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Protein

Leucine-rich repeat-containing protein 74A

Gene

LRRC74A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 74AImported
Alternative name(s):
Leucine-rich repeat-containing protein 74Imported
Gene namesi
Name:LRRC74AImported
Synonyms:C14orf166BImported, LRRC74Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:23346. LRRC74A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134862662.

Polymorphism and mutation databases

BioMutaiC14orf166B.
DMDMi308153427.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Leucine-rich repeat-containing protein 74APRO_0000306172Add
BLAST

Proteomic databases

PaxDbiQ0VAA2.
PRIDEiQ0VAA2.

PTM databases

iPTMnetiQ0VAA2.
PhosphoSiteiQ0VAA2.

Expressioni

Gene expression databases

BgeeiQ0VAA2.
CleanExiHS_C14orf166B.
ExpressionAtlasiQ0VAA2. baseline and differential.
GenevisibleiQ0VAA2. HS.

Organism-specific databases

HPAiHPA035094.

Interactioni

Protein-protein interaction databases

IntActiQ0VAA2. 2 interactions.
MINTiMINT-8407172.
STRINGi9606.ENSP00000377369.

Structurei

3D structure databases

ProteinModelPortaliQ0VAA2.
SMRiQ0VAA2. Positions 83-393, 427-486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati134 – 15522LRR 1Add
BLAST
Repeati162 – 18221LRR 2Add
BLAST
Repeati191 – 21222LRR 3Add
BLAST
Repeati219 – 23921LRR 4Add
BLAST
Repeati247 – 26822LRR 5Add
BLAST
Repeati275 – 29622LRR 6Add
BLAST
Repeati303 – 32422LRR 7Add
BLAST
Repeati331 – 35121LRR 8Add
BLAST

Sequence similaritiesi

Contains 8 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00730000110609.
HOGENOMiHOG000170751.
HOVERGENiHBG096360.
InParanoidiQ0VAA2.
OMAiANDIPPY.
OrthoDBiEOG79SDXM.
PhylomeDBiQ0VAA2.
TreeFamiTF329403.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0VAA2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHIQFPSKPT LPRACWEGRI TAGSPGMPPD EIEIEPVRQS SDKMLYCEAE
60 70 80 90 100
SPPTVEKVKP ARENSETDLE IEDDEKFFTT GQKELYLEAC KLMGVVPVSY
110 120 130 140 150
FIRNMEESYV NLNHHGLGPR GTKAIAIALV SNMAVTKLEL EDNCIMEEGV
160 170 180 190 200
LSLVEMLQEN YYLQEMNISN NHLGLEGARI ISDFFERNSS SIWSLELSGN
210 220 230 240 250
DFKEDSAALL CQALSTNYQI KKLDLSHNQF SDVGGEHLGQ MLAINVGLTS
260 270 280 290 300
LDLSWNNFHT RGAVALCNGL RGNVTLTKLD LSMNGFGNEV ALALGEVLRL
310 320 330 340 350
NRCLVYLDIG GNDIGNEGAS KISKGLESNE SLRVLKLFLN PINMDGAILL
360 370 380 390 400
ILAIKRNPKS RMEELDISNV LVSEQFMKTL DGVYAVHPQL DVVFKAVQGL
410 420 430 440 450
SPKKTIFLLT NPMKLIQSYA DQHKITIVDF FKSLNPTGTM KMSVDEFQKV
460 470 480
MIEQNKVPLN QYQVREVIKK LDEKTGMVNF SFLNTMKP
Length:488
Mass (Da):54,535
Last modified:October 5, 2010 - v2
Checksum:iF1D0B73BFCCCE933
GO
Isoform 2 (identifier: Q0VAA2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.
     273-311: NVTLTKLDLS...RCLVYLDIGG → KSSDSTAAWS...DWNPMKASEF
     312-488: Missing.

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):24,109
Checksum:i98DEBC00F2BEB4D9
GO

Sequence cautioni

The sequence AAD44364.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAI21160.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI21161.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW81265.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9292Missing in isoform 2. 1 PublicationVSP_028425Add
BLAST
Alternative sequencei273 – 31139NVTLT…LDIGG → KSSDSTAAWSTWISVAMTSA MKGPPKSAKDWNPMKASEF in isoform 2. 1 PublicationVSP_028426Add
BLAST
Alternative sequencei312 – 488177Missing in isoform 2. 1 PublicationVSP_028427Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125722 mRNA. Translation: BAC86259.1.
AF111169 Genomic DNA. Translation: AAD44364.1. Sequence problems.
CH471061 Genomic DNA. Translation: EAW81265.1. Sequence problems.
BC121159 mRNA. Translation: AAI21160.1. Different initiation.
BC121160 mRNA. Translation: AAI21161.1. Different initiation.
CCDSiCCDS9853.2. [Q0VAA2-1]
RefSeqiNP_919263.2. NM_194287.2. [Q0VAA2-1]
UniGeneiHs.147276.

Genome annotation databases

EnsembliENST00000393774; ENSP00000377369; ENSG00000100565. [Q0VAA2-1]
GeneIDi145497.
KEGGihsa:145497.
UCSCiuc001xsx.3. human. [Q0VAA2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125722 mRNA. Translation: BAC86259.1.
AF111169 Genomic DNA. Translation: AAD44364.1. Sequence problems.
CH471061 Genomic DNA. Translation: EAW81265.1. Sequence problems.
BC121159 mRNA. Translation: AAI21160.1. Different initiation.
BC121160 mRNA. Translation: AAI21161.1. Different initiation.
CCDSiCCDS9853.2. [Q0VAA2-1]
RefSeqiNP_919263.2. NM_194287.2. [Q0VAA2-1]
UniGeneiHs.147276.

3D structure databases

ProteinModelPortaliQ0VAA2.
SMRiQ0VAA2. Positions 83-393, 427-486.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ0VAA2. 2 interactions.
MINTiMINT-8407172.
STRINGi9606.ENSP00000377369.

PTM databases

iPTMnetiQ0VAA2.
PhosphoSiteiQ0VAA2.

Polymorphism and mutation databases

BioMutaiC14orf166B.
DMDMi308153427.

Proteomic databases

PaxDbiQ0VAA2.
PRIDEiQ0VAA2.

Protocols and materials databases

DNASUi145497.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393774; ENSP00000377369; ENSG00000100565. [Q0VAA2-1]
GeneIDi145497.
KEGGihsa:145497.
UCSCiuc001xsx.3. human. [Q0VAA2-1]

Organism-specific databases

CTDi145497.
GeneCardsiLRRC74A.
HGNCiHGNC:23346. LRRC74A.
HPAiHPA035094.
neXtProtiNX_Q0VAA2.
PharmGKBiPA134862662.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00730000110609.
HOGENOMiHOG000170751.
HOVERGENiHBG096360.
InParanoidiQ0VAA2.
OMAiANDIPPY.
OrthoDBiEOG79SDXM.
PhylomeDBiQ0VAA2.
TreeFamiTF329403.

Miscellaneous databases

GenomeRNAii145497.
PROiQ0VAA2.

Gene expression databases

BgeeiQ0VAA2.
CleanExiHS_C14orf166B.
ExpressionAtlasiQ0VAA2. baseline and differential.
GenevisibleiQ0VAA2. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-488 (ISOFORM 1).

Entry informationi

Entry nameiLR74A_HUMAN
AccessioniPrimary (citable) accession number: Q0VAA2
Secondary accession number(s): Q6ZUG6, Q9Y627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 5, 2010
Last modified: June 8, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-27 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.