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Q0VAV5

- Q0VAV5_MOUSE

UniProt

Q0VAV5 - Q0VAV5_MOUSE

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Protein
Submitted name:

RAS protein activator like 2

Gene
Rasal2
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. Ras GTPase activator activity Source: RefGenome

GO - Biological processi

  1. negative regulation of Ras protein signal transduction Source: RefGenome
  2. positive regulation of Ras GTPase activity Source: RefGenome
  3. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activationSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
RAS protein activator like 2Imported
Gene namesi
Name:Rasal2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:2443881. Rasal2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. intrinsic component of the cytoplasmic side of the plasma membrane Source: RefGenome
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ0VAV5.
PRIDEiQ0VAV5.

PTM databases

PhosphoSiteiQ0VAV5.

Expressioni

Gene expression databases

GenevestigatoriQ0VAV5.

Interactioni

Protein-protein interaction databases

IntActiQ0VAV5. 1 interaction.
STRINGi10090.ENSMUSP00000077423.

Structurei

3D structure databases

ProteinModelPortaliQ0VAV5.
SMRiQ0VAV5. Positions 414-754.

Family & Domainsi

Sequence similaritiesi

Contains 1 PH domain.UniRule annotation
Contains PH domain.SAAS annotations

Phylogenomic databases

eggNOGiNOG245428.
HOGENOMiHOG000231979.
HOVERGENiHBG006492.
InParanoidiQ0VAV5.
KOiK17633.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR021887. DUF3498.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF12004. DUF3498. 1 hit.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VAV5-1 [UniParc]FASTAAdd to Basket

« Hide

MFTGLESDSP LPPEDLDAVV PVSGAVAGGM LDRILLESVC QQQSWVRVFD     50
VKGPPTHRLS CGQSPYTETT SWERKYCILT DSQLVLLNKE KEMPVEGQDQ 100
QTDSTKGRCL RRTVSVPSEG QFPEYPQEGT TKLEVPAERS PRRRSISGTS 150
TSEKPNSMDT ANTSPFKVPG FFSKRLKGSI KRTKSQSKLD RNTSFRLPSL 200
RNADDRSRGL PKLKESRSHG SLLSPCSAVE CLDLGRGEPV SVKPLHSSIL 250
GQDFCFEVTY LSGSKCFSCS SASERDKWME NLRRTVQPNK DNCRRAENVL 300
RLWIIEAKDL APKKKYFCEL CLDDTLFART TSKTKADNIF WGEHFEFYSL 350
PPLHSITVHI YKDVEKKKKK DKNNYVGLVN IPTASVTGRQ FVEKWYPVST 400
PTPNKGKTGG PSIRIKSRFQ TITILPMEQY KEFAEFITSN YTMLCSVLEP 450
VISVRNKEEL ACALVHILQS TGRAKDFLTD LVMSEVDRCG EHDVLIFREN 500
TIATKSIEEY LKLVGQQYLH DALGEFIKAL YESDENCEVD PSKCSSSELM 550
DHQSNLKMCC ELAFCKIINS YCVFPRELKE VFASWKQQCL NRGKQDISER 600
LISASLFLRF LCPAIMSPSL FNLMQEYPDD RTSRTLTLIA KVIQNLANFA 650
KFGNKEEYMA FMNDFLEHEW GGMKRFLLEI SNPDTISNTP GFDGYIDLGR 700
ELSVLHSLLW EVVSQLDKGE NSFLQATVAK LGPLPRVLAD ITKSLTNPTP 750
IQQQLRRFAE HSSSPNVSGS LSSGLQRICE DPTDSDLHKL KSPSQDNTDS 800
YFRGKTLLLV QQASSQSMTY SEKDEKENSL PNGRSISLMD LQDTHAAQAE 850
HASVMLDVPM RLAGSQLSIT QVASIKQLRE TQSTPQSAPQ VRRPLHPALN 900
QPGSLQPLSF QNPVYHLNNP VPAMPKASAD SSLENLSTAS SRSQSNSEDF 950
KLSGPSNSSM EDFTKRSSHS EDFSRRHTVP DRHIPLALPR QNSTGQSQIR 1000
KLDHSGLGAR AKAPPSLPHS ASLRSTGSMS VASAALMAEP VQNGSRSRQQ 1050
SSSSRESPVP KVRAIQRQQT QQVQSPVDSA TMSPVERTAA WVLNNGQYEE 1100
DVEETEQNQD EAKHAEKYEQ EITKLKERLR VSSRRLEEYE RRLLVQEQQM 1150
QKLLLEYKAR LEDSEERLRR QQEEKDSQMK SIISRLMAVE EELKKDHAEM 1200
QAVIDAKQKI IDAQEKRIVS LDSANTRLMS ALTQVKERYS MQVRNGISPT 1250
NPTKLSITEN GEFKNSSC 1268
Length:1,268
Mass (Da):142,714
Last modified:September 5, 2006 - v1
Checksum:iB770CB1F05C0CCC0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC120902 mRNA. Translation: AAI20903.1.
RefSeqiNP_808312.3. NM_177644.5.
UniGeneiMm.235028.
Mm.439484.

Genome annotation databases

GeneIDi226525.
KEGGimmu:226525.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC120902 mRNA. Translation: AAI20903.1 .
RefSeqi NP_808312.3. NM_177644.5.
UniGenei Mm.235028.
Mm.439484.

3D structure databases

ProteinModelPortali Q0VAV5.
SMRi Q0VAV5. Positions 414-754.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q0VAV5. 1 interaction.
STRINGi 10090.ENSMUSP00000077423.

PTM databases

PhosphoSitei Q0VAV5.

Proteomic databases

PaxDbi Q0VAV5.
PRIDEi Q0VAV5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 226525.
KEGGi mmu:226525.

Organism-specific databases

CTDi 9462.
MGIi MGI:2443881. Rasal2.

Phylogenomic databases

eggNOGi NOG245428.
HOGENOMi HOG000231979.
HOVERGENi HBG006492.
InParanoidi Q0VAV5.
KOi K17633.

Miscellaneous databases

ChiTaRSi RASAL2. mouse.
NextBioi 378206.
SOURCEi Search...

Gene expression databases

Genevestigatori Q0VAV5.

Family and domain databases

Gene3Di 1.10.506.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
InterProi IPR000008. C2_dom.
IPR021887. DUF3498.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
[Graphical view ]
Pfami PF00168. C2. 1 hit.
PF12004. DUF3498. 1 hit.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view ]
SMARTi SM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEi PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescued clonesImported.

Entry informationi

Entry nameiQ0VAV5_MOUSE
AccessioniPrimary (citable) accession number: Q0VAV5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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