ID   Q0VAV5_MOUSE            Unreviewed;      1268 AA.
AC   Q0VAV5;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   24-JAN-2024, entry version 124.
DE   SubName: Full=RAS protein activator like 2 {ECO:0000313|EMBL:AAI20903.1};
GN   Name=Rasal2 {ECO:0000313|EMBL:AAI20903.1,
GN   ECO:0000313|MGI:MGI:2443881};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI20903.1};
RN   [1] {ECO:0000313|EMBL:AAI20903.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PCR rescued clones {ECO:0000313|EMBL:AAI20903.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC120902; AAI20903.1; -; mRNA.
DR   RefSeq; NP_808312.3; NM_177644.5.
DR   AlphaFoldDB; Q0VAV5; -.
DR   IntAct; Q0VAV5; 1.
DR   MINT; Q0VAV5; -.
DR   DNASU; 226525; -.
DR   GeneID; 226525; -.
DR   AGR; MGI:2443881; -.
DR   CTD; 9462; -.
DR   MGI; MGI:2443881; Rasal2.
DR   OrthoDB; 22721at2759; -.
DR   BioGRID-ORCS; 226525; 3 hits in 77 CRISPR screens.
DR   ChiTaRS; Rasal2; mouse.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0060612; P:adipose tissue development; IMP:MGI.
DR   GO; GO:0010467; P:gene expression; IMP:MGI.
DR   GO; GO:0035264; P:multicellular organism growth; IMP:MGI.
DR   GO; GO:2000257; P:regulation of protein activation cascade; IMP:MGI.
DR   GO; GO:0002021; P:response to dietary excess; IMP:MGI.
DR   GO; GO:0009749; P:response to glucose; IMP:MGI.
DR   CDD; cd04013; C2_SynGAP_like; 1.
DR   CDD; cd05136; RasGAP_DAB2IP; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR021887; DAB2P_C.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194:SF52; RAS GTPASE-ACTIVATING PROTEIN NGAP; 1.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF12004; DAB2P_C; 1.
DR   Pfam; PF00616; RasGAP; 2.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR   Genevisible; Q0VAV5; MM.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT   DOMAIN          57..287
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          278..396
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          456..648
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          92..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          179..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          757..799
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          878..1027
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1040..1084
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1245..1268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1095..1181
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        143..167
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..215
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        757..779
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        902..916
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        930..963
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        964..983
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1040..1082
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1268 AA;  142714 MW;  B770CB1F05C0CCC0 CRC64;
     MFTGLESDSP LPPEDLDAVV PVSGAVAGGM LDRILLESVC QQQSWVRVFD VKGPPTHRLS
     CGQSPYTETT SWERKYCILT DSQLVLLNKE KEMPVEGQDQ QTDSTKGRCL RRTVSVPSEG
     QFPEYPQEGT TKLEVPAERS PRRRSISGTS TSEKPNSMDT ANTSPFKVPG FFSKRLKGSI
     KRTKSQSKLD RNTSFRLPSL RNADDRSRGL PKLKESRSHG SLLSPCSAVE CLDLGRGEPV
     SVKPLHSSIL GQDFCFEVTY LSGSKCFSCS SASERDKWME NLRRTVQPNK DNCRRAENVL
     RLWIIEAKDL APKKKYFCEL CLDDTLFART TSKTKADNIF WGEHFEFYSL PPLHSITVHI
     YKDVEKKKKK DKNNYVGLVN IPTASVTGRQ FVEKWYPVST PTPNKGKTGG PSIRIKSRFQ
     TITILPMEQY KEFAEFITSN YTMLCSVLEP VISVRNKEEL ACALVHILQS TGRAKDFLTD
     LVMSEVDRCG EHDVLIFREN TIATKSIEEY LKLVGQQYLH DALGEFIKAL YESDENCEVD
     PSKCSSSELM DHQSNLKMCC ELAFCKIINS YCVFPRELKE VFASWKQQCL NRGKQDISER
     LISASLFLRF LCPAIMSPSL FNLMQEYPDD RTSRTLTLIA KVIQNLANFA KFGNKEEYMA
     FMNDFLEHEW GGMKRFLLEI SNPDTISNTP GFDGYIDLGR ELSVLHSLLW EVVSQLDKGE
     NSFLQATVAK LGPLPRVLAD ITKSLTNPTP IQQQLRRFAE HSSSPNVSGS LSSGLQRICE
     DPTDSDLHKL KSPSQDNTDS YFRGKTLLLV QQASSQSMTY SEKDEKENSL PNGRSISLMD
     LQDTHAAQAE HASVMLDVPM RLAGSQLSIT QVASIKQLRE TQSTPQSAPQ VRRPLHPALN
     QPGSLQPLSF QNPVYHLNNP VPAMPKASAD SSLENLSTAS SRSQSNSEDF KLSGPSNSSM
     EDFTKRSSHS EDFSRRHTVP DRHIPLALPR QNSTGQSQIR KLDHSGLGAR AKAPPSLPHS
     ASLRSTGSMS VASAALMAEP VQNGSRSRQQ SSSSRESPVP KVRAIQRQQT QQVQSPVDSA
     TMSPVERTAA WVLNNGQYEE DVEETEQNQD EAKHAEKYEQ EITKLKERLR VSSRRLEEYE
     RRLLVQEQQM QKLLLEYKAR LEDSEERLRR QQEEKDSQMK SIISRLMAVE EELKKDHAEM
     QAVIDAKQKI IDAQEKRIVS LDSANTRLMS ALTQVKERYS MQVRNGISPT NPTKLSITEN
     GEFKNSSC
//