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Protein

Keratin, type II cytoskeletal 80

Gene

Krt80

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei334Stutter1

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 80
Alternative name(s):
Cytokeratin-80
Short name:
CK-80
Keratin-80
Short name:
K80
Type-II keratin Kb20
Gene namesi
Name:Krt80
Synonyms:Kb20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1921377. Krt80.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148971 – 452Keratin, type II cytoskeletal 80Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ0VBK2.
PeptideAtlasiQ0VBK2.
PRIDEiQ0VBK2.

PTM databases

iPTMnetiQ0VBK2.
PhosphoSitePlusiQ0VBK2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037185.
CleanExiMM_KRT80.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

IntActiQ0VBK2. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ0VBK2.
SMRiQ0VBK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 82HeadAdd BLAST82
Regioni82 – 118Coil 1AAdd BLAST37
Regioni83 – 390RodAdd BLAST308
Regioni119 – 135Linker 1Add BLAST17
Regioni136 – 227Coil 1BAdd BLAST92
Regioni228 – 251Linker 12Add BLAST24
Regioni252 – 390Coil 2Add BLAST139
Regioni391 – 452TailAdd BLAST62

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGH5. Eukaryota.
ENOG411183I. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ0VBK2.
KOiK07605.
OMAiSCEVTPV.
OrthoDBiEOG091G0AOP.
PhylomeDBiQ0VBK2.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VBK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYRSCVVGF SSLSGCEMTP AGSPQPGTSG WGSCGLPGPG FSSRSLTSCR
60 70 80 90 100
PAGTIPKVTV NPSLLVPLDL KVDPAVQQQK NQEKEEMKAL NDKFASLIGK
110 120 130 140 150
VQALEQRNQL LETRWSFLQG QGSATFDLSH HYETFQGRLQ EELRKVSQER
160 170 180 190 200
GQLEANLLQV LEKVEEFRVR YEDEISKRTD LEFTFVQLKK DLDAECLRRT
210 220 230 240 250
ELETKLKGLQ GFLELMRTVY EQELKDLTAQ VKDVSVTVGL DSRCHIDLSG
260 270 280 290 300
IVEEVKAQYD AIAARSLEEA EAYSRSQLEE RAARSAEFGN SLQSSRCEIA
310 320 330 340 350
DLNVRIQKLR SQIVSVKSHC LKLEENIKVA EEQGELAFQD AKDKMAQLEN
360 370 380 390 400
ALQKAKQDMA RQLREYQDLM NTKLALDIEI ATYHKLMEGE ESRMDLPSAT
410 420 430 440 450
VVSTVKSGCR TTASKSGLTK TSSRKKKNRR GPVIKITEMS EKYLSQESEA

SE
Length:452
Mass (Da):50,660
Last modified:September 5, 2006 - v1
Checksum:iC40B0C724A43720C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119366 mRNA. Translation: AAI19367.1.
BC120601 mRNA. Translation: AAI20602.1.
CCDSiCCDS37216.1.
RefSeqiNP_083046.2. NM_028770.2.
UniGeneiMm.440055.

Genome annotation databases

EnsembliENSMUST00000077196; ENSMUSP00000076437; ENSMUSG00000037185.
GeneIDi74127.
KEGGimmu:74127.
UCSCiuc007xta.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119366 mRNA. Translation: AAI19367.1.
BC120601 mRNA. Translation: AAI20602.1.
CCDSiCCDS37216.1.
RefSeqiNP_083046.2. NM_028770.2.
UniGeneiMm.440055.

3D structure databases

ProteinModelPortaliQ0VBK2.
SMRiQ0VBK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ0VBK2. 1 interactor.

PTM databases

iPTMnetiQ0VBK2.
PhosphoSitePlusiQ0VBK2.

Proteomic databases

PaxDbiQ0VBK2.
PeptideAtlasiQ0VBK2.
PRIDEiQ0VBK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077196; ENSMUSP00000076437; ENSMUSG00000037185.
GeneIDi74127.
KEGGimmu:74127.
UCSCiuc007xta.1. mouse.

Organism-specific databases

CTDi144501.
MGIiMGI:1921377. Krt80.

Phylogenomic databases

eggNOGiENOG410IGH5. Eukaryota.
ENOG411183I. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ0VBK2.
KOiK07605.
OMAiSCEVTPV.
OrthoDBiEOG091G0AOP.
PhylomeDBiQ0VBK2.
TreeFamiTF317854.

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ0VBK2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037185.
CleanExiMM_KRT80.

Family and domain databases

InterProiIPR001664. IF.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK2C80_MOUSE
AccessioniPrimary (citable) accession number: Q0VBK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.