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Q0VA64

- UBP16_XENTR

UniProt

Q0VA64 - UBP16_XENTR

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Protein

Ubiquitin carboxyl-terminal hydrolase 16

Gene
usp16
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B By similarity.UniRule annotation

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi21 – 211Zinc 1 By similarity
Metal bindingi23 – 231Zinc 1 By similarity
Metal bindingi45 – 451Zinc 2 By similarity
Metal bindingi48 – 481Zinc 2 By similarity
Metal bindingi71 – 711Zinc 3 By similarity
Metal bindingi74 – 741Zinc 3 By similarity
Metal bindingi79 – 791Zinc 2 By similarity
Metal bindingi87 – 871Zinc 2 By similarity
Metal bindingi91 – 911Zinc 3 By similarity
Metal bindingi100 – 1001Zinc 3 By similarity
Metal bindingi113 – 1131Zinc 1 By similarity
Metal bindingi116 – 1161Zinc 1 By similarity
Active sitei205 – 2051Nucleophile By similarity
Active sitei798 – 7981Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri43 – 12280UBP-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. histone binding Source: UniProtKB
  3. transcription coactivator activity Source: UniProtKB
  4. ubiquitin binding Source: UniProtKB
  5. ubiquitin-specific protease activity Source: UniProtKB
  6. ubiquitin thiolesterase activity Source: UniProtKB
  7. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. histone deubiquitination Source: UniProtKB
  2. mitotic nuclear division Source: UniProtKB
  3. positive regulation of transcription, DNA-templated Source: UniProtKB
  4. protein homotetramerization Source: UniProtKB
  5. transcription, DNA-templated Source: UniProtKB-KW
  6. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 16 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 16
Ubiquitin thioesterase 16
Ubiquitin-specific-processing protease 16
Gene namesi
Name:usp16
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1007164. usp16.

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 864864Ubiquitin carboxyl-terminal hydrolase 16UniRule annotationPRO_0000367507Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini196 – 863668USPAdd
BLAST

Domaini

The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin By similarity.UniRule annotation

Sequence similaritiesi

Contains 1 USP domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri43 – 12280UBP-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5560.
GeneTreeiENSGT00750000117419.
HOGENOMiHOG000154755.
HOVERGENiHBG062704.
KOiK11844.
OMAiQCEDGEC.
TreeFamiTF326075.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
HAMAPiMF_03062. UBP16.
InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VA64-1 [UniParc]FASTAAdd to Basket

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MVKKRGKNLP AQDSLDAEPV CKHLRKALDE GSVKKALVNV EWTVCQECQA    50
DNKEKNNSDD ELVEDPSVWL CLKCGHRGCG RNSASQHALN HYNTPRSEPH 100
CLVLSVDMWS AWCYLCDNEV PYNRSSRLGQ LVDYLQRKAK AKSKSTDSAA 150
LDEEVKAEIV AENEVKIEDQ EEKPKGQAKW DKASSTQNNS TEPTVKGLSN 200
LGNTCFFNAV MQNLSQTPAV RELLNEAKTL KKPVTVPLPD SSSPTNVEVH 250
LEQQPGPLTL AMWQFLTEMQ ETKKGVVTPK EVFSQVCKKA IRFKGYQQQD 300
SQELLRYLLD GMRGEEIQRV SLAMSKSLQN TLDEEEIKKI VKDSEKRRTI 350
PNFVDHLFGG ELTSTIMCEE CHTVSLVHEP FLDLSLPVLD DVIVKKNSQK 400
SSAPAPERKE EEENDDGYIK ERDEASPGAS KHLQKKAKKA AKKQAKNQRR 450
QLKMQGKTVL LTDVAKQECS EDEEEIAPNN TESEANTRPD DEVPIADGLN 500
TMKSDLSALE NGSETIESAM ERVTEDTDLD TSGHNTESVE MNAMELVRNM 550
ENNNNNNTDV NKTLERTEGS GVDSMEATAA VDNGNADTVC VDDTEAANGL 600
LDCSAASMDN ELTNSLNRLK LSSDIEPTQV EIEILPDQQQ PHTQIYEVIN 650
EDPKTAFSTL SERKDLPLDG YSVLSCLYQF THKETLTGNN KLLCNVCTRK 700
QASRLNNSNK GEKTFVYTNA KKQMLVSDPS PILTLHLKRF QQNGFNLRKI 750
NRHIKFPEVL DLAPFCTSKC KNIPAGESRL LYSLYGVIEH SGSMRSGHYT 800
AFVKLRRPNQ QLCEMVLKGV IPEVSGSEPG QGSWYHISDS HVQAVSLSRV 850
LSSQAYLLFY ERML 864
Length:864
Mass (Da):96,666
Last modified:December 11, 2013 - v2
Checksum:i8600F3A72FCAF9C7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061V → M in AAI21231. 1 Publication
Sequence conflicti405 – 4051A → V in AAI21231. 1 Publication
Sequence conflicti452 – 4521L → Q in AAI21231. 1 Publication
Sequence conflicti495 – 4951I → T in AAI21231. 1 Publication
Sequence conflicti515 – 5151T → A in AAI21231. 1 Publication
Sequence conflicti529 – 5291L → I in AAI21231. 1 Publication
Sequence conflicti548 – 5481R → G in AAI21231. 1 Publication
Sequence conflicti572 – 5721V → G in AAI21231. 1 Publication
Sequence conflicti714 – 7141T → K in AAI21231. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAMC01089338 Genomic DNA. No translation available.
AAMC01089339 Genomic DNA. No translation available.
BC121230 mRNA. Translation: AAI21231.1.
RefSeqiNP_001072158.1. NM_001078690.1.
UniGeneiStr.20151.

Genome annotation databases

EnsembliENSXETT00000043701; ENSXETP00000043701; ENSXETG00000020255.
GeneIDi447956.
KEGGixtr:447956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAMC01089338 Genomic DNA. No translation available.
AAMC01089339 Genomic DNA. No translation available.
BC121230 mRNA. Translation: AAI21231.1 .
RefSeqi NP_001072158.1. NM_001078690.1.
UniGenei Str.20151.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000043701 ; ENSXETP00000043701 ; ENSXETG00000020255 .
GeneIDi 447956.
KEGGi xtr:447956.

Organism-specific databases

CTDi 10600.
Xenbasei XB-GENE-1007164. usp16.

Phylogenomic databases

eggNOGi COG5560.
GeneTreei ENSGT00750000117419.
HOGENOMi HOG000154755.
HOVERGENi HBG062704.
KOi K11844.
OMAi QCEDGEC.
TreeFami TF326075.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
HAMAPi MF_03062. UBP16.
InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiUBP16_XENTR
AccessioniPrimary (citable) accession number: Q0VA64
Secondary accession number(s): F7BZB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 11, 2013
Last modified: September 3, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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