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Protein
Submitted name:

Transient receptor potential cation channel, subfamily C, member 4

Gene

Trpc4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelSAAS annotation, ReceptorImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Transient receptor potential cation channel, subfamily C, member 4Imported
Submitted name:
Transient receptor potential cation channel, subfamily C, member 4, isoform CRA_cImported
Gene namesi
Name:Trpc4Imported
ORF Names:mCG_1661Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:109525 Trpc4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei326 – 350HelicalSequence analysisAdd BLAST25
Transmembranei362 – 381HelicalSequence analysisAdd BLAST20
Transmembranei401 – 418HelicalSequence analysisAdd BLAST18
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21
Transmembranei479 – 498HelicalSequence analysisAdd BLAST20
Transmembranei519 – 541HelicalSequence analysisAdd BLAST23
Transmembranei561 – 583HelicalSequence analysisAdd BLAST23
Transmembranei595 – 617HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000027748

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 173ANK_REP_REGIONInterPro annotationAdd BLAST33
Repeati141 – 173ANKPROSITE-ProRule annotationAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili227 – 254Sequence analysisAdd BLAST28
Coiled coili722 – 742Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the transient receptor (TC 1.A.4) family. [View classification]SAAS annotation

Keywords - Domaini

ANK repeatPROSITE-ProRule annotationSAAS annotation, Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
HOVERGENiHBG068337
KOiK04967
OMAiCILVDHR
OrthoDBiEOG091G029I

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR013555 TRP_dom
IPR005460 TRPC4_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF25 PTHR10117:SF25, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01645 TRPCHANNEL4
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q0VB97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQFYYKRNV NAPYRDRIPL RIVRAESELS PSEKAYLNAV EKGDYASVKK
60 70 80 90 100
SLEEAEIYFK ININCIDPLG RTALLIAIEN ENLELIELLL SFNVYVGDAL
110 120 130 140 150
LHAIRKEVVG AVELLLNHKK PSGEKQVPPI LLDKQFSEFT PDITPIILAA
160 170 180 190 200
HTNNYEIIKL LVQKGVSVPR PHEVRCNCVE CVSSSDVDSL RHSRSRLNIY
210 220 230 240 250
KALASPSLIA LSSEDPFLTA FQLSWELQEL SKVENEFKSE YEELSRQCKQ
260 270 280 290 300
FAKDLLDQTR SSRELEIILN YRDDNSLIEE QSGNDLARLK LAIKYRQKEF
310 320 330 340 350
VAQPNCQQLL ASRWYDEFPG WRRRHWAVKM VTCFIIGLLF PVFSVCYLIA
360 370 380 390 400
PKSPLGLFIR KPFIKFICHT ASYLTFLFLL LLASQHIDRS DLNRQGPPPT
410 420 430 440 450
IVEWMILPWV LGFIWGEIKQ MWDGGLQDYI HDWWNLMDFV MNSLYLATIS
460 470 480 490 500
LKIVAFVKYS ALNPRESWDM WHPTLVAEAL FAIANIFSSL RLISLFTANS
510 520 530 540 550
HLGPLQISLG RMLLDILKFL FIYCLVLLAF ANGLNQLYFY YEETKGLSCK
560 570 580 590 600
GIRCEKQNNA FSTLFETLQS LFWSIFGLIN LYVTNVKAQH EFTEFVGATM
610 620 630 640 650
FGTYNVISLV VLLNMLIAMM NNSYQLIADH ADIEWKFART KLWMSYFEEG
660 670 680 690 700
GTLPTPFNVI PSPKSLWYLV KWIWTHLCKK KMRRKPESFG TIGRRAADNL
710 720 730 740 750
RRHHQYQEVM RNLVKRYVAA MIREAKTEEG LTEENVKELK QDISSFRFEV
760 770 780 790 800
LGLLRGSKLS TIQSANAASS ADSDEKSQSE GNGKDKRKNL SLFDLTTLIH
810 820 830 840 850
PRSAAIASER HNLSNGSALV VQEPPREKQR KVNFVADIKN FGLFHRRSKQ
860 870 880 890 900
NAAEQNANQI FSVSEEITRQ QAAGALERNI ELESKGLASR GDRSIPGLNE
910 920 930 940 950
QCVLVDHRER NTDTLGLQVG KRVCSTFKSE KVVVEDTVPI IPKEKHAHEE
960 970
DSSIDYDLSP TDTAAHEDYV TTRL
Length:974
Mass (Da):111,575
Last modified:September 5, 2006 - v1
Checksum:i2D0BB2F235F5F8D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120729 mRNA Translation: AAI20730.1
BC131915 mRNA Translation: AAI31916.1
CH466530 Genomic DNA Translation: EDL35256.1
RefSeqiNP_058680.1, NM_016984.3
XP_006501359.1, XM_006501296.3
UniGeneiMm.10100
Mm.489865

Genome annotation databases

GeneIDi22066
KEGGimmu:22066

Similar proteinsi

Entry informationi

Entry nameiQ0VB97_MOUSE
AccessioniPrimary (citable) accession number: Q0VB97
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health