Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PI-PLC X domain-containing protein 2

Gene

PLCXD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei57 – 571PROSITE-ProRule annotation
Active sitei132 – 1321PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transducer

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
PI-PLC X domain-containing protein 2
Gene namesi
Name:PLCXD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:26462. PLCXD2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134928848.

Polymorphism and mutation databases

BioMutaiPLCXD2.
DMDMi121948095.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305PI-PLC X domain-containing protein 2PRO_0000305691Add
BLAST

Proteomic databases

PaxDbiQ0VAA5.
PeptideAtlasiQ0VAA5.
PRIDEiQ0VAA5.

PTM databases

iPTMnetiQ0VAA5.
PhosphoSiteiQ0VAA5.

Expressioni

Gene expression databases

BgeeiENSG00000240891.
CleanExiHS_PLCXD2.
ExpressionAtlasiQ0VAA5. baseline and differential.
GenevisibleiQ0VAA5. HS.

Organism-specific databases

HPAiHPA055947.

Interactioni

Protein-protein interaction databases

BioGridi129195. 1 interaction.
STRINGi9606.ENSP00000420686.

Structurei

3D structure databases

ProteinModelPortaliQ0VAA5.
SMRiQ0VAA5. Positions 30-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 215174PI-PLC X-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4306. Eukaryota.
ENOG410Z30Q. LUCA.
GeneTreeiENSGT00530000063361.
HOGENOMiHOG000007180.
HOVERGENiHBG069284.
InParanoidiQ0VAA5.
OMAiWVKTQKP.
OrthoDBiEOG091G0B2T.
PhylomeDBiQ0VAA5.
TreeFamiTF314457.

Family and domain databases

Gene3Di3.20.20.190. 1 hit.
InterProiIPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
[Graphical view]
SMARTiSM00148. PLCXc. 1 hit.
[Graphical view]
SUPFAMiSSF51695. SSF51695. 1 hit.
PROSITEiPS50007. PIPLC_X_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0VAA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLAVRKARRK LRMGTICSPN PSGTKTSSEV CNADWMASLP PHLHNLPLSN
60 70 80 90 100
LAIPGSHDSF SYWVDEKSPV GPDQTQAIKR LARISLVKKL MKKWSVTQNL
110 120 130 140 150
TFREQLEAGI RYFDLRVSSK PGDADQEIYF IHGLFGIKVW DGLMEIDSFL
160 170 180 190 200
TQHPQEIIFL DFNHFYAMDE THHKCLVLRI QEAFGNKLCP ACSVESLTLR
210 220 230 240 250
TLWEKNCQVL IFYHCPFYKQ YPFLWPGKKI PAPWANTTSV RKLILFLETT
260 270 280 290 300
LSERASRGSF HVSQAILTPR VKTIARGLVG GLKNTLVHSN RWNSHGPSLL

SQERS
Length:305
Mass (Da):34,777
Last modified:September 5, 2006 - v1
Checksum:i0684E6CFA9129D99
GO
Isoform 2 (identifier: Q0VAA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     289-303: SNRWNSHGPSLLSQE → RLALIPVYPLRFSR

Note: No experimental confirmation available.
Show »
Length:304
Mass (Da):34,767
Checksum:i37C638B0DACE364C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei289 – 30315SNRWN…LLSQE → RLALIPVYPLRFSR in isoform 2. 1 PublicationVSP_028349Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056141 mRNA. Translation: BAB71103.1.
BC121155 mRNA. Translation: AAI21156.1.
BC121156 mRNA. Translation: AAI21157.1.
CCDSiCCDS2961.1. [Q0VAA5-2]
CCDS54619.1. [Q0VAA5-1]
RefSeqiNP_001172035.1. NM_001185106.1. [Q0VAA5-1]
NP_695000.1. NM_153268.3. [Q0VAA5-2]
UniGeneiHs.477114.
Hs.603252.

Genome annotation databases

EnsembliENST00000393934; ENSP00000377511; ENSG00000240891. [Q0VAA5-2]
ENST00000477665; ENSP00000420686; ENSG00000240891. [Q0VAA5-1]
GeneIDi257068.
KEGGihsa:257068.
UCSCiuc003dxz.3. human. [Q0VAA5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056141 mRNA. Translation: BAB71103.1.
BC121155 mRNA. Translation: AAI21156.1.
BC121156 mRNA. Translation: AAI21157.1.
CCDSiCCDS2961.1. [Q0VAA5-2]
CCDS54619.1. [Q0VAA5-1]
RefSeqiNP_001172035.1. NM_001185106.1. [Q0VAA5-1]
NP_695000.1. NM_153268.3. [Q0VAA5-2]
UniGeneiHs.477114.
Hs.603252.

3D structure databases

ProteinModelPortaliQ0VAA5.
SMRiQ0VAA5. Positions 30-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129195. 1 interaction.
STRINGi9606.ENSP00000420686.

PTM databases

iPTMnetiQ0VAA5.
PhosphoSiteiQ0VAA5.

Polymorphism and mutation databases

BioMutaiPLCXD2.
DMDMi121948095.

Proteomic databases

PaxDbiQ0VAA5.
PeptideAtlasiQ0VAA5.
PRIDEiQ0VAA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393934; ENSP00000377511; ENSG00000240891. [Q0VAA5-2]
ENST00000477665; ENSP00000420686; ENSG00000240891. [Q0VAA5-1]
GeneIDi257068.
KEGGihsa:257068.
UCSCiuc003dxz.3. human. [Q0VAA5-1]

Organism-specific databases

CTDi257068.
GeneCardsiPLCXD2.
HGNCiHGNC:26462. PLCXD2.
HPAiHPA055947.
neXtProtiNX_Q0VAA5.
PharmGKBiPA134928848.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4306. Eukaryota.
ENOG410Z30Q. LUCA.
GeneTreeiENSGT00530000063361.
HOGENOMiHOG000007180.
HOVERGENiHBG069284.
InParanoidiQ0VAA5.
OMAiWVKTQKP.
OrthoDBiEOG091G0B2T.
PhylomeDBiQ0VAA5.
TreeFamiTF314457.

Miscellaneous databases

GenomeRNAii257068.
PROiQ0VAA5.

Gene expression databases

BgeeiENSG00000240891.
CleanExiHS_PLCXD2.
ExpressionAtlasiQ0VAA5. baseline and differential.
GenevisibleiQ0VAA5. HS.

Family and domain databases

Gene3Di3.20.20.190. 1 hit.
InterProiIPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
[Graphical view]
SMARTiSM00148. PLCXc. 1 hit.
[Graphical view]
SUPFAMiSSF51695. SSF51695. 1 hit.
PROSITEiPS50007. PIPLC_X_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLCX2_HUMAN
AccessioniPrimary (citable) accession number: Q0VAA5
Secondary accession number(s): Q96N12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 5, 2006
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.