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Protein

Small cell adhesion glycoprotein

Gene

SMAGP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Sialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Small cell adhesion glycoprotein
Alternative name(s):
Small transmembrane and glycosylated protein
Gene namesi
Name:SMAGP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:26918. SMAGP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36ExtracellularSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini58 – 97CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57228.
OpenTargetsiENSG00000170545.
PharmGKBiPA165513352.

Polymorphism and mutation databases

BioMutaiSMAGP.
DMDMi121940462.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003287951 – 97Small cell adhesion glycoproteinAdd BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2O-linked (GalNAc...)Sequence analysis1
Glycosylationi3O-linked (GalNAc...)Sequence analysis1
Glycosylationi6O-linked (GalNAc...)Sequence analysis1
Glycosylationi7O-linked (GalNAc...)Sequence analysis1
Glycosylationi9O-linked (GalNAc...)Sequence analysis1
Glycosylationi16O-linked (GalNAc...)Sequence analysis1
Glycosylationi17O-linked (GalNAc...)Sequence analysis1
Glycosylationi23O-linked (GalNAc...)Sequence analysis1

Post-translational modificationi

O-glycosylated. The O-glycan is modified with sialic acid residues.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ0VAQ4.
MaxQBiQ0VAQ4.
PaxDbiQ0VAQ4.
PeptideAtlasiQ0VAQ4.
PRIDEiQ0VAQ4.
TopDownProteomicsiQ0VAQ4.

PTM databases

iPTMnetiQ0VAQ4.
PhosphoSitePlusiQ0VAQ4.

Expressioni

Tissue specificityi

Detected in breast, endometrium, colon and biliary tract. Detected in polarized epithelial structures characterized by cell-cell adhesion (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000170545.
ExpressionAtlasiQ0VAQ4. baseline and differential.
GenevisibleiQ0VAQ4. HS.

Organism-specific databases

HPAiHPA039711.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SGTAO437653EBI-10226799,EBI-347996

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121462. 1 interactor.
IntActiQ0VAQ4. 1 interactor.
STRINGi9606.ENSP00000369446.

Structurei

3D structure databases

ProteinModelPortaliQ0VAQ4.
SMRiQ0VAQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SMAGP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3FG. Eukaryota.
ENOG410ZCM8. LUCA.
GeneTreeiENSGT00390000010077.
HOGENOMiHOG000154341.
HOVERGENiHBG100579.
InParanoidiQ0VAQ4.
OMAiDREKEEY.
OrthoDBiEOG091G16WO.
PhylomeDBiQ0VAQ4.
TreeFamiTF337016.

Sequencei

Sequence statusi: Complete.

Q0VAQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSLLTTPSP REELMTTPIL QPTEALSPED GASTALIAVV ITVVFLTLLS
60 70 80 90
VVILIFFYLY KNKGSYVTYE PTEGEPSAIV QMESDLAKGS EKEEYFI
Length:97
Mass (Da):10,679
Last modified:September 5, 2006 - v1
Checksum:i90BC88F950B94904
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC046135 Genomic DNA. No translation available.
AC139768 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW58184.1.
BC008712 mRNA. Translation: AAH08712.2.
BC120965 mRNA. Translation: AAI20966.1.
BC120966 mRNA. Translation: AAI20967.1.
CCDSiCCDS44889.1.
RefSeqiNP_001026798.1. NM_001031628.1.
NP_001029045.1. NM_001033873.1.
UniGeneiHs.652389.

Genome annotation databases

EnsembliENST00000398453; ENSP00000381471; ENSG00000170545.
ENST00000603798; ENSP00000475068; ENSG00000170545.
ENST00000603864; ENSP00000474892; ENSG00000170545.
GeneIDi57228.
KEGGihsa:57228.
UCSCiuc001ryd.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC046135 Genomic DNA. No translation available.
AC139768 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW58184.1.
BC008712 mRNA. Translation: AAH08712.2.
BC120965 mRNA. Translation: AAI20966.1.
BC120966 mRNA. Translation: AAI20967.1.
CCDSiCCDS44889.1.
RefSeqiNP_001026798.1. NM_001031628.1.
NP_001029045.1. NM_001033873.1.
UniGeneiHs.652389.

3D structure databases

ProteinModelPortaliQ0VAQ4.
SMRiQ0VAQ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121462. 1 interactor.
IntActiQ0VAQ4. 1 interactor.
STRINGi9606.ENSP00000369446.

PTM databases

iPTMnetiQ0VAQ4.
PhosphoSitePlusiQ0VAQ4.

Polymorphism and mutation databases

BioMutaiSMAGP.
DMDMi121940462.

Proteomic databases

EPDiQ0VAQ4.
MaxQBiQ0VAQ4.
PaxDbiQ0VAQ4.
PeptideAtlasiQ0VAQ4.
PRIDEiQ0VAQ4.
TopDownProteomicsiQ0VAQ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398453; ENSP00000381471; ENSG00000170545.
ENST00000603798; ENSP00000475068; ENSG00000170545.
ENST00000603864; ENSP00000474892; ENSG00000170545.
GeneIDi57228.
KEGGihsa:57228.
UCSCiuc001ryd.2. human.

Organism-specific databases

CTDi57228.
DisGeNETi57228.
GeneCardsiSMAGP.
HGNCiHGNC:26918. SMAGP.
HPAiHPA039711.
neXtProtiNX_Q0VAQ4.
OpenTargetsiENSG00000170545.
PharmGKBiPA165513352.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3FG. Eukaryota.
ENOG410ZCM8. LUCA.
GeneTreeiENSGT00390000010077.
HOGENOMiHOG000154341.
HOVERGENiHBG100579.
InParanoidiQ0VAQ4.
OMAiDREKEEY.
OrthoDBiEOG091G16WO.
PhylomeDBiQ0VAQ4.
TreeFamiTF337016.

Miscellaneous databases

ChiTaRSiSMAGP. human.
GenomeRNAii57228.
PROiQ0VAQ4.

Gene expression databases

BgeeiENSG00000170545.
ExpressionAtlasiQ0VAQ4. baseline and differential.
GenevisibleiQ0VAQ4. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSMAGP_HUMAN
AccessioniPrimary (citable) accession number: Q0VAQ4
Secondary accession number(s): A6NIL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: September 5, 2006
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.