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Protein

Syncollin

Gene

SYCN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Syncollin
Alternative name(s):
Insulin synthesis-associated protein 1
Gene namesi
Name:SYCN
Synonyms:INSSA1, SYL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18442. SYCN.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179751.
PharmGKBiPA142670850.

Polymorphism and mutation databases

BioMutaiSYCN.
DMDMi121948659.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000029527622 – 134SyncollinBy similarityAdd BLAST113

Post-translational modificationi

Contains intrachain disulfide bonds.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ0VAF6.
PeptideAtlasiQ0VAF6.
PRIDEiQ0VAF6.
TopDownProteomicsiQ0VAF6.

PTM databases

iPTMnetiQ0VAF6.
PhosphoSitePlusiQ0VAF6.

Expressioni

Gene expression databases

BgeeiENSG00000179751.
CleanExiHS_SYCN.
GenevisibleiQ0VAF6. HS.

Organism-specific databases

HPAiHPA047654.

Interactioni

Subunit structurei

Monomer and homooligomer; most probably hexameric. Interacts with GP2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000325564.

Structurei

3D structure databases

ProteinModelPortaliQ0VAF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0PE. Eukaryota.
ENOG4111ZQA. LUCA.
GeneTreeiENSGT00390000014835.
HOGENOMiHOG000154465.
HOVERGENiHBG100284.
InParanoidiQ0VAF6.
KOiK19935.
OMAiISALYCR.
OrthoDBiEOG091G0UES.
PhylomeDBiQ0VAF6.
TreeFamiTF338021.

Family and domain databases

InterProiIPR028137. Syncollin.
[Graphical view]
PANTHERiPTHR17503:SF0. PTHR17503:SF0. 1 hit.
PfamiPF15138. Syncollin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VAF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPLRPLLLA LALASVPCAQ GACPASADLK HSDGTRTCAK LYDKSDPYYE
60 70 80 90 100
NCCGGAELSL ESGADLPYLP SNWANTASSL VVAPRCELTV WSRQGKAGKT
110 120 130
HKFSAGTYPR LEEYRRGILG DWSNAISALY CRCS
Length:134
Mass (Da):14,405
Last modified:September 5, 2006 - v1
Checksum:i1928D95BA3EC4274
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033284111L → M.Corresponds to variant rs2082416dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121075 mRNA. Translation: AAI21076.1.
BC121076 mRNA. Translation: AAI21077.1.
CCDSiCCDS46070.1.
RefSeqiNP_001073937.1. NM_001080468.3.
UniGeneiHs.124123.

Genome annotation databases

EnsembliENST00000318438; ENSP00000325564; ENSG00000179751.
GeneIDi342898.
KEGGihsa:342898.
UCSCiuc002okr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121075 mRNA. Translation: AAI21076.1.
BC121076 mRNA. Translation: AAI21077.1.
CCDSiCCDS46070.1.
RefSeqiNP_001073937.1. NM_001080468.3.
UniGeneiHs.124123.

3D structure databases

ProteinModelPortaliQ0VAF6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000325564.

PTM databases

iPTMnetiQ0VAF6.
PhosphoSitePlusiQ0VAF6.

Polymorphism and mutation databases

BioMutaiSYCN.
DMDMi121948659.

Proteomic databases

PaxDbiQ0VAF6.
PeptideAtlasiQ0VAF6.
PRIDEiQ0VAF6.
TopDownProteomicsiQ0VAF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318438; ENSP00000325564; ENSG00000179751.
GeneIDi342898.
KEGGihsa:342898.
UCSCiuc002okr.3. human.

Organism-specific databases

CTDi342898.
GeneCardsiSYCN.
HGNCiHGNC:18442. SYCN.
HPAiHPA047654.
neXtProtiNX_Q0VAF6.
OpenTargetsiENSG00000179751.
PharmGKBiPA142670850.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0PE. Eukaryota.
ENOG4111ZQA. LUCA.
GeneTreeiENSGT00390000014835.
HOGENOMiHOG000154465.
HOVERGENiHBG100284.
InParanoidiQ0VAF6.
KOiK19935.
OMAiISALYCR.
OrthoDBiEOG091G0UES.
PhylomeDBiQ0VAF6.
TreeFamiTF338021.

Miscellaneous databases

GenomeRNAii342898.
PROiQ0VAF6.

Gene expression databases

BgeeiENSG00000179751.
CleanExiHS_SYCN.
GenevisibleiQ0VAF6. HS.

Family and domain databases

InterProiIPR028137. Syncollin.
[Graphical view]
PANTHERiPTHR17503:SF0. PTHR17503:SF0. 1 hit.
PfamiPF15138. Syncollin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYCN_HUMAN
AccessioniPrimary (citable) accession number: Q0VAF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: September 5, 2006
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.