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Q0VAV5

- Q0VAV5_MOUSE

UniProt

Q0VAV5 - Q0VAV5_MOUSE

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Protein
Submitted name:

RAS protein activator like 2

Gene

Rasal2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. Ras GTPase activator activity Source: RefGenome

GO - Biological processi

  1. negative regulation of Ras protein signal transduction Source: RefGenome
  2. positive regulation of Ras GTPase activity Source: RefGenome
  3. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
RAS protein activator like 2Imported
Gene namesi
Name:Rasal2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:2443881. Rasal2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. intrinsic component of the cytoplasmic side of the plasma membrane Source: RefGenome
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ0VAV5.
PRIDEiQ0VAV5.

PTM databases

PhosphoSiteiQ0VAV5.

Expressioni

Gene expression databases

GenevestigatoriQ0VAV5.

Interactioni

Protein-protein interaction databases

IntActiQ0VAV5. 1 interaction.
STRINGi10090.ENSMUSP00000077423.

Structurei

3D structure databases

ProteinModelPortaliQ0VAV5.
SMRiQ0VAV5. Positions 414-754.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 PH domain.UniRule annotation
Contains PH domain.SAAS annotation

Phylogenomic databases

eggNOGiNOG245428.
HOGENOMiHOG000231979.
HOVERGENiHBG006492.
KOiK17633.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR021887. DUF3498.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF12004. DUF3498. 1 hit.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VAV5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFTGLESDSP LPPEDLDAVV PVSGAVAGGM LDRILLESVC QQQSWVRVFD
60 70 80 90 100
VKGPPTHRLS CGQSPYTETT SWERKYCILT DSQLVLLNKE KEMPVEGQDQ
110 120 130 140 150
QTDSTKGRCL RRTVSVPSEG QFPEYPQEGT TKLEVPAERS PRRRSISGTS
160 170 180 190 200
TSEKPNSMDT ANTSPFKVPG FFSKRLKGSI KRTKSQSKLD RNTSFRLPSL
210 220 230 240 250
RNADDRSRGL PKLKESRSHG SLLSPCSAVE CLDLGRGEPV SVKPLHSSIL
260 270 280 290 300
GQDFCFEVTY LSGSKCFSCS SASERDKWME NLRRTVQPNK DNCRRAENVL
310 320 330 340 350
RLWIIEAKDL APKKKYFCEL CLDDTLFART TSKTKADNIF WGEHFEFYSL
360 370 380 390 400
PPLHSITVHI YKDVEKKKKK DKNNYVGLVN IPTASVTGRQ FVEKWYPVST
410 420 430 440 450
PTPNKGKTGG PSIRIKSRFQ TITILPMEQY KEFAEFITSN YTMLCSVLEP
460 470 480 490 500
VISVRNKEEL ACALVHILQS TGRAKDFLTD LVMSEVDRCG EHDVLIFREN
510 520 530 540 550
TIATKSIEEY LKLVGQQYLH DALGEFIKAL YESDENCEVD PSKCSSSELM
560 570 580 590 600
DHQSNLKMCC ELAFCKIINS YCVFPRELKE VFASWKQQCL NRGKQDISER
610 620 630 640 650
LISASLFLRF LCPAIMSPSL FNLMQEYPDD RTSRTLTLIA KVIQNLANFA
660 670 680 690 700
KFGNKEEYMA FMNDFLEHEW GGMKRFLLEI SNPDTISNTP GFDGYIDLGR
710 720 730 740 750
ELSVLHSLLW EVVSQLDKGE NSFLQATVAK LGPLPRVLAD ITKSLTNPTP
760 770 780 790 800
IQQQLRRFAE HSSSPNVSGS LSSGLQRICE DPTDSDLHKL KSPSQDNTDS
810 820 830 840 850
YFRGKTLLLV QQASSQSMTY SEKDEKENSL PNGRSISLMD LQDTHAAQAE
860 870 880 890 900
HASVMLDVPM RLAGSQLSIT QVASIKQLRE TQSTPQSAPQ VRRPLHPALN
910 920 930 940 950
QPGSLQPLSF QNPVYHLNNP VPAMPKASAD SSLENLSTAS SRSQSNSEDF
960 970 980 990 1000
KLSGPSNSSM EDFTKRSSHS EDFSRRHTVP DRHIPLALPR QNSTGQSQIR
1010 1020 1030 1040 1050
KLDHSGLGAR AKAPPSLPHS ASLRSTGSMS VASAALMAEP VQNGSRSRQQ
1060 1070 1080 1090 1100
SSSSRESPVP KVRAIQRQQT QQVQSPVDSA TMSPVERTAA WVLNNGQYEE
1110 1120 1130 1140 1150
DVEETEQNQD EAKHAEKYEQ EITKLKERLR VSSRRLEEYE RRLLVQEQQM
1160 1170 1180 1190 1200
QKLLLEYKAR LEDSEERLRR QQEEKDSQMK SIISRLMAVE EELKKDHAEM
1210 1220 1230 1240 1250
QAVIDAKQKI IDAQEKRIVS LDSANTRLMS ALTQVKERYS MQVRNGISPT
1260
NPTKLSITEN GEFKNSSC
Length:1,268
Mass (Da):142,714
Last modified:September 5, 2006 - v1
Checksum:iB770CB1F05C0CCC0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC120902 mRNA. Translation: AAI20903.1.
RefSeqiNP_808312.3. NM_177644.5.
UniGeneiMm.235028.
Mm.439484.

Genome annotation databases

GeneIDi226525.
KEGGimmu:226525.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC120902 mRNA. Translation: AAI20903.1 .
RefSeqi NP_808312.3. NM_177644.5.
UniGenei Mm.235028.
Mm.439484.

3D structure databases

ProteinModelPortali Q0VAV5.
SMRi Q0VAV5. Positions 414-754.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q0VAV5. 1 interaction.
STRINGi 10090.ENSMUSP00000077423.

PTM databases

PhosphoSitei Q0VAV5.

Proteomic databases

PaxDbi Q0VAV5.
PRIDEi Q0VAV5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 226525.
KEGGi mmu:226525.

Organism-specific databases

CTDi 9462.
MGIi MGI:2443881. Rasal2.

Phylogenomic databases

eggNOGi NOG245428.
HOGENOMi HOG000231979.
HOVERGENi HBG006492.
KOi K17633.

Miscellaneous databases

ChiTaRSi RASAL2. mouse.
NextBioi 378206.
SOURCEi Search...

Gene expression databases

Genevestigatori Q0VAV5.

Family and domain databases

Gene3Di 1.10.506.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
InterProi IPR000008. C2_dom.
IPR021887. DUF3498.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
[Graphical view ]
Pfami PF00168. C2. 1 hit.
PF12004. DUF3498. 1 hit.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view ]
SMARTi SM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEi PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescued clonesImported.

Entry informationi

Entry nameiQ0VAV5_MOUSE
AccessioniPrimary (citable) accession number: Q0VAV5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)