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Protein

Ras-GEF domain-containing family member 1B

Gene

RASGEF1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro).2 Publications

GO - Molecular functioni

  • Ras guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

SIGNORiQ0VAM2.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-GEF domain-containing family member 1B
Alternative name(s):
GPI gamma-4
Gene namesi
Name:RASGEF1B
Synonyms:GPIG4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:24881. RASGEF1B.

Subcellular locationi

  • Early endosome By similarity
  • Late endosome By similarity
  • Midbody 1 Publication

  • Note: May shuttle between early and late endosomes (By similarity). Localizes to midbody at telophase.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134927621.

Polymorphism and mutation databases

BioMutaiRASGEF1B.
DMDMi156633611.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Ras-GEF domain-containing family member 1BPRO_0000297638Add
BLAST

Proteomic databases

MaxQBiQ0VAM2.
PaxDbiQ0VAM2.
PRIDEiQ0VAM2.

PTM databases

iPTMnetiQ0VAM2.
PhosphoSiteiQ0VAM2.

Expressioni

Inductioni

Up-regulated in macrophages stimulated with IFNG, GPI-mucins or bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

BgeeiENSG00000138670.
CleanExiHS_RASGEF1B.
ExpressionAtlasiQ0VAM2. baseline and differential.
GenevisibleiQ0VAM2. HS.

Organism-specific databases

HPAiHPA044574.

Interactioni

Subunit structurei

Interacts with Ras family proteins (By similarity). Interacts with CCDC124 during cytokinesis.By similarity1 Publication

Protein-protein interaction databases

BioGridi127476. 2 interactions.
STRINGi9606.ENSP00000264400.

Structurei

3D structure databases

ProteinModelPortaliQ0VAM2.
SMRiQ0VAM2. Positions 38-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 164131N-terminal Ras-GEFPROSITE-ProRule annotationAdd
BLAST
Domaini204 – 452249Ras-GEFPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3417. Eukaryota.
KOG3541. Eukaryota.
ENOG410XRE3. LUCA.
GeneTreeiENSGT00810000125357.
HOGENOMiHOG000018026.
HOVERGENiHBG055252.
InParanoidiQ0VAM2.
OMAiDRWKTLR.
OrthoDBiEOG091G0B0J.
PhylomeDBiQ0VAM2.
TreeFamiTF313379.

Family and domain databases

CDDicd06224. REM. 1 hit.
Gene3Di1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR030710. RGF1B.
[Graphical view]
PANTHERiPTHR23113:SF197. PTHR23113:SF197. 1 hit.
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0VAM2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQTPPFSAM FDSSGYNRNL YQSAEDSCGG LYYHDNNLLS GSLEALIQHL
60 70 80 90 100
VPNVDYYPDR TYIFTFLLSS RLFMHPYELM AKVCHLCVEH QRLSDPDSDK
110 120 130 140 150
NQMRKIAPKI LQLLTEWTET FPYDFRDERM MRNLKDLAHR IASGEEQTYR
160 170 180 190 200
KNVQQMMQCL IRKLAALSQY EEVLAKISST STDRLTVLKT KPQSIQRDII
210 220 230 240 250
TVCNDPYTLA QQLTHIELER LNYIGPEEFV QAFVQKDPLD NDKSCYSERK
260 270 280 290 300
KTRNLEAYVE WFNRLSYLVA TEICMPVKKK HRARMIEYFI DVARECFNIG
310 320 330 340 350
NFNSLMAIIS GMNMSPVSRL KKTWAKVKTA KFDILEHQMD PSSNFYNYRT
360 370 380 390 400
ALRGAAQRSL TAHSSREKIV IPFFSLLIKD IYFLNEGCAN RLPNGHVNFE
410 420 430 440 450
KFWELAKQVS EFMTWKQVEC PFERDRKILQ YLLTVPVFSE DALYLASYES
460 470
EGPENHIEKD RWKSLRSSLL GRV
Length:473
Mass (Da):55,359
Last modified:August 21, 2007 - v2
Checksum:i8078400AD7B2CE94
GO
Isoform 2 (identifier: Q0VAM2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-100: Missing.
     147-147: Missing.

Show »
Length:431
Mass (Da):50,321
Checksum:i64A63596E9A010B9
GO
Isoform 3 (identifier: Q0VAM2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-147: Missing.

Show »
Length:472
Mass (Da):55,231
Checksum:i58CC06E158D5CD60
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei60 – 10041Missing in isoform 2. 1 PublicationVSP_027313Add
BLAST
Alternative sequencei147 – 1471Missing in isoform 2 and isoform 3. 1 PublicationVSP_027314

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056257 mRNA. Translation: BAB71130.1.
AC006287 Genomic DNA. No translation available.
AC093747 Genomic DNA. Translation: AAY40982.1.
AC093618 Genomic DNA. Translation: AAY41054.1.
BC121003 mRNA. Translation: AAI21004.1.
BC121004 mRNA. Translation: AAI21005.1.
CCDSiCCDS34022.1. [Q0VAM2-1]
CCDS75151.1. [Q0VAM2-2]
CCDS75152.1. [Q0VAM2-3]
RefSeqiNP_001287664.1. NM_001300735.1. [Q0VAM2-3]
NP_001287665.1. NM_001300736.1. [Q0VAM2-2]
NP_689758.1. NM_152545.2. [Q0VAM2-1]
UniGeneiHs.591696.

Genome annotation databases

EnsembliENST00000264400; ENSP00000264400; ENSG00000138670. [Q0VAM2-1]
ENST00000335927; ENSP00000338437; ENSG00000138670. [Q0VAM2-2]
ENST00000509081; ENSP00000425393; ENSG00000138670. [Q0VAM2-3]
GeneIDi153020.
KEGGihsa:153020.
UCSCiuc003hmi.2. human. [Q0VAM2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056257 mRNA. Translation: BAB71130.1.
AC006287 Genomic DNA. No translation available.
AC093747 Genomic DNA. Translation: AAY40982.1.
AC093618 Genomic DNA. Translation: AAY41054.1.
BC121003 mRNA. Translation: AAI21004.1.
BC121004 mRNA. Translation: AAI21005.1.
CCDSiCCDS34022.1. [Q0VAM2-1]
CCDS75151.1. [Q0VAM2-2]
CCDS75152.1. [Q0VAM2-3]
RefSeqiNP_001287664.1. NM_001300735.1. [Q0VAM2-3]
NP_001287665.1. NM_001300736.1. [Q0VAM2-2]
NP_689758.1. NM_152545.2. [Q0VAM2-1]
UniGeneiHs.591696.

3D structure databases

ProteinModelPortaliQ0VAM2.
SMRiQ0VAM2. Positions 38-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127476. 2 interactions.
STRINGi9606.ENSP00000264400.

PTM databases

iPTMnetiQ0VAM2.
PhosphoSiteiQ0VAM2.

Polymorphism and mutation databases

BioMutaiRASGEF1B.
DMDMi156633611.

Proteomic databases

MaxQBiQ0VAM2.
PaxDbiQ0VAM2.
PRIDEiQ0VAM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264400; ENSP00000264400; ENSG00000138670. [Q0VAM2-1]
ENST00000335927; ENSP00000338437; ENSG00000138670. [Q0VAM2-2]
ENST00000509081; ENSP00000425393; ENSG00000138670. [Q0VAM2-3]
GeneIDi153020.
KEGGihsa:153020.
UCSCiuc003hmi.2. human. [Q0VAM2-1]

Organism-specific databases

CTDi153020.
GeneCardsiRASGEF1B.
HGNCiHGNC:24881. RASGEF1B.
HPAiHPA044574.
MIMi614532. gene.
neXtProtiNX_Q0VAM2.
PharmGKBiPA134927621.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3417. Eukaryota.
KOG3541. Eukaryota.
ENOG410XRE3. LUCA.
GeneTreeiENSGT00810000125357.
HOGENOMiHOG000018026.
HOVERGENiHBG055252.
InParanoidiQ0VAM2.
OMAiDRWKTLR.
OrthoDBiEOG091G0B0J.
PhylomeDBiQ0VAM2.
TreeFamiTF313379.

Enzyme and pathway databases

SIGNORiQ0VAM2.

Miscellaneous databases

ChiTaRSiRASGEF1B. human.
GenomeRNAii153020.
PROiQ0VAM2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138670.
CleanExiHS_RASGEF1B.
ExpressionAtlasiQ0VAM2. baseline and differential.
GenevisibleiQ0VAM2. HS.

Family and domain databases

CDDicd06224. REM. 1 hit.
Gene3Di1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR030710. RGF1B.
[Graphical view]
PANTHERiPTHR23113:SF197. PTHR23113:SF197. 1 hit.
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGF1B_HUMAN
AccessioniPrimary (citable) accession number: Q0VAM2
Secondary accession number(s): Q0VAM1
, Q4W5L7, Q4W5M3, Q96MY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.