755.
PROQ0VBU9.
SOURCESearch...

Entry information

Entry namePPC1A_MOUSE
AccessionPrimary (citable) accession number: Q0VBU9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot