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Q0VAV5

- Q0VAV5_MOUSE

UniProt

Q0VAV5 - Q0VAV5_MOUSE

Protein
Submitted name:

RAS protein activator like 2

Gene

Rasal2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. Ras GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of Ras protein signal transduction Source: RefGenome
    2. positive regulation of Ras GTPase activity Source: RefGenome
    3. signal transduction Source: InterPro

    Keywords - Molecular functioni

    GTPase activationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    RAS protein activator like 2Imported
    Gene namesi
    Name:Rasal2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:2443881. Rasal2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. intrinsic component of the cytoplasmic side of the plasma membrane Source: RefGenome

    PTM / Processingi

    Proteomic databases

    PaxDbiQ0VAV5.
    PRIDEiQ0VAV5.

    PTM databases

    PhosphoSiteiQ0VAV5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ0VAV5.

    Interactioni

    Protein-protein interaction databases

    IntActiQ0VAV5. 1 interaction.
    STRINGi10090.ENSMUSP00000077423.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0VAV5.
    SMRiQ0VAV5. Positions 414-754.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 PH domain.UniRule annotation
    Contains PH domain.SAAS annotation

    Phylogenomic databases

    eggNOGiNOG245428.
    HOGENOMiHOG000231979.
    HOVERGENiHBG006492.
    InParanoidiQ0VAV5.
    KOiK17633.

    Family and domain databases

    Gene3Di1.10.506.10. 1 hit.
    2.30.29.30. 2 hits.
    2.60.40.150. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR021887. DUF3498.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001936. RasGAP.
    IPR023152. RasGAP_CS.
    IPR008936. Rho_GTPase_activation_prot.
    [Graphical view]
    PfamiPF00168. C2. 1 hit.
    PF12004. DUF3498. 1 hit.
    PF00169. PH. 1 hit.
    PF00616. RasGAP. 1 hit.
    [Graphical view]
    SMARTiSM00239. C2. 1 hit.
    SM00233. PH. 1 hit.
    SM00323. RasGAP. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    SSF49562. SSF49562. 1 hit.
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
    PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0VAV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFTGLESDSP LPPEDLDAVV PVSGAVAGGM LDRILLESVC QQQSWVRVFD     50
    VKGPPTHRLS CGQSPYTETT SWERKYCILT DSQLVLLNKE KEMPVEGQDQ 100
    QTDSTKGRCL RRTVSVPSEG QFPEYPQEGT TKLEVPAERS PRRRSISGTS 150
    TSEKPNSMDT ANTSPFKVPG FFSKRLKGSI KRTKSQSKLD RNTSFRLPSL 200
    RNADDRSRGL PKLKESRSHG SLLSPCSAVE CLDLGRGEPV SVKPLHSSIL 250
    GQDFCFEVTY LSGSKCFSCS SASERDKWME NLRRTVQPNK DNCRRAENVL 300
    RLWIIEAKDL APKKKYFCEL CLDDTLFART TSKTKADNIF WGEHFEFYSL 350
    PPLHSITVHI YKDVEKKKKK DKNNYVGLVN IPTASVTGRQ FVEKWYPVST 400
    PTPNKGKTGG PSIRIKSRFQ TITILPMEQY KEFAEFITSN YTMLCSVLEP 450
    VISVRNKEEL ACALVHILQS TGRAKDFLTD LVMSEVDRCG EHDVLIFREN 500
    TIATKSIEEY LKLVGQQYLH DALGEFIKAL YESDENCEVD PSKCSSSELM 550
    DHQSNLKMCC ELAFCKIINS YCVFPRELKE VFASWKQQCL NRGKQDISER 600
    LISASLFLRF LCPAIMSPSL FNLMQEYPDD RTSRTLTLIA KVIQNLANFA 650
    KFGNKEEYMA FMNDFLEHEW GGMKRFLLEI SNPDTISNTP GFDGYIDLGR 700
    ELSVLHSLLW EVVSQLDKGE NSFLQATVAK LGPLPRVLAD ITKSLTNPTP 750
    IQQQLRRFAE HSSSPNVSGS LSSGLQRICE DPTDSDLHKL KSPSQDNTDS 800
    YFRGKTLLLV QQASSQSMTY SEKDEKENSL PNGRSISLMD LQDTHAAQAE 850
    HASVMLDVPM RLAGSQLSIT QVASIKQLRE TQSTPQSAPQ VRRPLHPALN 900
    QPGSLQPLSF QNPVYHLNNP VPAMPKASAD SSLENLSTAS SRSQSNSEDF 950
    KLSGPSNSSM EDFTKRSSHS EDFSRRHTVP DRHIPLALPR QNSTGQSQIR 1000
    KLDHSGLGAR AKAPPSLPHS ASLRSTGSMS VASAALMAEP VQNGSRSRQQ 1050
    SSSSRESPVP KVRAIQRQQT QQVQSPVDSA TMSPVERTAA WVLNNGQYEE 1100
    DVEETEQNQD EAKHAEKYEQ EITKLKERLR VSSRRLEEYE RRLLVQEQQM 1150
    QKLLLEYKAR LEDSEERLRR QQEEKDSQMK SIISRLMAVE EELKKDHAEM 1200
    QAVIDAKQKI IDAQEKRIVS LDSANTRLMS ALTQVKERYS MQVRNGISPT 1250
    NPTKLSITEN GEFKNSSC 1268
    Length:1,268
    Mass (Da):142,714
    Last modified:September 5, 2006 - v1
    Checksum:iB770CB1F05C0CCC0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC120902 mRNA. Translation: AAI20903.1.
    RefSeqiNP_808312.3. NM_177644.5.
    UniGeneiMm.235028.
    Mm.439484.

    Genome annotation databases

    GeneIDi226525.
    KEGGimmu:226525.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC120902 mRNA. Translation: AAI20903.1 .
    RefSeqi NP_808312.3. NM_177644.5.
    UniGenei Mm.235028.
    Mm.439484.

    3D structure databases

    ProteinModelPortali Q0VAV5.
    SMRi Q0VAV5. Positions 414-754.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q0VAV5. 1 interaction.
    STRINGi 10090.ENSMUSP00000077423.

    PTM databases

    PhosphoSitei Q0VAV5.

    Proteomic databases

    PaxDbi Q0VAV5.
    PRIDEi Q0VAV5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 226525.
    KEGGi mmu:226525.

    Organism-specific databases

    CTDi 9462.
    MGIi MGI:2443881. Rasal2.

    Phylogenomic databases

    eggNOGi NOG245428.
    HOGENOMi HOG000231979.
    HOVERGENi HBG006492.
    InParanoidi Q0VAV5.
    KOi K17633.

    Miscellaneous databases

    ChiTaRSi RASAL2. mouse.
    NextBioi 378206.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q0VAV5.

    Family and domain databases

    Gene3Di 1.10.506.10. 1 hit.
    2.30.29.30. 2 hits.
    2.60.40.150. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR021887. DUF3498.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001936. RasGAP.
    IPR023152. RasGAP_CS.
    IPR008936. Rho_GTPase_activation_prot.
    [Graphical view ]
    Pfami PF00168. C2. 1 hit.
    PF12004. DUF3498. 1 hit.
    PF00169. PH. 1 hit.
    PF00616. RasGAP. 1 hit.
    [Graphical view ]
    SMARTi SM00239. C2. 1 hit.
    SM00233. PH. 1 hit.
    SM00323. RasGAP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    SSF49562. SSF49562. 1 hit.
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
    PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PCR rescued clonesImported.

    Entry informationi

    Entry nameiQ0VAV5_MOUSE
    AccessioniPrimary (citable) accession number: Q0VAV5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)