Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin, type II cytoskeletal 80

Gene

Krt80

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei334 – 3341Stutter

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 80
Alternative name(s):
Cytokeratin-80
Short name:
CK-80
Keratin-80
Short name:
K80
Type-II keratin Kb20
Gene namesi
Name:Krt80
Synonyms:Kb20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1921377. Krt80.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Keratin, type II cytoskeletal 80PRO_0000314897Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ0VBK2.
PaxDbiQ0VBK2.
PRIDEiQ0VBK2.

PTM databases

iPTMnetiQ0VBK2.
PhosphoSiteiQ0VBK2.

Expressioni

Gene expression databases

BgeeiQ0VBK2.
CleanExiMM_KRT80.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

IntActiQ0VBK2. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ0VBK2.
SMRiQ0VBK2. Positions 295-389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 8282HeadAdd
BLAST
Regioni82 – 11837Coil 1AAdd
BLAST
Regioni83 – 390308RodAdd
BLAST
Regioni119 – 13517Linker 1Add
BLAST
Regioni136 – 22792Coil 1BAdd
BLAST
Regioni228 – 25124Linker 12Add
BLAST
Regioni252 – 390139Coil 2Add
BLAST
Regioni391 – 45262TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGH5. Eukaryota.
ENOG411183I. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ0VBK2.
KOiK07605.
OMAiMACRSCV.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ0VBK2.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VBK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYRSCVVGF SSLSGCEMTP AGSPQPGTSG WGSCGLPGPG FSSRSLTSCR
60 70 80 90 100
PAGTIPKVTV NPSLLVPLDL KVDPAVQQQK NQEKEEMKAL NDKFASLIGK
110 120 130 140 150
VQALEQRNQL LETRWSFLQG QGSATFDLSH HYETFQGRLQ EELRKVSQER
160 170 180 190 200
GQLEANLLQV LEKVEEFRVR YEDEISKRTD LEFTFVQLKK DLDAECLRRT
210 220 230 240 250
ELETKLKGLQ GFLELMRTVY EQELKDLTAQ VKDVSVTVGL DSRCHIDLSG
260 270 280 290 300
IVEEVKAQYD AIAARSLEEA EAYSRSQLEE RAARSAEFGN SLQSSRCEIA
310 320 330 340 350
DLNVRIQKLR SQIVSVKSHC LKLEENIKVA EEQGELAFQD AKDKMAQLEN
360 370 380 390 400
ALQKAKQDMA RQLREYQDLM NTKLALDIEI ATYHKLMEGE ESRMDLPSAT
410 420 430 440 450
VVSTVKSGCR TTASKSGLTK TSSRKKKNRR GPVIKITEMS EKYLSQESEA

SE
Length:452
Mass (Da):50,660
Last modified:September 5, 2006 - v1
Checksum:iC40B0C724A43720C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119366 mRNA. Translation: AAI19367.1.
BC120601 mRNA. Translation: AAI20602.1.
CCDSiCCDS37216.1.
RefSeqiNP_083046.2. NM_028770.2.
UniGeneiMm.440055.

Genome annotation databases

EnsembliENSMUST00000077196; ENSMUSP00000076437; ENSMUSG00000037185.
GeneIDi74127.
KEGGimmu:74127.
UCSCiuc007xta.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119366 mRNA. Translation: AAI19367.1.
BC120601 mRNA. Translation: AAI20602.1.
CCDSiCCDS37216.1.
RefSeqiNP_083046.2. NM_028770.2.
UniGeneiMm.440055.

3D structure databases

ProteinModelPortaliQ0VBK2.
SMRiQ0VBK2. Positions 295-389.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ0VBK2. 1 interaction.

PTM databases

iPTMnetiQ0VBK2.
PhosphoSiteiQ0VBK2.

Proteomic databases

MaxQBiQ0VBK2.
PaxDbiQ0VBK2.
PRIDEiQ0VBK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077196; ENSMUSP00000076437; ENSMUSG00000037185.
GeneIDi74127.
KEGGimmu:74127.
UCSCiuc007xta.1. mouse.

Organism-specific databases

CTDi144501.
MGIiMGI:1921377. Krt80.

Phylogenomic databases

eggNOGiENOG410IGH5. Eukaryota.
ENOG411183I. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ0VBK2.
KOiK07605.
OMAiMACRSCV.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ0VBK2.
TreeFamiTF317854.

Miscellaneous databases

PROiQ0VBK2.
SOURCEiSearch...

Gene expression databases

BgeeiQ0VBK2.
CleanExiMM_KRT80.

Family and domain databases

InterProiIPR001664. IF.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Pancreas.

Entry informationi

Entry nameiK2C80_MOUSE
AccessioniPrimary (citable) accession number: Q0VBK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.